Yazar "Sireci, Nihat" seçeneğine göre listele
Listeleniyor 1 - 19 / 19
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe 1,3-Difurfurylbenzimidazolium chloride monohydrate(Wiley-Blackwell, 2009) Akkurt, Mehmet; Sireci, Nihat; Deniz, Selma; Kucukbay, Hasan; Buyukgungor, OrhanThe title compound, C17H15N2O2+center dot Cl-center dot H2O, was synthesized from benzimidazole and furfryl chloride in dimethylformamide. The cationic benzimidazolium ring is connected to two furan rings via methylene bridges. The furan rings make dihedral angle of 79.09 (18)degrees with respect to each other, and make dihedral angles of 73.92 (12) and 72.58 (13)degrees with respect to the benzimidazole ring. O-H center dot center dot center dot Cl, C-H center dot center dot center dot O and C-H center dot center dot center dot Cl hydrogen bonds and C-H center dot center dot center dot pi interactions contribute to the stabilization of the crystal structure. Furthermore, there is a pi-pi interaction between adjacent five- and six-membered rings of the benzimidazole groups [centroid-centroid distance = 3.5305 (8) angstromÖğe 1-(Prop-2-en-1-yl)-3-[(trimethylsilyl)methyl]benzimidazolium bromide monohydrate(Int Union Crystallography, 2010) Baktir, Zeliha; Akkurt, Mehmet; Sireci, Nihat; Kucukbay, HasanIn the title compound, C14H21N2Si+center dot Br-center dot H2O, the benzimidazole ring system is almost planar [maximum deviation = 0.021 (2) angstrom]. In the crystal, O-H center dot center dot center dot Br and C-H center dot center dot center dot O hydrogen bonds link the ions via the O atoms of the water molecules. In addition, there are pi-pi stacking interactions between the centroids of the benzene and imidazole rings of the benzimidazole ring system [centroid-centroid distances = 3.521 (3) and 3.575 (2) angstrom].Öğe 1-Benzyl-3-[(trimethylsilyl)methyl]benzimidazolium chloride monohydrate(Wiley-Blackwell, 2010) Akkurt, Mehmet; Celik, Ismail; Kucukbay, Hasan; Sireci, Nihat; Buyukgungor, OrhanThe title compound, C(18)H(23)N(2)Si(+)center dot Cl(-)center dot H(2)O, was synthesized from 1-[(trimethylsilyl)methyl]benzimidazole and benzyl chloride in dimethylformamide. The benzimidazole ring system is approximately planar, with a maximum deviation of 0.022 (2) angstrom, and makes an angle of 74.80 (12)degrees with the phenyl ring. The crystal packing is stabilized by O-H center dot center dot center dot Cl, C-H center dot center dot center dot Cl, C-H center dot center dot center dot O and C-H center dot center dot center dot pi interactions between symmetry-related molecules together with pi-pi stacking interactions between the imidazolium and benzene rings [centroid-centroid distance = 3.5690 (15) angstrom] and between the benzene rings [centroid-centroid distance = 3.7223 (14) angstrom].Öğe 1-cyclohexylmethyl-3-methyl-2-[(phenyl-imino)(sulfido)methyl]benzimidazolium(Int Union Crystallography, 2008) Akkurt, Mehmet; Karaca, Selvi; Kucukbay, Hasan; Sireci, Nihat; Buyukgungor, OrhanIn the zwitterionic title compound, C22H25N3S, the benzimidazole ring system makes a dihedral angle of 55.69 (11) degrees with the phenyl ring. In the crystal structure, inter- and intramolecular C-H center dot center dot center dot S interactions occur.Öğe 1-{[Dimethyl(phenyl) silyl] methyl}-3-(2-phenylethyl)-1H-benzimidazol-3-ium bromide monohydrate(Int Union Crystallography, 2012) Akkurt, Mehmet; Kucukbay, Hasan; Sireci, Nihat; Buyukgungor, OrhanThe title compound, C24H27N2Si+center dot Br-center dot H2O, was synthesized from 1-(dimethylphenylsilylmethyl)-1H-benzimidazole and (2-bromoethyl) benzene in dimethylformamide. The benzimidazole ring system is nearly planar, with a maximum deviation of 0.015 (5) angstrom, and forms dihedral angles of 73.0 (3) and 39.6 (2)degrees, with the phenyl rings. In the crystal, molecules are linked by O-H center dot center dot center dot Br, C-H center dot center dot center dot Br and C-H center dot center dot center dot O hydrogen bonds. In addition, the structure features pi-pi stacking interactions, with a face-to-face separation of 3.644 (3) angstrom between parallel benzimidazole ring systems.Öğe Crystal Structure of Dichloridobis[5-nitro-1-trimethylsilylmethyl-1H-benzimidazole-?N3] cobalt (II) N,N-dimethylformamide solvate.(Int Union Crystallography, 2010) Yalcin, Serife Pinar; Akkurt, Mehmet; Sireci, Nihat; Kucukbay, Hasan; Tahir, M. Nawaz[Abstract Not Available]Öğe Dichloridobis[5-nitro-1-trimethylsilylmethyl-1H-benzimidazole-?N3]cobalt(II) N,N-dimethylformamide solvate(Int Union Crystallography, 2010) Akkurt, Mehmet; Yalcin, Serife Pinar; Sireci, Nihat; Kucukbay, Hasan; Tahir, M. NawazThe title compound, [CoCl2(C11H15N3O2Si)(2)]center dot C3H7NO, was synthesized from 5-nitro-1-trimethylsilylmethyl-1H-benzimidazole and cobalt(II) chloride in dimethylformamide. The Co-II atom is coordinated in a distorted tetrahedral environment by two Cl atoms and two N atoms. In the crystal structure, there are a number of C-H center dot center dot center dot Cl and C-H center dot center dot center dot O hydrogen-bonding interactions between symmetry-related molecules.Öğe (E)-1,1?-Bis[(E)-but-2-enyl]-3,3?-(propane-1,3-diyl)bis(1H-benzimidazol-3-ium) dibromide monohydrate(Wiley-Blackwell Publishing, Inc, 2008) Akkurt, Mehmet; Yildirim, Sema Oeztuerk; Sireci, Nihat; Kuecuekbay, Hasan; Bueyuekguengoer, OrhanThe title compound, C(25)H(30)N(4)(2+)center dot 2Br(-)center dot H(2)O, was synthesized from 1,1'-propylenedibenzimidazole and (E)-1-bromobut-2-ene in dimethylformamide solution. The two benzimidazole ring systems are essentially planar, with maximum deviations of 0.011 (4) and 0.023 (3) angstrom. The dihedral angle between these two ring systems is 25.87 (15)degrees. The crystal structure is stabilized by intermolecular O-H center dot center dot center dot Br and C-H center dot center dot center dot Br hydrogen-bonding interactions. Atmospheric water was incorporated into the crystal structure.Öğe Evaluation of in vitro and in vivo toxic effects of newly synthesized benzimidazole-based organophosphorus compounds(Academic Press Inc Elsevier Science, 2013) Gungordu, Abbas; Sireci, Nihat; Kucukbay, Hasan; Birhanli, Ayse; Ozmen, MuratThis paper reports the toxic properties of eight newly synthesized benzimidazole-based organophosphorus (OP) compounds in Xeno pus laevis in both in vivo and in vitro conditions. For both experiments, a commercial solution of azinphos methyl (AzM, Gusathion M WP25) was used as a reference compound. The 24-h median lethal concentrations (LC50) of all tested compounds were determined for 46th stage tadpoles in the range of 9.54-140.0 mu M. For evaluation of the lethality of the compounds, the activity of the enzyme biomarkers acetylcholinesterase (AChE), carboxylesterase, glutathione S-transferase (GST), glutathione peroxidase, glutathione reductase, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase were determined in vivo in X. laevis tadpoles exposed to three concentrations (LC50, LC50/2, and LC50/4) of tested compounds. All exposure concentrations of AzM and seven of eight tested compounds caused CaE inhibition in in vivo conditions. Furthermore, the AChE inhibition capacity of tested compounds in commercial electric eel AChE and in X. laevis homogenates and also CaE inhibition capacity in only X. laevis homogenates were assayed for a 30-min in vitro exposure period. Eight OP compounds did not inhibit AChE activity more than 23 percent, but AzM exposure inhibited AChE activity by 26 percent for X. laevis homogenates and 97 percent for electric fish AChE in in vitro conditions. Also. CaE inhibition levels in X. laevis tadpole homogenates were 46 percent for AzM and between 8 percent and 33 percent for other compounds in in vitro conditions. (C) 2012 Elsevier Inc. All rights reserved.Öğe Microwave Assisted Catalytic Activity of Some bis-5(6)-Nitrobenzimidazole Salts for Heck and Suzuki Cross-Coupling Reactions(Asian Journal Of Chemistry, 2010) Sireci, Nihat; Yilmaz, Ulku; Kucukbay, HasanA mixture of bis-5(6)-nitrobenzimidazole salts (2a-h), Pd(OAc)(2) and K2CO3 in DMF-H2O catalyzes, in good yield the Suzuki and Heck cross-coupling reactions for synthesis of biaryl and stilbene derivatives assisted by microwave irradiation in the short time.Öğe Microwave Assisted Suzuki-Miyaura and Ullmann Type Homocoupling Reactions of 2-and 3-Halopyridines Using a Pd(OAc)2/Benzimidazolium Salt and Base Catalyst System(Mdpi, 2013) Yilmaz, Ulku; Deniz, Selma; Kucukbay, Hasan; Sireci, NihatA number of novel benzimidazole derivatives 1-4 were synthesized and the catalytic activity of these compounds in a catalytic system consisting of a benzimidazolium salt/Pd(OAc)(2)/K2CO3 were investigated in the Suzuki-Miyaura and Ullmann type homocoupling reactions under microwave irradiation. We obtained both cross coupling and homocoupling products of pyridine and some side products such as dimethylaminopyridine and unsubstituted pyridine.Öğe Preparation and characterization of trimethylsilyl-substituted benzimidazole metal complexes and structural characterization of dichlorobis[1-(trimethylsilyl)methyl-1H-benzimidazole-N3]cobalt(II)(Taylor & Francis Ltd, 2010) Sireci, Nihat; Kucukbay, Hasan; Akkurt, Mehmet; Yalcin, Serife Pinar; Tahir, M. Nawaz; Ott, HolgerThe ligands 1-trimethylsilylmethylbenzimidazole, 5-methyl-1-trimethylsilylmethylbenzimidazole, and 5-nitro-1-trimethylsilylmethylbenzimidazole and their Co(II) and Zn(II) complexes were synthesized and characterized by 1H-NMR, 13C-NMR, and elemental analyses. The crystal structure of dichlorobis[1-(trimethylsilyl)methyl-1H-benzimidazole-N3]cobalt(II) has been determined by single crystal X-ray diffraction.Öğe Synthesis and microwave-assisted catalytic activity of novel bis-benzimidazole salts bearing furfuryl and thenyl moieties in Heck and Suzuki cross-coupling reactions(Wiley-Blackwell, 2010) Yilmaz, Uelkue; Sireci, Nihat; Deniz, Selma; Kucukbay, HasanA mixture of bis-benzimidazole salts (1-7), Pd(OAc)(2) and K(2)CO(3) in DMF-H(2)O catalyzes, in high yield, the Suzuki and Heck cross-coupling reactions assisted by microwave irradiation in a short time. In particular, the yields of the Heck and Suzuki reactions with aryl bromides were found to be nearly quantative. The synthesized bis-benzimidazole salts (1-7) were identified by (1)H-(13)C NMR, IR spectroscopic methods and micro analysis. Copyright (C) 2010 John Wiley & Sons, Ltd.Öğe Synthesis of 1-substituted benzimidazole metal complexes and structural characterization of dichlorobis(1-phenyl-1H-benzimidazole-?N3)cobalt(II) and dichlorobis (1-phenyl-1H-benzimidazole-?N3)zinc(II)(Taylor & Francis Ltd, 2011) Sireci, Nihat; Yilmaz, Ulku; Kucukbay, Hasan; Akkurt, Mehmet; Baktir, Zeliha; Turktekin, Sevim; Buyukgungor, OrhanThe Co(II), Zn(II), Ni(II), Cu(II), and Fe(II) complexes of 1-phenylbenzimidazole were synthesized and characterized by NMR and elemental analyses. The crystal structures of dichlorobis(1-phenyl-1H-benzimidazole-kappa N-3) cobalt(II) and dichlorobis(1-phenyl-1H-benzimidazole-kappa N-3)zinc(II) have been determined by single-crystal X-ray diffraction.Öğe Synthesis, Antibacterial and Antifungal Activities of New Bis-5(6)-nitrobenzimidazoles(Asian Journal Of Chemistry, 2010) Kucukbay, Hasan; Durmaz, Riza; Sireci, Nihat; Gunal, SelamiSeventeen bis-5(6)-nitrobenzimidazole compounds and their salt derivatives were synthesized from the reaction of 5(6)-nitrobenzimidazole and appropriate alkyl dihalides and alkyl halides. The synthesized compounds were identified by (1)H, (13)C NMR, FT-TR spectroscopic techniques and elemental analysis. All compounds studied in this work were screened for their in vitro antimicrobial activitiy against the standard strains such as Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and the yeasts Candida albicans and Candida tropicalis. Ten of the compounds were found effective to inhibit the growth of gram positive (E.faecalis and S. aureus) at MIC values between 50-400 mu g/mL. Seven of the compounds exhibit antimicrobial activity against gram negative bactreria (E. coli and P aeruginosa) at the concentrations studied (50-400 mu g/mL). Nearly all compounds tested in this work showed antifungal activity with a range of the MICs between 50 and 800 mu g/mL.Öğe Synthesis, characterization and microwave-assisted catalytic activity of novel benzimidazole salts bearing piperidine and morpholine moieties in Heck cross-coupling reactions(Wiley-Blackwell, 2011) Kucukbay, Hasan; Sireci, Nihat; Yilmaz, Ulku; Akkurt, Mehmet; Yalcin, Serife Pinar; Tahir, M. Nawaz; Ott, HolgerA mixture of novel benzimidazole salts (2a-f), Pd(OAc)(2) and K(2)CO(3) in DMF-H(2)O catalyzes, in high yield, the Heck cross-coupling reaction assisted by microwave irradiation in a short time. All synthesized novel benzimidazole derivatives were characterized by elemental analysis and NMR spectroscopy. In addition, the molecular structure of 2a was determined by X-ray crystallography. Copyright (C) 2011 John Wiley & Sons, Ltd.Öğe Synthesis, Characterization and Microwave-Promoted Catalytic Activity of Novel N-phenylbenzimidazolium Salts in Heck-Mizoroki and Suzuki-Miyaura Cross-Coupling Reactions under Mild Conditions(Mdpi, 2013) Yilmaz, Ulku; Kucukbay, Hasan; Deniz, Selma; Sireci, NihatA number of novel benzimidazolium salts having aryl substituents such as N-phenyl, 4-chlorophenyl and various alkyl substituents were synthesized. Their microwave-assisted catalytic activities were evaluated in Heck-Mizoroki and Suzuki-Miyaura cross-coupling reactions using a catalytic system consisting of Pd(OAc)(2)/K2CO3 in DMF/H2O under mild reaction conditions with consistent high yields, except those of 2-bromopyridine.Öğe Synthesis, microwave-promoted catalytic activity in Suzuki-Miyaura cross-coupling reactions and antimicrobial properties of novel benzimidazole salts bearing trimethylsilyl group(Wiley, 2011) Yilmaz, Ulku; Kucukbay, Hasan; Sireci, Nihat; Akkurt, Mehmet; Gunal, Selami; Durmaz, Riza; Tahir, M. NawazA mixture of benzimidazole salts (2-7), Pd(OAc)(2) and K2CO3 in DMF-H2O catalyzes the Suzuki-Miyaura cross-coupling reactions promoted by microwave irradiation resulting in high yield within a short time. In particular, the yield of the Suzuki-Miyaura reactions with aryl bromides was found to be nearly quantitative. The synthesized benzimidazole salts (2-7) were identified by H-1-C-13, NMR, IR spectroscopic methods and microanalysis. The molecular structure of 1 was determined by X-ray crystallography. The antibacterial and antifungal activities of the novel benzimidazole derivatives (1-7) were also tested against standard strains. Copyright (C) 2011 John Wiley & Sons, Ltd.Öğe Synthesis, spectroscopic characterization and antimicrobial properties of silyl-tethere d benzimidazolium salts(Elsevier, 2022) Yigit, Murat; Sireci, Nihat; Guenal, Selami; Onderci, Muhittin; Ozdemir, Namik; Arinc, Ali; Yigit, BeyhanA series of new silyl-substituted benzimidazolium salts were synthesized in good yield by the reaction of 1-(dimethylvinylsilyl)methylbenzimidazole and various alkyl halides. These salts were characterized by spectroscopic techniques. Also, crystal structure of 2c has been determined by the single-crystal X-ray diffraction method. Newly synthesized compounds were tested for antibacterial and antifungal activities and the minimum inhibitory concentrations were determined. The results indicates that some of compounds exert effective antibacterial activity against four Gram (-) bacterial and four Gram ( + ) bacterial strains and two yeast strains.
