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Öğe Bernard-Soulier Syndrome from the Perspective of the Obstetrician: A Case Report with a Review of the Literature(Georg Thieme Verlag Kg, 2023) Saridogan, Erdinc; Onat, Taylan; Duz, Senem Arda; Tuncay, Gorkem; Abdurahmanova, Nuray; Orujova, Lumayat; Karaer, AbdullahObjective Bernard-Soulier syndrome (BSS) is one of the rare inherited platelet disorders that is characterized by macrothrombocytopenia and adhesion abnormality due to the absence or malfunctioning of the membrane GPIb-IX-V complex. There is no high-quality evidence on obstetric management of BSS owing to its rarity. Here we report an uncomplicated delivery of an adolescent with BSS and review the literature on the topic of BSS and pregnancy.Methods PUBMED, EMBASE, COCHRANE, and Google Scholar databases were searched up to April 2022 without language and year restriction using the terms Bernard Soulier and Pregnancy . The primary objectives were to evaluate maternal and fetal outcomes. The secondary objectives were to analyze pregnancy complications, gestational age at delivery, mode of delivery, administered prophylaxis, treatment approaches, duration of postpartum hospitalization, and the postpartum requirement of blood and blood product.Results The patient was a 19-year-old and 39-week pregnant woman who was diagnosed with BSS at the age of 10 by flow cytometry and genetic analysis. Single donor platelet transfusions and oral tranexamic acid were administered as prophylaxis at the peripartum period. She was delivered by cesarean section due to failure of labor. The postpartum period was uneventful for both mother and neonate. In the literature review, postpartum hemorrhage (PPH) was found in 52.9% (27/51) of deliveries. Late PPH occurred more frequently than early PPH (35.3 and 31.4%, respectively). 49% (25/51) of pregnancies had severe thrombocytopenia, and antepartum hemorrhage was observed in 11.8% (6/51) of those. The platelet count was in close relation to antenatal complications. 64.7% (33/51) of the patients were delivered via cesarean section. PPH and late PPH were found to be more common in those who delivered vaginally compared to those who delivered by caesarean section. It was observed that PPH was less common in women who were given prophylaxis in the peripartum period.Conclusion BSS is an inherited macro-thrombocytopathy that may cause adverse maternal and neonatal outcomes. The optimal mode and timing of delivery remain unclear. A multidisciplinary approach with prophylaxis at the peripartum period should be applied.Öğe Blood cadmium concentrations in women with ectopic pregnancy(Humana press ınc, 999 rıvervıew drıve suıte 208, totowa, nj 07512 usa, 2018) Karaer, Abdullah; Tuncay, Gorkem; Tanrikut, Emrullah; Ozgul, OnurThe purpose of this study is to investigate the relationship between the blood level of cadmium and the occurrence of ectopic pregnancy. Forty-one (41) case patients with ectopic pregnancy and 41 uncomplicated intrauterine pregnant patients as controls were recruited. The concentrations of cadmium (Cd) were measured from blood samples using atomic absorption spectrometry. The cases and controls were similar in age, body mass index, and smoking habits. The median blood level of Cd was 0.32 mu g/l (interquartile range [IQR] 0.00-0.71) in the women with ectopic pregnancies and 0.34 mu g/l (IQR 0.09-0.59) in the controls. There was no significant association between blood cadmium levels and ectopic pregnancy.Öğe Blood Cadmium Concentrations in Women with Ectopic Pregnancy(Humana Press Inc, 2018) Karaer, Abdullah; Tuncay, Gorkem; Tanrikut, Emrullah; Ozgul, OnurThe purpose of this study is to investigate the relationship between the blood level of cadmium and the occurrence of ectopic pregnancy. Forty-one (41) case patients with ectopic pregnancy and 41 uncomplicated intrauterine pregnant patients as controls were recruited. The concentrations of cadmium (Cd) were measured from blood samples using atomic absorption spectrometry. The cases and controls were similar in age, body mass index, and smoking habits. The median blood level of Cd was 0.32 mu g/l (interquartile range [IQR] 0.00-0.71) in the women with ectopic pregnancies and 0.34 mu g/l (IQR 0.09-0.59) in the controls. There was no significant association between blood cadmium levels and ectopic pregnancy.Öğe Clinical and hormonal characteristics of women with various phenotypes of polycystic ovary syndrome(2020) Arda Duz, Senem; Tuncay, Gorkem; Karaer, AbdullahAim: The goal of this study is to identify clinical and hormonal characteristics of women with various phenotypes of polycystic ovary syndrome. Material and Methods: One hundred seventy eight cases, between the ages 18-30, diagnosed with PCOS, up to Rotterdam criteria, in our clinic between February 2015 -November 2018 were recruited in this cross sectional study. Results: The number was declined 89 by using National Institutes of Health criteria, 132 up to Androgen Excess and PCOS Society criteria. 34.83% of the patients were phenotype A, 15.16% were phenotype B, 24.15% were phenotype C and 25.84% were phenotype D. When we compared the different phenotypes with each other, body mass index, fasting glucose, postprandial glucose, fasting insulin and homeostatic model assessment for insulin resistance were found to be higher in phenotype A. In addition, luteinizing hormone and luteinizing hormone to follicle stimulating hormone ratio was higher in phenotype D than in B and C. When multivariate analysis was performed, body mass index was found to be as a single statistically significant predictive factor on IR. Conclusion: Body mass index was the most effective factor on insulin resistance and the mean body mass index was significantly higher in phenotype A.Öğe Comparison of the administration of dual and standard trigger in patients undergoing IVF Treatment(2021) Yigit, Fatih; Karaer, Abdullah; Tuncay, GorkemAim: This study aimed to compare in vitro fertilization (IVF) outcomes in patients who were administered dual trigger due to OHSS risk in the GnRH antagonist protocol with patients who were administered standard trigger.Materials and Methods: The medical files were retrospectively scanned for all the patients who were admitted to Inonu Unıversity department of obstetrics and gynecology.While the dual trigger group was composed of patients with OHSS risk who were stimulated with GnRH antagonist and received dual trigger(hCG + GnRHa) for final oocyte maturation, the age-matched (20-40) control group consisted of patients who were administered standard trigger (10000 IU uhCG or 500 μgrrhCG and obtained oocyte counts of 500 μgr recombinant hCG). Thetwo groups were compared in terms of the oocyte count, MII oocyte count, and pregnancy and birth outcomes.Results: There was no statistically significant difference between the two groups in terms of age, weight, height, BMI, duration of marriage, presence of previous pregnancy, number of previous parities, number of pre-existing children, number of previous abortus stories, number of smokers, duration of infertility, LH, E2, prolactin, TSH levels, infertility causes, and hCG dose endometrium thickness. The number of oocytes and MII oocytes obtained was significantly higher in the dual trigger group compared to the control group. There was no statistically significant difference between the two groups in terms of the number of pregnancies and number of deliveries. Conclusion: Although the number of oocytes and MII oocytes was higher in the dual trigger group compared to the control group, there was no significant difference in terms of the pregnancy ratios and the number of deliveries.Öğe Comparison of umbilical coiling index in term pregnancies with and without fetal growth restriction(2022) Arda Duz, Senem; Cengiz, Murat; Tuncay, Gorkem; Karaca, AbdullahAbstract Aim: To investigate pregnancies with and without fetal growth restriction, giving birth after 37 weeks of gestation in terms of umbilical coiling index and neonatal outcomes. Materials and Methods: Twenty-nine patients with fetal growth restriction and 46 patients who have normal pregnancy and delivered after the 37th week of gestation were recruited in this study. The umbilical coiling index was measured by ultrasound, following the patients who were hospitalized for delivery. Results: There were statistically significant differences between the groups regarding to umbilical artery pulsatility index, gestational age at delivery and birth weight of the newborn. The need for a cesarean section because of non-reassuring fetal condition was statistically significantly higher in the fetal growth restriction group. The mean antenatal umbilical coiling index in fetal growth restriction and control patients was 0.29±0.08 and 0.27±0.08, respectively and the difference was not statistically significant. Conclusion: There was no statistically significant difference between the patients diag- nosed with and without fetal growth restriction who delivered after the 37th gestational week, regarding the umbilical coiling index and perinatal outcomes, except umbilical artery pulsatility index, gestational age at birth and birth weight of the newborn.Öğe The Definition of the Upper Limit of Adolescent Age in Terms of Adverse Pregnancy Outcomes(Springernature, 2021) Duz, Senem Arda; Tuncay, Gorkem; Cengiz, Murat; Karaer, AbdullahIntroduction This study aims to reveal the maternal and neonatal adverse outcomes, associated with adolescent pregnancies in our country, to investigate whether the 20 to 21-year-age group, which is very close to the adolescent age, is similar to the adolescent age group in terms of adverse outcomes, and so to contribute to the definition of the upper limit in adolescent age for pregnancy. Methods Four hundred and twenty-four pregnant women under the 20-year-age, 450 pregnant women at 20 to 21year-age, and 450 pregnant women between 22 and 25-year-age were included in this retrospective study. Maternal demographic features, clinical characteristics, obstetric complications, maternal outcomes, neonatal complications, and neonatal outcomes were collected from the medical records of the participants. Results There were statistically significant differences between under 20-year-age and 22 to 25-year-age, regarding gestational age at birth, maternal duration of hospitalization after delivery, mode of delivery, preterm delivery rate, very low birth weight, and low birth weight, first minute Apgar score, the presence of transient tachypnea of the newborn. Conclusion The upper age limit for the adolescent age, which is considered risky in terms of maternal and neonatal adverse outcomes, was found to be compatible with the upper age limit, which is 19 years, defined by World Health Organization.Öğe The effect of premature ovarian failure on inner ear function(Taylor & Francis Inc, 2020) Karaer, Isil; Tuncay, GorkemThe aim of this study was to test whether hearing function is impaired in women with premature ovarian failure. Thirty (30) women with premature ovarian failure (POF), 30 women in menopause and 30 healthy controls were recruited in this study. Pure tone audiometric (PTA), transiently evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) of the study participants were analysed. At PTA, 6 and 8 kHz were lower in menopause group compared with both women with POF and controls. At TEOAE 3 and 4 kHz and at DPOAE 1, 2, 4 and 6 kHz were lower in menopause group compared with the controls. At DPOAE 6 kHz was lower in the POF group compared with the controls. Women with POF comparing to menopause group at TEOAE 3, 4 kHz and at DPOAE 4 and 6 kHz were lower in the menopause group. Inner ear function of both women in menopause and women with POF was declined compared to the healthy controls. Clinically, evaluation of hearing status may be considered in women with POF.Impact statement What is already known on this subject: Premature ovarian failure (POF) affects 1%-2% of women, and it adversely effects on health status (such as cardiovascular, psychological and cognitive disorders). Previous studies suggested that a lack of oestrogen might play a role in hearing disorders in women. However, we do not know POF's adversely effect on cochlea and hearing. What the results of this study add: The present study demonstrates that lower serum oestrogen has a negative effect hearing in women with POF at DPOAE 6 kHz.Öğe The effect of premature ovarian insufficiency on nasal mucociliary clearance time(Taylor & Francis Ltd, 2020) Karaer, Isil; Tuncay, GorkemPremature ovarian insufficiency (POI) is a global health concern for women and affects several systems, such as cardiovascular system, autoimmune disease, and psychological status. The aim of this study was to investigate the effect of POI on nasal mucociliary clearance time via saccharin test by comparing postmenopausal women and healthy controls. Thirty-five (35) patients with POI, 35 healthy postmenopausal women and 35 healthy controls were recruited in this study. All study participants underwent measurements of nasal mucociliary clearance time via saccharine test. When women with POI and postmenopausal women compared with the controls, nasal mucociliary clearance time was longer in both women with POI and postmenopausal women. When women with POI were compared with postmenopausal women, the nasal mucociliary clearance time was not difference between two groups. There was a significant prolonged nasal mucociliary clearance time in the women with POI and postmenopausal women. Lower serum estradiol levels in women with POI as well as postmenopausal women had an adverse effect of nasal mucociliary clearance time.Öğe The effect of seminal plasma cadmium and lead levels on semen parameters in male subjects of infertile couples: a prospective cohort study(Taylor & Francis Inc, 2021) Tuncay, Gorkem; Karaer, Abdullah; Tanrikut, Emrullah; Ozgul, OnurThe aim of this prospective study was to investigate whether there is a relationship between seminal plasma cadmium (Cd) and lead (Pb) levels and semen parameters in male partners of infertile couples. Two hundred fifty one (251) men recruited with no history of occupational exposure to toxic metals. After semen analysis, seminal Cd and Pb levels were measured using atomic absorption spectrometry. Cadmium levels in men with hypospermia was significantly higher than men with normal semen volume (p = .049). In contrast, there was no statistically significant difference in median seminal Pb levels between men with hypospermia and men with normal semen volume (p = .13). There was no statistically significant association between seminal plasma Cd and Pb levels sperm concentration, motility, morphology and total progressively motile sperm count. These findings suggest that environmental Cd exposure may contribute to low semen volume in male partners of infertile couples. IMPACT STATEMENT What is already known on this subject? Toxic metals may adversely affect both male and female reproductive system. What the results of this study add? Seminal plasma cadmium levels in men with hypospermia were statistically significantly higher than men with normal semen volume. What the implications are of these findings for clinical practice and/or further research? Patients should be informed about possible adverse effects of toxic metals.Öğe Impact of Serum and Follicular Vitamin D Levels on Assisted Reproductive Techniques Outcome(Sci Printers & Publ Inc, 2018) Tuncay, Gorkem; Taskapan, CagatayOBJECTIVE: To compare vitamin D levels in the serum and follicular fluids of in vitro fertilization (IVF) patients with regard to their pregnancy outcomes. STUDY DESIGN: This study enrolled 170 female patients (20-44 years old) who underwent intracytoplasmic sperm injection (ICSI) cycles between February 2015 and February 2016. The serum vitamin D was isolated by centrifugation. The follicular fluid samples were centrifuged and the supernatant was evaluated after the oocyte puncture procedure. RESULTS: Fifty-six patients had clinical pregnancies and 106 did not, and we did not find any statistically significant differences between these 2 groups in their basic or cycle characteristics. The basal follicle-stimulating hormone level was significantly lower in the pregnant group (p=0.003). A significant difference was detected in the serum vitamin D, and the follicular vitamin D concentrations were higher in the pregnant group (p=0.01 and p=0.003, respectively). There was a significant linear correlation between the 25-hydroxy vitamin D levels in the serum and follicular fluid (r=0.77, p<0.001). CONCLUSION: High vitamin D levels can improve the implantation rate and IVF outcome. The serum vitamin D level should be determined prior to IVF/ICSI cycles and supplemented if an insufficiency is established.Öğe The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome(Bmc, 2018) Tuncay, Gorkem; Karaer, Abdullah; Coskun, Ebru Inci; Baloglu, Demet; Tecellioglu, Ayse NihanBackground: The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women. Methods: A retrospective cohort study was conducted. A total of 302 women who started their first IUI cycle in our fertility center were included in this study. The patients were categorized into two groups based on their preconception TSH values: 0.38-2.49 mIU/L and 2.50-4.99 mIU/L. The clinical pregnancy rate was the main outcome parameter. As secondary parameters, we evaluated the differences in spontaneous abortion rate, live-birth delivery rate, and perinatal outcomes according to the preconception TSH threshold (< 2.5 and < 5.00 mIU/L). Results: There was no significant difference between the two groups with respect to clinical pregnancy, miscarriage, and live-birth rates with an odds ratio of 1.67 (95% CI: 0.79-3.53), 1.08 (95% CI: 0.09-13.1), and 1.79 (95% CI: 0.77-4.2), respectively. In addition, there were no significant differences in perinatal outcomes (gestation at delivery, birth weight, and neonatal intensive care unit-administration rate) between the two groups. Conclusions: Our findings indicate that among euthyroid patients, preconception TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) do not have a negative effect on IUI outcomes.Öğe The impact of thyroid-stimulating hormone levels in euthyroid women onintrauterine insemination outcome(Bıomed central ltd, 236 grays ınn rd, floor 6, london wc1x 8hl, england, 2018) Tuncay, Gorkem; Karaer, Abdullah; Coskun, Ebru Inci; Baloglu, Demet; Tecellioglu, Ayse NihanBackground: The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women. Methods: A retrospective cohort study was conducted. A total of 302 women who started their first IUI cycle in our fertility center were included in this study. The patients were categorized into two groups based on their preconception TSH values: 0.38-2.49 mIU/L and 2.50-4.99 mIU/L. The clinical pregnancy rate was the main outcome parameter. As secondary parameters, we evaluated the differences in spontaneous abortion rate, live-birth delivery rate, and perinatal outcomes according to the preconception TSH threshold (< 2.5 and < 5.00 mIU/L). Results: There was no significant difference between the two groups with respect to clinical pregnancy, miscarriage, and live-birth rates with an odds ratio of 1.67 (95% CI: 0.79-3.53), 1.08 (95% CI: 0.09-13.1), and 1.79 (95% CI: 0.77-4.2), respectively. In addition, there were no significant differences in perinatal outcomes (gestation at delivery, birth weight, and neonatal intensive care unit-administration rate) between the two groups. Conclusions: Our findings indicate that among euthyroid patients, preconception TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) do not have a negative effect on IUI outcomes.Öğe Metabolomic analysis of endometrial cancer by high-resolution magic angle spinning NMR spectroscopy(Springer Heidelberg, 2022) Duz, Senem Arda; Mumcu, Akin; Dogan, Berat; Yilmaz, Ercan; Coskun, Ebru Inci; Saridogan, Erdinc; Tuncay, GorkemPurpose To analyze endometrial metabolite profiles between patients with endometrial cancer and controls. Methods Seventeen (17) women with endometrium cancer and 18 controls were enrolled in this study. H-1 HR-MAS (High Resolution-Magic Angle Spinning) NMR (Nuclear Magnetic Resonance) spectroscopy data obtained from endometrial tissue samples of patients with endometrial cancer and control group were analyzed with bioinformatics methods. Results Principal component analysis (PCA) and the partial least squares discriminant analysis (PLS-DA) score plots obtained with the multivariate statistical analysis of pre-processed spectral data shows a separation between the samples from patients with endometrial cancer and controls. Analysis results suggest that the levels of lactate, glucose, o-phosphoethanolamine, choline, glycerophosphocholine, phosphocholine, leucine, isoleucine, valine, glutamate, glutamine, n-acetyltyrosine, methionine, taurine, alanine, aspartate and phenylalanine are increased in patients with endometrial cancer compared to the controls. Conclusion The metabolomics signature of patients with endometrial cancer is different from that of benign endometrial tissue.Öğe Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization(Taylor & Francis Inc, 2019) Karaer, Abdullah; Tuncay, Gorkem; Mumcu, Akin; Dogan, BeratThe purpose of this study was to investigate whether a change in the follicular fluid metabolomics profile due to endometrioma is identifiable. Twelve women with ovarian endometriosis (aged<40 years, with a body mass index [BMI] of <30 kg/m(2)) and 12 age- and BMI-matched controls (women with infertility purely due to a male factor) underwent ovarian stimulation for intracytoplasmic sperm injection (ICSI). Follicular fluid samples were collected from both of groups at the time of oocyte retrieval for ICSI. Next, nuclear magnetic resonance (NMR) spectroscopy was performed for the collected follicular fluids. The metabolic compositions of the follicular fluids were then compared using univariate and multivariate statistical analyses of NMR data. Univariate and multivariate statistical analyses of NMR data showed that the metabolomic profiles of the follicular fluids obtained from the women with ovarian endometriosis were distinctly different from those obtained from the control group. In comparison with the controls, the follicular fluids of the women with ovarian endometriosis had statistically significant elevated levels of lactate, beta-glucose, pyruvate, and valine. We conclude that the levels of lactate, beta-glucose, pyruvate, and valine in the follicular fluid of the women with endometrioma were higher than those of the controls.Öğe Metabolomics analysis of placental tissue obtained from patients with fetal growth restriction(Wiley, 2022) Karaer, Abdullah; Mumcu, Akin; Arda, Senem; Tuncay, Gorkem; Dogan, BeratAim The aim of this study was to determine whether there was a difference in placental metabolite profiles between patients with fetal growth restriction (FGR) and healthy controls. Methods The study included 10 patients with FGR diagnosis with 14 healthy controls with both matched maternal age and body mass index. H-1 HR-MAS NMR spectroscopy data obtained from placental tissue samples of patients with FGR and healthy control group were analyzed with bioinformatics methods. The obtained results of metabolite levels were further validated with the internal standard (IS) quantification method. Results Principal component analysis (PCA) and the partial least squares discriminant analysis (PLS-DA) score plots obtained with the multivariate statistical analysis of preprocessed spectral data shows a separation between the samples from patients with FGR and healthy controls. Bioinformatics analysis results suggest that the placental levels of lactate, glutamine, glycerophosphocholine, phosphocholine, taurine, and myoinositol are increased in patients with FGR compared to the healthy controls. Conclusions Placental metabolic dysfunctions are a common occurrence in FGR.Öğe Microarray analysis of cumulus cells in women with ovarian endometriosis undergoing intracytoplasmic sperm injection(Sage Publications Ltd, 2020) Karaer, Abdullah; Tuncay, Gorkem; Dogan, Berat; Tecellioglu, Nihan; Cigremis, YilmazObjective: The aim of this study was to find the significantly altered genes in cumulus cells of women with ovarian endometriosis by using microarray and quantitative polymerase chain reaction analysis. Methods: Thirty women with ovarian endometriosis and 30 age-body mass index matched controls (women with infertility as a result of pure male factor) were enrolled in this study. Cumulus cells from study participants who underwent controlled ovarian hyperstimulation were isolated mechanically. Microarray comparative genomic hybridization was used to compare the transcriptome of cumulus cells from women with ovarian endometriosis and controls. According to the different expression levels in the microarrays and their putative functions, KRAS, ZNF322, and SDHA were selected and analyzed by real-time quantitative polymerase chain reaction. Results: There was no significant difference in the basal conditions between patients with endometriosis and controls, such as age, body mass index, basal follicle stimulating hormone and estradiol levels, and total gonadotrophin dosage. The gene expression profile of cumulus cells from patients with endometriosis was significantly different from that of controls. A total of 295 genes were significantly up- or down-regulated (p-value < 0.05 and absolute fold change > 1.5). For all of the genes adjusted p-value was found to be 0.999. Polymerase chain reaction analysis showed that KRAS and ZNF322 mRNA levels in the cumulus cells of patients with ovarian endometriosis were significantly up-regulated compared to controls (fold changes: 3.05 and 3.22, respectively). Conclusion: KRAS and ZNF322 mRNA levels in the cumulus cells of patients with ovarian endometriosis were significantly up-regulated.Öğe Prevalence of Various Sexually Transmitted Pathogens in Infertile Couples and Their Effects on In Vitro Fertilization Success(Bilimsel Tip Yayinevi, 2019) Gursoy, Nafia Canan; Tuncay, Gorkem; Karaer, Abdullah; Tecellioglu, Ayse Nihan; Yigit, Hande; Yakupogullari, Yusuf; Otlu, BarisIntroduction: Sexually transmitted infections can cause problems such as infertility, ectopic pregnancy and miscarriage due to tissue damage and function loss in female and male genital system. Although the role of bacterial agents in the etiopathogenesis of infertility is well known, the association of some viral agents that can be transmitted by sexual intercourse with infertility is relatively little known. The aim of this study was to investigate the presence of cytomegalovirus (CMV), human papillomavirus (HPV), herpes simplex virus (HSV 1 and HSV 2), human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Chiamydia trachomatis in infertile patients undergoing in vitro fertilization (IVF) treatment. Materials and Methods: Semen and cervical samples were taken from 149 infertile couples during one year, and the presence of agents was investigated with polymerase chain reaction (PCR). The effect of these agents on in vitro fertilization (IVF) treatment success was evaluated. Results: It was found that 8.1% (12/149) of the 149 infertile couples receiving IVF treatments were infected with CMV, and CMV-DNA positivity was found as 2% (3/149) in sperm samples and 6% (9/149) in cervical samples. CMV infection was not observed in both pairs. HPV infection was observed in 9.4% (14/149) of the couples and HPV-DNA was found to be 5.4% (8/149) in sperm samples and 7.4% (11/149) in cervical samples. The oncogenic high-risk HPV (HR-HPV) genotype ratio in sperm samples was 37.5% (3/8) and the most common genotypes were HPV 18, 35 and 39, respectively. HR-HPV genotype ratio in cervical samples was 63.6% (7/11) and HPV 35, 16, 18, 45 and 53 were the most common genotypes. While HPV-DNA was found to be positive in 3.4% (5/149) in both of the pairs, interpair consistency was 40% (2/5) for HPV genotypes. HPV or CMV positivity did not have a statistically significant effect on sperm parameters, number of oocytes, embryos, and clinical pregnancy and live birth rate after IVF. C. trachomatis, HSV-1/2, HBV, HCV and HIV viruses were not detected in any of the sperm and cervical samples of the couples. Conclusion: More extensive studies are needed to investigate the possible agents in infertile patients. In order to eliminate the lack of epidemiological data on this subject, it would be useful to give priority to patients admitted to IVF clinics that are easier to reach first and to bacterial/viral factors that are seen endemic in our country, especially.Öğe Renal cell carcinoma diagnosed during pregnancy: a case report and literature review(Sage Publications Ltd, 2018) Yilmaz, Ercan; Oguz, Fatih; Tuncay, Gorkem; Melekoglu, Rauf; Beytur, Ali; Coskun, Ebru Inci; Gunes, AliDiagnosing cancer during pregnancy is uncommon. Although pregnancies with concomitant malignancies have been reported, urological tumours are possibly the most rarely identified tumours during pregnancy. Renal cell carcinoma appears to be the most common urological malignancy during pregnancy. In this case report, we discuss successful management of a patient who was diagnosed with renal cell carcinoma during the antenatal period.Öğe Reply to Letter to the editor related to the article Stress in couples undergoing assisted reproductive technology(Springer Heidelberg, 2021) Tuncay, Gorkem; Karaer, Abdullah[Abstract Not Available]
