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    The comparative effects of genetically modified maize and conventional maize on rats
    (Journal of Clinical and Analytical Medicine, 2013) Gürsul, Cebrail; Sunar, Mukadder; Gökşen, Gülden; Kılıçgün, Hasan
    Abstract: Aim: Genetically modified crops have a potential to solve many of the world’s nutrition problems. On the other hand, the impact of these novel crops on environmental, animal and human health should be tested and their risk assessment is required. In this study, the aim of this study was to investigate the positive or possible negative effects of genetically modified maize on offspring rats which were between the start of dry food feeding and the time interval until they reached puberty. Material and Method: Thirty Wistar albino rats were used in this study. The rats were fed with transgenic Bacillus thuringiensis maize and conventional maize during 40 days. After the experimental period, the length, height and weight of organs and serum chemistry and hematology values were measured. Results: The length, height and weight of liver, spleen, lung and kidneys in Bacillus thuringiensis maize group of rats were different from those in control and conventional groups. When mean values of serum chemistry and hematology parameters, which were glucose, urea, total protein, cholesterol, triglyceride, very low-density lipoprotein, low-density lipoprotein, calcium, phosphorus, sodium, potassium, chlorine were examined, some obvious differences were found between the rats fed with transgenic maize and its conventional counterpart and control groups. Discussion: The results of this study showed that Bacillus thuringiensis maize may not only have an effect on the length, height and weight of organs of the maturing term of rats but also lead to alterations in serum chemistry and hematology values.
  • Küçük Resim
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    Evaluation of the effect of chronic smoking habit on corneal endothelial cells, central corneal thickness and dry eye tests
    (2019) Karakurt, Yucel; Sunar, Mukadder; Tasli, Nurdan Gamze; Ucak, Turgay; Agcayazi, Sumeyye Burcu; Ugurlu, Adem; Icel, Erel
    Aim: The aim of our study was to evaluate the effects of chronic smoking habit on corneal endothelial cells, central corneal thickness, and dry eye tests. Material and Methods: A total of 160 eyes of 160 chronic smokers and 160 eyes of 160 control cases were included in the study. The smokers were grouped into 4 groups according to pack-year smoking as follows: 0-10, 10-20, 20-30, >30. Endothelial cell density (CD), average cell size (AVG), percentage of hexagonal cell (HEX), and coefficient of variation (CV), central corneal thickness (CCT) were measured using a specular microscope. The Tear Break-Up Time (TUBT) and Schirmer tests were performed. Results: In Group 1 and Group 2, there was no significant difference between the smoker and the control groups in terms of CD, AVG, HEX and CV. In Group 3 and Group 4, there was a significant decrease in CD and HEX values, while there was a significant increase in AVG and CV values. CCT values were not significantly different in the Groups 1,2 and 3, whereas there was a significant decrease in the Group 4. TBUT and Schirmer tests were significantly decreased in all groups. Conclusion: It was found that as the number of pack-year increased, CD and HEX values decreased and AVG and CV values increased. Dry eye tests were affected in a shorter period of time, while CCT was affected in a longer period of time than the time required for CD, HEX, AVG and CV parameters to be affected.