Autoimmune polyglandular syndrome type III which accompanies to multiple sclerosis: A case report

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Tarih

2019

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info:eu-repo/semantics/openAccess

Özet

Autoimmune polyglandular syndrome type III (APS III) is characterised by autoimmune destruction of various endocrine and nonendocrine tissues. It differs from APS I and APS II in terms of without adrenal involvement. Although APS III includes a series of autoimmune disorders, it is rarely associated with multiple sclerosis (MS). A 41-year-old female patient had diplopia, visual blurring, dizziness, and giddiness for 2 weeks. In her medical history, she had a diagnosis of MS and using Teriflunomide. It was detected positivity of antinuclear antibody (ANA), anti-thyroid peroxidase (Anti-TPO) and anti-thyroglobulin (Anti-TG) antibodies. Based on these results, the patient with MS who has chronic autoimmune thyroiditis and primary ovarian failure was diagnosed with APS III. The coexistence of APS-III and MS is a rare clinical entity. Moreover, hypothyroidism has been detected during teriflunomide therapy in the patient. Hypothyroidism was most likely a component of APS-III in our case, but it may also have been triggered by teriflunomide.

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Annals of Medical Research

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Gorgel, A., Tecellioglu, M., & Cankaya, C. (2021). Autoimmune polyglandular syndrome type III which accompanies to multiple sclerosis: A case report . Annals of Medical Research