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Öğe ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats(Pergamon-Elsevier Science Ltd, 2017) Cakir, Murat; Duzova, Halil; Tekin, Suat; Taslidere, Elif; Kaya, Gul Busra; Cigremis, Yilmaz; Ozgocer, TubaAim: In recent studies, it has been shown that the Transient Receptor Potential Melastatin-2 Channels (TRPM2) and Phospholipases A2 (PLA(2)) inhibitors may have a protective effect on neurons. This study was aimed to investigate the protective effect of TRPM2 and PLA(2) inhibitor N-(p-amylcinnamoyl) Anthranilic Acid (ACA) in a neurodegenerative model induced by Okadaic Acid (OKA). Main methods: OKA (200 ng/10 mu l) was administered bilateral intracerebroventricularly as a single injection. Key findings: OKA-treated rats showed significant impairments of spatial memory in Morris Water Maze Test. OKA-induced memory-impaired rats showed increased numbers of degenerated neurons and Caspase-3, tau phosphorylated ser396, beta-amyloid positive cells in the hippocampus and cerebral cortex. Furthermore, OKA-treated rats exhibited significantly increased MDA, TNF-alpha levels, and decreased SOD, GSH-PX enzyme activates and GSH levels of the tissues. ACA administration ameliorated OKA-induced memory impairment in rats. The ACA treatment also increased SOD and GSH-PX enzyme activation and GSH levels, and conversely decreased the levels of MDA, TNF-alpha. It was found that the numbers of the degenerated neurons and Caspase-3 positive cells of cortex and hippocampus regions were significantly reduced. Significance: ACA administration attenuates the oxidative stress and neuroinflammation of OKA-induced neurodegeneration; and ameliorates the cognitive decline and neurodegeneration. (C) 2017 Elsevier Inc. All rights reserved.Öğe Analysis of long-term antibody response in COVID-19 patients by symptoms grade, gender, age, BMI, and medication(Wiley, 2022) Ozgocer, Tuba; Dagli, Seyda N.; Ceylan, Mehmet R.; Disli, Faruk; Ucar, Cihat; Yildiz, SedatThe first aim of the study was to analyze the change in antibody titer at 15-day intervals until 60 days postsymptom onset (PSO). The second aim was to analyze the relationship between antibody titer and symptom grade, gender, age, body mass index (BMI), medications, vitamin supplements, and herbal therapies. Blood samples were collected from 43 patients (5 mild, 21 moderate, 17 severe diseases), 18 women (41.9%), and 25 men (58.1%), on 15, 30, 45, and 60 days PSO after COVID-19 infection. The serum antibody titers were determined by measuring the COVID-19 immunoglobulin G (IgG) antibodies by enzyme-linked immunoassay (ELISA). Associations between the duration of symptoms, demographic and clinical parameters, medications and vitamins used, and herbal therapies were evaluated by interviewing the participants. Within the first 15 days of illness, 81.4% of the patients were positive. From Day 45 PSO, seropositivity was 89.5%. The anti-SARS-CoV-2 antibody titers were statistically higher in men than women at all times (p < 0.01). Antibody titer was higher in older participants compared to younger participants (p < 0.02). Plaquenil or favipiravir use did not affect antibody response (p > 0.05). Men had a higher fever (p = 0.006), shortness of breath (p = 0.004), and chest pain (p = 0.03) than women. We found powerful antibody response by 60 days PSO, as well as higher antibody response and severity of symptoms in the men gender. Data also showed that SARS-CoV-2 antibodies are higher in individuals with older age, whereas BMI, concomitant chronic disease, and medications had no effect on antibody titers.Öğe Comparison of Cortisol Awakening Response, Estradiol and Progesterone Levels Between Normally Cycling and Premenopausal Women(Wiley, 2017) Ozgocer, Tuba; Ucar, Cihat; Yildiz, Sedat[Abstract Not Available]Öğe Cortisol Awakening Response and Heart Rate Variability in the Menstrual Cycle of Sportswomen(Routledge Journals, Taylor & Francis Ltd, 2021) Kayacan, Yildirim; Makaraci, Yucel; Ozgocer, Tuba; Ucar, Cihat; Yildiz, SedatPurpose: This study aimed to examine the activities of heart rate variability (HRV) and cortisol secretion as markers of the autonomous nervous system (ANS) and the hypothalamic-pituitary-adrenal axis (HPA) during the menstrual cycle in female athletes.Method: Saliva samples of the participants (n = 28) were collected successively at 0, 15, 30, and 60 min after awakening to assess cortisol awakening response (CAR) during each of four phases of the menstrual cycle (the menstruation, ovulation, luteal, and premenstrual phases). Diurnal saliva samples were collected at noon, in the evening (17:00) and 22:00 for cortisol analysis. HRV was measured in the menstrual and premenstrual phases at rest (12:00-14:00).Results: There was no difference betweenCARparameters in the menstrual phases.CARparameters and diurnal cortisol levels were significantly correlated with each other throughout the menstrual cycle. Mean cortisol was a strong predictor of the area under the curve (AUC: S = 0.042; R-Sq = 98.4%). Time-dependent parameters of HRV (standard deviation of the N-N interval [SDNN;P= .049] and the root mean square of the successive R-R differences [rMSSD;P= .038]) were significantly higher in the menstrual phase. There were no correlations betweenCARand HRV parameters.Conclusions: We suggest that the hypothalamic-pituitary-adrenal axis activity and the autonomic nervous system work in a separate manner that is not affected by the menstrual phases in sportswomen. The present study contributed to a better understanding of the relationship between the dynamics of cortisol release and the autonomic nervous system in different phases of the menstrual cycle in female athletes.Öğe Cortisol awakening response is blunted and pain perception is increased during menses in cyclic women(Pergamon-Elsevier Science Ltd, 2017) Ozgocer, Tuba; Ucar, Cihat; Yildiz, SedatBackground and aims: The incidence of menstrual symptoms is reported to be as high as 90% in cyclic women. These symptoms, including anxiety and pain, might be associated with cortisol, as its receptors are widely distributed in the brain areas associated with behavior. Therefore, the current study aimed to assess the cortisol awakening response (CAR) throughout the menstrual cycle and correlate it with pain perception and trait anxiety. Materials and methods: CAR was assessed by measuring salivary cortisol at 0, 15, 30, and 60 min following awakening in the same women (n = 59, age 22.2 +/- 0.37 years) at various stages of the menstrual cycle (menses, midcycle, luteal and premenstrual phases). Progesterone and estradiol concentrations were also determined in saliva samples to assess cyclic changes. Self-reported pain, trait anxiety, and menstrual symptoms were assessed by visual analog scale (VAS), state-trait anxiety inventory (STAI-T), and the Daily Record of Severity of Problems (DRSP), respectively. Results: Estradiol was significantly elevated during the midcycle period and remained high during the early luteal phase (p < 0.05). Progesterone was increased during the luteal phase (p < 0.05). Post awakening cortisol values increased during midcycle, luteal phase, and premenstrual phase (p < 0.05, classical CAR), but not during the menses (p > 0.05, blunted or flat CAR). Positive and significant correlations were found between cortisol and estradiol (R-2 = 0.322; p = 0.000), cortisol and progesterone (R-2 = 0.156; p = 0.000), and estradiol and progesterone (R-2 = 0.349; p = 0.001). Premenstrual symptom scores were higher in the menses and premenstrual phases than in the midcycle and luteal phases (p < 0.001). Pain perception was the highest during the menses followed by the premenstrual phase (p < 0.01). Conclusions: CAR was blunted during the menses, suggesting that cortisol might play a phase-specific role in the regulation of the cycle. Additionally, premenstrual symptoms, including pain, were more severe when ovarian steroid levels reduced (i.e., menses and the premenstrual phase). (C) 2016 Elsevier Ltd. All rights reserved.Öğe Cortisol awakening response is lower during menstrual stage in cyclic women with premenstrual syndrome(Wiley-Blackwell, 2016) Ozgocer, Tuba; Ucar, Cihat; Yildiz, Sedat[Abstract Not Available]Öğe Cortisol Awakening Response, Ovarian Steroids and Premenstrual Symptoms in Healthy Premenopausal Women(Wiley-Blackwell, 2016) Ozgocer, Tuba; Ucar, Cihat; Yildiz, Sedat; Barutcu, Ozlem[Abstract Not Available]Öğe Cytokines and Biochemical Parameters in rats Challenged Neonatally with Lipopolysaccharide and Fed Long-term with Fat-based diet(Wiley, 2017) Ucar, Cihat; Ozgocer, Tuba; Yildiz, Sedat[Abstract Not Available]Öğe Daily cortisol awakening response and menstrual symptoms in young females(Wiley, 2022) Ozgocer, Tuba; Ucar, Cihat; Yildiz, SedatMenstrual symptoms include some rhythmical changes and stress perception but women differ in duration and severity of these symptoms. It is not known whether these differences are associated with cortisol awakening response (CAR). The aim of the current study was to follow young women daily for the CAR and menstrual parameters throughout the whole menstrual cycle. Healthy and regularly cycling young women (n = 16, 17 to 31-year-old) participated in the current study. The daily records of severity of problems (DRSP) was filled in daily by the participants. CAR was also assessed daily form the salivary samples collected at a 0-, 15-, 30- and 60-min post-awakening. In terms of daily awakening cortisol profiles, women had either 2-20 (n = 3), or 20-200 (n = 8) or 200-2000 (n = 5) ng/ml cortisol according to the median levels throughout their cycle. CAR was weakly and negatively correlated with DRSP scores but strongly and positively with oestradiol (R-2 = 0.300; p = 0.000) and progesterone (R-2 = 0.490; p = 0.000) concentrations. Individuals with higher oestradiol and progesterone concentrations did not have high DRSP scores. In conclusion, CAR had a very high between-subject difference but had a low within-subject difference throughout the days of menstrual cycle, suggesting that CAR is a relatively stable personal trait. Moreover, the interplay between cortisol, progesterone and oestradiol appears to be important for the severity of menstrual symptoms.Öğe Decreased Sleep Duration Reduces Hypothalamo-pituitary-adrenal Axis Activity Without Affecting Autonomic Nervous System(Wiley-Blackwell, 2016) Ucar, Cihat; Ozgocer, Tuba; Yildiz, Sedat[Abstract Not Available]Öğe Development and validation of a corticosterone enzyme immunoassay for rat plasma(Wiley-Blackwell, 2016) Cakan, Pinar; Ozgocer, Tuba; Yildiz, Sedat[Abstract Not Available]Öğe Diurnal cortisol pattern rather than cortisol awakening response is higher during menstruation in cyclic women(Wiley-Blackwell, 2016) Ozgocer, Tuba; Ucar, Cihat; Yildiz, Sedat[Abstract Not Available]Öğe Does Maternal Viral Infection At A Critical Window Of Fetal Hypthalamic Nuclei Development Program Puberty And Gonadal Development In Male Rat Offsprings?(Wiley-Blackwell, 2015) Cakan, Pinar; Yildiz, Sedat; Ozgocer, Tuba; Yildiz, Azibe; Vardi, Nigar[Abstract Not Available]Öğe Does Psychodrama Affect Perceived Stress, Anxiety-Depression Scores and Saliva Cortisol in Patients with Depression?(Korean Neuropsychiatric Assoc, 2018) Erbay, Lale Gonenir; Reyhani, Ismail; Unal, Suheyla; Ozcan, Cemal; Ozgocer, Tuba; Ucar, Cihat; Yildiz, SedatObjective Little is known about the effects of psychodrama group therapy on the level of stress, anxiety and depression of the group members, and the biological markers of stress. The aim of this study test cortisol level as a biological reflection of some mental characteristics gained by the psychodrama method in coping with stress. Methods Depressive patients aged between 18 and 65 years, who diagnosed with depression according to DSM-5, without psychiatric comorbidity, who do not use drugs and were available for psychodrama were enrolled into the study. These patients were evaluated using the Perceived Stress Scale, State-Trait Anxiety Inventory and Beck Depression Inventory. In order to observe the circadian rhythm of cortisol, samples were collected from the participants before lunch, before dinner and before going to sleep on the day before psychodrama and on the 0, 15th, and 30th minutes after awakening in the morning of the psychodrama day; as well as just before and after the psychodrama session. Saliva cortisol level just before the initial session of psychodrama group therapy was compared with the saliva cortisol level just after the last psychodrama session at the end of 16 weeks. Results Statistically significant difference was determined between the scores of perceived stress scale, STAI-1, STAI-2, beck depression inventory and salivary cortisol level before and after psychodrama session. There was significant decrease in both the scale scores and salivary cortisol after vs. before psychodrama. Conclusion This results is important as it shows the biological aspect of clinical improvement. Further studies would provide us with better understanding of the effects of psychodrama group psychotherapy on depressive mood and biological projections by means of short-term and long-term follow-up studies.Öğe Does psychodrama affect perceived stress, anxiety-depression scores and saliva cortisol in patientswith depression?(Korean neuropsychıatrıc assoc, rn 522, g-fıve central plaza 1685-8 seocho 4-dong, seocho-gu, seoul, 137-882, south korea, 2018) Erbay, Lale Gonenir; Reyhani, Ismail; Unal, Suheyla; Ozcan, Cemal; Ozgocer, Tuba; Ucar, Cihat; Yildiz, SedatObjective Little is known about the effects of psychodrama group therapy on the level of stress, anxiety and depression of the group members, and the biological markers of stress. The aim of this study test cortisol level as a biological reflection of some mental characteristics gained by the psychodrama method in coping with stress. Methods Depressive patients aged between 18 and 65 years, who diagnosed with depression according to DSM-5, without psychiatric comorbidity, who do not use drugs and were available for psychodrama were enrolled into the study. These patients were evaluated using the Perceived Stress Scale, State-Trait Anxiety Inventory and Beck Depression Inventory. In order to observe the circadian rhythm of cortisol, samples were collected from the participants before lunch, before dinner and before going to sleep on the day before psychodrama and on the 0, 15th, and 30th minutes after awakening in the morning of the psychodrama day; as well as just before and after the psychodrama session. Saliva cortisol level just before the initial session of psychodrama group therapy was compared with the saliva cortisol level just after the last psychodrama session at the end of 16 weeks. Results Statistically significant difference was determined between the scores of perceived stress scale, STAI-1, STAI-2, beck depression inventory and salivary cortisol level before and after psychodrama session. There was significant decrease in both the scale scores and salivary cortisol after vs. before psychodrama. Conclusion This results is important as it shows the biological aspect of clinical improvement. Further studies would provide us with better understanding of the effects of psychodrama group psychotherapy on depressive mood and biological projections by means of short-term and long-term follow-up studies.Öğe The Effect of Daily Activities on the Activity of Stress Axes in Preschool Children(Wiley, 2023) Cevizci, Hediye; Barutcu, Ozlem; Cevizci, Nuri; Ozgocer, Tuba; Ucar, Cihat; Yildiz, Sedat; Gul, Mustafa[Abstract Not Available]Öğe Effects of Fasting in the Month of Ramadan on Circadian Cortisol Levels(Wiley-Blackwell, 2015) Ozgocer, Tuba; Ucar, Cihat; Yildirim, Hilal; Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Effects of late-night eating of easily-or slowly-digestible meals on sleep, hypothalamo-pituitary-adrenal axis, and autonomic nervous system in healthy young males(Wiley, 2021) Ucar, Cihat; Ozgocer, Tuba; Yildiz, SedatAim of the current study was to assess the effects of the digestibility of late-night high calorie meal on sleep and the activities of the hypothalamo-pituitary-adrenal (HPA) and autonomous nervous system (ANS) in healthy young males. For that purpose, effects of an easily digestible meal (starch + sugar-rich meal, SSR, i.e., dessert) or a slowly digestible meal (protein + fat-rich, PFR, i.e. kebab) were investigated in a crossover design in 16 participants (20-26 year old). They did not eat anything after 07:00 PM on Day 0; had an SSR meal on Day 1 and a PFR meal on Day 2 at 10:00 PM. HPA and ANS activities were measured by cortisol awakening response (CAR) and heart rate variability (HRV), respectively. The participants provided salivary samples for CAR; had a 5-min continuous electrocardiogram recording for HRV; and filled in sleep questionnaires. Late-night eating of SSR and PFR diets increased the area under the curve of CAR (p < 0.05) but did not affect HRV parameters (p > 0.05). PFR meal significantly disturbed sleep (p < 0.05). The data suggests that increased activity of HPA, but not ANS, might be involved in pathophysiology of late-night eating and that this might be due to disturbed sleep if slowly-digestible meal is consumed.Öğe Effects of Maternal and Post-Pubertal Endotoxin Exposure on Immune Stress and Gonadotropins in Female Rats(Wiley-Blackwell, 2015) Yildirim, Hilal; Ozgocer, Tuba; Yildiz, Sedat[Abstract Not Available]Öğe Effects of Maternal Viral Mimetic Administration on Reproductive System of Female Rat Offsprings(Wiley-Blackwell, 2015) Cakan, Pinar; Yildiz, Sedat; Yildiz, Azibe; Ozgocer, Tuba; Vardi, Nigar[Abstract Not Available]
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