Synthesis, spectroscopic properties and biological activity of new Cu(I) N-Heterocyclic carbene complexes

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dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridHarrath, Abdel Halim/0000-0002-2170-1303
dc.authorwosidTouj, Nedra/AAM-2982-2021
dc.authorwosidMANSOUR, Lamjed/AAO-6201-2020
dc.authorwosidchakchouk, ahlem/JYP-3425-2024
dc.authorwosidAl-Tamimi, Jameel H/F-2374-2019
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.contributor.authorTouj, N.
dc.contributor.authorChakchouk-Mtibaa, A.
dc.contributor.authorMansour, L.
dc.contributor.authorHarrath, A. H.
dc.contributor.authorAl-Tamimi, J.
dc.contributor.authorMellouli, L.
dc.contributor.authorOzdemir, I
dc.date.accessioned2024-08-04T20:45:40Z
dc.date.available2024-08-04T20:45:40Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNew benzimidazolium salts (2) and their copper N-heterocyclic carbene complexes (3 4) were designed, synthesized and structurally characterized by NMR (H-1 and C-13), IR, HRMS and elemental analysis. All obtained complexes especially compounds 3d and 3e, presented significant inhibitory activity against the tested food-borne pathogens and clinical microorganisms. The compound 3b presents against S. aureus a MIC value of 0.0195 mg/ml quite similar to that of ampicillin (0.0195 mg/ml) used as standard. Compounds 3a and 3b, from a concentration of 0.5 mg/ml, present an identical scavenging activity to that of the two used controls butylated hydroxytoluene (BHT) and gallic acid (GA). Concerning acetylcholinesterase inhibition activity (AChEI), compound 3e presents an interesting AChEI activity with 32.80% of inhibition. (C) 2018 Published by Elsevier B.V.en_US
dc.description.sponsorshipDeanship of Scientific Research at King Saud University [RG-1435-023]en_US
dc.description.sponsorshipThe authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding this research group (No. RG-1435-023).en_US
dc.identifier.doi10.1016/j.molstruc.2018.12.093
dc.identifier.endpage219en_US
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85059585733en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2018.12.093
dc.identifier.urihttps://hdl.handle.net/11616/98598
dc.identifier.volume1181en_US
dc.identifier.wosWOS:000458612300023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopper-N-heterocyclic carbene complexen_US
dc.subjectBenzimidazolium saltsen_US
dc.subjectBiological activitiesen_US
dc.titleSynthesis, spectroscopic properties and biological activity of new Cu(I) N-Heterocyclic carbene complexesen_US
dc.typeArticleen_US

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