Yazar "Toplu, Sibel Altunışık" seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Infections in Liver Retransplantation: A Prospective Study of Microbial Patterns, Immune Biomarkers, and Survival(Elsevier Inc., 2026) Karakaş, Ezgi Erdal; Toplu, Sibel Altunışık; Şahin, Tevfik Tolga; Karakaş, Serdar; Satılmış, Basri; Akbulut, Sami; Bayındır, YaşarBackground: Liver retransplantation (Re-Tx) recipients are at elevated risk for infectious complications due to increased immunologic and clinical vulnerability. However, prospective data on infection incidence, microbial etiology, immune biomarkers, and survival outcomes in this population remain limited. Methods: We conducted a prospective cohort study of 26 adult Re-Tx recipients treated between 2021 and 2023 at the Inonu University Liver Transplantation Institute (Malatya, Türkiye). Demographic, clinical, and laboratory data—including preoperative immune biomarkers (TNF-α, TGF-β, IL-1β, IL-4, IL-6, IL-22, β-galactosidase, GDH, IFN-γ, GM-CSF)—were collected. Infections were classified as early (0–30 days) or early-intermediate (1–6 months) post-transplant. Multivariate logistic regression was used to assess infection risk factors. Kaplan–Meier analysis was performed to evaluate survival. Results: Female sex (OR = 7.377) and elevated procalcitonin levels on postoperative day 3 (OR = 1.054) were independently associated with early infections. Early infections were predominantly caused by gram-negative bacteria and fungi, including E. coli, Klebsiella spp., and Acinetobacter baumannii. These infections significantly reduced 1-, 3-, and 5-year survival rates (log-rank P < .05). No significant differences were found in preoperative immune biomarker levels between infected and non-infected patients (P > .05). Conclusions: Re-Tx recipients face high early infection risk, especially from multidrug-resistant organisms such as Candida spp. and A. baumannii. Female sex and postoperative PCT elevation may serve as early warning indicators. Although biologically relevant, preoperative immune biomarkers showed limited prognostic value. Tailored prophylactic and monitoring strategies are needed in this high-risk group. © 2026 Elsevier Inc.Öğe Laboratuvar kaynaklı bruselloz: bir olgu sunumu(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Toplu, Sibel Altunışık; Yıldız, FatimeDünyada yaygın olarak görülen zoonozlardan biri olan bruselloz ülkemizde halen endemiktir. En sık geçiş enfekte süt ve süt ürünlerinin tüketilmesi ile olmaktadır. Farklı olarak laboratuvar çalışanlarında hem direk inhalasyon hemde hasarlı derinin enfekte materyallere teması sonucu bulaş olabilmektedir. Mikrobiyoloji teknisyeni olan 42 yaşındaki erkek olgumuzda, yaklaşık 10 gündür başlayan, özellikle diz ve kalça ekleminde belirgin eklem ağrısı, halsizlik ve gece terlemesi mevcuttu. Pastörize edilmemiş süt ve süt ürünü tüketim öyküsü bulunmayan hastanın sonrasında Brucella spp. üremesi saptanmış bir kültür plağına dokunma ve koklama öyküsü mevcuttu. Hastanın alınan kan kültüründe de Brucella melitensis üremesi saptandı. Brusellozda yüksek laboratuvar geçiş riskini hatırlatmak amacı ile bu olguyu sunmaktayız.Öğe Laboratuvar Kaynaklı Bruselloz: Bir Olgu Sunumu(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Toplu, Sibel Altunışık; Yıldız, FatimeDünyada yaygın olarak görülen zoonozlardan biri olan bruselloz ülkemizde halen endemiktir. En sık geçiş enfekte süt ve süt ürünlerinin tüketilmesi ile olmaktadır. Farklı olarak laboratuvar çalışanlarında hem direk inhalasyon hemde hasarlı derinin enfekte materyallere teması sonucu bulaş olabilmektedir. Mikrobiyoloji teknisyeni olan 42 yaşındaki erkek olgumuzda, yaklaşık 10 gündür başlayan, özellikle diz ve kalça ekleminde belirgin eklem ağrısı, halsizlik ve gece terlemesi mevcuttu. Pastörize edilmemiş süt ve süt ürünü tüketim öyküsü bulunmayan hastanın sonrasında Brucella spp. üremesi saptanmış bir kültür plağına dokunma ve koklama öyküsü mevcuttu. Hastanın alınan kan kültüründe de Brucella melitensis üremesi saptandı. Brusellozda yüksek laboratuvar geçiş riskini hatırlatmak amacı ile bu olguyu sunmaktayız.Öğe Outbreak of adenovirus type-8 conjunctivitis among healthcare workers in the ophthalmology clinic of a tertiary hospital: Management and infection control measures(Elsevier Inc., 2025) Memişoğlu, Funda; Yilmaz, Zeynep Burcin; Yakupoğulları, Yusuf; Toplu, Sibel Altunışık; Tanrıverdi, Elif Seren; Cumurcu, Tongabay; Otlu, BarışBackground This study documents an outbreak of Human adenovirus (HAdV) keratoconjunctivitis originating in the ophthalmology department of a tertiary hospital and spreading to the neonatal intensive care unit. Methods Following ORION guidelines, the Hospital Infection Control Committee launched an investigation after clusters of keratoconjunctivitis in healthcare workers reported over 4-week. Patient records were reviewed, environmental and patient samples collected, and PCR analyses performed. Infection control measures were implemented, and their effectiveness was assessed through follow-up testing. The institutional burden of the outbreak was analyzed. Results Twelve healthcare workers were affected (8 ophthalmology, 4 neonatal intensive care unit). PCR confirmed HAdV in conjunctival swabs from 11 tested individuals, including cases infected more than 3 weeks earlier. Viral contamination was detected on 10/16 environmental surfaces in the ophthalmology clinic. Genotyping identified HAdV type-8. The outbreak imposed major operational burdens, especially workforce loss. Chlorine solution achieved rapid surface disinfection, while 0.36% hydrogen peroxide required repeated applications for chlorine-sensitive devices. Following enhanced disinfection protocols and temporary clinic closure during a holiday, no new cases occurred. Discussion This outbreak, which continued until the Infection Control Committee intervened, underlines the high environmental contamination of HAdV and the critical importance of a swift, evidence-based, and multidisciplinary response. Conclusions This study demonstrates that targeted disinfection and strict Infection control measures are essential for containing such outbreaks and mitigating their significant operational and financial impact on healthcare institutions. Copyright © 2025. Published by Elsevier Inc.
