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Öğe Acil Serviste Gerçekleşen Kardiyak Arrestler ve Kardiyopulmoner Resüsitasyon Deneyimlerimiz(Kafkas Tıp Bilimleri Dergisi, 2011) Oğuztürk, Hakan; Turtay, Muhammet Gökhan; Tekin, Yusuf Kenan; Sarıhan, EdizÖz: AMAÇ: Bu çalışmada acil serviste kardiyak arrest gelişen hastalarda var olan hastalık gruplarını, arrest ritimlerinin türlerini, kardiyopulmoner resüsitasyon (KPR) süresi ile mortalite oranlarını araştırmayı amaçladık YÖNTEM: Bir yıllık süre içinde hastane içinde arrest olan 70 hastanın dosyası geriye dönük incelendi. Yaş, cinsiyet, etiyoloji, arrest sırasındaki kardiyak ritim, kardiyopulmoner resüsitasyon süresi ve sonuçları araştırılan parametrelerdi. Kardiyopulmoner resüsitasyon kalp atımı ve kan basıncının devamlılığı sağladığında girişim başarılı kabul edildi. Grup içi karşılaştırmalarda ?2 testi ve kardiyak arrest sırasındaki ritim farklılıklarına göre cinsiyetlerin karşılaştırılmasında Kruskal Wallis testi kullanıldı. BULGULAR: Yaş ortalaması 63,4±17,3 olan 70 hastaya ileri yaşam desteği verildi. Hastaların 41'i (%58,6) erkek ve 29'u (%41,4) kadındı. Arrestin başlangıcındaki kardiyak ritimler incelendiğinde en sık ventriküler fibrilasyon 32(%45,7) ve asistoli 28(%40) izlendi. Kardiyopulmoner resüsitasyon yapılan 11 (%11,7) hastada resüsitasyona yanıt alınamadı. Arresti takiben uygulanan kardiyopulmoner resüsitasyon süresi ortalama 17,64±14,30 dakikaydı. Kardiyopulmoner resüsitasyona yanıt alınan hastaların 18'i (%25,7) iyileşti ve taburcu edildi. SONUÇ: Kardiyak arrestlerin önemli bir kısmı kardiyak hastalıkların sonucudur ve arrest sırasında en sık ventriküler fibrilasyon görülür. Buna ek olarak ventriküler fibrilasyonla başlayan arrest hastalarında hem spontane dolaşımın sağlanması hem de hastaneden taburculuk şansı daha fazladır Başlık (İngilizce): Cardiac Arrests in the Emergency Ward and Our Experiences on the Cardiopulmonary Resuscitation Öz (İngilizce): AIM: We aimed to analyse the patients diagnosed with cardiac arrest in the emergency ward in accordance to their chronic illnesses, cardiac rhythm at the beginning of the cardiac arrest, the duration of the cardiopulmonary resuscitation and the mortality rates.METHODS: The records of 70 patients diagnosed with in-hospital cardiac arrest in one year period were analysed retrospectively. Age, sex, etiology, cardiac rhythm at the time of cardiac arrest, the duration and the results of the cardiopulmonary resuscitation were the searched parameters. Cardiopulmonary resuscitation was considered successful following the establishment of spontaneous heart beats and a steady blood pressure. ?2 test was used for intra group analysis and Kruskal Wallis test used to compare the genders of the patients according to the cardiac rhythm at the time of the cardiac arrest.RESULTS: Seventy patients with a mean age of 63.4±17.3 received advanced life support. There were 41 (58.6%) male and 29 (41.4%) female patients. In the analysis of the cardiac rhythms at the beginning of the arrests, ventricular fibrillation in 32 (45.7%) and asystole in 28 (40%) patients were the most frequent ones. Eleven (11.7%) patients were unresponsive to cardiopulmonary resuscitation. The mean cardiopulmonary resuscitation time was 17.64±14.30 minutes. Eighteen (25.7%) of the patients recovered and were discharged.CONCLUSION: Most of the cardiac arrests are the results of cardiac diseases and ventricular fibrillation is the most frequent cardiac rhythm at the time of the arrest. In addition, in patients with ventricular fibrillation at the time of the cardiac arrest, the chance of establishment of a spontaneous circulation and hospital discharge is higherÖğe Acil Serviste Göğüs Ağrısının Nadir Bir Nedeni: Subklavian Çalma Sendromu(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2010) Turtay, Muhammet Gökhan; Çolak, Cengiz; Doğan, Metin; Oğuztürk, Hakan; Çelik, Emrah; Akgün, Sinem; Kutlu, RamazanAcil servislere başvuru nedenlerinin önemli bir kısmını sol kol ve göğüs ağrısı oluşturmaktadır. Göğüs ağrısı, sol kolunu aşırı kullandığında sol kolda ağrısı olan ve bu şikâyetlerle birlikte koroner arter hastalığı için risk faktörü taşıyan hastaların ayırıcı tanısında subklavian çalma sendromu düşünülmelidir. Bu hastalarda nabız ve kan basıncı değerlendirmeleri tanı açısından en önemli muayene bulgularıdır.Öğe Acil serviste göğüs ağrısının nadir bir nedeni: Subklavian çalma sendromu(2010) Turtay, Muhammet Gökhan; Çolak, Cengiz; Doğan, Metin; Oğuztürk, Hakan; Çelik, Emrah; Akgün, Feride Sinem; Kutlu, RamazanAcil servislere başvuru nedenlerinin önemli bir kısmını sol kol ve göğüs ağrısı oluşturmaktadır. Göğüs ağrısı, sol kolunu aşırı kullandığında sol kolda ağrısı olan ve bu şikâyetlerle birlikte koroner arter hastalığı için risk faktörü taşıyan hastaların ayırıcı tanısında subklavian çalma sendromu düşünülmelidir. Bu hastalarda nabız ve kan basıncı değerlendirmeleri tanı açısından en önemli muayene bulgularıdır.Öğe Antiepileptik tedaviye bağlı gelişen hipokalseminin yol açtığı dirençli konvülsiyon(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2010) Oğuztürk, Hakan; Turtay, Muhammet Gökhan; Kablan, YükselÖz: Yazımızda antiepileptik ilaçların uzun süreli kullanımı sonucunda gelişen hipokalseminin yol açtığı dirençli konvulsiyon olgusu sunulmuştur. Dört yıldır sodyum valproat, fenitoin ve okskarbazepin almakta olan 37 yaşındaki zihinsel engelli kadın hastanın düzenli ilaç kullamasına rağmen son 3 aydır nöbetleri olmaktaymış. 30 yıl önce tonik klonik epilepsi tanısı alan hastamıza 7 yaşından beri antiepileptik ilaç (AEİ) verilmekteymiş. İncelemelerimizde, antiepileptik ilaçların serum konsantrasyonlarının terapötik aralık içinde olduğu belirlendi. Serum biyokimyasında alkalen fosfataz düzeyi normal olmasına rağmen hipokalsemi saptandı. Hastaya uygulanan kalsiyum ve vitamin D tedavisi sonrası nöbetler kontrol altına alındı. Hipokalsemiye neden olabilecek AİE kullanımı dışındaki nedenler dışlandı. Uzun süreli AEİ kullanımı sonrası gelişebilen hipokalsemik nöbetler nadirdir. Düzenli AEİ alımına rağmen nöbet gelişiyorsa hastanın kalsiyum düzeyini kontrol etmek gerekir. Kalsiyum metabolizmasına etkisi olan AEİ’ları kullanan hastalarda bu ilaçların yan etkileri yakın takip edilmeli ve gerekli önlemleri alma konusunda geç kalınmamalıdır. Başlık (İngilizce): Resistant convulsion due to emergent hipocalsemia dependent upon antiepileptic treatment Öz (İngilizce): A case of resistant convulsion led by hypocalcemia in association with long-term treatment with antiepileptic drugs has been reported. A 37-year-old, mentally retarded woman was presented with a 12-month history of loss of seizure control, after being seizure-free for 4 years on a fixed regimen of oxcarbazepine, sodium valproate and phenytoin. She had been institutionalized at the age of 7 years and had received anticonvulsant drugs since she was diagnosed with tonic-clonic epilepsy 30 years ago. On investigation, serum concentrations of the anticonvulsant drugs were within the therapeutic range, indicating adequate medication dosages. Serum biochemistry was consistent with hypocalcemia, normal alkaline phosphatase. Seizure control was regained after serum calcium had been normalized with administration of vitamin D and calcium. All possible etiologic factor for hypocalcemia other than antiepileptic therapy were ruled out. Hypocalcemic seizures are uncommon long-term therapy with AEDs. Loss of seizure control in a patient stabilized on AEDs is an indication to check the patient's calcium status. Phsicians should be aware of this rare but devastating side effect AEDs which influence calcium metabolism and strictly fallow up the course to take necessary precautions in early stage.Öğe Application of knowledge discovery process on the prediction of stroke(Computer Methods and Programs in Biomedicine, 2015) Çolak, Cemil; Karaman, Esra; Turtay, Muhammet GökhanObjective: Stroke is a prominent life-threatening disease in the world. The current study was performed to predict the outcome of stroke using knowledge discovery process (KDP) methods, artificial neural networks (ANN) and support vector machine (SVM) models. Materials and methods: The records of 297 (130 sick and 167 healthy) individuals were acquired from the databases of the department of emergency medicine. Nine predictors (coronary artery disease, diabetes mellitus, hypertension, history of cerebrovascular disease, atrial fibrillation, smoking, the findings of carotid Doppler ultrasonography [normal, plaque, plaque + stenosis ≥ 50%], the levels of cholesterol and C-reactive protein) were used for predicting the stroke. Feature selection based on the Cramer’s V test was carried outfor reducing the predictors. Multilayer perceptron (MLP) ANN and SVM with radial basis function (RBF) kernel were used for the prediction based on the selected predictors. Results: The accuracy values were 81.82% for ANN and 80.38% for SVM in the training dataset (n = 209), and 85.9% for ANN and 84.62% for SVM in the testing dataset (n = 78), respectively. ANN and SVM models yielded area under curve (AUC) values of 0.905 and 0.899 in the training dataset, and 0.928 and 0.91 in the testing dataset, consecutively. Conclusion: The findings of the current study pointed out that ANN had more predictive performance when compared with SVM in predicting stroke. The proposed ANN model would be useful when making clinical decisions regarding strokeÖğe Assessment of change in neutrophil-lymphocyte ratio, platelet-lymphocyteratio in patients with acute and chronic urticaria(2018) Gür, Ali; Turgut, Kasım; Güven, Taner; Aytemur, Zeynep Ayfer; Oğuztürk, Hakan; Turtay, Muhammet Gökhan; Yumrutepe, SevgiAbstract: Aim: Urticaria is a skin disease characterized by erythematous, oedematous, itchy,and spontaneously disappearing urticaria lesions. One of the most common skin diseases, it is the most common reason underlying the presentations to emergency departments. Our objective is to investigate the role of systemic inflammation in urticaria pathogenesis by measuring the indicators of Neutrophil-Lymphocyte ratio (NLR) and Platelet-Lymphocyte ratio (PLR) in routine hemograms in patients with acute and chronic urticaria. Material and Methods: Of patients visiting the Dermatology Policlinic of İnönü University Medical School Hospital between July 2017 and February 2018, 69 patients diagnosed with acute urticaria and 188 patients diagnosed with chronic urticaria as well as 90 healthy people taken as controls with an age range of 18to 70 were included in our study. Blood values of patients were studied retrospectively. (For the study, a Research Ethics Approval was obtained from Malatya Research Ethics Board.) Results: No significant difference was detected among the study groups in terms of demographic properties. Whereas a significant difference was noted among the three groups with regard to NLR values, no statistically significant difference was detected among the groups with respect to PLR values. No statistically significant difference was observed between the group of patients with urticaria and the control group in terms of erythrocyte distribution(p: 0.01). On the other hand, when the patient group with chronic urticaria was divided into two subgroups as patients with a complaint duration of 90 days and less, and those with a complaint duration of more than 90 days and evaluated, no statistically significant difference was detected between these groups in terms of RDW, lymphocytes, neutrophils, platelets, NLR and PLR values Conclusion: In our study, we have determined that systemic inflammation has increased in the group of patients with urticaria as compared to the control group. What’s more interesting in this study is our conclusion that the pathways involved in continued inflammation do not change by time in chronic urticaria.Öğe Bacak ağrısıyla karakterize akut aort diseksiyonu(2011) Akgün, Feride Sinem; Turtay, Muhammet Gökhan; Dişli, Olcay Murat; Oğuztürk, Hakan; Doğan, MetinÖz: Amaç: Klasik olarak aort diseksiyonu ani, şiddetli, yırtıcı göğüs, sırt, bel ve karın ağrısı ile karakterizedir. Akut aort diseksiyonlarının sadece alt ekstremite iskemi semptomlarıyla ortaya çıkması nadir bir durumdur. Olgu sunumu: Altmışdokuz yaşında sağ bacakta ağrı nedeni ile acil servisimize başvuran ve akut aort diseksiyon tanısı alan erkek hasta sunuldu. Sonuç: Aort diseksiyonu tanının konması gecikir veya atlanırsa ölümcül sonuçlar ortaya çıkabilir. Bu nedenle alt ekstremite iskemisiyle başvuran hastalarda bu tanı akılda tutulmalıdır.Öğe Beneficial effects of hesperidin following cis diamminedichloroplatinum induced damage in heart of rats(Niger J Clin Pract., 2016) Oğuztürk, Hakan; Çiftçi, Osman; Çetin, Aslı; Kaya, Kürşat; Dişli, Om; Turtay, Muhammet Gökhan; Gürbüz, Şükrü; Başak, NeşeBackground: Increased oxidative stress and histopathological damage have been implicated in the cardiotoxicity that limits the clinical therapy of cisplatin (CP) as an anti-cancer drug. Objectives: This study aimed to investigate the protective effect of hesperidin (HP) against CP-induced cardiotoxicity in rats. Materials and Methods: Rats were divided into four groups (n = 7/group), and the first group served as the control group. Animals in Group CP and Group CP + HP received a single dose of CP (CP - 7 mg/kg); animals in Group HP and Group CP + HP received 50 mg/kg/day HP with gavage for 14 days. At the end of day 14, cardiac tissue samples were histologically and biochemically examined. Results: In this experimental study, thiobarbituric acid reactive substances levels in the cardiac tissue were significantly higher in the CP group, whereas glutathione (GSH), superoxide dismutase (SOD), and CAT levels were significantly lower in this group. On the other hand, GSH and SOD levels in the CP + HP group were similar to the control group. There was no significant difference in cardiac CAT levels between Group CP and Group CP + HP. Conclusion: Hesperetin treatment leads to a decrease in oxidative stress, and associated histological damage. The findings of the current study suggest that HP has a protective effect against CP‑induced cardiotoxicity.Öğe Bilateral Peripheral Facial Paralysis in a Pregnant Patient Admitted to Emergency Service: A case of Guillain-Barre Syndrome(2016) Gürbüz, Şükrü; Güven, Taner; Kamışlı, Suat; Turtay, Muhammet Gökhan; Oğuztürk, HakanUnilateral facial paralysis is frequently seen in emergency services but bilateral facialparalysis (BFP) is rare. The most common causes of bilateral facial paralysis are GullianBarre syndrome, lyme disease, Bell paralysis, skull fracture, moebius, multiple sclerosis,and infectious mononucleosis. Gullian Barre Syndrome is a demyelinatingpolyneuropathy which is associated with acute infection. The majority of cases presentwith symmetric muscle weakness and areflexia. Gullian Barre Syndrome can bediagnosed by clinical findings together with lumbar puncture and/or electrodiagnosticresults. It is a rare disease in pregnancy. Plasma exchange or gamma globulin treatmentis the preferred treatment. In this report, we present the case of a 20-week pregnantwoman who presented with bilateral facial paralysis and was eventually diagnosed withGullian Barre syndrome.Öğe Bilateral Peripheral Facial Paralysis in a Pregnant Patient Admitted to Emergency Service: A case of Guillain-Barre Syndrome(2016) Gürbüz, Şükrü; Güven, Taner; Kamışlı, Suat; Turtay, Muhammet Gökhan; Oğuztürk, HakanAcil Serviste tek taraflı periferik fasiyal sinir paralizisi sık görülmektedir, fakat bilateral fasiyal sinir paralizisi (BFP) nadir görülür. Bilateral fasiyal sinir paralizisinin en yaygın nedenleri; Guillain Barre sendromu, lyme hastalığı, Bell paralizisi, kafatası fraktürü, moebius, multipl skleroz, enfeksiyoz mononükleozdur. Guillain Barre sendromu akut enfeksiyonla ilişkili demiyelizan bir polinöropatidir. Hastaların büyük çoğunluğu simetrik kas güçsüzlüğü ve arefleksi ile başvururlar. Klinik bulgular, lumbal ponksiyon ve/veya elektrotanısal testler ile desteklenerek Guillain Barre sendromu tanısı konur. Gebelikte nadir görülen bir hastalıktır. Tedavide gama globulin ya da plasma exchange uygulanır. Bu yazıda, bilateral periferik fasiyal sinir paralizi ile başvuran ve Guillain Barre tanısı konulan, 20 haftalık gebe vakası sunulmuştur.Öğe Clinical analysis of the cancer patients who admitted to the emergency room(Biomedical research-India, 2016) Gürbüz, Şükrü; Turtay, Muhammet Gökhan; Oğuztürk, Hakan; Güven, Taner; Gür, Ali; Çolak, Cemil; Durak, Mehmet AkifObjective: Patients with cancer diagnosis often admit to emergency room with complaints that are directly or indirectly related to their current condition. We aimed to analyze what complaints the cancer patients admit with most, how long the cancer patients who are treated with antitumor treatment admit to the emergency room after the antitumor treatment, which departments were consulted with these patients most and the outcomes of these patients in the emergency room. Method: In this study, 1946 male and female patients older than 18 years old with oncological diseases who admitted to the emergency room for any complaints were analyzed retrospectively. Results: 879 (45.2%) of the patients were females and 1067 (54.8%) of them were males. The mean age was 59.1. The most common complaint was abdominal pain with 344 (17.7%) patients. The most common malignancy was lung cancer with 335 (17.3%) patients. 610 (31.3%) of the patients in the study were still receiving chemotherapy whereas 1052 (54%) of the patients never had chemotherapy. 285 (14.6%) patients were not receiving chemotherapy although they previously had. It was found that the patients admitted to the emergency room a mean of 69.9 days after the chemotherapy. 651 (33.5%) of the patients were not consulted with any departments whereas other patients were consulted with other departments, with medical oncology being the most consulted department. 1017 (52.2%) patients were discharged from the emergency room and 895 (46%) patients were hospitalized. 33 patients (1.7%) died in the emergency room. Conclusions: Patients with lung cancer admitted to the emergency rooms more often. Cancer patients admitted to the emergency department with abdominal pain and shortness of breath most. Emergency physicians have increased responsibility for tests, treatment and hospitalization of these patients as the patients are generally older and have multiple conditions.Öğe Coagulopathy in multiple traumas(Ulusal Travma ve Acil Cerrahi Dergisi, 2010) Turtay, Muhammet Gökhan; Kırımlıoğlu, Vedat; Ceylan, CengizÖz: AMAÇ Erken dönemde genel vücut travmalı (GVT) hastalarda, kafa travmasının ve diğer bölge travmalarının koagülasyon üzerine etkisi ve bu hastalarda koagülasyon parametreleri ile Glaskow Koma Skoru (GCS) ve travma şiddet skoru (ISS) ilişkilerinin araştırılması amaçlandı. GEREÇ VE YÖNTEM Acil servise GVT ile başvuran, 50 hasta (9 kadın, 41 erkek) çalışmaya alındı. Hastaların GCS, ISS, koagülasyon parametreleri düzeyleri belirlendi. GCS, ISS ile koagülasyon parametreleri arasında korelasyon değerlendirildi. Hastalar; önemli bir travma tespit edilmeyen (A), sadece kafa travması olanlar (B), kafa travması ve diğer bölge travması olanlar (C), kafa travması olmayan ancak diğer bölge travmaları olanlar (D) olarak ayrıldı. BULGULAR ISS ile uluslararası normalize oranı (INR), aktif parsiyel tromboplastin zamanı (aPTT), D-dimer ve fibrin yıkım ürünleri (FDP) düzeyleri arasında pozitif, ISS ile antitrombin (AT) ve fibrinojen düzeyleri arasında negatif bir ilişki saptandı (p<0,05). C grubuyla diğer gruplardaki INR, D-dimer, fibrinojen, aPTT, AT parametreleri karşılaştırıldığında istatistiksel anlamlılık saptandı (p<0,05). Kafa travması olan ve olmayan gruplar arasındaki INR, D-dimer ve fibrinojen parametrelerinde istatistiksel anlamlılık saptandı (p<0,05). SONUÇ Kafa travması olan hastalarda koagülasyon parametrelerinin bozulduğu, ancak kafa travmasına diğer bölge travmaları eşlik ettiğinde koagülasyon parametrelerinin daha fazla anormalleştiği belirlendi. Başlık (İngilizce): Çoklu travmalarda koagülopati Öz (İngilizce): BACKGROUND This study aimed at analyzing the effect on coagulation of head trauma and other local traumas in patients exposed to multiple traumas in the early stage, and also the relations of Glasgow Coma Scale (GCS) and Injury Severity Score (ISS) with coagulation parameters in these patients. METHODS Fifty consecutive patients (9 women, 41 men) with multiple traumas were included in this study. The GCS, ISS and coagulation parameter levels were measured. Presence of a correlation between GCS and ISS with coagulation parameters was analyzed. Patients exposed to multiple traumas were assessed in four categories as the patients with no significant traumas (A), only head traumas (B), head trauma and other local traumas (C), and no head traumas but other local traumas (D). RESULTS A marked relationship was found between ISS and international normalized ratio (INR), activated partial thromboplastin time (aPTT), D-dimer, fibrin degradation product (FDP), antithrombin (AT), and fibrinogen (p<0.05). There was a statistically significant difference between Group C and the other groups in INR, D-dimer, fibrinogen, aPTT, and AT parameters (p<0.05). There was also a statistically significant difference between the groups with and without head trauma in INR, D-dimer and fibrinogen (p<0.05). CONCLUSION The coagulation parameters were observed to diverge in patients with head trauma, but in cases with head injuries accompanying other local traumas, more coagulation parameters became abnormal.Öğe Comparıson of pulmonary functıon testıng among non-smokers, hand-rolledcıgarette smokers and factory made cıgarette smokers(SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION, SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND, 2018) Turtay, Muhammet Gökhan; Kılıç, Talat; Oğuztürk, Hakan; Gür, Ali; Güven, Taner; Çolak, CemilTobacco use causes significant health problems. The aim of this study was to compare the following factors among factory-made cigarette (FMC) smokers, hand-rolled cigarette (HRC) smokers and non-smokers (NS): demographic characteristics, pulmonary function testing (PFT) and carboxyhemoglobin (COHb) levels. PFT included checking: forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, forced expiratory flow from 25-75% of the vital capacity (FEF25-75) and peak expiratory flow (PEF). We wanted to determine the impact of smoking on pulmonary function testing and to determine any differences in PFTs and COHb levels between FMC and HRC smokers. A total of 182 participants (all males) were included in the study. The subjects in the study were randomly chosen from emergency service admissions which had complaints other than respiratory system. The mean age of study subjects was 40.8 (range: 22-92) years. Mean age of starting smoking among HRC smokers was not significantly different from FMC smokers (95% CI: -0.55-2.37, p=0.220). HRC smokers had significantly lower economic and education levels than FMC smokers (95% CI: 9.0-45.2, p<0.01). NS had highest economic and educational levels (95% CI: 35.9-66.6, p<0.01) of the 3 study groups. The mean [+/- standard deviation(SD)] FEV1/FVC was 76.66 (+/- 7.45) among FMC smokers (95% CI: 74.82-78.51), 77.36 (+/- 8.14) among HRC smokers (95% CI: 75.36-79.36) and 83.13 (+/- 5.08) among NS (95% CI: 81.70-84.56, p<0.01). The mean (+/- SD) FEV1 was 84.50 (+/- 17.80) among FMC smokers (95% CI: 80.12-88.92 ), 89.4 (+/- 15.8) among HRC smokers (95% CI: 85.56-93.32) and 95.30 (+/- 13.3) among NS (95% CI: 91.59-99.07, p<0.01). The mean (+/- SD) PEF was 81.90 (+/- 19.30) among HRC smokers (95% CI: 77.19-86.69), 78.10 (+/- 18.70) among FMC smokers (95% CI: 73.47-82.74) and 86.20 (+/- 16.0) among NS (95% CI: 81.70-90.69, p=0.06). The mean FVC, FEV1, FEV1/FVC, FEF25-75%, and PEF values among NS were significantly (p<0.05) higher for each variable than the mean of these values among FMC and HRC smokers. The mean COHb level among NS was significantly (p<0.05) lower than the mean COHb levels in the two smoking groups. There were no significant differences in PFT results or COHb levels between the two smoking groups (p>0.05). Cigarette smoking cause impairment of pulmonary function equally independent of the cigarette type (FMC, HRC) smoked.Öğe Datura Stramonium'a Bağlı Gelişen İntoksikasyon(2014) Oğuztürk, Hakan; Turtay, Muhammet Gökhan; Sarıhan, Mehmet Ediz; Bayhan, İrfan; Demir, Bilgehan[Abstract Not Acailable]Öğe A descriptive analysis of 188 liver transplant patient visits to an emergency department(European review for medical and pharmacological sciences, 2012) Turtay, Muhammet Gökhan; Oğuztürk, Hakan; Aydın, Cemalettin; Çolak, Cemil; Işık, Burak; Yılmaz, SezaiBackground: The aim of the study is to seek the causes of application, the demographic and clinical characteristics of liver transplant patients and to share the experiences of our Emergency Department. Materials and Methods: One hundred eightyeight Emergency Department visits of ninety patients who underwent liver transplant operations between 2002 and 2009 were evaluated retrospectively. Results: The patients applied to the Emergency Department with the complaints of fever 28.2% and abdominal pain 30.9%. It was detected that the final diagnosis of 52.4% of the patient visits was associated with the gastrointestinal system. It was observed that the most common treatment was drug therapy by 45.2% and that antibiotics treatment was the most applied method in drug treatment. Alanine aminotransferase (ALT) median value of hospitalized patients (45.5 U/L) is significantly higher than that of discharged patients (35 U/L) (p = 0.04). From the records of the patients, positive correlations between the length of hospitalization and levels of total bilirubin, direct bilirubin, ALT and fever during the visit were detected (p = 0.001, p < 0.001, p = 0.01, p = 0.01, respectively). Conclusions: Most frequently liver transplant recipients visited the Emergency Departments with the complaints of fever and abdominal pain. The diagnosis was generally associated with gastrointestinal system disorders. The percentage of hospitalization was high and the length of stay at the hospital was long. The treatment of these patients required a multidisciplinary approach and antibiotics constituted the most used drug treatment. Also, fever and liver function tests examined at the time of admittance to the Emergency Department affected the length of hospitalization.Öğe A descriptive analysis of 188 liver transplant patient visits to an emergency department(European review for medical and pharmacological sciences, 2012) Turtay, Muhammet Gökhan; Oğuztürk, Hakan; Aydın, Cemalettin; Çolak, Cemil; Işık, Burak; Yılmaz, SezaiBackground: The aim of the study is to seek the causes of application, the demographic and clinical characteristics of liver transplant patients and to share the experiences of our Emergency Department. Materials and Methods: One hundred eightyeight Emergency Department visits of ninety patients who underwent liver transplant operations between 2002 and 2009 were evaluated retrospectively. Results: The patients applied to the Emergency Department with the complaints of fever 28.2% and abdominal pain 30.9%. It was detected that the final diagnosis of 52.4% of the patient visits was associated with the gastrointestinal system. It was observed that the most common treatment was drug therapy by 45.2% and that antibiotics treatment was the most applied method in drug treatment. Alanine aminotransferase (ALT) median value of hospitalized patients (45.5 U/L) is significantly higher than that of discharged patients (35 U/L) (p = 0.04). From the records of the patients, positive correlations between the length of hospitalization and levels of total bilirubin, direct bilirubin, ALT and fever during the visit were detected (p = 0.001, p < 0.001, p = 0.01, p = 0.01, respectively). Conclusions: Most frequently liver transplant recipients visited the Emergency Departments with the complaints of fever and abdominal pain. The diagnosis was generally associated with gastrointestinal system disorders. The percentage of hospitalization was high and the length of stay at the hospital was long. The treatment of these patients required a multidisciplinary approach and antibiotics constituted the most used drug treatment. Also, fever and liver function tests examined at the time of admittance to the Emergency Department affected the length of hospitalization.Öğe Diffusion-weighted magnetic resonance imaging of thorax in diagnosis of pulmonary embolism(2018) Gür, Ali; Turgut, Kasım; Güven, Taner; Aytemur, Zeynep Ayfer; Oğuztürk, Hakan; Turtay, Muhammet Gökhan; Yumrutepe, SevgiAbstract: Pulmonary embolism (PE) has a high mortality rate and a considerable incidence in emergency care. Thorax computed tomography (CT) angiography is the primary diagnosis method for PE, but has many contraindications. In the present study, we aimed to determine the usability of Diffusion-weighted magnetic resonance imaging (DWMRI) in diagnosis of pulmonary embolism. Patients, diagnosed as pulmonary embolism previously by thorax CT angiography, were taken DWMRI. Demographic parameters, complaints, laboratory values and imaging findings were recorded on standart forms. Twenty nine patients, who were diagnosed as pulmonary emboli, were evaluated. Many of them were female(69%) and the mean of age was 61 years. Dyspnea and chest pain were the main complaints. Atelectasis(69,1%) and pulmonary infarct(30,9%) were determined lesions on CT and DWMRI. Region of interest (ROI) were determined by using MRI (T2) images. Three different ROI values were placed on areas and apparent diffusion coefficient (ADC) values were calculated for peripheric lung lesions. Significant difference was determine between mean ADC values of atelectasis and pulmonary infarct lesions (p<0.05). DWMRI can differentiate peripheric lesions in PE patients, but it is not adequate for diagnosis of PE.Öğe Effects of montelukast on burn wound healing in a rat model(CLINICAL AND INVESTIGATIVE MEDICINE, 2008) Turtay, Muhammet Gökhan; Fırat, Cemal; Şamdancı, Emine; Oğuztürk, Hakan; Erbatur, Serkan; Çolak, CemilPURPOSE: Montelukast, a selective cysteinyl leukotriene D4-receptor antagonist, is used in the treatment of asthma. In a rat model, our aim was to investigate the effects of montelukast, alone or in combination with topical antibiotics, on local burn wound healing. METHODS: Rats were randomly allocated to four groups after local burn development: Group 1; rats were left to secondary healing without treatment, Group 2; a dose of 10 mg/kg montelukast was given by gastric gavage once a day for 10 days, Group 3; rats were treated with topical pomade (bacitracin neomycin sulphate), and Group 4; rats were treat with a combination of topical antibiotic and montelukast (10 mg/kg were given by gastric gavage once a day for 10 days). Skin biopsies were taken on days 3, 10, 14, and 20 relative to burn induction. RESULTS: Reepithelialization in the pomade and montelukast+pomade groups on the 10th day was significantly greater, in comparison with control and montelukast groups (p < 0.05). For the montelukast group, edema (on the 14th day) and angiogenesis, fibroblast proliferation, edema and macrophage infiltration (on the 20th day) were statistically improved in comparison with the control group (p < 0.05). For the montelukast+pomade group, angiogenesis, fibroblast proliferation and macrophage infiltration (on the 10th day), and angiogenesis, fibroblast proliferation, edema and macrophage infiltration (on the 14th and 20th days) were statistically improved in comparison with the control group (p < 0.05). CONCLUSION: In conclusion, montelukast was effective on burn wound healing. Moreover, the effect was amplified when combined with topical antibiotics applied in the early stage of burn wound healing.Öğe Effects of montelukast on burn wound healing in a rat model(Clinical and investigative medicine, 2008) Turtay, Muhammet Gökhan; Fırat, Cemal; Şamdancı, Emine; Oğuztürk, Hakan; Erbatur, Serkan; Çolak, CemilPurpose: Montelukast, a selective cysteinyl leukotriene D4-receptor antagonist, is used in the treatment of asthma. In a rat model, our aim was to investigate the e!ects of montelukast, alone or in combination with topical antibiotics, on local burn wound healing. Methods: Rats were randomly allocated to four groups a"er local burn development: Group 1; rats were le" to secondary healing without treatment, Group 2; a dose of 10 mg/ kg montelukast was given by gastric gavage once a day for 10 days, Group 3; rats were treated with topical pomade (bacitracin neomycin sulphate), and Group 4; rats were treat with a combination of topical antibiotic and montelukast (10 mg/kg were given by gastric gavage once a day for 10 days). Skin biopsies were taken on days 3, 10, 14, and 20 relative to burn induction. Results: Reepithelialization in the pomade and montelukast+pomade groups on the 10th day was signi$cantly greater, in comparison with control and montelukast groups (p<0.05). For the montelukast group, edema (on the 14th day) and angiogenesis, $broblast proliferation, edema and macrophage in$ltration (on the 20th day) were statistically improved in comparison with the control group (p<0.05). For the montelukast+pomade group, angiogenesis, $broblast proliferation and macrophage in$ltration (on the 10th day), and angiogenesis, $broblast proliferation, edema and macrophage in$ltration (on the 14th and 20th days) were statistically improved in comparison with the control group (p<0.05). Conclusion: In conclusion, montelukast was e!ective on burn wound healing. Moreover, the e!ect was ampli$ed when combined with topical antibiotics applied in the early stage of burn wound healing.Öğe Elektrik yaralanmaları: Demografik ve klinik özellikler(2010) Oğuztürk, Hakan; Turtay, Muhammet Gökhan; Ertan, Cem; Akgün, Feride Sinem; Tekin, Yusuf KenanÖz: Amaç: Elektrik yaralanmaları tüm dünyada oldu¤u gibi ülkemizde de önemli bir sağlık sorunu olup, bu yaralanmalarla ilgili ülkemiz için yeterli veri bulunmamaktadır. Çalışmamızın amacı elektrik yaralanmalarının demografik özellikleri, komplikasyonları ve bu yaralanmalara bağlı gelişen mortalitenin araştırılmasıdır. Yöntemler: Bu çalışmada Ekim 2008-Ekim 2010 tarihleri arasında İnönü Üniversitesi Tıp Fakültesi Acil Tıp Anabilim dalına elektrik yaralanması ile getirilen ve tedavi edilen 38 hasta araştırıldı. Hastalarla ilgili bilgiler retrospektif olarak incelendi Bulgular: Olguların 28’i (%73,7) erkek, 10’u (%26,3) kadındı. Elektrik yaralanmalarının en sık 17-29 yaş aralı¤ında olduğu saptandı. Olguların 30’u (%78,9) düşük voltaj, 8’i (%21,1) ise yüksek voltajlı elektrik yaralanmasıydı. Elektrik yaralanmasına yol açan koşullar arasında ev kazaları (%63,2) iş kazalarından (36,8%) daha çok görülmekteydi. İki hastada ölüm nedeni sepsisti. Mortalite oranı %5,3, ortalama hastanede kalış süresi ise 4,1±5,2 gündü. Sonuç: Bu araştırmadan elde edilen bulgular demografik ve klinik özellikleri göz önüne alarak elektrik yaralanmasını önlemeye yönelik farklı bir strateji oluşturmasına hizmet edebilir. (Haseki Tıp Bülteni 2010; 48: 139-41)
