Cortisol awakening response is blunted and pain perception is increased during menses in cyclic women
Küçük Resim Yok
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and aims: The incidence of menstrual symptoms is reported to be as high as 90% in cyclic women. These symptoms, including anxiety and pain, might be associated with cortisol, as its receptors are widely distributed in the brain areas associated with behavior. Therefore, the current study aimed to assess the cortisol awakening response (CAR) throughout the menstrual cycle and correlate it with pain perception and trait anxiety. Materials and methods: CAR was assessed by measuring salivary cortisol at 0, 15, 30, and 60 min following awakening in the same women (n = 59, age 22.2 +/- 0.37 years) at various stages of the menstrual cycle (menses, midcycle, luteal and premenstrual phases). Progesterone and estradiol concentrations were also determined in saliva samples to assess cyclic changes. Self-reported pain, trait anxiety, and menstrual symptoms were assessed by visual analog scale (VAS), state-trait anxiety inventory (STAI-T), and the Daily Record of Severity of Problems (DRSP), respectively. Results: Estradiol was significantly elevated during the midcycle period and remained high during the early luteal phase (p < 0.05). Progesterone was increased during the luteal phase (p < 0.05). Post awakening cortisol values increased during midcycle, luteal phase, and premenstrual phase (p < 0.05, classical CAR), but not during the menses (p > 0.05, blunted or flat CAR). Positive and significant correlations were found between cortisol and estradiol (R-2 = 0.322; p = 0.000), cortisol and progesterone (R-2 = 0.156; p = 0.000), and estradiol and progesterone (R-2 = 0.349; p = 0.001). Premenstrual symptom scores were higher in the menses and premenstrual phases than in the midcycle and luteal phases (p < 0.001). Pain perception was the highest during the menses followed by the premenstrual phase (p < 0.01). Conclusions: CAR was blunted during the menses, suggesting that cortisol might play a phase-specific role in the regulation of the cycle. Additionally, premenstrual symptoms, including pain, were more severe when ovarian steroid levels reduced (i.e., menses and the premenstrual phase). (C) 2016 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Cortisol awakening response, Menstrual cycle phase, Estradiol, Progesterone, Pain, Premenstrual symptoms
Kaynak
Psychoneuroendocrinology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
77
