Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Associations between 25 hydroxy vitamin D [25(OH)D], adipokines levels, and insulin resistance have been reported. The aim of this study was to explore the effects of cholecalciferol supplementation on vitamin D levels, insulin resistance, leptin, and adiponectin levels in vitamin D-deficient peritoneal dialysis (PD) patients. In nineteen vitamin D-deficient PD patients, who were treated with cholecalciferol, fasting serum glucose, insulin, adiponectin, leptin, 25(OH)D and parathyroid hormone (PTH) were measured before and after cholecalciferol replacement therapy. Eighteen (94.7 %) PD patients with vitamin D deficiency were receiving active vitamin D compounds (alphacalciferol) for PTH control. Alphacalciferol dosing was kept constant during treatment with cholecalciferol. While mean 25(OH)D significantly increased from (10.2 +/- A 4.9 ng/ml) to (82.9 +/- A 56.5 ng/ml) (p < 0.05), mean homeostatic model assessment-insulin resistance index significantly decreased from (4.6 +/- A 3.6) to (2.8 +/- A 2.0) after cholecalciferol replacement therapy (p < 0.05). Serum leptin levels (12.9 +/- A 17.6 ng/ml) significantly increased (18.1 +/- A 19.5 ng/ml) (p < 0.05), while there was no change in serum adiponectin, calcium, and phosphate after vitamin D replacement. Serum PTH levels significantly decreased from 551.9 +/- A 276.6 pg/ml to 434.0 +/- A 273.4 ng/ml. Cholecalciferol replacement therapy significantly decreases PTH levels and insulin resistance. The results of this study need to be confirmed in larger clinical trials.
Açıklama
Anahtar Kelimeler
Cholecalciferol replacement, Insulin sensitivity, Vitamin D deficiency, Adiponectin, Leptin
Kaynak
International Urology and Nephrology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
45
Sayı
3
