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    Bioactivity guided fractionation for investigation of antidiabetic activity on the different Origanum species from the Brevifilamentum section
    (Marmara Univ, Fac Pharmacy, 2025) Tanriverdi, Basak; Sen, Ali; Sadikoglu, Narin; Bitis, Leyla
    The aim of this study was to evaluate antidiabetic activities of Origanum bargyli (OB), Origanum haussknechtii (OH), Origanum rotundifolium (OR) species from Brevifilamentum section of genus Origanum and to investigate their roles in diabetes with the support of their antioxidant effects. Antidiabetic activities on OB, OH, and OR were investigated for the first time in the present study. DPPH and ABTS radicals scavenging, alpha-glucosidase inhibition methods were performed for antioxidant, antidiabetic activities, respectively. OB (12.70 and 32.62 mu g/mL) and OR (10.61 and 32.28 mu g/mL) exhibited strong antioxidant activity against DPPH and ABTS radicals with remarkable IC50 values. The amounts of total phenolic and total flavonoid compounds of OB, OH and OR were 67.55, 68.97, 68.93 mg/g and 48.46, 40.54 and 62.28 mg/g, respectively. Whereas OH and OR showed IC50 values of 259 and 404 mu g/mL for antidiabetic activity, OB was found to be the most antidiabetic active species, showing more significant inhibitory activity against alpha-glucosidase enzyme than the standard with an IC50 value of 204.20 mu g/ml. Therefore, the OB ethanol extract was fractionated with solvents of different polarity (hexane, chloroform and ethyl acetate, respectively). In the fractions of OB species, chloroform fraction(OBC) showed a much higher inhibitory activity against alpha-glucosidase enzyme with an IC50 value of 126.50 mu g/mL compared to the standard acarbose (261.7 mu g/mL) and was found to be the most antidiabetic active fraction. These results suggest that OB species with significant antidiabetic and antioxidant activity may play a good potential role in developing new herbal medicines against diabetes.
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    THE IMPACT OF EXTERNAL SHOCKS ON TOURISM SECTOR: THE CASE OF TURKEY
    (Ekonomski Fak Sveucilista, Katedra Trgovinu & Turizam, 2007) Karagoz, Murat; Sen, Ali; Kocyigit, Ali
    The objective of this study is to assess the temporal impacts on Turkey's tourist arrivals. An econometric strategy is selected to determine the existence of unit roots in data series containing the quarterly number of tourist arrivals between 1993:1 and 2005:3. The present study finds that the data series contain deterministic trend and seasonal components together with detected structura! changes. Hence any form of exogenous shocks, will not have permanent impact on Turkey's tourist arrivals.
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    THE IMPACT OF FOREIGN DIRECT INVESTMENT INFLOWS ON THE PERFORMANCE OF ECONOMIC GROWTH: EVIDENCE FROM SELECTED DEVELOPING COUNTRIES
    (Editura Ase, 2014) Sen, Ali; Senturk, Mehmet; Ozkan, Gokcen
    In this study, developing countries which are Argentina, Brazil, Thailand and Turkey were analyzed over the period of 1980-2011 in order to determine whether there is a cointegration relationship between those countries' Foreign Direct Investment (FDI) inflows and Gross Domestic Product (GDP) growth. In this context, at first panel unit root analysis (LLC and IPS) and then Pedroni panel cointegration analysis were applied. All of the series were I(1) at the end of the stationary tests. In addition, null hypothesis imply that cointegration was rejected and alternative hypothesis which was state cointegration is accepted. It is concluded that there is a significant relationship between FDI inflows and GDP growth of Argentina, Brazil, Thailand and Turkey over the period of 1980-2011.
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    Myrtus communis reduces radiation-induced genitourinary histopathological damage and apoptosis in rats: TROD-GROG-004
    (Marmara Univ, Fac Medicine, 2025) Ozkurt, Selnur; Dogan, Bedriye; Ozyilmaz, Nagehan; Aykac, Asli; Ertas, Busra; Sen, Ali; Ceylan, Cemile
    Objective: To investigate the radioprotective and prophylactic effects of Myrtus communis (MC) in kidney, bladder, and ovary samples in an animal model. Materials and Methods: Female rats (n=30) were divided into four groups. The control group (C) (n=6) received only oral saline (SF) for four days. Ionizing radiation (IR) groups were organized as follows: IR group (IR) (n=8) received oral SF for four days starting on the day of administration; MC treatment group (MC-tx) (n=8) received oral MC for four days beginning on the day of irradiation; and MC pretreatment group (MC-Ptx) (n=8) received oral MC for a total of eight days, starting four days before irradiation. MC was administered via oral gavage. Irradiation was performed at 10 Gray (Gy) in a single dose. On the fourth day of irradiation, all rats were sacrificed, the tissues were examined histopathologically, and caspase-9 and caspase-3 levels were examined using western blotting to assess mitochondrial apoptosis. Results: Radiation-induced damage decreased across all treatment groups. Caspase-9 and caspase-3 levels were significantly lower in the MC-Ptx and MC-tx groups compared to the IR group in all tissues (p<0.01). Conclusion: Myrtus communis significantly ameliorated IR-induced damage to genitourinary tissues by both prophylactic and therapeutic applications. Therefore, the findings of this study may contribute to the development of new strategies in radioprotection.