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Öğe The association between vitamin D receptor polymorphisms and multiple sclerosis in a Turkish population(Elsevier Sci Ltd, 2018) Kamisli, Ozden; Acar, Ceren; Sozen, Mert; Tecellioglu, Mehmet; Yucel, Fatma Ebru; Vaizoglu, Dilara; Ozcan, CemalBackground: Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system (CNS). Genetic and environmental factors are important in disease development. Many studies have investigated the relationship between MS and VDR polymorphisms. VDR gene polymorphism has not been previously studied in Turkish MS patients. We aimed to investigate the relationship between MS and VDR genotypes Taq I, Apa I and Fok I polymorphisms in a Turkish population. Methods: 167 MS patients and 146 healthy control subjects were included in the present study. MS and the VDR TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) polymorphisms were investigated. Results: The study enrolled 167 patients (121 females, 46 males) with MS and 146 healthy individuals (88 females, 58 males). The frequency of only the Fok I polymorphism differed significantly between the two groups (p = 0.002). The TaqI (rs731236) and ApaI (rs7975232) genotype distributions were not significantly different between MS patients and healthy controls (p = 0.626 and p = 0.990, respectively). Also there were no significant gender difference between patients and controls for Taq I and Apa I. Conclusion: In conclusion, we found a significant association between MS and the FokI polymorphism in our region of Turkey. However, the results may be different in other populations. More epidemiological and genetic studies are needed to explain the association between genetic factors and MS.Öğe Autoimmune polyglandular syndrome type III which accompanies to multiple sclerosis: A case report(2019) Gorgel, Ahmet; Tecellioglu, Mehmet; Cankaya, CemAutoimmune polyglandular syndrome type III (APS III) is characterised by autoimmune destruction of various endocrine and nonendocrine tissues. It differs from APS I and APS II in terms of without adrenal involvement. Although APS III includes a series of autoimmune disorders, it is rarely associated with multiple sclerosis (MS). A 41-year-old female patient had diplopia, visual blurring, dizziness, and giddiness for 2 weeks. In her medical history, she had a diagnosis of MS and using Teriflunomide. It was detected positivity of antinuclear antibody (ANA), anti-thyroid peroxidase (Anti-TPO) and anti-thyroglobulin (Anti-TG) antibodies. Based on these results, the patient with MS who has chronic autoimmune thyroiditis and primary ovarian failure was diagnosed with APS III. The coexistence of APS-III and MS is a rare clinical entity. Moreover, hypothyroidism has been detected during teriflunomide therapy in the patient. Hypothyroidism was most likely a component of APS-III in our case, but it may also have been triggered by teriflunomide.Öğe Beneficial effects of ?-glucan against cisplatin side effects on the nervous system in rats(Acta Cirurgica Brasileira, 2016) Kaya, Kursat; Ciftci, Osman; Cetin, Asli; Tecellioglu, Mehmet; Basak, NesePURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, beta g was orally administered at the dose of 50 mg/kg/day for 14 days. In the fourth group, CP and beta g were given together at the same doses. RESULTS: CP treatment caused significant oxidative damage via induction of lipid peroxidation and reductions antioxidant defense system potency in the brain tissue. In addition, histopathological damage increased with CP treatment. On the other hand, beta g treatment largely prevented oxidative and histopathological negative effects of CP. CONCLUSIONS: Cisplatin has severe neurotoxic effects in rats and ag supplementation has significant beneficial effects against CP toxicity depending on its antioxidant properties. Thus, it appears that Ag might be useful against CP toxicity in patients with cancer in terms of nervous system.Öğe Clinical and Molecular Findings in a Turkish Family Who Had a (c.869-1G>A) Splicing Variant in PSEN1 Gene with A Rare Condition: The Variant Alzheimer's Disease with Spastic Paraparesis(Bentham Science Publ Ltd, 2022) Dogan, Mustafa; Eroz, Recep; Tecellioglu, Mehmet; Gezdirici, Alper; Cevik, Betul; Baris, IbrahimBackground: Early-onset Alzheimer's disease (EOAD) is commonly diagnosed with an onset age of earlier than 65 years and accounts for 5-10% of all Alzheimer's disease (AD) cases. To date, although only 10-15% of familial EOAD cases have been explained, the genetic cause of the vast proportion of cases has not been explained. The variant Alzheimer's disease with spastic paraparesis (varAD) is defined as a rare clinical entity characterized by early-onset dementia, spasticity of the lower extremities, and gait disturbance. Although the disease was first associated with variants in exon 9 of the PSEN1 gene, it was later shown that variations in other exons were also responsible for the disease. Objective: The current study aims to raise awareness of varAD, which occurs as a rare phenotype due to pathogenic variants in PSEN1. In addition, we aimed to evaluate the spectrum of mutations in varAD patients identified to date. Methods: Detailed family histories and clinical data were recorded. Whole exome sequencing was performed and co-segregation analysis of the family was done by Sanger sequencing. Also, a review of the molecularly confirmed patients with (varAD) from the literature was evaluated. Results: We identified a heterozygous splicing variant (c.869-1G>A) in the PSEN1 gene, in a family with two affected individuals who present with varAD. We reported the clinical and genetic findings from the affected individuals. Conclusion: We present the detailed clinical and genetic profiles of a Turkish patient with the diagnosis of varAD together with subjects from the literature. Together, we think that the clinical characteristics and the effect of the (c.869-1G>A) variant will facilitate our understanding of the PSEN1 gene in AD pathogenesis.Öğe Clinical Features and Risk Factors of Diabetic Polyneuropathy(Karger, 2018) Tecellioglu, Mehmet[Abstract Not Available]Öğe Clinical features and risk factors of diabetic polyneuropathy(Karger, allschwılerstrasse 10, ch-4009 basel, swıtzerland, 2018) Tecellioglu, MehmetÖğe Coexistence of pituitary incidentaloma and primary hyperparathyroidism mimicking multiple endocrine neoplasia Type 1: A case report(2021) Gorgel, Ahmet; Tecellioglu, Mehmet; Cankaya, CemThe widespread use of imaging procedures has led to an increased discovery of incidental masses in the pituitary gland. Although the majority of pituitary incidentalomas are non-functioning benign adenomas but their increased prevalence poses a diagnostic and therapeutic challenge. These masses may cause various hormonal disturbances as well as they might also be a component of multiple endocrine neoplasia syndromes type 1 (MEN-1) or type 4 (MEN-4). In both syndromes, primary hyperparathyroidism frequently accompanies with pituitary adenomas. Herein we present a 56-year-old man with pituitary incidentaloma who is also detected primary hyperparathyroidism. Contrary to our expectations, any gene defects could be found related with neither MEN-1 nor MEN-4 in the genetic examination.Öğe Coexistence of pituitary incidentaloma and primary hyperparathyroidism mimicking multiple endocrine neoplasia Type 1: A case report(2021) Gorgel, Ahmet; Tecellioglu, Mehmet; Cankaya, CemThe widespread use of imaging procedures has led to an increased discovery of incidental masses in the pituitary gland. Although the majority of pituitary incidentalomas are non-functioning benign adenomas but their increased prevalence poses a diagnostic and therapeutic challenge. These masses may cause various hormonal disturbances as well as they might also be a component of multiple endocrine neoplasia syndromes type 1 (MEN-1) or type 4 (MEN-4). In both syndromes, primary hyperparathyroidism frequently accompanies with pituitary adenomas. Herein we present a 56-year-old man with pituitary incidentaloma who is also detected primary hyperparathyroidism. Contrary to our expectations, any gene defects could be found related with neither MEN-1 nor MEN-4 in the genetic examinatioÖğe Comparative study of multiple sclerosis patients based on distance from the advanced health center(2021) Tosun, Hatice; Tecellioglu, MehmetAim: There are several reasons for presenting to a hospital for multiple sclerosis (MS), a neurodegenerative disorder. We aimed to determine how distance affects presentation by patients with MS to an advanced health center in Malatya, Turkey. Materials and Methods: The study was performed on 109 patients at the Neurology Department of Inonu University Hospital in 2017. The patients were divided into group-1, who lived in Malatya, and group-2, who live in the upstate region. Demographic and clinical data were analyzed retrospectively from medical records. Chi-square tests, independent sample T-tests, and Mann–Whitney U-tests were used to analyze the data. Results: The duration of the disease was longer among patients who lived in Malatya. In terms of mean expanded disability status scale scores, patients who lived in Malatya had higher scores and patients who lived upstate exhibited more clinical complaints. Among patients who lived upstate, there were more motor problems, vertigo, cognitive impairment, psychiatric disturbances, and visits for blood tests. Conclusion: Distance affected admission to MS outpatient clinics. We should be more careful in terms of attack when assessing the reasons of patients present from outside the province. More meaningful results can be obtained by following more patients for longer periods.Öğe Comparative study of multiple sclerosis patients based ondistance from the advanced health center(2021) Tecellioglu, Mehmet; Tosun, HaticeAim: There are several reasons for presenting to a hospital for multiple sclerosis (MS), a neurodegenerative disorder. We aimed todetermine how distance affects presentation by patients with MS to an advanced health center in Malatya, Turkey. Materials and Methods: The study was performed on 109 patients at the Neurology Department of Inonu University Hospital in 2017.The patients were divided into group-1, who lived in Malatya, and group-2, who live in the upstate region. Demographic and clinicaldata were analyzed retrospectively from medical records. Chi-square tests, independent sample T-tests, and Mann–Whitney U-testswere used to analyze the data. Results: The duration of the disease was longer among patients who lived in Malatya. In terms of mean expanded disability statusscale scores, patients who lived in Malatya had higher scores and patients who lived upstate exhibited more clinical complaints.Among patients who lived upstate, there were more motor problems, vertigo, cognitive impairment, psychiatric disturbances, andvisits for blood tests. Conclusion: Distance affected admission to MS outpatient clinics. We should be more careful in terms of attack when assessingthe reasons of patients present from outside the province. More meaningful results can be obtained by following more patients forlonger periods.Öğe Epilepsy, Antiepileptic Drugs and Lipid Mechanisms(Kare Publ, 2018) Kamisli, Ozden; Tecellioglu, MehmetHigh levels of lipids and lipoproteins in young adults are significant risk factors for the development of heart disease in older ages. Increased levels of total cholesterol and triglycerides, high levels of low-density lipoprotein and low levels of high-density lipoprotein contribute to cardiovascular disease. Therefore, when starting antiepileptics, it is important to assess changes in serum lipid levels and choose the safety drug, thus contributing to the prevention of cardiovascular complications in older ages. This paper is a review of the e effects of AED use on plasma lipid parameters.Öğe Evaluation of Cervical Vestibular Evoked Myogenic Potentials in Patients with Migraine(Turkish Neurological Soc, 2013) Kaplan, Yuksel; Tecellioglu, Mehmet; Kamisli, Ozden; Kamisli, Suat; Ozcan, CemalObjective: Recent studies have indicated that the brain stem may contribute in the pathogenesis of migraine through different mechanisms. In addition to being used mainly in otologic diseases, vestibular evoked myogenic potentials (VEMP) testing is also used in neurological diseases affecting the brain stem such as stroke and multipl sclerosis in the literature. Studies involving VEMP testing in patients with migraine are novel and few in number. The purpose of this study was to evaluate whether VEMP values in patients with migraine provide additional information regarding the pathogenesis. Methods: This study included 52 patients with migraine and 52 control subjects. In both patients and controls, VEMP examination was performed using click stimuli, and all responses were recorded for both portions of the sternocleidomastoid muscle. Latency, amplitude and threshold values of the P1-N1 wave were compared between the two groups. Results: The amplitude of the left p1 was 4.47 +/- 3.52 mu v in patients and 6.15 +/- 4.79 mu v in the controls, and the difference was statistically significant. On the left, the average difference in the P1-N1 amplitude was 9.04 +/- 6.13 mu v in patients and 12.03 +/- 7.79 mu v in the controls; this difference was also statistically significant. Conclusion: The available studies on the pathophysiology of migraine show that the brain stem is particularly affected at the upper part. However, VEMP testing is mainly used for the assessment of the neuronal pathway starting from the saccula-macula and finishing at the sternocleidomastoid muscle in the lower brain stem. In this study, the only significant differences in amplitude were found in left-P1 and P1-N1. The results of our study show that in patients with migraine, neuroanatomical structures in the lower brain stem can be asymmetrically affected.Öğe Evaluation of macular and retinal nerve fiber layer thicknesses in episodic-type cluster headache patients by optical coherence tomography(2019) Tecellioglu, Mehmet; Cankaya, CemAim: This study evaluated macular and retinal nerve fiber layer (RNLF) thicknesses using spectral domain optical coherence tomography (SD-OCT) in patients with episodic-type cluster headaches. Material and Methods: In total, 33 eyes of 33 patients with episodic-type cluster headaches were included in this study. The eyes were ipsilateral to the pain, and all measurements were performed during attacks. The control group consisted of 33 eyes of 33 ageand sex-matched healthy individuals. The average RNFL thickness and macular thickness (MT) obtained from nine macular areas in the Early Treatment Diabetic Retinopathy Study (ETDRS) were evaluated using SD-OCT (RS-3000; Nidek Inc., Fremont, CA, USA) following a detailed ophthalmologic examination. The results of the two groups were then compared. Results: The mean RNFL thickness was 104.73 ± 8.7 in the cluster headache patients and 106.86 ± 8.6 in the controls. The difference in RNFL thickness between the groups was not significant (p = 0.418). The MT measurements according to the ETDRS showed statistically significant thinning of the outer temporal area in the cluster headache patients (295.95 ± 13.5 vs. 312.77 ± 15.9 in the controls, p = 0.001). The differences between the two groups with respect to the other ETDRS areas (central macula, superior-inner, inferior-inner, nasal-inner, temporal-inner, superior-outer, inferior-outer, nasal-outer, and total average macula) were not significant (p = 0.482, p = 0.672, p = 0.65, p = 0.679, p = 0.062, p = 0.455, p = 0.818, p = 0.845, and p = 0.189, respectively). Conclusion: Although the difference in thinning of the internal temporal region was not statistically significant between the patient and control groups, a vascular aetiology leading to thinning of the temporal region and thus to cell damage may contribute to the aetiology of episodic-type cluster headaches.Öğe Evaluation of macular and retinal nerve fiber layer thicknesses in episodic-type cluster headache patients by optical coherence tomography(2019) Tecellioglu, Mehmet; Çankaya, CemAbstract: Aim: This study evaluated macular and retinal nerve fiber layer (RNLF) thicknesses using spectral domain optical coherence tomography (SD-OCT) in patients with episodic-type cluster headaches.Material and Methods: In total, 33 eyes of 33 patients with episodic-type cluster headaches were included in this study. The eyes were ipsilateral to the pain, and all measurements were performed during attacks. The control group consisted of 33 eyes of 33 age- and sex-matched healthy individuals. The average RNFL thickness and macular thickness (MT) obtained from nine macular areas in the Early Treatment Diabetic Retinopathy Study (ETDRS) were evaluated using SD-OCT (RS-3000; Nidek Inc., Fremont, CA, USA) following a detailed ophthalmologic examination. The results of the two groups were then compared.Results: The mean RNFL thickness was 104.73 ± 8.7 in the cluster headache patients and 106.86 ± 8.6 in the controls. The difference in RNFL thickness between the groups was not significant (p = 0.418). The MT measurements according to the ETDRS showed statistically significant thinning of the outer temporal area in the cluster headache patients (295.95 ± 13.5 vs. 312.77 ± 15.9 in the controls, p = 0.001). The differences between the two groups with respect to the other ETDRS areas (central macula, superior-inner, inferior-inner, nasal-inner, temporal-inner, superior-outer, inferior-outer, nasal-outer, and total average macula) were not significant (p = 0.482, p = 0.672, p = 0.65, p = 0.679, p = 0.062, p = 0.455, p = 0.818, p = 0.845, and p = 0.189, respectively).Conclusion: Although the difference in thinning of the internal temporal region was not statistically significant between the patient and control groups, a vascular aetiology leading to thinning of the temporal region and thus to cell damage may contribute to the aetiology of episodic-type cluster headaches.Öğe Evaluation of the Relationship Between Serum Metallothionein and Trace Element Levels in Multiple Sclerosis Patients(Wiley, 2023) Yuce, Hande; Tecellioglu, Mehmet; Tanbek, Kevser; Yasar, Seyma; Turkmen, Nese Basak; Ates, Ilker; Unuvar, Songul[Abstract Not Available]Öğe Guillain-Barré Syndrome after COVID-19 accompanied by Dysautonomia(2021) Tecellioglu, Mehmet; Ozcan, CemalThe COVID-19 pandemic that emerged in Wuhan, Hubei Province, China in December 2019 is ongoing. COVID-19 may also cause neurological symptoms with central or peripheral nervous system or skeletal muscle involvement. Guillain–Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system that is usually triggered by bacterial or viral infections. Autonomic nerve involvement can be seen in GBS. Case reports suggest that GBS is linked to COVID-19 infection. Here, we present a case of GBS occurring after COVID-19, accompanied by dysautonomia.Öğe Guillain-Barré Syndrome after COVID-19 accompanied byDysautonomia(2021) Tecellioglu, Mehmet; Özcan, CemalThe COVID-19 pandemic that emerged in Wuhan, Hubei Province, China in December 2019 is ongoing. COVID-19 may also cause neurological symptoms with central or peripheral nervous system or skeletal muscle involvement. Guillain–Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system that is usually triggered by bacterial or viral infections. Autonomic nerve involvement can be seen in GBS. Case reports suggest that GBS is linked to COVID-19 infection. Here, we present a case of GBS occurring after COVID-19, accompanied by dysautonomia.Öğe Hirayama disease: An unusual case report(2018) Calisgan, Elisa; Canbay, Ali; Talu, Burcu; Tecellioglu, Mehmet; Sevimli, ReşitHirayama disease is an uncommon and rarely seen lower motor neuron disease. It is usually seen during periods of rapid growth (15-25 years). Distal upper extremities characteristically show weakness and atrophy. In this paper a case is presented of this rare, and difficult to diagnose disease, not previously reported in this age group, and the findings are discussed in the light of information of earlier cases in Turkey. A 53-year old male patient presented at Inonu University Neurology Polyclinic with complaints of motion tremor and atrophy in the left arm, which had been ongoing for 4 years. After electromyography, the deltoid, biceps, triceps, extensor digitorum communis, abductor pollicis brevis and abduction digiti minimi muscles were identified in the upper left limb. This case report presents information about the differential diagnosis, detailed symptoms and treatment methods of a Hirayama patient applying for physical therapy.Öğe Lipoid proteinosis and epilepsy: Molecular analysis(2019) Tecellioglu, Mehmet; Kamisli, Ozden; Acar, Ceren; Merge, Hatice; Sozen, Mert; Karaduman, Tugce; Sarac, Gulbahar; Erbay, Mehmet FatihAim: Lipoid proteinosis (LP) is also known as Urbach-Wiethe disease which is a rare autosomal recessive disorder characterized by intracellular accumulation of hyaline material in skin and mucosae. LP has typical neurological, dermatological and radiological findings. The pathogenesis of disease is unknown. In literature several cases have been reported up to date. Mutations in extracellular matrix protein 1 (ECM1) gene have been found to cause the disease. We evaluated the molecular features of a family diagnosed with LP and evaluate the known and novel mutations of LP. Material and Methods: Genomic DNA was extracted from peripheral blood of the patients and family members including clinically normal parents and two siblings of the two affected subjects by using a commercial DNA extraction kit. Polymerase chain reaction was performed for all 10 exons of ECM1 gene by using the primers defined. Results: All of the exons of the ECM1 gene were sequenced and this revealed a 2-bp deletion in exon 7 of the ECM1 gene in both patients and both parents. Patients have the homozygous 2-bp deletions (c735del TG) and the parents and two healthy siblings showed heterozygous 2-bp deletion. Conclusions: Our patients found to be homozygous for the deletion in ECM1 gene. In order to understand the molecular pathology of the disease in detail, further functional analysis of the mutations should be performed.Öğe Listeria monocytogenes rhombencephalitis in a patient with multiple sclerosis during fingolimod therapy(Elsevier Sci Ltd, 2019) Tecellioglu, Mehmet; Kamisli, Ozden; Kamisli, Suat; Erdogmus, Umut Adem; Ozcan, CemalObjective: To describe a case of Listeria monocytogenes rhombencephalitis in a patient receiving fingolimod. Methods: This is a case study. Results: Our patient developed acute rhombencephalitis with hydrocephalus induced with Listeria monocytogenes while on fingolimod. Shunt surgery was performed for the hydrocephalus and patient recovered partially after medical and surgical therapy. Conclusion: We describe the first probable case of fingolimod-associated Listeria monocytogenes rhombencephalitis in a patient with multiple sclerosis. Clinicians should be aware of listeriosis and implement measures for its prevention.
