The Antiedema Effect of Intracisternal Hyperosmolar Albumine on Experirnental Created Brain Edema
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Derman Medical Publ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim The brain edema caused by central nervous system diseases and trauma is an important reason of morbidity and mortality currently. Although the most of physiopathology of traumatic brain edema has been elucidated through many clinical and laboratory studies, the treatment of edema couldn't been standardized. For this purpose, from past to the present although many treatment principles have been accepted, also different treatment agents are being used. Material and Methods In this experimental study thirty six New Zealander rabbits weighing between 2.2 and 2.8 kg were used. Craniectomi was applied to the subjects and gravity was dropped from high in order to develop traumatic brain edema. The subjects were divided into six groups and hyperosmolar albumine was given to each group on different time periods. It was aimed to resolve the edema by drawing the edema liquid to subarachnoid distance by giving human albumin a physiologic macromolecule through cysterna manga. The efficacy of tretment was evaluated through two parameters: the first cerebrospinal fluid osmolality and the second the rate of brain tissue fluid. Results Cerebrospinal fluid osmolality and brain tissue fluid ratio gained at the result of the study were statistical evaluated by Kruskal-Wallis nonparametric ANOVA test and Mann-Whitney U test. p value<0,05 was accepted statistical significant. Conclusion When compared the results of the study groups the difference was significant between trauma and control group and the difference was relatively close to the control group at the treatment group. The treatment was significantly efficient at the groups which were applied hyperosmolar albumine two or three times in the first 72 hours after trauma. According to these results we can declare this experimental study has reached to the purpose and can contribute to future studies about the same subject.
Açıklama
Anahtar Kelimeler
Traumatic Brain Injury, Brain Edema, Hyperosmolar Albumine
Kaynak
Journal of Clinical and Analytical Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
1
Sayı
1
