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Öğe Akciğer ve kalp hastalıklarında plazma BNP düzeyinin prognostik değeri(İnönü Üniversitesi, Tıp Fakültesi, 2007) Yetkin, Özkan; Aksoy, Yüksel; Turhan, Hasan; İn, Erdal; Karahan, Mukadder; Kılıç, Talat; Hacıevliyagil, Süleyman Savaş; Günen, HakanÖz: BNP 32 aminoasitli bir peptiddir, vazorelaksan ve natriüretik etkileri vardır, insanlarda daha çok ventriküllerdan salınır. Çalışmamızda, sol ve sağ kalp yetmezliğine neden olan hastalıklarda plazma BNP değerini karşılaştırmayı amaçladık. Çalışmamıza 35 sol kalp yetmezliği, 49 kronik obstrüktif akciğer hastalığı (KOAH)’na sekonder kor pulmonale, 26 KOAH ve 20 pulmoner tromboemboli olgusu ile kontrol grubu olarak 25 sağlıklı bireyden oluşan toplam 155 olgu dahil edildi. Çalışmamızda plazma BNP değeri sol kalp yetmezliği grubunda KOAH-kor pulmonale ve kontrol grubuna göre anlamlı yüksek saptandı (sırasıyla 1167 ± 746, 434 ± 55, 32 ± 12 pg/mL) (p< 0.001). Yine kor pulmonaleli grupta kor pulmonalesi olmayan KOAH grubuna ve kontrol grubuna göre anlamlı düzeyde yüksek olarak ölçüldü (434 ± 55, 32 ± 36 ve 32 ± 12 pg/mL) (p< 0.001). Pulmoner emboli grubunda plazma BNP düzeyinin kontrol grubuna göre anlamlı düzeyde yüksek olduğu (357 ± 391, 32 ± 12 pg/mL) (p< 0.001) ve masif embolisi olan olguların masif olmayanlara göre daha yüksek plazma BNP değerine sahip oldukları gözlendi (699 ± 394 vs. 166 ± 213 pg/mL) (p< 0.001). Sonuç olarak; ventriküllerde yetmezliğin artışına paralel olarak plazma BNP değerinin arttığı, ejeksiyon fraksiyonu ile BNP’nin ters korele olduğu, pulmoner arter basıncı ile korele olduğu izlendi. Pulmoner embolili hastalarda yüksek BNP düzeylerinin artan pulmoner basınç nedeniyle sağ ventrikülde ortaya çıkan fonksiyon bozukluğuna bağlı olduğu düşünüldü.Öğe Aort Kapak kalsifikasyonu: Koroner Anjiografi Yapılan Hastalarda Kardiyovasküler Risk Faktörlerinin ve Kemik Mineral Dansitesinin Değerlendirilmesi(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2008) Tekin, Gülaçan Özgün; Yağmur, Jülide; Kekilli, Ersoy; Yağmur, Cengiz; Uçkan, Ahmet; Aksoy, Yüksel; Turhan, Hasan; Yetkin, Ertan; Özdemir, Ramazan; Koşar, FeridunAort kapak kalsifikasyonu (AKK) yüksek kardiyovasküler risk insidansına sahip görünmekte olup, aterosklerozun bir sonucu olarak kabul edilebilir. Düşük kemik mineral dansitesi ve artmış aort kalsifikasyon prevalensi arasındaki ilişki esas olarak toplum tabanlı çalışmalarda yaşlı bayanlarda gösterilmiştir. Ancak bazı çalışmalar kemik mineral dansitesi ile aort kalsifikasyonu arasında ilişki olmadığını bildirmiştir. Bu yüzden. biz koroner angiografi yapılan hastalarda AKK’nu değerlendirmeyi ve AKK olan ve olmayan hastaların kardiyovasküler risk faktörlerini ve kemik mineral dansitelerini karşılaştırmayı amaçladık. Materyal ve metod: Çalışma populasyonu koroner angiografi yapılan 585 ardışık hasta (372 erkek, 213 kadın, ortalama yaş=59±10 yıl) içeriyordu. Bütün hastalara transtorasik ekokardiyografik inceleme yapıldı. AKK bir yada daha fazla küspis üzerinde birden fazla parlak yoğun ekoların izlenmesi ve tutulan küspisin azalmış hareketi olarak tanımlandı. Bütün hastalar dual energy x-ray absorpsiyometri (DEXA) yöntemi ile kemik mineral dansitesi (T scor) ölçümü için Nükleer Tıp bölümüne yönlendirildi. Tüm hastalarda yaş, cinsiyet, vücut kitle indeksi, hipertansiyon, diyabetes mellitus, koroner arter hastalığı, hiperkolesterolemi ve sigara içiciliği kaydedildi. Bulgular: Çalışmamızda AKK prevalensı %27 (160/585) bulundu. Her iki grup arasında diyabetes mellitus, hiperkolesterolemi ve sigara içiciliği yönünden istatistiksel olarak anlamlı fark yoktu (p>0.05 hepsi için). Yaş ve hipertansiyon AKK için bağımsız risk faktörü olmasına karşılık vücut kitle indeksi AKK için bağımsız ve negatif risk faktörü olarak saptandı. AKK ile ilişkili bulunmasada AKK olan grupta koroner arter hastalığı anlamlı oranda yüksek saptandı. Ne T skoru, ne de yaş ve cinsiyete uyarlanmış T skoru AKK ile ilişkili bulunmadı. Sonuç: Biz bu çalışmada yaş, hipertansiyon ve vücut kitle indeksi ile AKK arasında bağımsız ilişki olduğunu gösterdik. Kemik mineral dansite ölçümünde yaş-cinsiyet uyarlanmış T skoru AKK ile ilişkisiz bulundu. Her ne kadar çalışmamızda koroner arter hastalığı ile AKK arasında ilişki olmadığı gösterilmiş olsada bu konunun aydınlanması için ileri çalışmalara ihtiyaç vardır.Öğe Aortic valve calcification: Assessment of cardiovascular risk factors and bone mineral density in patients undergoing coronary angiography(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2008) Özgün Tekin, Gülaçan; Yağmur, Jülide; Kekilli, Ersoy; Yağmur, Cengiz; Uçkan, Ahmet; Aksoy, Yüksel; Turhan, Hasan; Yetkin, Ertan; Özdemir, Ramazan; Koşar, FeridunÖz: ÖZET: Amaç: Aort kapak kalsifikasyonu (AKK) yüksek kardiyovasküler risk insidansına sahip görünmekte olup, aterosklerozun bir sonucu olarak kabul edilebilir. Düşük kemik mineral dansitesi ve artmış aort kalsifikasyon prevalensi arasındaki ilişki esas olarak toplum tabanlı çalışmalarda yaşlı bayanlarda gösterilmiştir. Ancak bazı çalışmalar kemik mineral dansitesi ile aort kalsifikasyonu arasında ilişki olmadığını bildirmiştir. Bu yüzden. biz koroner angiografi yapılan hastalarda AKK’nu değerlendirmeyi ve AKK olan ve olmayan hastaların kardiyovasküler risk faktörlerini ve kemik mineral dansitelerini karşılaştırmayı amaçladık. Materyal ve metod: Çalışma populasyonu koroner angiografi yapılan 585 ardışık hasta (372 erkek, 213 kadın, ortalama yaş=59±10 yıl) içeriyordu. Bütün hastalara transtorasik ekokardiyografik inceleme yapıldı. AKK bir yada daha fazla küspis üzerinde birden fazla parlak yoğun ekoların izlenmesi ve tutulan küspisin azalmış hareketi olarak tanımlandı. Bütün hastalar dual energy x-ray absorpsiyometri (DEXA) yöntemi ile kemik mineral dansitesi (T scor) ölçümü için Nükleer Tıp bölümüne yönlendirildi. Tüm hastalarda yaş, cinsiyet, vücut kitle indeksi, hipertansiyon, diyabetes mellitus, koroner arter hastalığı, hiperkolesterolemi ve sigara içiciliği kaydedildi. Bulgular: Çalışmamızda AKK prevalensı %27 (160/585) bulundu. Her iki grup arasında diyabetes mellitus, hiperkolesterolemi ve sigara içiciliği yönünden istatistiksel olarak anlamlı fark yoktu (p>0.05 hepsi için). Yaş ve hipertansiyon AKK için bağımsız risk faktörü olmasına karşılık vücut kitle indeksi AKK için bağımsız ve negatif risk faktörü olarak saptandı. AKK ile ilişkili bulunmasada AKK olan grupta koroner arter hastalığı anlamlı oranda yüksek saptandı. Ne T skoru, ne de yaş ve cinsiyete uyarlanmış T skoru AKK ile ilişkili bulunmadı. Sonuç: Biz bu çalışmada yaş, hipertansiyon ve vücut kitle indeksi ile AKK arasında bağımsız ilişki olduğunu gösterdik. Kemik mineral dansite ölçümünde yaş-cinsiyet uyarlanmış T skoru AKK ile ilişkisiz bulundu. Her ne kadar çalışmamızda koroner arter hastalığı ile AKK arasında ilişki olmadığı gösterilmiş olsada bu konunun aydınlanması için ileri çalışmalara ihtiyaç vardır.Öğe Cep telefonlarının kalıcı pacemaker fonksiyonları üzerine etkileri(İnönü Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Malatya, Türkiye, 2001) Tandoğan, İzzet; Temizhan, Ahmet; Yetkin, Ertan; Aksoy, Yüksel; Turhan, Hasan; Duru, Erdal; Şaşmaz, AliÖz:Cep telefonlarının (CT) pacemaker (PM) fonksiyonları üzerindeki muhtemel olumsuz etkilerini araştırmak, ayrıca bu etkileşimde hangi türlerin etkili olduğunu ortaya koymaktır. GEREÇ VE YÖNTEM: Bu amaçla PM implantasyonu yapılmış 644 hasta üzerinde çalışıldı (518 VVI, 84 DDD, 30 AAA, 12 VDD). Çalışmanın birinci basamağında PM cebine göre 50 cm uzakta konumlandırılmış iki CT arasında temas sağlandı, çaldırıldı, konuşuldu ve CT kapatıldı (her ma 20 saniye sürdü). Daha sonra CT'ler 20 cm'lik mesafeye getirilerek aynı işlemler yapıldı. Son aşamada CT'lerden biri 20cm'lik mesafede bırakılırken diğer CT'nin anteni PM cebi ile temas ettirildi ve aynı işlemler yapıldı. İkinci basamakta 587 PM'li hastanın (503 VVI, 62 DDD, 22 AAI) ' sensing polaritesi unipolara çevrildi, sensitivitesi en üst düzeye çıkarıldı ve aynı işlemler tekrarlandı. Birinci basamakta 20 cm 'lik mesafede CT çaldırılırken altı VVI PM'li hastada, temas esnasında ise iki VVI PM'li hastada PM'nin asenkron moda geçtiği görüldü (toplam PM hastalarının %1,24 'ü, VVI PM'li hastaların %1,54'ü). İkinci basamakta 20cm'lik mesafede konuşma esnasında 11 VVI PM'li hastada PM'nin asenkron moda geçtiği görüldü. Temas esnasında ise CT çaldırılırken 11 VVI PM'li hastada PM'nin asenkron moda geçtiği, üç VVI PM'li hastada PM'nin inhibe olduğu saptandı (toplam P M hastalarının %4,25'i, VVI PM'li hastaların %4,97'si). SONUÇ: CT'ler tarafından oluşturulan elektromanyetik alanın PM fonksiyonları üzerine olumsuz etkileri mevcuttur. PM'nin etkilenme riski unipolar ve yüksek sensitivite değerlerinde ve CT, PM cebine 20 cm 'den yakın olduğunda daha fazladırÖğe Comparison of major coronary risk factors in female and male patients with premature coronary artery disease(Taylor & Francis Ltd, 2008) Yasar, Ayse Saatci; Turhan, Hasan; Basar, Nurcan; Metin, Fatma; Erbay, Ali Riza; Ilkay, Erdogan; Sabah, IrfanObjective -The present study was designed to analyse and compare the major coronary risk factors of female and male patients with premature coronary artery disease (CAD) aged <= 45 years. Methods - We evaluated 4613 consecutive patients who underwent coronary angiography at our institution; 572 symptomatic patients (489 men and 83 women) diagnosed as having premature CAD (age <= 45 years) were included in our analysis. For each patient, the presence of major coronary risk factors such as family history of CAD, hypercholesterolaemia, diabetes mellitus, hypertension and cigarette smoking were recorded. Besides, clinical presentation and angiographic findings were also recorded. Results - The most common risk factor was cigarette smoking in young men (70.3%). However, the major coronary risk factor was hypercholesterolaemia in young women (67.5%).When we compared two groups with respect to major coronary risk factors, we found that the prevalence of diabetes mellitus and hypertension were significantly higher in young women than in young men (diabetes mellitus: 27.7% vs. 12.3%, respectively, P < 0.001, hypertension: 56.6% vs. 23.4%, respectively, P < 0.00 1). However, cigarette smoking was found to be significantly higher in men than in women (70.3% vs. 28.9% respectively, P < 0.00 1). Conclusion - We have shown for the first time the impact of gender on the coronary risk factor profile in young Turkish patients with premature CAD.These findings may be useful for gender-based management and risk factor modification of young patients with premature CAD.Öğe Decreased endothelium dependent vasodilatation in patients with migraine a new aspect to vascular pathophysiology of migraine(Coronary Artery Disease, 2006) Ertan, Yetkin; Özışık Karaman, Handan Işın; Özcan, Abdulcemal; Aksoy, Yüksel; Turhan, HasanBackground Migraine is a common neurovascular disorder characterized by attacks of severe headache, autonomic and neurological symptoms. We hypothesized that patients with migraine had abnormal endothelial function. The vascular theory of migraine assumes that the major pathophysiological events that initiate the migraine attack occur in the perivascular nerves of the major cerebral vessels. Accordingly, we aimed to measure endothelium-dependent vasodilatation in migraineurs by means of flow-mediated dilatation, which reflects endothelium-dependent vasodilatation capacity. Materials and methods Forty-five patients who fulfilled the diagnostic criteria for migraine and 45 age and sexmatched healthy participants were enrolled in the study. Flow-mediated dilatation of the brachial artery was determined using a high-resolution B-mode ultrasonographic system. Flow-mediated vasodilatation was expressed as the change in post-stimulus diameter as a percentage of the baseline diameter. Results Mean ages of the patients were 33 ± 10 years in migraineurs (range: 18–52 years, 36 female, 9 male) and 33 ± 9 years in non-migraineurs (range: 17–50 years, 36 female and 9 male). Flow-mediated dilatation of patients with migraine is significantly lower than that of the controls (8.02 ± 4.095% vs. 10.72 ± 3.52%, respectively, P = 0.001). Conclusion We have shown that migraineurs have decreased endothelium-dependent vasodilatation capacity compared with non-migraineurs. Migraine may be a local manifestation of systemic vascular vasomotion abnormalities.Öğe Evaluation of cardiovascular risk factors and bone mineral density in post menopausal women undergoing coronary angiography(Elsevier Ireland Ltd, 2008) Tekin, Gulacan Ozgun; Kekilli, Ersoy; Yagmur, Julide; Uckan, Ahmet; Yagmur, Cengiz; Aksoy, Yuksel; Turhan, HasanBackground: The underlying mechanism by which osteoporosis and cardiovascular disease may be linked is not fully understood. However studies mainly focused on the association between bone mineral density (BMD) and cardiovascular risk factors or atherosclerosis itself by only assessing the presence of vascular calcification. In this study we aimed to evaluate both cardiovascular risk factors, and presence of coronary artery disease (CAD) in post-menopausal women patients with and without low BMD. Materials and methods: Study population consisted of post menopausal women who were scheduled to coronary angiography. Two hundred and twenty seven consecutive female patients were included in the study and evaluated for the presence of cardiovascular risk factors and CAD. Bone mineral density was measured in all patients either the day before or the day after coronary angiography. Low BMD was defined as T score<-1 and normal BMD was defined as T score >=-1. For statistical analysis patients were divided into two groups: patients with low BMD and patients with normal BMD. Results: There were not statistically significant differences between two groups in respect to body mass index, presence of diabetes mellitus, hypercholesterolemia, and smoking status. Age and presence of CAD was found to be statistically different between two groups being higher in patients with low BMD. Logistic regression analysis revealed that age was positively and independently associated with low BMD in post menopausal female patients (Odds ratio=1.072 CI: 1.036-1.11, p=0.001). Conclusion: Age is found to be an independent predictor of decreased BMD in our study population recruited from the coronary angiography laboratory. However, neither cardiovascular risk factors, nor coronary artery disease itself has been found to be associated with low BMD. (C) 2007 Published by Elsevier Ireland Ltd.Öğe Identification of viable myocardium in patients with chronic coronary artery disease and myocardial dysfunction comparison of low dose dobutamine stress echocardiography and echocardiography during glucose insulin potassium infusion Angiology(Angiology, 2002) Yetkin, Ertan; Şenen, Kubilay; İleri, Mehmet; Atak, Ramazan; Battaloğlu, Bektaş; Yetkin, Özkan; Tandoğan, İzzet; Turhan, Hasan; Cehreli, SengülLow-dose dobutamine stress echocardiography (LDDSE) is one of the methods most used to assess myocardial viability. Glucose-insulin-potassium (GIK) has been shown to increase contraction of the ischemic zone. The aim of this study was to compare LDDSE and echocardiography during GIK infusion for detection of myocardial viability in patients with chronic coronary artery disease (CAD) and myocardial dysfunction. Twenty-one patients who had chronic CAD and myocardial dysfunction were included in the study. Glucose-insulin-potassium protocol consisted of a fixed dose of insulin (100 μU/kg/hour IV) and a variable glucose/potassium infusion rate. GIK echocardiography was made at baseline and after 60 minutes of GIK infusion. During continuous electrocardiographic, blood pressure, and echocardiographic monitoring, an intravenous infusion of dobutamine (3 μg/kg body weight/min) was started with an infusion pump and continued for 5 minutes and then increased to 5 μg/kg/min and 10 μg/kg/min for another 5 minutes. The detected viable myocardium was defined as 1 or 2 scores decreasing in at least 2 adjacent abnormal segments during LDDSE and GIK echocardiography. Viability was detected in 19% (52 segments) of the asynergic segments at baseline with GIK echocardiography and 16% (44 segments) of those segments with LDDSE (p > 0.05). Left ventricular wall motion score index at baseline was 2.24 ±0.35 and it decreased significantly during both LDDSE (p = 0.004 vs 2.11 ±0.36) and GIK echocardiography (p=0.001 vs 2.09 ±0.32). The agreement between LDDSE and GIK echocardiography for detection of myocardial viability was 95%. This study shows that GIK echocardiography is similar to LDDSE for detection of myocardial viability. With the support of further clinical studies GIK echocardiography can be used to detect myocardial viability in patients with chronic CAD.Öğe Ignored Identity of Age-Dependent Increase in Pulmonary Embolism Atrial Fibrillation(Elsevier, 2019) Yetkin, Ertan; Cuglan, Bilal; Turhan, Hasan; Ozturk, Selcuk; Yetkin, Ozkan[Abstract Not Available]Öğe The impact of metabolic syndrome on left ventricular function: Evaluated by using the index of myocardial performance(Elsevier Ireland Ltd, 2009) Turhan, Hasan; Yasar, Ayse Saatci; Yagmur, Julide; Kurtoglu, Ertugrul; Yetkin, ErtanAim: To evaluate the impact of metabolic syndrome on global left ventricular function by using the index of myocardial performance. Methods: The study population included 106 patients with metabolic syndrome (66 male, 40 female, mean age=54 +/- 11 years) and 106 control subjects without metabolic syndrome (71 male, 35 female, mean age=53 +/- 10). The diagnosis of metabolic syndrome was based on The National Cholesterol Education Program Adult Treatment Panel III criteria. All patients underwent two-dimensional and Doppler echocardiographic examination. The index of myocardial performance was determined as the sum of isovolumic relaxation time and isovolumic contraction time divided by left ventricular ejection time. Results: The index of myocardial performance was found to be significantly higher in patients with metabolic syndrome compared with control subjects without metabolic syndrome (0.55 +/- 0.06 vs 0.38 +/- 0.04 respectively, p < 0.001). Conclusion: In the present study, we have shown the presence of impaired global left ventricular function in patients with metabolic syndrome compared with control subjects without metabolic syndrome. This finding emphasizes the importance of early diagnosis and management of metabolic syndrome to prevent the progression of ventricular dysfunction to overt structural and symptomatic cardiac disease. (C) 2008 Published by Elsevier Ireland Ltd.Öğe Increased dilator response to nitrate and decreased flow mediated dilatation in migraineurs(Headache: The Journal of Head and Face Pain, 2007) Yetkin, Ertan; Özışık, Handan Işın; Özcan, Abdulcemal; Aksoy, Yüksel; Turhan, HasanBackground.—It has been known that in a migraine attack intracranial and extracranial arteries on the headache side dilate and when the migraine attack has subsided, the intracranial arteries show segmental narrowing. We hypothesized that patients with migraine had an underlying systemic vasomotion abnormality and there might be an increased nitrate-mediated vasodilatory response in the brachial artery of migraineurs. Accordingly we aimed to measure endothelium dependent and independent functions of brachial artery in migraineurs and healthy subjects. Materials and Methods.—Twenty-four patients who fulfilled the diagnostic criteria of migraine were enrolled in the study. Twenty-six age- and sex-matched healthy control subjects comprised the control group. Flow-mediated dilatation and nitrate-mediated dilatation were measured in all patients and control subjects by means of brachial artery ultrasonography. Results.—Flow-mediated dilatation of patients with migraine was significantly lower than that of control subjects (7.6 ± 3.7% vs 10.4 ± 3.5%, respectively, P = .008). However, nitrate-mediated dilatation in migraineurs was significantly higher than that of nonmigraineurs (25% vs 14%, respectively, P< .001). Conclusion.—We have shown that migraineurs have decreased endothelium dependent function whereas increased nitrate-mediated response in their brachial artery. It can be suggested that the mechanism underlying migraine may be a diffuse vascular vasomotion abnormalities and migraine may be a local manifestation of systemic vascular abnormality rather than a primary cerebral phenomenon.Öğe Increased P-wave dispersion in patients with Behcet's disease: Is there an exaggeration in explaining the meaning?(Elsevier Ireland Ltd, 2008) Turhan, Hasan; Yetkin, Ertan[Abstract Not Available]Öğe Increased thrombolysis in myocardial infarction frame counts in patients with isolated coronary artery ectasia(Heart Vessels, 2003) Senen, Kubilay; Yetkin, Ertan; Turhan, Hasan; Atak, Ramazan; Sivri, Nasir; Battaloğlu, Bektaş; Tandoğan, İzzet; İleri, Mehmet; Koşar, Feridun; Özdemir, Ramazan; Cehreli, ŞengülThe Thrombolysis in myocardial infarction (TIMI) frame count is a simple clinical tool for assessing quantitative indexes of coronary blood flow. This measurement has been significantly correlated with flow velocity measured with a flow-wire by several investigators during baseline conditions or hyperemia. In this study we aimed to evaluate the coronary flow in patients with isolated coronary artery ectasia by means of the TIMI frame count and to compare the results with those of patients with angiographically normal coronary arteries. The study population consisted of 37 patients with coronary artery ectasia only in the right coronary artery (RCA). The control group consisted of 31 patients with angiographically proven normal coronary arteries. Coronary artery ectasia was defined as nonobstructive lesions of the coronary arteries with a luminal dilatation 1.5-fold or more of the adjacent normal coronary segments. The TIMI frame count was determined for each major coronary artery in each patient according to the methods first described by Gibson et al. The TIMI frame count of RCA in the study group was significantly higher than in that of the control group (51 17 vs 25 8, P 0.0001). The TIMI frame counts of the study group for the left anterior descending and left circumflex coronary artery were also significantly higher than those of the control group (corrected TIMI frame count for LAD 42 11 vs 24 7, P 0.001; TIMI frame count for LCx 44 15 vs 25 9, P 0.001). In patients with coronary artery ectasia, the TIMI frame count of the RCA was higher than that of the left anterior descending and left circumflex coronary artery (51 17 vs 42 11 and 44 15, respectively, P 0.05). We have shown increased TIMI frame counts in patients with isolated coronary artery ectasia and suggest that the pathophysiological mechanism of coronary artery ectasia is not a focal disease. TIMI frame counts can be regarded as an index of the severity of impaired coronary flow in patients with coronary artery ectasia.Öğe A potential source of cardioembolic cerebrovascular event: Accessory mitral valve tissue(Elsevier Ireland Ltd, 2009) Turhan, Hasan; Yetkin, Ertan[Abstract Not Available]Öğe Transient hyperglycemia in patients with acute myocardial infarction: Time to define optimal glucose levels(Elsevier Ireland Ltd, 2008) Celik, Turgay; Iyisoy, Atila; Turhan, Hasan; Isik, ErsoyAlthough hyperglycemia during acute myocardial infarction ( AMI) is associated with worse short and long-term cardiovascular outcomes, whether control of glycemia is sufficient to reduce morbidity and mortality is not proven at the present time. On the other hand, the target glucose levels in patients with AMI have yet to be defined. We believe that future major outcome studies will clearly define optimal glucose concentrations in patients with AMI. (c) 2007 Elsevier Ireland Ltd. All rights reserved.Öğe What is the best choice for combination therapy in the management of dyslipidemia of metabolic syndrome?(Karger, 2006) Turhan, Hasan; Yetkin, Ertan[Abstract Not Available]
