Yazar "Simsek, Omer Yavuz" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim Yok
    Öğe
    Amniotic fluid urocortin-1 concentrations for the prediction of preterm delivery
    (Wiley, 2013) Karaer, Abdullah; Celik, Ebru; Celik, Onder; Simsek, Omer Yavuz; Ozerol, Ibrahim Halil; Yilmaz, Ercan; Turkcuoglu, Ilgin
    Aim The aim of this study was to analyze whether urocortin-1 concentration in midtrimester amniotic fluid could serve as an indicative marker of preterm labor. Material and Methods A retrospective cohort study was conducted. Urocortin-1 concentrations in midtrimester amniotic fluid were measured in 22 pregnant women with preterm deliveries and 45 women who delivered at term using enzyme-linked immunosorbent assay. Results The median amniotic fluid urocortin-1 concentration was significantly lower in the women with preterm birth (40.06pg/mL; range, 13.77-67.58pg/mL) than in the women who gave birth at term (49.56pg/mL; range, 26.25-175.9pg/mL; P=0.022). The result of receiver-operator curve analysis indicates that an amniotic fluid urocortin-1 concentration57.88pg/mL had an area under the curve of 0.673 (95% confidence interval, 0.55-0.78; P=0.01) with a sensitivity of 81.8%, specificity of 40.0%, positive predictive value of 40%, and a negative predictive value of 82% in identifying which of the patients subsequently delivered prematurely. Conclusions These results suggest that low urocortin-1 concentration in midtrimester amniotic fluid could be used as an indicative marker of preterm birth.
  • Küçük Resim
    Öğe
    Is there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status
    (2019) Yildirim, Engin; Derici, Mehmet Kursat; Simsek, Omer Yavuz; Demir, Emre
    Aim: Endometrial polyps are frequently associated with abnormal uterine bleeding. The kispeptin family is one of the peptides that play a role in reproductive functions and whose expression varies in various uterine pathologies. The aim of the study was to determine the relationship between serum Kisspeptin levels and endometrial polyps in women with premenopausal status.Material and Methods: The blood was collected prior to endometrial sampling from women admitted to the hospital due to abnormal uterine bleeding. According to the pathology results, patients were identified as polyp group (n=38) (endometrial polyps) and control group (n=50) (normal endometrial findings). Kisspeptin-54 levels were determined by ELISA method from serum obtained from venous blood. Results: There were no difference was found between the patients’ age, body mass index, gravida, para, abortus and the number of living children were compared (p>0.05). There was no statistically significant difference between the groups in terms of follicle stimulating hormone, luteinizing hormone and thyroid stimulating hormone values (p>0.05). Plasma kisspeptin (1.84±0.93 ng/dL and 1.32±0.47 ng/dL, p= 0.008) and estradiol (90.34±13.02 pg/mL and 81.75±12.36 pg/mL, p=0.002) levels were significantly higher in the polyp group than in the control group. After the Receiver Operating Characteristic (ROC) analysis the area under the curve (AUC) was 1.26 (p= 0.08), (95% CI, 0.550-0.782). The sensitivity value was 0.684 (0.512-0.819), the specificity was 0.620 (0.471-0.750).Conclusion: The serum Kisspeptin-54 and estradiol levels were found higher in patients with endometrial polyps.Keywords: Abnormal uterine bleeding; endometrial polyps; kisspeptin.
  • Küçük Resim Yok
    Öğe
    Prediction of spontaneous preterm delivery in women with preterm labor: Analysis of interleukin-17, migration inhibitory factor, monocyte chemotactic protein-1 in maternal serum and cervicovaginal fluid
    (Walter De Gruyter Gmbh, 2012) Karaer, Abdullah; Celik, Onder; Dogan, Cagdas; Ozerol, Ibrahim Halil; Simsek, Omer Yavuz; Celik, Ebru; Ozerol, Elif
    Background: To analyze whether, interleukin (IL)-17, migration inhibitory factor (MIF), monocyte chemotactic protein (MCP)-1 in maternal serum and cervicovaginal fluid, can identify women in preterm labor with intact membranes who will deliver spontaneously within 7 days of sampling. Material and Methods: Forty-four (44) singleton pregnancies between 26-34 weeks of gestation that had threatened preterm labor, enrolled from October 2010 and October 2011. Cervical length was evaluated with transvaginal ultrasonography. Serum and cervicovaginal fluid IL-17, MIF, and MCP-1 were measured with the use of enzyme linked immune assay. Subjects were followed up for premature delivery within 7 days. Results: Seventeen of 44 patients (39%) had preterm delivery and 15 of 44 (34%) delivered within 7 day from admission. The only significant predictor for establishment of preterm delivery within 7 days was cervical length. The median cervical length was 18 mm (range: 5-27) in women who delivered in 7 days and 27 mm (range: 9-44) in women who delivered beyond 7 days of presentation (p-0.001). There was no association between serum and cervicovaginal fluid IL-17, MIF and MCP-1 levels and preterm delivery within 7 days. Conclusions: Cervical length could serve as a predictive factor for the progress of threatened preterm labor to true preterm labor. Serum and cervicovaginal fluid IL-17, MIF and MCP-1 can not be used to differentiate true preterm labor.
  • Küçük Resim Yok
    Öğe
    The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study
    (Galenos Yayincilik, 2021) Yildirim, Engin; Turkler, Can; Gorkem, Umit; Simsek, Omer Yavuz; Yilmaz, Ercan; Aladag, Hulya
    Objective: Endometrial hyperplasia (EH) is considered an endometrial cancer precursor. This study aimed to determine the role of oxidative stress and thiol groups with antioxidant properties in EH pathogenesis. Materials and Methods: In our prospective case-control study, participants were washed with 5 mL of saline before the endometrial biopsy. Endometrial washing fluid was taken into microtubules, and thiol and disulfide levels were analyzed using the Ellman reagent. Results: A total of 108 patients were in the EH group and 84 patients in the control group. The total and native thiol levels were higher values in the control group (p<0.001, for both). Disulfide levels were higher in the EH group (p<0.001). Native/total thiol ratio and disulfide/total thiol ratio were higher in the EH group (p<0.001, for both). The analysis performed in the control group revealed a significant positive correlation between estradiol and disulfide levels (r=0.322, p=0.033). No significant correlation was found between estradiol and disulfide in the EH group. Conclusion: Oxidative stress level was higher in the washing fluids of patients with EH and this stress plays a role in the EH etiology.