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  • Küçük Resim
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    Evaluation by N terminal prohormone of brain natriuretic peptide cocentrations and Ross scoring of the efficacy of digoxin in the treatment of heart failure secondary to congenital heart disease with left to right shunts
    (Pediatr Cardiol, 0–0., 2013) Elkıran, Özlem; Sandıkkaya, Ayse; Koçak, Gülemdar; Karakurt, Cemşit; Taşkapan, Çağatay; Yoloğlu, Saim
    This study aimed to evaluate the effectiveness of digoxin in children with heart failure secondary to leftto-right shunt lesions and normal left ventricular systolic function. The study registered 37 such patients (ages 10 days to 24 months, groups 1 and 2) and used 20 healthy children as a control group (group 3). Left ventricular systolic function, as assessed by conventional echocardiography, was normal in all the subjects. Congestive heart failure was diagnosed by clinical evaluation and modified Ross scoring. Plasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP) concentrations and complete blood counts were assessed in all the children. Group 1 was treated with digoxin, enalapril, and furosemide and group 2 with enalapril and furosemide. Approximately 1 month after starting treatment, the patients were reevaluated by physical and echocardiographic examinations, modified Ross scoring, plasma NT-proBNP concentrations, and complete blood counts. The pre- and posttreatment Ross scores of group 1 (p = 0.377) and group 2 (p = 0.616) did not differ significantly. The NT-proBNP values in both groups decreased after treatment (p = 0.0001). The pre- and posttreatment NT-proBNP values did not differ significantly in group 1 (p = 0.094)) and group 2 (p = 0.372). The pretreatment NT-proBNP values in groups 1 and 2 (p = 0.0001) were significantly higher than in the control group (p = 0.003). A smaller difference was observed between posttreatment NT-proBNP values in group 1 and the control group (p = 0.045). We found no significant difference between the posttreatment NT-proBNP values of group 2 and those of the control group (p = 0.271). The study showed that both treatments currently used to treat heart failure secondary to congenital heart disease with left-to-right shunts and preserved left ventricular systolic function are effective and do not differ significantly. Thus, digoxin does not provide any extra benefit in the treatment of such patients.
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    Giardiosisli hastalarda serum çinko (Zn) düzeyleri
    (Türkiye Parazitoloji Dergisi, 2007) Taşkapan, Çağatay; Atambay, Metin; Aycan, Özlem M.; Özyalın, Fatma; Yoloğlu, Saim; Miman, Özlem; Daldal, Nilgün
    Öz: Giardiosisde ortaya çıkan emilim eksikliği nedeni ile eser elementlerin düzeylerinde düşme beklenmektedir. Bu çalışmada giardiosisde serum çinko düzeyinin kontrol grubu ile karşılaştırılarak değişikliğin belirlenmesi amaçlanmıştır. Araştırmaya dışkı mikroskobisinde Giardia intestinalis saptanan 30 kişi ile hiçbir paraziter enfeksiyonu ve diğer hastalıkları bulunmayan 31 kişiden oluşturulan toplam 61 kişi dahil edilmiştir. İki ortalama arasındaki farkın önemlilik testine göre G. intestinalis saptanan olgularda serum çinko düzeylerinde kontrol grubuna göre anlamlı bir düşüş görülmüştür (p<0,0001). Sonuç olarak, serum çinko düzeylerinin azaldığı olgularda paraziter hastalıkların da göz önünde bulundurulması gerektiği kanısına varılmıştır.
  • Küçük Resim Yok
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    Impact of serum and follicular vitamin d levels on assisted reproductive techniques outcome
    (SCI PRINTERS & PUBL INC, PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA, 2018) Tuncay, Görkem; Taşkapan, Çağatay
    OBJECTIVE: To compare vitamin D levels in the serum and follicular fluids of in vitro fertilization (IVF) patients with regard to their pregnancy outcomes. STUDY DESIGN: This study enrolled 170 female patients (20-44 years old) who underwent intracytoplasmic sperm injection (ICSI) cycles between February 2015 and February 2016. The serum vitamin D was isolated by centrifugation. The follicular fluid samples were centrifuged and the supernatant was evaluated after the oocyte puncture procedure. RESULTS: Fifty-six patients had clinical pregnancies and 106 did not, and we did not find any statistically significant differences between these 2 groups in their basic or cycle characteristics. The basal follicle-stimulating hormone level was significantly lower in the pregnant group (p=0.003). A significant difference was detected in the serum vitamin D, and the follicular vitamin D concentrations were higher in the pregnant group (p=0.01 and p=0.003, respectively). There was a significant linear correlation between the 25-hydroxy vitamin D levels in the serum and follicular fluid (r=0.77, p<0.001). CONCLUSION: High vitamin D levels can improve the implantation rate and IVF outcome. The serum vitamin D level should be determined prior to IVF/ICSI cycles and supplemented if an insufficiency is established.
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    Serum pentraxin 3 and hs crp levels in children with severe pulmonary hypertension
    (Balkan Med J, 31(3), 0–0., 2014) Karakurt, Cemşit; Başpınar, Osman; Çelik, Serkan Fazlı; Taşkapan, Çağatay; Şahin, Aydın Derya; Yoloğlu, Saim
    Background: Pulmonary arterial hypertension secondary to untreated left-to-right shunt defects leads to increased pulmonary blood flow, endothelial dysfunction, increased pulmonary vascular resistance, vascular remodelling, neointimal and plexiform lesions. Some recent studies have shown that inflammation has an important role in the pathophysiology of pulmonary arterial hypertension. Aims: The aim of this study is to evaluate serum pentraxin 3 and high sensitive (hs)-C reactive protein (hs-CRP) levels in children with severe pulmonary arterial hypertension (PAH) secondary to untreated congenital heart defects and evaluate the role of inflammation in pulmonary hypertension. Study Design: Cross sectional study. Methods: After ethics committee approval and receiving consent from parents, there were 31 children were selected for the study with severe PAH, mostly with a left-to-right shunt, who had been assessed by cardiac catheterisation and were taking specific pulmonary vasodilators. The control group consisted of 39 age and gender matched healthy children. After recording data about all the patients including age, gender, weight, haemodynamic studies and vasodilator testing, a physical examination was done for all subjects. Blood was taken from patients and the control group using peripheral veins to analyse serum Pentraxin 3, N-terminal pro-Brain Natriuretic Peptide (NT-ProBNP) and hs-CRP levels. Serum Pentraxin-3 levels were measured by enzyme linked immunosorbent assay (ELISA) and expressed as ng/mL. Serum hs-CRP levels were measured with an immunonephelometric method and expressed as mg/dL. The serum concentration of NT-proBNP was determined by a chemiluminescent immunumetric assay and expressed as pg/mL. Results: Serum Pentraxin- 3 levels were determined to be 1.28±2.12 (0.12-11.43) in the PAH group (group 1) and 0.40±0.72 (0.07-3.45) in group 2. There was a statistically significant difference between the two groups (p<0.01). Serum hs-CRP levels were measured as 2.92±2.12 (0.32-14.7) mg/dL in group 1 and 0.35±0.16 (0.07-3.45) mg/dL in group 2. The hs-CRP level was increased in the PAH group to a significant degree (p<0.01). Conclusion: Our study showed that pentraxin 3 and hs-CRP levels were increased significantly in the PAH group. We consider that inflammation plays an important role in severe pulmonary hypertension and progressive pulmonary arterial hypertension in children with PAH.