Smart Ocular Drug Delivery Systems: Design Principles and Recent Advances
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hacettepe University, Faculty of Pharmacy
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The effective treatment of ocular diseases is confronted by various factors, including ocular barriers, limited drug bioavailability, invasive procedures, and low patient compliance. Moreover, new ocular delivery systems have only overcome these problems to a certain extent. In response, smart ocular drug delivery systems have gained attention due to their ability to enable modified drug release along with the additional features they provide to the delivery system, the drug, and the treatment. Smart materials (endogenous and exogenous stimuli responsive) allow the carrier systems to exhibit a variety of properties. Studies on smart ocular drug delivery systems are relatively new and the interest in exogenous stimuli sensitive smart materials has increased in recent years. Therefore, in this review we focused on scientific advancements of these technologies to present a clear understanding of design principles which is key to developing more efficient and reliable ocular drug delivery systems. This review covers ocular barriers, diseases, drug delivery routes, conventional and novel ocular delivery systems along with a focus on the achievements of the smart ocular drug delivery systems developed in recent years. Special emphasis was given to the improved, reduced, or enabled properties of these drug delivery systems. © 2025, Hacettepe University, Faculty of Pharmacy. All rights reserved.
Açıklama
Anahtar Kelimeler
Endogenous stimuli, Exogenous stimuli, Ocular delivery, Smart materials
Kaynak
Hacettepe University Journal of the Faculty of Pharmacy
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
45
Sayı
2
