Yazar "Taskapan, Mehmet Cagatay" seçeneğine göre listele
Listeleniyor 1 - 10 / 10
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome (vol 19, pg 166, 2019)(Bentham Science Publ Ltd, 2019) Dikci, Seyhan; Ozturk, Emrah; Firat, Penpe Gul; Yilmaz, Turgut; Taskapan, Mehmet Cagatay; Yologlu, Saim[Abstract Not Available]Öğe The effect of active vs passive recovery and use of compression garments following a single bout of muscle-damaging exercise(Ios Press, 2022) Sahin, Fatma Beyza; Kafkas, Armagan Sahin; Kafkas, Muhammed Emin; Taskapan, Mehmet Cagatay; Jones, Andrew MarkBACKGROUND: Some recovery strategies are needed to reduce or eliminate the effect of negative symptoms caused by exercise. OBJECTIVE: The aim of this study was to determine the effect of different types of recovery after single-bout strength exercises on biomarkers of muscle damage, cytokine release and lactate elimination. METHODS: Following familiarization, 10 male volunteers performed four randomized recovery protocols (passive or active recovery with or without compression garments) following a single bout of resistance exercise (squat and deadlift exercises). The blood creatine kinase (CK), lactate dehydrogenase (LDH), interleukine-6 (IL-6), and tumor necrosis factor-alfa (TNF-alpha) values were measured before and after exercise, and after 24, 48, 72 hours. RESULTS: The CK analysis showed that all protocols significantly increased (p < 0.05) CK activity compared to the pre and 24 h post time points. Interestingly, protocol 3 and 4 significantly decreased (p < 0.05) CK activity compared 24 and 72 h post-exercise. LDH, IL-6, and TNF values did not show significant difference (p > 0.05) at the time points tested. CONCLUSIONS: Active recovery is an effective method for reducing the severity and duration of muscle damage and for accelerating the clearance of blood lactate (BLa) following a single bout of strength training. There is no added benefit of using compression garments.Öğe The effect of Ramadan fasting on mental health and some hormonal levels in healthy males(Springer, 2023) Akan, Mustafa; Unal, Suheyla; Gonenir Erbay, Lale; Taskapan, Mehmet CagatayBackgroundMillions of Muslims around the world fast during the holy month of Ramadan as a requirement of their religion Islam. Studies have reported varying effects of Ramadan fasting on mental health and various hormones. This study aimed to examine the effects of Ramadan fasting on mental health and plasma Leptin, Ghrelin, Neuropeptide Y (NPY), Growth Hormone levels in healthy individuals, and to evaluate the possible relationship between their hormone values and scale scores. Male healthcare professionals working at a university hospital without any psychiatric disease were included in the study. In the last week before Ramadan and in the first week after Ramadan, participants' blood samples were taken at 8.00 in the morning after 12 h of fasting, taking into account the release pattern and pulsatile release of these hormones in order to measure plasma Leptin, Ghrelin, NPY and Growth Hormone levels. Simultaneously, a sociodemographic data form, the Brief Symptom Inventory (BSI) and the Scale of Dimensions of Interpersonal Relationships were applied to participants.ResultsThe sample of the study included a total of 40 healthcare professionals. Participants' BSI interpersonal sensitivity and phobic anxiety subscales scores and their general severity and positive symptom distress index scores decreased significantly after Ramadan compared to those measured before Ramadan. (p < 0.001, p = 0.020, p = 0.042, p = 0.006 respectively). Also participants' ghrelin levels increased significantly after Ramadan compared to those measured before Ramadan (p < 0.001).ConclusionsThe effects of Ramadan fasting on mental health may be mediated by some psychoneuroendocrine mechanisms. In order to elucidate these mechanisms that mediate the effect of Ramadan fasting on mental health, there is a need for better-structured studies with larger samples and more variables.Öğe How do vegetable oils (hazelnut and canola) affect the reproductive system in male rats?(Pagepress Publ, 2018) Kati, Bulent; Oguz, Fatih; Yilmaz, Ismet; Akdemir, Ender; Altintas, Ramazan; Akpolat, Nusret; Taskapan, Mehmet CagatayObjective: Vegetable oils have an important place in our daily diet. This study starts from this point to investigate the effects of canola oil and hazelnut oil in the male reproductive system in rats. Material and methods: 30 male rats were used in this 16-week study. The animals were divided into three groups: the animals in group I served as the control group, while the animals in group II and group III were fed with hazelnut and canola oil, respectively. The testes of all rats were excised for histopathologic evaluation and immunohistochemical (IHC) evaluation with a standard method. Blood samples were obtained for determination of serum hormone levels. Results: No significant differences were noted with respect to behavior or weight among the three groups. Rats in the canola oil group (group III) had higher luteinizing hormone (LH) and higher testosterone levels than rats in the control group. Rats who received hazelnut oil (group II) exhibited similar findings, with these levels being higher than they were in the control group. No statistical differences were shown for histopathology or IHC testosterone antibody levels across all treatment groups. Conclussion: Canola oil was shown to have a greater effect on serum LH and testosterone compared to the control group and the group fed with hazelnut oil. Further investigation is required into how these oils affect serum hormone and sperm activity.Öğe Impact of differing eccentric-concentric phase durations on muscle damage and anabolic hormones(Ios Press, 2024) Kizilay, Fatma; Kafkas, Muhammed Emin; Taskapan, Mehmet Cagatay; Demirel, Ali Haydar; Radak, ZsoltBACKGROUND: Resistance exercises are widely used to enhance muscle hypertrophy. Hypertrophy occurs with effect of mechanical loading, metabolic stress, and muscle damage. The time under tension in eccentric, isometric, and concentric phases of resistance exercises can alter muscle damage and anabolic hormone responses. OBJECTIVES: The aim of the study was to reveal the effect of the time spent in the concentric and eccentric phases of the movement on muscle damage and anabolic hormone response during resistance exercise. METHODS: Ten male subjects participated in the study. A, B, C tempo protocols were created by changing the time under tension to be 1 or 2 seconds in the eccentric and concentric phases of bench press and squat movements. In all protocols, isometric phases were 0 sec. The metronome was used to apply tempos. Blood samples were taken before each protocol, after administration, and in the 24th, 48th and 72nd hours after exercise; and serum insulin, testosterone, Insuline-like Growth Factor-1 (IGF-1), Creatine Kinase (CK) and Lactate Dehydrogenase (LDH) levels were evaluated. RESULTS: Time-wise changes in CK were statistically different for all protocols (p < 0.05). CK levels in the 24th hour of the protocol C and the 48th hour of the protocol B were significantly higher than those in the other protocols ( p < 0.05). IGF-1 and testosterone levels were significantly higher in the protocol B in the post-test, compared to the other protocols ( p < 0.05). Insulin levels in the 24th hour were significantly higher in the protocol B compared to those in others (p < 0.05). Time-wise changes in LDH parameters were not statistically significant in any hours (p > 0.05). CONCLUSIONS: Extending time under tension in the eccentric phase of a bout of resistance exercise appears to affect the anabolic hormone response and muscle damage. In this way, increased metabolic response and mechanical stress can induce muscle mass gain.Öğe NGAL and NT-proBNP levels in diabetic patients with macroproteinuria(Taylor & Francis Ltd, 2013) Taskapan, Hulya; Taskapan, Mehmet Cagatay; Orman, Ibrahim; Ulutas, Ozkan; Yigit, Ali; Ozyalin, Fatma; Yologlu, SaimBackground: In patients with heart failure plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are correlated to urine neutrophil gelatinase-associated lipocalin (NGAL) levels. We prospectively evaluated the relationship among glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (ACR), urine and serum NGAL and NT-proBNP levels in 20 type II diabetic patients with macroalbuminuria at 4-month intervals. Results: Compared with 20 age, gender-matched healthy controls, diabetic patients had higher urine and serum NGAL, serum NT-proBNP and lower eGFR. The eGFR of the patients at the baseline, the 4th and the 8th month were 29.6 +/- 12.0, 27.8 +/- 13.7 and 22.9 +/- 10.4 mL/min/1.73m(2), respectively. No significant change in urine NGAL levels was detected (p > 0.05), whereas there were significant increases in NT-proBNP, serum NGAL and urine ACR and significant decrease in eGFR as the study progressed (p < 0.05). Both the baseline and the 4th month urine ACR were positively correlated to NT-proBNP levels measured at the same periods (r: 0.451; p: 0.046; r: 0.489; p: 0.029 respectively). In all measurements, urine ACR was negatively correlated to serum albumin levels measured at the same periods (r: -0.792; p: 0.000; r: -0.716; p: 0.000; r: -0.531; p: 0.016 respectively). None of eGFR measurements was correlated with NT-proBNP (p > 0.05). Neither serum NGAL nor urinary NGAL levels are associated with NT-proBNP (p > 0.05). Conclusion: Our findings show an association between NT-proBNP and proteinuria in type II diabetic patients with macroalbuminuria but not with serum and urine NGAL.Öğe Serum Fetuin-A Levels, QT Dispersion and P Dispersion in Dialysis Patients(Taylor & Francis Ltd, 2013) Taskapan, Mehmet Cagatay; Taskapan, Hulya; Comert, Melda; Temel, Ismail; Yagmur, Julide; Ulutas, OzkanBackground: This study aims to find association of fetuin-A with serum lipids, QT dispersion (QT-d), and P dispersion (P-d) in dialysis patients. Methods: Fetuin-A serum levels were assessed in 50 dialysis patients. Results: Serum fetuin-A levels were significantly associated with QT-d (r = 0.289, p = 0.044), P-d (r = 0.39, p = 0.005), total cholesterol (r = 0.526, p = 0.000), low-density lipoprotein cholesterol (LDL-C) (r = 0.456, p = 0.00), triglyceride (r = 0.360, p = 0.011) and highly sensitive C-reactive protein (hsCRP) (r = -0.347, p = 0.030). In step-wise multiple regression analysis including being on hemodialysis (HD), presence of diabetes mellitus (DM), total cholesterol, LDL-C, triglycerides, hsCRP, only total cholesterol (b = 0.419, p = 0.03), and hsCRP (b = -0.316, p = 0.03) proved to be independent predictors of serum fetuin-A levels. QT-d showed a linear correlation with total cholesterol (r = 0.309, p = 0.029), LDL-C (r = 0.304, p = 0.038), P-d (r = 0.390, p = 0.005), and fetuin-A levels (r = 0.289, p = 0.044). In multiple regression analyses, the independent predictor of QT-d was being on HD (b = -0.417, p = 0.004), whereas total cholesterol, LDL-C, presence of DM, serum fetuin-A levels, and P-d had no independent effect on corrected QT (QT-C). Being on HD and age were important determinants of P-d whereas presence of DM, total cholesterol, LDL-C, fetuin-A, and QT-d had no independent effect on P-d. Conclusions: Lower fetuin-A levels are associated with high hsCRP and low cholesterol levels in dialysis patients.Öğe Thioredoxin reductase activity, serum IL6, HsCRP and NT-proBNP levels in patients on dialysis(2016) Demir, Meltem; Taskapan, Mehmet Cagatay; Taşkapan, Hülya; Özyalın, Fatma; Doğan, AliAmaç: Sitokinler natriüretik petid sekresyonunda direk uyarıcı etkiye sahiptir. N terminal probeyin tip natriüretik peptid diyaliz hatalarının mortalitesinde önemli bir biyobelirteçtir. Bu çalışmanın amacı peritonel diyaliz(PD) ve hemodiyaliz(HD) hastalarında; tiyoredoksin redüktaz aktivitesi ile NT-proBNP, IL6 ve yüksek duyarlıklı C reaktif protein seviyelerini (HsCRP)karşılaştırmak ve aralarındaki ilişkiyi araştırmaktır. Gereç ve Yöntemler: Yaş ve cinsiyet değişkenlerine gore 30 HD, 30 PD ve 20 kontrol sağlıklı denek gruplara ayrılarak HsCRP, serum IL6, NT-proBNP seviyeleri ile tiyoredoksin redüktaz aktivitesi ölçüldü. Sonuç: HsCRP, serum IL6, NT-proBNP seviyeleri HD ve PD hastalarında kontrol grubuna kıyasla istatiksel olarak anlamlı derecede yüksek bulundu (p<0,05). HsCRP, IL6, and NTproBNP düzeyleri bakımından HD ve PD grupları arasında anlamlı fark bulunamamışken (p>0,05), tiyoredoksin redüktaz aktivitesi 3 grupta da fark göstermedi. Ayrıca tiyoredoksin redüktaz aktivitesi çalışmadaki hiçbir parametre ile korelasyon göstermedi. HsCRP; BMI(r:0.275, p:0.034), IL6 (r:0.633, p:0.000), NT proBNP (r:0.277, p:0.032) ile pozitif korelasyon gösterirken, serum albumin konsantrasyonu ile negative korelasyon (r:-0.425, p:0.001) gösterdi. Serum IL6 seviyeleri HsCRP (r:0.633, p:0.000) ve BMI (r:0.775, p:0.034) ile pozitif, albumin ile negative (r:-0.342, p:0.007) korelasyon gösterdi. Serum NT-proBNP seviyeleri ise serum albumini ile negatif; yaş (r:0.315, p:0.002), HsCRP (r:0.277, p:0.032), sistolik (r:0.421, p:0.001) ve ortalama kan basıncı ile (r:0.311, p:0.015) ise pozitif korelasyon gösterdi.Öğe The use of ischemia modified albumin as a predictive and prognostic biomarker in patients with non-acetaminophen- induced acute liver failure(2022) Aktas, Aydin; Gunes, Orgun; Budak, Fatma Olmez; Diller, Nilufer; Tuncer, Adem; Akbulut, Sami; Taskapan, Mehmet CagatayAim: This study aimed to investigate to usability of ischemia modified albumin (IMA) and IMA/albumin ratio (IMAR) values in the follow-up of ALF patients. King College criteria (KCC) and Model for End-Stage Liver Disease (MELD) score are the most commonly used criteria in the follow-up of patients with acute liver failure (ALF). However, these criteria cannot always predict prognosis and the need for liver transplantation (LT). Materials and Methods: IMA and IMAR values of 23 ALF patients and 43 healthy volunteers were measured. Then IMA and IMAR values were compared with KCC and MELD score to predict LT requirement and prognosis in ALF patients. Results: IMA and IMAR values were significantly higher in ALF patients compared healthy volunteers (p=0.001, p=0.001; respectively). IMA and IMAR values predicted LT requirement in ALF patients such as KCC and MELD (?30) score (p=0.006, p=0.04, p=0.001, p=0.03; respectively). IMA values were found to better than KCC in predicting mortality (p=0.008, p=0.02; respectively). MELD (?30) score failed to predict mortality (p=0.44). Conclusion: IMA and IMAR values can be used as diagnostic biomarkers in ALF pa- tients. IMA is a better prognostic biomarker in the follow-up of ALF patients.Öğe Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients(Springer, 2013) Ulutas, Ozkan; Taskapan, Hulya; Taskapan, Mehmet Cagatay; Temel, IsmailAssociations between 25 hydroxy vitamin D [25(OH)D], adipokines levels, and insulin resistance have been reported. The aim of this study was to explore the effects of cholecalciferol supplementation on vitamin D levels, insulin resistance, leptin, and adiponectin levels in vitamin D-deficient peritoneal dialysis (PD) patients. In nineteen vitamin D-deficient PD patients, who were treated with cholecalciferol, fasting serum glucose, insulin, adiponectin, leptin, 25(OH)D and parathyroid hormone (PTH) were measured before and after cholecalciferol replacement therapy. Eighteen (94.7 %) PD patients with vitamin D deficiency were receiving active vitamin D compounds (alphacalciferol) for PTH control. Alphacalciferol dosing was kept constant during treatment with cholecalciferol. While mean 25(OH)D significantly increased from (10.2 +/- A 4.9 ng/ml) to (82.9 +/- A 56.5 ng/ml) (p < 0.05), mean homeostatic model assessment-insulin resistance index significantly decreased from (4.6 +/- A 3.6) to (2.8 +/- A 2.0) after cholecalciferol replacement therapy (p < 0.05). Serum leptin levels (12.9 +/- A 17.6 ng/ml) significantly increased (18.1 +/- A 19.5 ng/ml) (p < 0.05), while there was no change in serum adiponectin, calcium, and phosphate after vitamin D replacement. Serum PTH levels significantly decreased from 551.9 +/- A 276.6 pg/ml to 434.0 +/- A 273.4 ng/ml. Cholecalciferol replacement therapy significantly decreases PTH levels and insulin resistance. The results of this study need to be confirmed in larger clinical trials.