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    Comparison of the dental serial patch test outcomes of lichen planus patients with and without oral involvement
    (Deri Zuhrevi Hastaliklar Dernegi, 2015) Altunisik, Nihal; Sener, Serpil; Sarac, Gulbahar Ceylan
    Background and Design: Lichen planus (LP) is a chronic and enflammatory cutaneous disease. Numereous diseases and agents have been accused in the etiology of LP. The materials used in dental treatment are one of these factors. We aimed to compare the results of dental series patch test in LP patients with and without oral involvement to determine whether the dental restorative materials play a role in the etiology of LP and to detect the effect of dental materials in cases where there is no oral involvement. Materials and Methods: The study involved a total of 38 patients who were admitted to the Dermatology Department and Dentistry Faculty Oral and Maxillofacial Surgery Department and were diagnosed with LP clinically and/or histopathologically. Nineteen of patients had oral involvement and the other 19 patients had no oral involvement. All of the patients received dental serial patch test. Results: Fourteen of the 19 patients with oral involvement (73.7%) and 15 patients without oral involvement (78.9%) showed positive reaction against at least one material. There was no statistically significant difference between the groups in terms of patch test positivity (p= 1.00). The allergens that mostly caused positive reaction against patch test in the group with oral involvement were copper sulfate and cobalt (II) cloride hexahydrate (23.3%). In the group without oral involvement the most common allergen that caused positive reaction was copper sulfate (% 47.3). Conclusion: The similarity of the allergens that caused positive reaction and the rate of positivity in dental serial patch test in the groups with and without oral involvement promote that the dental restorative materials may trigger the disease even in cases without oral LP. This study is a preliminary study due to the lack of a healthy control group and the small number of subjects.
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    The effects of Ankaferd, a hemostatic agent, on wound healing
    (Deri Zuhrevi Hastaliklar Dernegi, 2015) Sezgin, Sevgi Ozbaysar; Sarac, Gulbahar Ceylan; Samdanci, Emine; Senol, Mustafa
    Background and Design: There have been a lot of topical and systemic agents to provide an ideal scar formation and to decrease the periods of wound healing process by affecting the factors of healing (inflammatory cells, thrombocytes, extracellular matrix etc.). In this study, we investigated the effects of Ankaferd on wound healing. Materials and Methods: Wounds were created with 8 mm punch biopsy knots on the back of 32 rats which were separated into 4 groups of 9 rats. No treatment was done in group D which was the control group while group A received topical Ankaferd treatment twice a day; group B treated with silver sulfadiazine twice a day, and group C put on base cream, which did not include any active agent, twice a day. The rats were followed for 15 days macroscopically and examined histopathologically on days 0., 3., 7., and 15. by taking biopsy specimens. Result: At the end of our study, it was detected that Ankaferd accelerated the healing process in comparison to control and base cream groups according to the macroscopic and histopathologic results. Additionally, similar to this situation, it was observed that the healing process in silver sulfadiazine group was faster than in control and base cream groups. Conclusion: More experimental and clinical studies in larger populations are needed to prove and confirm its efficacy.