Yazar "Touj, N." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Copper-catalyzed azide-alkyne cycloaddition (CuAAC) under mild condition in water: Synthesis, catalytic application and biological activities
    (Elsevier Science Sa, 2017) Touj, N.; Chakchouk-Mtibaa, A.; Mansour, L.; Harrath, A. H.; Al-Tamimi, J. H.; Ozdemir, I.; Mellouli, L.
    A series of Cu-N-heterocyclic carbene (Cu-NHC) complexes, 3a-c, were synthesized and characterized by spectroscopic methods such as NMR, HRMS and elemental analysis. The performance of these (Cu-NHC) complexes, 3a-c showed excellent activity in 1,3-dipolar cycloaddition reactions between alkynes and azides to obtain 1,4-disubstituted triazoles 6a-d in 80%-91% isolated yields. All obtained complexes especially compounds 3a and 3c, presented significant inhibitory activity against the tested food-borne pathogens and clinical microorganisms. The compound 3a presents against S. aureus a MIC value of 4.8 mg/ml quite similar to that of ampicillin (4 mg/ml) used as standard. Compounds 3a and 3b, from a concentration of 0.5 mg/ml, present an identical scavenging activity to that of the two used controls butylated hydroxytoluene (BHT) and gallic acid (GA). Concerning acetylcholinesterase inhibition activity (AChEI), compound 6a presents an interesting AChEI activity with 68.3% of inhibition. (C) 2017 Published by Elsevier B.V.
  • Küçük Resim Yok
    Öğe
    Synthesis, spectroscopic properties and biological activity of new Cu(I) N-Heterocyclic carbene complexes
    (Elsevier, 2019) Touj, N.; Chakchouk-Mtibaa, A.; Mansour, L.; Harrath, A. H.; Al-Tamimi, J.; Mellouli, L.; Ozdemir, I
    New benzimidazolium salts (2) and their copper N-heterocyclic carbene complexes (3 4) were designed, synthesized and structurally characterized by NMR (H-1 and C-13), IR, HRMS and elemental analysis. All obtained complexes especially compounds 3d and 3e, presented significant inhibitory activity against the tested food-borne pathogens and clinical microorganisms. The compound 3b presents against S. aureus a MIC value of 0.0195 mg/ml quite similar to that of ampicillin (0.0195 mg/ml) used as standard. Compounds 3a and 3b, from a concentration of 0.5 mg/ml, present an identical scavenging activity to that of the two used controls butylated hydroxytoluene (BHT) and gallic acid (GA). Concerning acetylcholinesterase inhibition activity (AChEI), compound 3e presents an interesting AChEI activity with 32.80% of inhibition. (C) 2018 Published by Elsevier B.V.