Synthesis, spectroscopic properties and biological activity of new Cu(I) N-Heterocyclic carbene complexes
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
New benzimidazolium salts (2) and their copper N-heterocyclic carbene complexes (3 4) were designed, synthesized and structurally characterized by NMR (H-1 and C-13), IR, HRMS and elemental analysis. All obtained complexes especially compounds 3d and 3e, presented significant inhibitory activity against the tested food-borne pathogens and clinical microorganisms. The compound 3b presents against S. aureus a MIC value of 0.0195 mg/ml quite similar to that of ampicillin (0.0195 mg/ml) used as standard. Compounds 3a and 3b, from a concentration of 0.5 mg/ml, present an identical scavenging activity to that of the two used controls butylated hydroxytoluene (BHT) and gallic acid (GA). Concerning acetylcholinesterase inhibition activity (AChEI), compound 3e presents an interesting AChEI activity with 32.80% of inhibition. (C) 2018 Published by Elsevier B.V.
Açıklama
Anahtar Kelimeler
Copper-N-heterocyclic carbene complex, Benzimidazolium salts, Biological activities
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
1181
