Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients

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dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authoridulutas, ozkan/0000-0002-2155-8340
dc.authoridtaskapan, hulya/0000-0001-8736-4779
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.authorwosidulutas, ozkan/ABI-6332-2020
dc.authorwosidtaskapan, hulya/ABI-7737-2020
dc.contributor.authorUlutas, Ozkan
dc.contributor.authorTaskapan, Hulya
dc.contributor.authorTaskapan, Mehmet Cagatay
dc.contributor.authorTemel, Ismail
dc.date.accessioned2024-08-04T20:37:42Z
dc.date.available2024-08-04T20:37:42Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAssociations between 25 hydroxy vitamin D [25(OH)D], adipokines levels, and insulin resistance have been reported. The aim of this study was to explore the effects of cholecalciferol supplementation on vitamin D levels, insulin resistance, leptin, and adiponectin levels in vitamin D-deficient peritoneal dialysis (PD) patients. In nineteen vitamin D-deficient PD patients, who were treated with cholecalciferol, fasting serum glucose, insulin, adiponectin, leptin, 25(OH)D and parathyroid hormone (PTH) were measured before and after cholecalciferol replacement therapy. Eighteen (94.7 %) PD patients with vitamin D deficiency were receiving active vitamin D compounds (alphacalciferol) for PTH control. Alphacalciferol dosing was kept constant during treatment with cholecalciferol. While mean 25(OH)D significantly increased from (10.2 +/- A 4.9 ng/ml) to (82.9 +/- A 56.5 ng/ml) (p < 0.05), mean homeostatic model assessment-insulin resistance index significantly decreased from (4.6 +/- A 3.6) to (2.8 +/- A 2.0) after cholecalciferol replacement therapy (p < 0.05). Serum leptin levels (12.9 +/- A 17.6 ng/ml) significantly increased (18.1 +/- A 19.5 ng/ml) (p < 0.05), while there was no change in serum adiponectin, calcium, and phosphate after vitamin D replacement. Serum PTH levels significantly decreased from 551.9 +/- A 276.6 pg/ml to 434.0 +/- A 273.4 ng/ml. Cholecalciferol replacement therapy significantly decreases PTH levels and insulin resistance. The results of this study need to be confirmed in larger clinical trials.en_US
dc.description.sponsorshipInonu University Medical Research Centeren_US
dc.description.sponsorshipThis study was supported by Inonu University Medical Research Center.en_US
dc.identifier.doi10.1007/s11255-012-0308-8
dc.identifier.endpage884en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue3en_US
dc.identifier.pmid23065434en_US
dc.identifier.scopus2-s2.0-84879504116en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage879en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-012-0308-8
dc.identifier.urihttps://hdl.handle.net/11616/96115
dc.identifier.volume45en_US
dc.identifier.wosWOS:000320843400041en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholecalciferol replacementen_US
dc.subjectInsulin sensitivityen_US
dc.subjectVitamin D deficiencyen_US
dc.subjectAdiponectinen_US
dc.subjectLeptinen_US
dc.titleVitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patientsen_US
dc.typeArticleen_US

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