Yazar "Shahbazi, Fatemeh" seçeneğine göre listele

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    EVALUATION OF THE YIELDS AND ANTIOXIDANT ACTIVITIES OF ESSENTIAL OILS, FIXED OILS AND EXTRACTS OBTAINED USING CONVENTIONAL METHODS FROM NIGELLA SATIVA L. AND NIGELLA DAMASCENA L. SEEDS
    (University of Ankara, 2026) Çaprak, Burak Emre; Shahbazi, Fatemeh; Torun, Zehra
    Objective: Yields and antioxidant properties of essential oils, fixed oils, and extracts from Nigella sativa L. and Nigella damascena L. seeds were evaluated using conventional extraction methods with solvents of different polarity. Material and Method: The seeds from both species were divided into three segments for the production of fixed oil, essential oil, and essential oil from extracts. Fixed oils and extracts were obtained using Soxhlet extraction with n-hexane, petroleum ether, acetone, chloroform, and methanol, followed by hydrodistillation using a Clevenger apparatus to obtain essential oils from the extracts. Essential oils were also obtained from powdered seeds by hydrodistillation. Oils and extract yields were calculated, and antioxidant activities were evaluated using DPPH. and ABTS+ assays. Result and Discussion: For both species, the continuous extraction method with n-hexane produced the highest yield and the essential oils were obtained only from these extracts. Notably, extracting the essential oil directly from the seed resulted in low yields. N. sativa exhibited higher essential oil yields than N. damascena; however, the obtained yields were inadequate for activity studies. Antioxidant assays revealed that the ABTS⁺ method was more discriminative, with acetone extracts showing higher activity. Overall, N. sativa demonstrated greater antioxidant activity compared to N. damascena. © 2026, University of Ankara. All rights reserved.
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    Smart Ocular Drug Delivery Systems: Design Principles and Recent Advances
    (Hacettepe University, Faculty of Pharmacy, 2025) Çaprak, Burak Emre; Shahbazi, Fatemeh; Öztürk, Naile
    The effective treatment of ocular diseases is confronted by various factors, including ocular barriers, limited drug bioavailability, invasive procedures, and low patient compliance. Moreover, new ocular delivery systems have only overcome these problems to a certain extent. In response, smart ocular drug delivery systems have gained attention due to their ability to enable modified drug release along with the additional features they provide to the delivery system, the drug, and the treatment. Smart materials (endogenous and exogenous stimuli responsive) allow the carrier systems to exhibit a variety of properties. Studies on smart ocular drug delivery systems are relatively new and the interest in exogenous stimuli sensitive smart materials has increased in recent years. Therefore, in this review we focused on scientific advancements of these technologies to present a clear understanding of design principles which is key to developing more efficient and reliable ocular drug delivery systems. This review covers ocular barriers, diseases, drug delivery routes, conventional and novel ocular delivery systems along with a focus on the achievements of the smart ocular drug delivery systems developed in recent years. Special emphasis was given to the improved, reduced, or enabled properties of these drug delivery systems. © 2025, Hacettepe University, Faculty of Pharmacy. All rights reserved.