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Öğe Anaesthesia Management of a Morbid Obese Woman Undergoing Transsphenoidal Hypophysectomy(Karger, 2018) Ozkan, Ahmet Selim[Abstract Not Available]Öğe Anesthesia management in sleeve gastrectomy: Single center experience(2018) Ozkan, Ahmet SelimAim: Sleeve gastrectomy surgery is performed by laparoscopic method and preferred by obesity surgeons, frequently. Because these patients are morbidly obese,many additional diseases are seen and anesthesia management is challenging for anesthesiologist. In this study, demographic and perioperative data of 23 patients undergoing sleeve gasterectomy surgery (SGS) in our hospital were presented. Material and Methods: This study was performed in 23 adult patients undervent SGS with laparoscopic bariatric surgery. The demographic and operative data, hemodynamics and blood glucose values of the cases were recorded at specified times. The data were evaluated by mean ± SD and the ranges of the data were also calculated. Results: The mean age of patients was 37.6±10.2 years.The mean body mass index was 45.8±5.4 kg/m2 . The mean duration of anesthesia was 153.3±65.6 min, and the mean duration of surgery was 136.6±63.8 min.There were no statistically differences in terms of heart rate and peripheral oxygen saturation. There was significant increase in mean arterial pressure at T3 when compared to T2(p=0,09). End-tidal carbon dioxide value significantly decreased at T2 when compared toT1(p<0,001) and significantly increased at T6 when compared toT5 (p=0,005). Blood glucose values were increased significantly at T2 and T7 when compared to T0 values (p<0,001). Conclusion: Anesthesia management of morbid obese patients is challenging for anesthesiologist, because the hemodynamic stability and hormonal values of the patients can be changed due to the increased BMI. Preoperative hemodynamics and blood glucose values should be closely monitored and necessary interventions should be applied considering the operation periods.Öğe Assessment of Sepsis Risk at Admission to the Emergency Department: Clinical Interpretable Prediction Model(Mdpi, 2024) Aygun, Umran; Yagin, Fatma Hilal; Yagin, Burak; Yasar, Seyma; Colak, Cemil; Ozkan, Ahmet Selim; Ardigo, Luca PaoloThis study aims to develop an interpretable prediction model based on explainable artificial intelligence to predict bacterial sepsis and discover important biomarkers. A total of 1572 adult patients, 560 of whom were sepsis positive and 1012 of whom were negative, who were admitted to the emergency department with suspicion of sepsis, were examined. We investigated the performance characteristics of sepsis biomarkers alone and in combination for confirmed sepsis diagnosis using Sepsis-3 criteria. Three different tree-based algorithms-Extreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), Adaptive Boosting (AdaBoost)-were used for sepsis prediction, and after examining comprehensive performance metrics, descriptions of the optimal model were obtained with the SHAP method. The XGBoost model achieved accuracy of 0.898 (0.868-0.929) and area under the ROC curve (AUC) of 0.940 (0.898-0.980) with a 95% confidence interval. The five biomarkers for predicting sepsis were age, respiratory rate, oxygen saturation, procalcitonin, and positive blood culture. SHAP results revealed that older age, higher respiratory rate, procalcitonin, neutrophil-lymphocyte count ratio, C-reactive protein, plaque, leukocyte particle concentration, as well as lower oxygen saturation, systolic blood pressure, and hemoglobin levels increased the risk of sepsis. As a result, the Explainable Artificial Intelligence (XAI)-based prediction model can guide clinicians in the early diagnosis and treatment of sepsis, providing more effective sepsis management and potentially reducing mortality rates and medical costs.Öğe The clinical and histopathological effects of perineural dexmedetomidine and in combination with sodium bicarbonate in sciatic nerve block in rabbits after sevoflurane anesthesia: A placebo controlled, randomized experimental study(2019) Akbas, Sedat; Ozkan, Ahmet Selim; Sevimli, Reşit; Alan, SaadetAim: Peripheral nerve blockade is a common regional anesthetic technique in surgical procedures in daily clinical practice. The aim of this experimental study was to compare perineural dexmedetomidine alone with perineural sodium bicarbonate added to dexmedetomidine for measurement of analgesia, sensorial and motor blockade and histopathologic evaluation. Material and Methods: Twenty-four rabbits were randomly allocated to 3 groups; Group S: sham, Group D: perineural dexmedetomidine (20 mcg/kg) and Group D+SB: perineural dexmedetomidine (20 mcg/kg) plus sodium bicarbonate. (8.4%, 0.125 mL). Analgesia measurement was evaluated by hotplate test, the paw withdrawal response was performed for sensorial and motor blockades, also were recorded at baseline, 30, 60, 90 and 120 min after drug administration. Dissected nerve tissue was also examined for histopathologic evaluation. Results: Latency times of Group D or Group D+SB were significantly longer when compared with Group S at 30, 60, 90 and 120 min. There was no significant difference between Group D and Group D+SB for the all scheduled times. Sensorial and motor blockade scores were similar in all groups. Group D or Group D+SB caused edema, inflammation with neutrophil leukocytes, and degeneration of myelin fibers, increased in vacuolization, granulation tissue and fibrosis. Conclusion: Perineural dexmedetomidine alone or in combination with sodium bicarbonate prolonged the duration of analgesia, but did not enhance the sensorial and motor blockade, when compared with placebo. Perineural dexmedetomidine combined with sodium bicarbonate didn’t enhance the blockage. Dexmedetomidine caused edema, inflammation and degeneration of myelin fibers, increased in granulation tissue and fibrosis.Öğe Comparison of effects of low-flow and normal-flow anesthesia on cerebral oxygenation and bispectral index in morbidly obese patients undergoing laparoscopic sleeve gastrectomy: a prospective, randomized clinical trial(Termedia Publishing House Ltd, 2019) Akbas, Sedat; Ozkan, Ahmet SelimIntroduction: The effects of low-flow anesthesia on cerebral oxygenation in high-risk, morbidly obese patients are not well known. Aim: In this prospective randomized study, we compared the effects of low-flow (0.75 l/min) and normal-flow (1.5 l/min) anesthesia on regional cerebral oxygen saturation (rSO(2)) and the bispectral index (BIS) in morbidly obese patients undergoing laparoscopic bariatric surgery. Material and methods: Fifty-two morbidly obese patients undergoing laparoscopic bariatric surgery (sleeve gastrectomy) were enrolled in this study. Patients were randomly allocated to two study groups: low flow and normal-flow anesthesia groups. Heart rate, mean arterial pressure, peripheral oxygen saturation, end-tidal carbon dioxide, BIS, left and right rSO(2) and duration of anesthesia and surgery were recorded. Results: The groups were similar with respect to age, gender, height, weight, body mass index, American Society of Anesthesiology physical status, heart rate, duration of anesthesia, and procedure. Mean arterial pressure and end-tidal carbon dioxide, both before and after insufflation of carbon dioxide and after the reverse Trendelenburg position, were significantly higher in the low-flow group. BIS values and left and right rSO(2) during the preoperative and intraoperative periods were similar. Although the difference in right rSO(2) between the two groups after awakening from anesthesia was statistically significant, the results of both groups remained within the normal range and were not clinically meaningful. Conclusions: Low-flow anesthesia is safe regarding hemodynamic and respiratory characteristics, depth of anesthesia, and regional cerebral oxygen saturation in morbidly obese patients undergoing laparoscopic bariatric surgery.Öğe A comparison of general versus regional anesthesia in patients over 100 years old: A retrospective cohort study(2021) Akbas, Sedat; Ozkan, Ahmet Selim; Korkmaz, Mehmet HakanAim: As the life expectancy maintains to rise, the number of centenarians applied for surgery is increasing. Functional and anatomical changes in elderly patients may cause postoperative morbidity and mortality. The aim of this retrospective cohort study is to analyze and compare general and regional anesthesia in centenarians underwent different surgeries. Material and Methods: Patients aged over 100 years (American Society of Anesthesiology scores of II–IV) were included in our study. The centenarians were divided into two study groups: general anesthesia (Group GA, n=20) and regional anesthesia (Group RA, n=18). The demographic characteristics, procedure, and hospital data were evaluated. Results: There were no significant differences betveen two groups with regards to gender, height, weight, body mass index, ASA scores, perioperative colloid and crystalloid fluid consumptions. Duration of anesthesia and procedure in Group RA was shorter than that in Group GA. The requirement for invasive arterial monitorization, central venous catheterisation, and nasogastric tube in Group GA was higher than that in Group RA. Postoperative delirium was similar in both groups. Heart rate, mean arterial pressure, and peripheral oxygen saturation were similar. In-hospitality mortality was 26.3% in the entire group of centenarians. Conclusions: This study examined the role of different anesthetic methods in extremely elderly patients over 100 years old during different surgeries. Anesthetic agent preferences, long duration of anesthesia and surgery, and hemodynamic instability can cause serious complications. We therefore conclude that careful considerations are required in extremely elderly patients.Öğe A comparison of laryngeal mask airway-supreme and endotracheal tube use with respect to airway protection in patients undergoing septoplasty: a randomized, single-blind, controlled clinical trial(Bmc, 2021) Karaaslan, Erol; Akbas, Sedat; Ozkan, Ahmet Selim; Colak, Cemil; Begec, ZekineBackground There are doubts among anesthesiologists on the use of the Laryngeal Mask Airway (LMA) in nasal surgeries because of concerns about the occurrence of blood leakages to the airway. We hypothesized that the use of LMA-Supreme (LMA-S) in nasal surgery is comparable with endotracheal tube (ETT) according to airway protection against blood leakage through the fiberoptic bronchoscopy, oropharyngeal leakage pressure (OLP), heart rate (HR), mean arterial pressure (MAP), and postoperative adverse events. Methods The present study was conducted in a prospective, randomized, single-blind, controlled manner on 80 patients, who underwent septoplasty procedures under general anesthesia, after dividing them randomly into two groups according to the device used (LMA-S or ETT). The presence of blood in the airway (glottis/trachea, distal trachea) was analyzed with the fiberoptic bronchoscope and a four-point scale. Both groups were evaluated for OLP; HR; MAP; postoperative sore throat, nausea, and vomiting; dysphagia; and dysphonia. Results In the fiberoptic evaluation of the airway postoperatively, less blood leakage was detected in both anatomic areas in the LMA-S group than in the ETT group (glottis/trachea, p = 0.004; distal trachea, p = 0.034). Sore throat was detected less frequently in the LMA-S group at a significant level in the 2nd, 6th, and 12th hours of postoperative period; however, other adverse events were similar in both groups. Hemodynamic parameters were not different between the two groups. Conclusion The present findings demonstrate that the LMA-S provided more effective airway protection than the ETT in preventing blood leakage in the septoplasty procedures. We believe that the LMA-S can be used safely and as an alternative to the ETT in septoplasty cases.Öğe A Comparison of McGrath MAC Versus C-MAC Videolaryngoscopes in Morbidly Obese Patients Undergoing Bariatric Surgery: A Randomized, Controlled Clinical Trial(Mary Ann Liebert, Inc, 2019) Akbas, Sedat; Ozkan, Ahmet Selim; Karaaslan, ErolIntroduction: Airway management in morbidly obese patients is a technical challenge for the anesthesiologists. In this study, we aimed to compare the McGrath MAC with C-MAC videolaryngoscopes for tracheal intubation in morbidly obese patients. Materials and Methods: Eighty morbidly obese patients, scheduled for bariatric surgery, were randomly allocated to two study groups: McGrath-MACA (R) and C-MACA (R). The preoperative airway assessment, incidence and attempts for successful intubation, time to intubation, position for successful intubation, percentage of glottic opening (POGO score), ease of intubation, hemodynamic response, and adverse events of tracheal intubation were recorded. Results: Incidence and attempts for successful intubation and position for successful intubation were similar. Time to intubation was significantly shorter in C-MAC than McGrath (p < 0.001). The POGO scores were similar in both groups (p = 0.057). The heart rate and mean arterial pressure of McGrath was significantly higher than C-MAC after tracheal intubation at first minute (p = 0.002). Also adverse events of tracheal intubation were similar. Conclusions: Both devices were efficient and improved the glottic view. However, the C-MAC demonstrated shorter tracheal intubation times, better glottic visualization, and less hemodynamic response than the McGrath. We, therefore, conclude that the C-MAC videolaryngoscope may contribute advantages in performing tracheal intubations in morbidly obese patients.Öğe Comparison of the effects of the McGRATH MAC, C-MAC, and Macintosh laryngoscopes on the intraocular pressures of non-ophthalmic patients: A prospective, randomised, clinical trial(Elsevier France-Editions Scientifiques Medicales Elsevier, 2021) Ozkan, Ahmet Selim; Akbas, Sedat; Karaaslan, Erol; Polat, NihatIntroduction: In this prospective, randomised study, we compared the effects of the Macintosh, McGRATH MAC, and C-MAC laryngoscopes on intraocular pressure (IOP) and [13_TD$DIFF]haemodynamics of non-ophthalmic patients during endotracheal intubation. Methods: [14_TD$DIFF]One hundred and twenty adult patients undergoing non[15_TD$DIFF]ophthalmic surgeries performed in the supine position under general [16_TD$DIFF]anaesthesia requiring orotracheal intubation [17_TD$DIFF]were included in this study. The patients were separated randomly and prospectively into 3 groups: Macintosh group (n = 40), McGRATH MAC group (n = 40), and C-MAC group (n = 40). Mean arterial pressure (MAP), heart rate (HR) and IOP of left and right eye were measured at specified times. Results: There were no significant differences with regard to patients characteristics. After intubation, the HR increased significantly in the Macintosh group when compared to the other groups ([18_TD$DIFF]p = 0.001) and the MAP increased significantly in the Macintosh group when compared to the McGRATH MAC group ([18_TD$DIFF]p = 0.001) and the C-MAC group ([19_TD$DIFF]p < 0.001). The IOP values increased in the Macintosh group when compared to the McGRATH MAC group ([20_TD$DIFF]p < 0.001) and the C-MAC group ([20_TD$DIFF]p < 0.001) after intubation. [21_TD$DIFF]Additionally, there was a significant difference between the McGRATH MAC group and C-MAC group in the IOP values of the eyes after intubation ([19_TD$DIFF]p < 0.001). According to the evaluation within the groups, there were significant differences in all of the groups at all times when compared with the baseline values ([19_TD$DIFF]p < 0.001). Conclusions: In this study, we concluded that the C-MAC VL may be preferable when compared to the Macintosh and McGRATH MAC laryngoscopes for use in ophthalmic patients in whom a rise in the IOP is undesirable. (C) 2021 Socie acute accent te acute accent franc , aise d'anesthe acute accent sie et de re acute accent animation (Sfar). Published by Elsevier Masson SAS. All rights reserved.Öğe Comparsion of %6 Hydroxyethyl Starch and %4 Gelatine Solutions in Major Surgery(Derman Medical Publ, 2015) Korkmaz, Mehmet Fatih; Ozkan, Ahmet Selim[Abstract Not Available]Öğe Dexmedetomidine, Remifentanil, and Sevoflurane in the Perioperative Management of a Patient During a Laparoscopic Pheochromocytoma Resection(W B Saunders Co-Elsevier Inc, 2015) Erdogan, Mehmet Ali; Ozkan, Ahmet Selim; Ozgul, Ulku; Colak, Yusuf; Ucar, Muharrem[Abstract Not Available]Öğe Difficult Airway Control in a Neonatal Patient with Oropharynx Mass(Medicine Science, 2016) Ozkan, Ahmet Selim; Ucar, Muharrem; Erdogan, Mehmet Ali; Firat, Cemal; Yucel, Aytac; Durmus, MahmutYıl: 2016Cilt: 5Sayı: supplement 1ISSN: 2147-0634Sayfa Aralığı: 155 - 157 Metin Dili: İngilizce Öz: Başlık (İngilizce): Öz (İngilizce): Tracheal intubation using direct laryngoscopy has become an essential part in the anesthesia management of the surgical patient. Big oropharynx mass can cause serious problems depending on their locations. Mass lesions of oropharynx may lead to difficult intubation. In this letter, we present a successful application of airway management with general anesthesia in a neonatal patient with big oropharynx mass.Öğe Difficult Airway Management in Field Conditions: Somalia Experience(Aves, 2015) Ozkan, Ahmet Selim; Nasir, Serdar NazifDifficult airway is defined as having the patient's mask ventilation or difficult tracheal intubation of an experienced anaesthesiologist. A number of reasons, such as congenital or acquired anatomical anomalies, can cause difficult intubation and difficult ventilation. Keeping all equipment ready for airway management of patients will reduce mortality and complications. In this case, it is intended that the submission of difficult airway management who encountered in mandibular reconstruction for mandible bone defect repairing with reconstruction plates before at the field conditions in Somalia.Öğe Difficult airway management of a child with Blepharophimosis Syndrome: Case report(2018) Ozkan, Ahmet Selim; Polat, Nihat; Akbas, Sedat; Koylu, Zeynep; Durmus, MahmutBlepharophimosis syndrome (BS) is a rare autosomal dominant syndrome characterized by eyelid malformations, and abnormal facial morphology. Flat and wide nasal roots, short neck, restricted mouth opening and neck extension, characteristic facial appearance, microcephaly and micrognathia make airway management of patients with BS important for anesthesiologists. Due to systemic pathologies and craniofacial anomalies, difficult airway may be seen in these patients and anesthesia management is important in patients with BS. Because of the difficult airway risk, it is important to determine the anesthetic method and make the necessary preparations. In this case report, we aimed to present difficult airway management of a patient with BS who underwent surgery for ocular disorders. This case report is the second case presented by successful airway management in general anesthesia practiceÖğe The effect of intracameral bevacizumab on current hyphema(2019) Polat, Nihat; Ozkan, Ahmet Selim; Parlakpınar, Hakan; Akpolat, NusretAbstract: Aim: The aim of this study was to investigate the effect of intracameral bevacizumab on the current hyphema.Material and Methods: The animals were assigned to the following 4 groups; Group 1: One 2.5 mg bevacizumab injection to theanterior chamber; Group 2: One 1.25 mg bevacizumab injection to the anterior chamber; Group 3: One 1cc balanced salt solutioninjection to the anterior chamber; and Group 4: Untreated hyphema group. Non-heparinized blood that obtained from the rabbit earwas used to fill the anterior chamber to create total hyphema. Intraocular pressures (IOP), hyphema resorption time, clot formation,peripheral synechia formation, and corneal staining were recorded.Results: IOP results were 26±1.2, 30±2.1, 24±2.9, and 22±0.0 mm Hg for groups 1, 2, 3, and 4, respectively, and were significantlyhigher in group 2 than in the other groups (p= 0.001). Resorption times of hyphema were 13±2.2, 13±3.2, 9±1.7, and 9±1.6 days forgroups 1, 2, 3, and 4, respectively, and were significantly longer for the groups receiving bevacizumab than for the others (p=0.018).The clot formation scores were 0.16±0.41, 0.14±0.38, 0.86±0.38, and 1.0±0.0 for groups 1, 2, 3, and 4, respectively, and weresignificantly lower for the groups receiving bevacizumab than in the other groups (p= 0.002). The peripheral synechia formationscores were 0.0±0.0, 0.0±0.0, 0.43±0.53, and 0.50±0.54 for groups 1, 2, 3, and 4, respectively, and were not significantly different (p=0.213). The corneal staining scores were 0.85±0.35, 0.86±0.38, 0.14±0.38, and 0.14±0.38 for groups 1, 2, 3, and 4, respectively, andwere significantly higher for the groups receiving bevacizumab (p= 0.035).Conclusion: Intracameral bevacizumab may increase complications that related current hyphema.Öğe The effect of intracameral bevacizumab on current hyphema(2019) Polat, Nihat; Ozkan, Ahmet Selim; Akbas, Sedat; Parlakpinar, Hakan; Akpolat, NusretAim: The aim of this study was to investigate the effect of intracameral bevacizumab on the current hyphema. Material and Methods: The animals were assigned to the following 4 groups; Group 1: One 2.5 mg bevacizumab injection to the anterior chamber; Group 2: One 1.25 mg bevacizumab injection to the anterior chamber; Group 3: One 1cc balanced salt solution injection to the anterior chamber; and Group 4: Untreated hyphema group. Non-heparinized blood that obtained from the rabbit ear was used to fill the anterior chamber to create total hyphema. Intraocular pressures (IOP), hyphema resorption time, clot formation, peripheral synechia formation, and corneal staining were recorded. Results: IOP results were 26±1.2, 30±2.1, 24±2.9, and 22±0.0 mm Hg for groups 1, 2, 3, and 4, respectively, and were significantly higher in group 2 than in the other groups (p= 0.001). Resorption times of hyphema were 13±2.2, 13±3.2, 9±1.7, and 9±1.6 days for groups 1, 2, 3, and 4, respectively, and were significantly longer for the groups receiving bevacizumab than for the others (p=0.018). The clot formation scores were 0.16±0.41, 0.14±0.38, 0.86±0.38, and 1.0±0.0 for groups 1, 2, 3, and 4, respectively, and were significantly lower for the groups receiving bevacizumab than in the other groups (p= 0.002). The peripheral synechia formation scores were 0.0±0.0, 0.0±0.0, 0.43±0.53, and 0.50±0.54 for groups 1, 2, 3, and 4, respectively, and were not significantly different (p= 0.213). The corneal staining scores were 0.85±0.35, 0.86±0.38, 0.14±0.38, and 0.14±0.38 for groups 1, 2, 3, and 4, respectively, and were significantly higher for the groups receiving bevacizumab (p= 0.035). Conclusion: Intracameral bevacizumab may increase complications that related current hyphema.Öğe The effect of perineural application of bupivacaine combined with sodium bicarbonate on the synatic nerve block in rabbits after sevofluran anesthesia(2020) Sevimli, Reşit; Ozkan, Ahmet Selim; Akbas, Sedat; Alan, Saadet; Turkmen, ErsenAim: The aim of this study was to investigate the effect of combining sodium bicarbonate with bupivacaine on prolonging peripheral nerve block time.Material and Method: Following the approval of the required Ethics Committee, 24 male New Zealand rabbit (4250-5350 g) were randomized and divided into three groups. Group 1 sham n:8; Group 2 (bupivacaine): 0.5 mL of 0.5% bupivacaine (0.5 mg / kg) injected into the perineural area. n:8; and Group 3 (bupivacaine + sodium bicarbonate): 0.5 ml of 0.5% bupivacaine + sodium bicarbonate (125 ml of 8.4% injected into the perineural area. n: 8. After the skin was closed in all groups, the paw pull response was monitored and recorded every 30 minutes until the sensory block of the experimental animal returned back. Hot-plate test was used for analgesia evaluation. In addition, tissue histopathology was examined for histopathological evaluation of the injection site. Sensory block was evaluated with claw tightening test and claw pull test (hot-plate) response. The measurements were carried out every 30 minutes for 120 minutes or until the block was completely resolved.Results: 30., 60. and 90.min paw pull response in Group 2 and Group 3 showed statistically significant elongation when compared to Group 1, this difference disappeared in 120 minutes. Compared to the sham group, the 30 min hot plate and claw pull response was significantly longer in group 3 (sodium bicarbonate and bupivacaine), this difference disappeared in 60 minutes (p = 0.018).Conclusion: When sodium bicarbonate and bupivacaine are combined, it was seen in this study that the sensory block was prolonged. We believe that the current results can be used as a guide for future studies.Öğe The Effect of Sevoflurane Anesthesia on the Corneal Endothelium(2017) Polat, Nihat; Ozkan, Ahmet Selim; Gunduz, Abuzer; Ulucan, Pamuk Betul; Colak, CemilAim: To evaluate the mean changes in corneal endothelial cells in eyes that operated under sevoflurane general anesthesia.Öğe Effects of preemptive intravenous paracetamol and ibuprofen on headache and myalgia in patients after electroconvulsive therapy A placebo-controlled, double-blind, randomized clinical trial(Lippincott Williams & Wilkins, 2019) Karaaslan, Erol; Akbas, Sedat; Ozkan, Ahmet Selim; Zayman, Esra PorgaliBackground: The aim of this study is to determine the efficacy of preemptive analgesia with paracetamol and ibuprofen to reduce the intensity and incidence of headache and myalgia after electroconvulsive therapy (ECT). Methods: Sixty patients with major depression who were treated with ECT were randomized to receive ECT 3 times a week. The first 3 sessions were included in the study. The patients were divided into 3 groups; Group C (Control, Saline, n = 20), Group P (Paracetamol, n = 20), and Group I (Ibuprofen, n = 20). Demographics, duration of seizure, visual analog scale (VAS) for headache and myalgia and nausea, vomiting and pruritus were evaluated at postoperative 24 hours period. Results: Duration of seizure after ECT was similar in all groups (P=.148). In the study, heart rate and mean arterial pressure were found to be some changes in some of the sessions. There were no significant differences in any comparison for all groups in all sessions regarding VAS scores for headache and myalgia. Incidence of headache and myalgia in Group I was lower than the other groups (P=.233, P=.011, respectively). But, there was no significant difference between the other groups. There was no significant difference in vomiting, intergroups, and intragroup. Conclusions: The findings of our study indicate that pain intensity of headache and myalgia did not show a significant change between groups and within groups. While pain intensity of myalgia between the groups reached no statistical significance, ibuprofen was significantly lowered the incidence of myalgia at postoperative 24 hours period.Öğe The Effects of Secondhand Smoke Exposure on Postoperative Pain and Ventilation Values During One-Lung Ventilation: A Prospective Clinical Trial(W B Saunders Co-Elsevier Inc, 2019) Ozkan, Ahmet Selim; Ucar, Muharrem; Akbas, SedatObjectives: To investigate the relationships between secondhand smoke (SHS) exposure and oxygenation during one-lung ventilation (OLV) in lobectomy surgery and between SHS exposure and postoperative analgesic consumption. Design: Prospective study. Setting: University, Faculty of Medicine, operating room. Participants: Sixty adult patients with American Society of Anesthesiologists score II to III, aged 18 to 65 years, with a body mass index (BMI) <35 kg/m(2) scheduled for lobectomy surgery by open thoracotomy. Interventions: Patients were divided into 2 groups: the SHS group (n = 30) (urine cotinine level >= 6.0 ng/mL) and the NS (nonsmoker) group (n = 30) (urine cotinine level <6.0 ng/mL and no smoking history). SHS exposure was defined according to a previously published algorithm. Measurements and Main Results: Noninvasive blood pressure, electrocardiography, capnography, and peripheral oxygen saturation were monitored, and intra- and postoperative arterial oxygen tension (PaO2), arterial carbon dioxide tension (PaCO2), and intraoperative peak airway pressure were compared between the 2 groups. Postoperative analgesic consumption was calculated. No significant differences in demographics or preoperative data were noted between the 2 groups. PaO2 values 10 minutes after OLV onset and 10 minutes after the end of OLV were increased significantly in the NS group compared with those in the SHS group (p < 0.05). PaO2 values after 10 minutes of OLV in the NS and SHS groups were 285.5 +/- 90 mmHg and 186.7 +/- 66 mmHg, respectively. PaO2 values after OLV termination in the NS and SHS groups were 365.8 +/- 58 mmHg and 283.6 +/- 64 mmHg (p < 0.05), respectively. PaCO2 values 10 minutes after OLV onset, 10 minutes after the end of OLV, at the end of surgery, and upon arrival in the intermediate care unit were significantly different between the 2 groups (p < 0.05). Conclusion: The present study demonstrated that during OLV, patients exposed to SHS exhibited significantly lower arterial oxygen pressure compared with nonsmokers. Arterial carbon dioxide values were increased significantly in SHS-exposed patients. Morphine consumption for postoperative analgesia also was increased in patients exposed to SHS compared with that in nonsmokers. (C) 2018 Elsevier Inc. All rights reserved.
