Prediction of spontaneous preterm delivery in women with preterm labor: Analysis of interleukin-17, migration inhibitory factor, monocyte chemotactic protein-1 in maternal serum and cervicovaginal fluid
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walter De Gruyter Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: To analyze whether, interleukin (IL)-17, migration inhibitory factor (MIF), monocyte chemotactic protein (MCP)-1 in maternal serum and cervicovaginal fluid, can identify women in preterm labor with intact membranes who will deliver spontaneously within 7 days of sampling. Material and Methods: Forty-four (44) singleton pregnancies between 26-34 weeks of gestation that had threatened preterm labor, enrolled from October 2010 and October 2011. Cervical length was evaluated with transvaginal ultrasonography. Serum and cervicovaginal fluid IL-17, MIF, and MCP-1 were measured with the use of enzyme linked immune assay. Subjects were followed up for premature delivery within 7 days. Results: Seventeen of 44 patients (39%) had preterm delivery and 15 of 44 (34%) delivered within 7 day from admission. The only significant predictor for establishment of preterm delivery within 7 days was cervical length. The median cervical length was 18 mm (range: 5-27) in women who delivered in 7 days and 27 mm (range: 9-44) in women who delivered beyond 7 days of presentation (p-0.001). There was no association between serum and cervicovaginal fluid IL-17, MIF and MCP-1 levels and preterm delivery within 7 days. Conclusions: Cervical length could serve as a predictive factor for the progress of threatened preterm labor to true preterm labor. Serum and cervicovaginal fluid IL-17, MIF and MCP-1 can not be used to differentiate true preterm labor.
Açıklama
Anahtar Kelimeler
Cervical length, interleukin-17, migration inhibitory factor, monocyte chemotactic protein-1, preterm birth
Kaynak
Turkish Journal of Biochemistry-Turk Biyokimya Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
37
Sayı
2
