The Antiedema Effect of Intracisternal Hyperosmolar Albumine on Experirnental Created Brain Edema

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dc.authoridtekiner, ayhan/0000-0002-3835-2568
dc.authorwosiderdem, yavuz/AGW-7926-2022
dc.authorwosidtekiner, ayhan/HIZ-6473-2022
dc.contributor.authorTekiner, Ayhan
dc.contributor.authorOnal, Cagatay
dc.contributor.authorKocak, Ayhan
dc.contributor.authorCayhli, Suleyman Rustu
dc.contributor.authorBayar, Mehmet Akif
dc.contributor.authorTektas, Sevket
dc.date.accessioned2024-08-04T20:32:43Z
dc.date.available2024-08-04T20:32:43Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim The brain edema caused by central nervous system diseases and trauma is an important reason of morbidity and mortality currently. Although the most of physiopathology of traumatic brain edema has been elucidated through many clinical and laboratory studies, the treatment of edema couldn't been standardized. For this purpose, from past to the present although many treatment principles have been accepted, also different treatment agents are being used. Material and Methods In this experimental study thirty six New Zealander rabbits weighing between 2.2 and 2.8 kg were used. Craniectomi was applied to the subjects and gravity was dropped from high in order to develop traumatic brain edema. The subjects were divided into six groups and hyperosmolar albumine was given to each group on different time periods. It was aimed to resolve the edema by drawing the edema liquid to subarachnoid distance by giving human albumin a physiologic macromolecule through cysterna manga. The efficacy of tretment was evaluated through two parameters: the first cerebrospinal fluid osmolality and the second the rate of brain tissue fluid. Results Cerebrospinal fluid osmolality and brain tissue fluid ratio gained at the result of the study were statistical evaluated by Kruskal-Wallis nonparametric ANOVA test and Mann-Whitney U test. p value<0,05 was accepted statistical significant. Conclusion When compared the results of the study groups the difference was significant between trauma and control group and the difference was relatively close to the control group at the treatment group. The treatment was significantly efficient at the groups which were applied hyperosmolar albumine two or three times in the first 72 hours after trauma. According to these results we can declare this experimental study has reached to the purpose and can contribute to future studies about the same subject.en_US
dc.identifier.doi10.4328/JCAM.10.1.16
dc.identifier.endpage38en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-79952285929en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.10.1.16
dc.identifier.urihttps://hdl.handle.net/11616/95268
dc.identifier.volume1en_US
dc.identifier.wosWOS:000215538700007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTraumatic Brain Injuryen_US
dc.subjectBrain Edemaen_US
dc.subjectHyperosmolar Albumineen_US
dc.titleThe Antiedema Effect of Intracisternal Hyperosmolar Albumine on Experirnental Created Brain Edemaen_US
dc.typeArticleen_US

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