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Öğe The evaluation of the outcomes of long-term follow-up of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome(Turkiye Klinikleri, 2014) Tekin M.; Toplu Y.; Gülyüz A.; Konca Ç.; Uzuner S.; Üçkardeş F.Objective: Evaluation of the long-term outcomes of patients as with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Material and Methods: In this study, 57 patients admitted to the pediatrics and otorhinolaryngology clinics, and diagnosed as PFAPA syndrome, between 2005 and 2013 were analyzed retrospectively. Age, gender, age of attacks onset, age at diagnosis, frequency of attacks, duration of fever, the major clinical findings, concomitant clinical findings, seasonal difference in attack frequency, concomitant diseases during long term follow-up, the efficiency of single dose prednisolone (1 mg/kg) or tonsillectomy treatment and related resolution rates, and spontaneous remission rates were analyzed. Results: In this retrospective study, 57 patients diagnosed as PFAPA syndrome were followed for an median of 6.1 years (3-8 years). The number of patients whoes the attacks showed no seasonal differences were significantly higher than these showed seasonal differences (p<0.001). Asthma was the most common concomitant diseases with PFAPA syndrome. A single dose of prednisolone (1 mg/kg) was highly effective in controlling symptoms (in 96.4% of patients). Spontaneous remission of fever episodes was observed in twenty six patients during follow-up. The mean duration of disease was 6.6 years, and the mean age of remission was 8.9 years in patients with spontaneous remission. Tonsillectomy or adenotonsillectomy was performed to 10 patients and complete remission was observed in 8 of these patients. Totally 34 (60.7%) patients were recovered spontaneously or after tonsillectomy-adenotonsillectomy. Conclusion: In the long term follow-up, the most cases of patients diagnosed as PFAPA syndrome recovered spontaneously with no sequelae. Single dose of prednisolone (1 mg/kg) was highly effective in controlling symptoms. Tonsillectomy or adenotonsillectomy was very effective for permanent remission. Copyright © 2014 by Türkiye Klinikleri.Öğe Giant desmoid tumor in the neck(2014) Toplu Y.; Öztanır N.; Çetinkaya Z.; Koç A.; Kızılay A.Desmoid tumor is a benign tumor which originates from musculoaponeurotic system, can reach greater sizes with local invasion among facial plans, and cause severe deformities, morbidity and even mortality by compression of adjacent structures. These tumors are rarely seen in the head and neck region. The treatment of advanced desmoid tumors of head and neck region is surgery and radiotherapy. In this paper, we present -to the best of our knowledge- the greatest desmoid tumor case of the head and neck region in the literature.Öğe Ototoxic drugs, diagnosis and monitoring(Nova Science Publishers, Inc., 2019) Toplu Y.; Tan M.Ototoxicity is a cochlear or vestibular dysfunction caused by chemical, physical or biological effects. It affects the internal ear and hearing nerve and might be reversible or irreversible. Besides hearing loss, it can also cause tinnitus or dizziness. In practice, drug-induced ototoxicity is in the foreground. Ototoxic drugs have harmful effects on the cochlea and the vestibular system. When the cochlea is affected, it may result in hearing dysfunction. When the vestibular system is affected, it may result in vertigo. Although ototoxic drugs have harmful effects, they must be used in clinical practices. Aminoglycoside antibiotics, loop diuretics, platinum-based chemotherapeutic agents, macrolide antibiotics and antimalarial are among the 600 frequently used ototoxic drugs. The ototoxic drugs cause a wide range of symptoms on the auditory system. Otological problems can be hearing loss, tinnitus, hyperacusis, aural fullness, dizziness and vertigo. The degree of these symptoms may vary between patients. The symptoms may occur together, individually, gradually or rapidly. The most important symptom is hearing loss which is not life-threatening; however, it significantly decreases the quality of life. It also impairs communication with the environment. The most important step in ototoxicity is the diagnosis and the first step of the diagnosis is to think of ototoxicity. The diagnosis is made based on anamnesis, symptoms and audiological test results. High frequency audiometry, distortion product of otoacoustic emissions (DPOAEs) and tympanometry can be performed as audiological tests. The results of these tests must be compared before and after drug use. Nowadays, ototoxicity can be prevented with close monitoring and follow-up during the use of ototoxic drugs. If hearing loos is diagnosed during treatment, the treatment must be reevaluated. In the case of permanent hearing loss, options such as hearing aids and cochlear implants can be considered. © 2019 by Nova Science Publishers, Inc. All rights reserved.Öğe [Our results of endoscopic dacryocystorhinostomy and bicanalicular silicone tube intubation surgery].(2012) Toplu Y.; Balbaba M.; Kalcio?lu M.T.; Ozcan K.In this study, we evaluated the results of endoscopic dacryocystorhinostomy and bicanalicular silicone tube intubation (EDCR + BSTI) surgery in the patients with epiphora due to nasolacrimal duct obstruction. A total of 120 eyes in 112 patients (40 males, 72 females; mean age 42; range 6 to 74 years) who underwent EDCR + BSTI surgery under general anesthesia between August 2006 and December 2010 were analyzed retrospectively. Of the patients, 104 underwent unilateral surgery, while eight underwent bilateral surgery. One hundred nine of 120 surgeries were primary, whereas 11 were revision surgery. Follow-up was performed on a regular basis in the first week, at one, three, six, and 12 months following surgery. Successful results were obtained in 113 of 120 operation, however seven patients required revision surgery. Repeated EDCR + BSTI surgery gave successful results in all cases, as assessed during the follow-up visits. EDCR + BSTI surgery is a primary treatment of choice for the patients with epiphora due to nasolacrimal duct obstruction with a high success rate.
