The clinical and histopathological effects of perineural dexmedetomidine and in combination with sodium bicarbonate in sciatic nerve block in rabbits after sevoflurane anesthesia: A placebo controlled, randomized experimental study
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Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Peripheral nerve blockade is a common regional anesthetic technique in surgical procedures in daily clinical practice. The
aim of this experimental study was to compare perineural dexmedetomidine alone with perineural sodium bicarbonate added to
dexmedetomidine for measurement of analgesia, sensorial and motor blockade and histopathologic evaluation.
Material and Methods: Twenty-four rabbits were randomly allocated to 3 groups; Group S: sham, Group D: perineural dexmedetomidine
(20 mcg/kg) and Group D+SB: perineural dexmedetomidine (20 mcg/kg) plus sodium bicarbonate. (8.4%, 0.125 mL). Analgesia
measurement was evaluated by hotplate test, the paw withdrawal response was performed for sensorial and motor blockades,
also were recorded at baseline, 30, 60, 90 and 120 min after drug administration. Dissected nerve tissue was also examined for
histopathologic evaluation.
Results: Latency times of Group D or Group D+SB were significantly longer when compared with Group S at 30, 60, 90 and 120 min.
There was no significant difference between Group D and Group D+SB for the all scheduled times. Sensorial and motor blockade
scores were similar in all groups. Group D or Group D+SB caused edema, inflammation with neutrophil leukocytes, and degeneration
of myelin fibers, increased in vacuolization, granulation tissue and fibrosis.
Conclusion: Perineural dexmedetomidine alone or in combination with sodium bicarbonate prolonged the duration of analgesia,
but did not enhance the sensorial and motor blockade, when compared with placebo. Perineural dexmedetomidine combined with
sodium bicarbonate didn’t enhance the blockage. Dexmedetomidine caused edema, inflammation and degeneration of myelin fibers,
increased in granulation tissue and fibrosis.
Açıklama
Anahtar Kelimeler
Kaynak
Annals of Medical Research
WoS Q Değeri
Scopus Q Değeri
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Künye
Akbas, S., Selim Ozkan, A., Sevimli, R., & Alan, S. (2021). The clinical and histopathological effects of perineural dexmedetomidine and in combination with sodium bicarbonate in sciatic nerve block in rabbits after sevoflurane anesthesia: A placebo controlled, randomized experimental study . Annals of Medical Research
