The evaluation of the outcomes of long-term follow-up of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Evaluation of the long-term outcomes of patients as with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Material and Methods: In this study, 57 patients admitted to the pediatrics and otorhinolaryngology clinics, and diagnosed as PFAPA syndrome, between 2005 and 2013 were analyzed retrospectively. Age, gender, age of attacks onset, age at diagnosis, frequency of attacks, duration of fever, the major clinical findings, concomitant clinical findings, seasonal difference in attack frequency, concomitant diseases during long term follow-up, the efficiency of single dose prednisolone (1 mg/kg) or tonsillectomy treatment and related resolution rates, and spontaneous remission rates were analyzed. Results: In this retrospective study, 57 patients diagnosed as PFAPA syndrome were followed for an median of 6.1 years (3-8 years). The number of patients whoes the attacks showed no seasonal differences were significantly higher than these showed seasonal differences (p<0.001). Asthma was the most common concomitant diseases with PFAPA syndrome. A single dose of prednisolone (1 mg/kg) was highly effective in controlling symptoms (in 96.4% of patients). Spontaneous remission of fever episodes was observed in twenty six patients during follow-up. The mean duration of disease was 6.6 years, and the mean age of remission was 8.9 years in patients with spontaneous remission. Tonsillectomy or adenotonsillectomy was performed to 10 patients and complete remission was observed in 8 of these patients. Totally 34 (60.7%) patients were recovered spontaneously or after tonsillectomy-adenotonsillectomy. Conclusion: In the long term follow-up, the most cases of patients diagnosed as PFAPA syndrome recovered spontaneously with no sequelae. Single dose of prednisolone (1 mg/kg) was highly effective in controlling symptoms. Tonsillectomy or adenotonsillectomy was very effective for permanent remission. Copyright © 2014 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Complications, Remission, spontaneous, Tonsillectomy
Kaynak
Turkiye Klinikleri Pediatri
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
23
Sayı
1
