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  • Küçük Resim Yok
    Öğe
    The Antiedema Effect of Intracisternal Hyperosmolar Albumine on Experirnental Created Brain Edema
    (Derman Medical Publ, 2010) Tekiner, Ayhan; Onal, Cagatay; Kocak, Ayhan; Cayhli, Suleyman Rustu; Bayar, Mehmet Akif; Tektas, Sevket
    Aim The brain edema caused by central nervous system diseases and trauma is an important reason of morbidity and mortality currently. Although the most of physiopathology of traumatic brain edema has been elucidated through many clinical and laboratory studies, the treatment of edema couldn't been standardized. For this purpose, from past to the present although many treatment principles have been accepted, also different treatment agents are being used. Material and Methods In this experimental study thirty six New Zealander rabbits weighing between 2.2 and 2.8 kg were used. Craniectomi was applied to the subjects and gravity was dropped from high in order to develop traumatic brain edema. The subjects were divided into six groups and hyperosmolar albumine was given to each group on different time periods. It was aimed to resolve the edema by drawing the edema liquid to subarachnoid distance by giving human albumin a physiologic macromolecule through cysterna manga. The efficacy of tretment was evaluated through two parameters: the first cerebrospinal fluid osmolality and the second the rate of brain tissue fluid. Results Cerebrospinal fluid osmolality and brain tissue fluid ratio gained at the result of the study were statistical evaluated by Kruskal-Wallis nonparametric ANOVA test and Mann-Whitney U test. p value<0,05 was accepted statistical significant. Conclusion When compared the results of the study groups the difference was significant between trauma and control group and the difference was relatively close to the control group at the treatment group. The treatment was significantly efficient at the groups which were applied hyperosmolar albumine two or three times in the first 72 hours after trauma. According to these results we can declare this experimental study has reached to the purpose and can contribute to future studies about the same subject.
  • Küçük Resim
    Öğe
    İntrasisternal uygulanan hiperosmolar albuminin tavşanlarda oluşturulan deneysel beyin ödemine etkisi
    (İnönü Üniversitesi, 2001) Tekiner, Ayhan
    Travmatik beyin ödemi ile ilgili olarak son yıllarda birçok klinik ve laboratuar çalışma yapılmaktadır. Beyin ödemi fızyopatolojisinin çoğu yönünün açıklık kazanmasına rağmen tedavi tamamen standartize edilememiştir. Bu amaçla geçmişten günümüze birçok tedavi ilkesi kabul edildiği gibi değişik tedavi ajanlarının da kullanıldığı görülmektedir. Ancak etkin tedavi olanaklarının kısıtlı olması halen travmatik beyin ödeminin mortalité ve morbidité nedeni oluşuna yol açmaktadır.Bu deneysel çalışmada; denek olarak kullanılan tavşanlara kraniektomi yapılarak, yüksekten ağırlık düşürme yöntemi uygulanmış ve travmatik beyin ödemi oluşturulmuştur. Denekler altı değişik çalışma gruplarına ayrılarak, tedavi gruplarına değişik zamanlarda hiperosmolar albumin verilmiştir. Fizyolojik bir makromolekül olan insan albumininin sisterna magnadan verilerek ödem sıvısını subaraknoid mesafeye çekerek ödemin çözülmesi amaçlanmıştır.