Effects of montelukast on burn wound healing in a rat model
Yükleniyor...
Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Clinical and investigative medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: Montelukast, a selective cysteinyl leukotriene D4-receptor antagonist, is used in
the treatment of asthma. In a rat model, our aim was to investigate the e!ects of montelukast,
alone or in combination with topical antibiotics, on local burn wound healing.
Methods: Rats were randomly allocated to four groups a"er local burn development:
Group 1; rats were le" to secondary healing without treatment, Group 2; a dose of 10 mg/
kg montelukast was given by gastric gavage once a day for 10 days, Group 3; rats were
treated with topical pomade (bacitracin neomycin sulphate), and Group 4; rats were treat
with a combination of topical antibiotic and montelukast (10 mg/kg were given by gastric
gavage once a day for 10 days). Skin biopsies were taken on days 3, 10, 14, and 20 relative to
burn induction.
Results: Reepithelialization in the pomade and montelukast+pomade groups on the 10th
day was signi$cantly greater, in comparison with control and montelukast groups
(p<0.05). For the montelukast group, edema (on the 14th day) and angiogenesis, $broblast
proliferation, edema and macrophage in$ltration (on the 20th day) were statistically improved
in comparison with the control group (p<0.05). For the montelukast+pomade
group, angiogenesis, $broblast proliferation and macrophage in$ltration (on the 10th day),
and angiogenesis, $broblast proliferation, edema and macrophage in$ltration (on the 14th
and 20th days) were statistically improved in comparison with the control group (p<0.05).
Conclusion: In conclusion, montelukast was e!ective on burn wound healing. Moreover,
the e!ect was ampli$ed when combined with topical antibiotics applied in the early stage
of burn wound healing.
Açıklama
Anahtar Kelimeler
Kaynak
Clinical and investigative medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
33
Sayı
6
Künye
Turtay, M. G. Fırat, C. Şamdancı, E. Oğuztürk, H. Erbatur, S. Çolak, C. (2008). Effects of montelukast on burn wound healing in a rat model. Clinical and investigative medicine. 33(6), 413–421.
