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Öğe A case of sporotrichosis treated with itraconazole(Taylor & Francis Ltd, 2003) Ozcan, A; Senol, M; Karaca, S; Sener, S; Polat, M; Ozerol, IHLymphocutaneous sporotrichosis is caused by Sporothrix schenckii, a dimorphic fungus commonly existing on decaying plants and in the soil. The fungus has a worldwide distribution but is more prevalent in temperate and tropical climates. Infection may result from traumatic inoculation of contaminated material such as soil, hay, moss, plant debris, splinters, thorns and barbs. Inoculation is also possible through some animal scratches and bites. We describe a typical case of lymphocutaneous sporotrichosis, which was confirmed by clinical, histological and microbiological features. The patient was successfully treated with 400 mg daily systemic itraconazole for 4 months.Öğe Disseminated lupus vulgaris and papulonecrotic tuberculid: Case report(Blackwell Science Inc, 2000) Senol, M; Ozcan, A; Aydin, A; Karincaoglu, Y; Sasmaz, S; Sener, SThe incidence of tuberculosis and extrapulmonary forms of this disease is increasing all over the world. Lupus vulgaris is the most prevalent form of cutaneous tuberculosis in Europe and the Middle East, Papulonecrotic tuberculid, the most common form of hyperergic response to mycobacteria or their fragments, is uncommon in children. We report lupus vulgaris with papulonecrotic tuberculid in a 12-year-old girl who had a 3-year history of slowly growing plaques on her trunk, extremities, and the tip of her nose and papuloulcerative lesions over her entire body. A skin biopsy specimen showed minimally caseating granulomatous inflammation, Staining for acid-fast bacilli was negative in both plaques and papules. Polymerase chain reaction identified Mycobacterium tuberculosis DNA in the patient's sputum, gastric fluid, and plaques and was negative in the papules. She was started on antituberculous therapy with four drugs and her lesions responded rapidly.Öğe Fox-Fordyce disease(European Acad Dermatology & Venereology, 2003) Ozcan, A; Senol, M; Aydin, NE; Karaca, S; Sener, S[Abstract Not Available]Öğe In vitro and in vivo acetylcholinesterase-inhibiting effect of new classes of organophosphorus compounds(Wiley, 1999) Ozmen, M; Sener, S; Mete, A; Kucukbay, HAnticholinesterase properties of 14 new synthesized organophosphorus (OP) compounds and four of their starting substances were tested in vitro and in vivo using electric eel acetylcholinesterase (AChE) and Rana ridibunda (frog of lowland) tadpoles, respectively. Gusathion-M(R) was used as a reference anti-AChE agent. Acetylcholinesterase inhibition capacity of tested compounds was assayed for 30-min period in vitro studies using electric eel AChE, of which 14 OP compounds inhibited enzyme activity more than 50% within 30 min, excluding Gusathion-M. However, four of the compounds inhibited AChE less than 50% during the test period. On the other hand, 12 of the OPs did not bring about mortality, whereas six of the tested compounds were found to be lethal agents for R. ridibunda tadpoles, for which values of concentration causing 50% lethality ranged from 14.42 to 89.95 ppm. Also, the highest degree of enzyme inhibition occurred by diethyl chlorophosphate (ETCP), which inhibited AChE activity 62% at 2.89 ppm in 24-h toxicity tests and which was more effective than Gusathion-M. The lethal OP compounds represented good correlation between dose and enzyme-inhibition capability in in vivo tests, but only ETCP showed such a relation for anti-AChE effect in both in vitro and in vivo conditions.Öğe Natural pyrophyllite and M(OR)x based MxOy powders as new adsorbents for heavy metal adsorption(Trans Tech Publications Ltd, 2004) Erdemoglu, M; Sayilkan, F; Erdemoglu, S; Sener, S; Akarsu, M; Sayilkan, HHeat treated hydrolysis-condensation products of aluminiumtri-sec-butoxide (Al(OBus)(3)) and alcohol modified Al(OBus)(3) were synthesised by sol-gel process. These synthetic powders, natural pyrophyllite and their 3-mercaptoprophyltrimethoxysilane coated forms were utilised as adsorbents for the removal of Cu(II) ions from aqueous solutions. The adsorption increased when natural and synthetic powders coated with SH-Si were used. It was concluded that the dried powders obtained from the hydrolysis-condensation product of Al(OBus)(3) and its alcohol modified form, and coated pyrophyllite would substitute for Amberlite IR 120 Na form resin.Öğe New adsorbents from Ti(OPrn)4 by the sol-gel process: Synthesis, characterization and application for removing some heavy metal ions from aqueous solution(Tubitak Scientific & Technological Research Council Turkey, 2004) Sayilkan, F; Sayilkan, H; Erdemoglu, S; Sener, S; Akarsu, MNew adsorbents were synthesized by the sol-gel process from the product of a hydrolysis reaction and its coated form of titanium(IV)-n-propoxide for removing some heavy metal ions from aqueous solution. Titanium(IV)-n-propoxide was uncatalyst hydrolyzed with different amounts of water at room temperature and was found to react in a 1:1.6 ratio (mole of Ti:mole of H2O). It was found that the condensation following the hydrolysis reflection was alcohol condensation. The hydrolysis-condensation product was characterized in detail by GC. Karl-Fischer coulometric titrator, NIR-spectroscopy, FT-IR spectroscopy, TG-DTA and elemental analysis. The hydrolysis-condensation product of titanium(TV)-n-propoxide was calcinated at 900degreesC after drying at 100degreesC and some of this product was coated with hydrolyzed NH2-functional silanes [3-(2-aminoethylamino)ethylamino)propyl-trimethoxy silane] (Amino-and [3-(2-aminoethylamino)propylmethyldimetoxysilane] (Amino-2), separately. Adsorption capacities of uncoated and NH2-functional silane coated hydrolysis-condensation products for Fe3+, Cu2+ and Pb2+ ions in aqueous solution were investigated by FAAS. It was observed that the extent of adsorption was influenced significantly by the type and concentrations of coating materials, e.g., Amino-1 coated adsorbent prepared in methyl alcohol as 50% (w/w) and 100% (without methyl alcohol) adsorbed 90-67% and 100% of Fe3+, respectively. while the uncoated form adsorbed only 5%. The adsorption isotherm was determined and the data were analyzed according to the Freundlich model.Öğe New phosphorylated derivatives of piperidine and pyrrolidine(Marcel Dekker Inc, 1997) Sener, S; Mete, APhosphorylation reactions of piperidine and pyrrolidine with dialkyl chlorophosphates are described. Expected products are obtained in good yields at room temperature.Öğe Organo-functional modified pyrophyllite: preparation, characterisation and Pb(II) ion adsorption property(Elsevier, 2004) Erdemoglu, M; Erdemoglu, S; Sayilkan, F; Akarsu, M; Sener, S; Sayilkan, HSurface modification of clay minerals has become increasingly important for improving the practical applications of clays such as fillers and adsorbents. In this study, the surface of pyrophyllite mineral was modified by coating with 3-(2-aminoethylamino) propyl-methyidimethoxysilane (APMDS) coupling agent and utility of the APMDS-modified pyrophyllite was investigated as an adsorbent for removal of Pb(II) ions from aqueous solutions. XRD, FT-IR and SEM analysis were used to characterise the surface modification and it was suggested that hydrogen bonding takes place between the hydroxyl groups and/or oxygen atoms within the structure of pyrophyllite and hydroxyl groups of APMDS. The APMDS-modified pyrophyllite adsorbed approximately 93% of Pb(II) ions at an initial concentration of 20 mg/l, while natural pyrophyllite did only 35% under the same conditions. The adsorption of Pb(II) increased with increasing pH and reached a maximum value in the pH range 6.5-7. The effects of various factors on the adsorption, such as pH of the solution, contact time, amount of adsorbent and initial Pb(II) concentration, were studied. The adsorption isotherm has been determined and data have been analysed according to the Langmuir model and found to be favourable, i.e., the separation parameter is less than unity (R-L < 1). (C) 2003 Elsevier B.V. All rights reserved.Öğe Removal of inorganic-organic bound Cu(II) from different aqueous solutions by new adsorbents synthesized by sol-gel process(Taylor & Francis Inc, 2004) Erdemoglu, S; Sayilkan, F; Emre, FB; Akarsu, M; Sener, S; Sayilkan, HHydrolysis product of alcohol modified titanium(IV)-n-propoxide and its coated form were prepared as new and regenerable adsorbents for adsorbing and removing Cu(II) ions from its different aqueous solutions. The hydrolysis and alcoholysis products and adsorbents were characterized using GC, H-1-NMR, FT-IR, SEM, and TG-DTA analysis. It was found that Cu(II) ion adsorption rather increased when hydrolysis product of alcohol modified titanium(IV)-n-propoxide was coated with prehydrolyzed 3-mercaptopropyltrimethoxy silane in n-propanol and this coated material was used as adsorbent. Depending on the results of experiments performed at optimum conditions of initial Cu(II) concentration, amount of adsorbent, contact time, and pH, maximum adsorption of Cu(II), i.e., >98% has been achieved under the non-competitive conditions, while almost 60% is achieved under the competitive conditions of Pb(II), Zn(II), Fe(III), and alkali and earth alkali metals. It was also concluded that Cu(II) adsorption efficiency is not affected from the media containing acetate, tannic acid, or Turkish Blue dye. The adsorbent was easily regenerated with 5 N HNO3 solution and used over and over again for the adsorption of Cu(II) ions.Öğe The removal of Pb2+, Cu2+ and Fe3+ from aqueous solution by a new adsorbent synthesized from Ti(OPrn)4 by sol-gel process(Parlar Scientific Publications (P S P), 2003) Erdemoglu, S; Sayilkan, F; Akarsu, M; Sener, S; Sayilkan, HRemoval of Cu(II), Pb(II) and Fe(III) ions from aqueous solutions was studied by using a new adsorbent synthesised by hydrolysis and subsequent condensation of Ti(OPrII)(4) by sol-gel process. Metal ion adsorption was highly increased when the adsorbent surface was covered with a coating solution of hydrolysed NH2- and SH-functional silanes prepared in methanol. Adsorption conditions for Cu, Pb and Fe ions were optimized. It was concluded that Cu was retained to 100% on SH-functional silane coated adsorbents, whereas Fe(III) and Pb(II), 89% and 100%, resp., on NH2-functional silane coated adsorbents.Öğe The risk of coronary heart disease in men with androgenetic alopecia(Elsevier Science Bv, 1999) Sasmaz, S; Senol, M; Ozcan, A; Dogan, G; Tuncer, C; Akyol, O; Sener, SBackground The meaningful association of androgenetic alopecia and coronary heart disease has been well documented, but few studies have focused on the importance of lipid parameters, such as total cholesterol, triglycerides, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, lipoprotein (a), apolipoprotein A1 and apolipoprotein B in patients with androgenetic alopecia. Objective The aim of this study is to investigate the relation between androgenetic alopecia and coronary heart disease and to determine the significance of certain lipid parameters on this relationship. Subjects Forty-one men with vertex type androgenetic alopecia (study group) and 36 men, age-matched, with normal hair status (control group) were the subjects of this study. Results We found significant differences in serum lipoprotein (a) and triglyceride levels between the study and control groups (P < 0,05). Forty-seven percent of patients and 30% of controls had a lipoprotein (a) level more than 30 mg/dl higher than the level critical for atherosclerotic heart disease. Conclusion Dermatologists should investigate lipid profile, especially lipoprotein (a), of patients with androgenetic alopecia and refer to a cardiologist if necessary. (C) 1999 Elsevier Science B.V. All rights reserved.Öğe The sol-gel synthesis and application of some anticorrosive coating materials(Consultants Bureau, 2003) Sayilkan, H; Sener, S; Sener, E; Sülü, MOn the basis of organic-inorganic monomers, we develop new coatings aimed at the protection of iron and aluminum surfaces against the action of atmospheric and chemical factors. The coatings are first sprayed and then polymerized. The quality of the coatings and their chemical resistance are checked in natural and model media according to the ASTM standard. In most cases, the durability of the coatings is satisfactory.Öğe Surface modification of pyrophyllite with amino silane coupling agent for the removal of 4-nitrophenol from aqueous solutions(Academic Press Inc Elsevier Science, 2004) Sayilkan, H; Erdemoglu, S; Sener, S; Sayilkan, F; Akarsu, M; Erdemoglu, MThe surface of naturally hydrophobic mineral pyrophyllite was modified to hydrophilic by treatment with prehydrolyzed N-(2-aminoethyl)3-ammopropyltrimethoxysilane (APEO) coupling agent to prepare a novel and effective adsorbent for the removal of 4-nitrophenol (4-NP) from aqueous solutions. XRD, FTIR, and SEM analyses were used to characterize the surface modification. It was found that after the grafting procedure, heat treatment at 110 degreesC results in condensation reaction between the OH groups of the APEO molecule and the hydroxyl groups and/or oxygen atoms on the pyrophyllite surface and the adsorption of 4-NP by APEO-modified pyrophyllite involves interactions between dissociated 4-NP molecules and protonated amine groups of APEO molecules attached to the mineral surface. Adsorption equilibrium data for 4-NP adsorption on APEO-treated and untreated pyrophyllite were most satisfactorily fitted using the Freundlich adsorption isotherm and adsorption capacity was found to be 0.268 mg/g for modified pyrophyllite whereas it was only 0.105 mg/g for untreated pyrophyllite. (C) 2004 Elsevier Inc. All rights reserved.Öğe The synthesis and application of new adsorbents for removal of heavy metal ions and phenols from aqueous solution(Parlar Scientific Publications (P S P), 2003) Sener, S; Sayilkan, F; Erdemoglu, SB; Akarsu, M; Sayilkan, HIn this study, a TiO2 adsorbent powder was synthesized from Titan (IV)-n-propoxyallyl acetoacetate by the sol-gel process. This powder and its coated forms (SH-and NH2- functional silanes) were investigated for their phenol, p-chlorophenol, Cu2+, Ph2+ and Zn2+ adsorption. It was found that Pb2+ and Zn2+ adsorption on the adsorbent coated with NH2-functional silane and Cu2+, Pb2+ adsorption on the adsorbent coated with SH-functional silane were nearly complete.Öğe Synthesis of some heterocyclic phosphonates and their antibacterial and antifungal activities(Council Scientific & Industrial Res, 1999) Mete, A; Sener, S; Kücükbay, H; Günal, S; Durmaz, RFifteen heterocyclic phosphonate derivatives and their starting compounds have been evaluated in vitro for antibacterial and antifungal activities against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and yeast-like fungi; Candida albicans and Candida tropicalis. The compounds newly synthesised have been identified by H-1-NMR, FT-IR and micro analysis. Among the tested compounds 12, 13, 16, 17, 18, 22 and 23 are found effective to inhibit the growth of Candida albicans and Candida tropicalis at the MICs between 100-800 mu g/mL. The compounds tested here generally do not exhibit considerable antibacterial activity at the concentration studied (100-800 mu g/mL), except compound 18 which exhibits antibacterial activity against gram-positive bacteria at the MIC of 400 mu g/mL.Öğe Synthesis of some new sol-gel derived metal-organic compounds and their hydrolysis-condensation reactions(Chemical Soc Japan, 2000) Sener, S; Sayilkan, H; Sener, EThis work comprised the following parts: a) hydrolysis of Ti(OEt)(4) and Zr(OPr)(4) with different amounts of water, b) complexation of the same alkoxides with varying amounts of 2-methylbutanoic and 3-methylbutanoic acids, and c) hydrolysis of complexation products with varying amounts of water. All reactions were carried out at room temperature. The complex products were [Ti(OEt)(3.2)(2-MBA)(0.8)], [Ti(OEt)(3.2)(3-MBA)(0.8)], [Zr(OPr)(2.5)(2-MBA)(1.5)], and [Zr(OPr)(3.3)(3-MBA)(0.7)] (2-MBA: 2-methylbutanoate, 3-MBA: 3-methylbutanoate). The products were characterized by H-1 NMR, FT-IR, and elemental analysis. While Ti(OEt)(4), [Ti(OEt)(3.2)(2- MBA)(0.8)], and [Ti(OEt)(3.2)(3-MBA)(0.8)] were hydrolyzed with 1.30, 1.28, and 1.30 mol of water, Zr(OPr)(4), [Zr(OPr)(2.5)(2-MBA)(1.5)], and [Zr(OPr)(3.3)(3-MBA)(0.7)] were hydrolyzed with 2.0, 0.96, and 1.10 mol of water, respectively. These products were characterized by gas chromatography (GC), Karl-Fischer coulometric titrations, and thermal analysis.Öğe Two novel adsorbents synthesized by sol-gel process for removing of 4-nitrophenol from aqueous solutions(Parlar Scientific Publications (P S P), 2005) Sayilkan, F; Sener, SIn this work, a new titanium alkoxide complex [titanium(IV)-n-propoxide-(4-nitrophenoxide)] was synthesized by the reaction between titanium(IV)-n-propoxide [Ti(OPrn)(4)] and 4-nitrophenol (4-NP) in different mole ratios at room temperature. GC, FT-IR and H-1-NMR analyses showed that each Ti(OPrn)4 mole reacts with 2 moles of 4-NP in maximum. This complex was hydrolyzed with 2 moles water per mole of Ti(OPrn)4, and hydrolysis products were characterized by thermal analyses and FT-IR. The optimum conditions for the adsorption of 4-NP on the calcinated powder from its aqueous solutions were determined. Adsorption experiments showed that the calcinated powder is a quite suitable material for the removal of 4-NP.
