Yazar "Unver, Nurcan" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • Küçük Resim
    Öğe
    The association of GLUT-1, Galectin 3 and Claudin 1 staining with the type of renal tumors
    (2019) Turna, Seval; Coban, Ganime; Yildiz, Pelin; Unver, Nurcan; Buyukpinarbasili, Nur; Ersoz, Cevper; Gucin, Zuhal
    Aim: The mechanism of carcinogenesis and prognostic parameters of renal cell carcinomas(RCC) exhibiting an increasing incidence trend are still obscure. Even though new tumors types are identified, diagnostic difficulty is even experienced occasionally for the most common tumor types. Various immunohistochemical and molecular-genetic studies are conducted for tumor type identification and prognostic evaluation. The present study examined glucose transporter protein (GLUT-1), galectin-3 that is associated with cell growth, differentiation, proliferation, adhesion, angiogenesis and apoptosis, and Claudin 1, a transmembrane protein of intercellular tight junctions, immunohistochemically for the most commonly encountered renal tumors. The staining patterns were compared in terms of Fuhrman nuclear grade, stage, metastasis, and demographic data. Material and Methods: Methods: The study consisted of a total of 99 renal tumor cases including 40 Clear Cell Renal Cell Carcinoma (CCRCC), 22 Chromophobe Renal Cell Carcinoma (CrRCC), 16 Oncocytoma and 19 Papillary Renal Cell Carcinoma (PRCC) cases. Results: Overexpression of GLUT-1 was observed in 92.5% of CCRCC cases and 36.8% of PRCC cases whereas the loss of expression was observed in CrRCC and Oncocytoma. Claudin-1 was seen in 77.5% of the CCRCCs, 45.4% of the CrRCCs, 81.25% of the oncocytomas and 84.2% of the PRCCs. Galectin-3 was present in 90% of the CCRCCs, 81% of the CrRCCs, 50% of the oncocytomas and 21% of the PRCC Conclusion: Diffuse membranous staining pattern was observed for GLUT-1 in case of CCRCC, however, no correlation with prognostic parameters was noticed. Claudin-1 expression was observed in high nuclear grade tumors. Thus, it may be regarded as a poor prognostic factor. Galectin 3 expression was observed in the tumors with sarcomatoid differentiation.
  • Küçük Resim
    Öğe
    Evaluation of clinicopathological characteristics and prognosis of lung ınvasive mucinous adenocarcinomas based on computed tomography (CT) findings
    (2021) Unver, Nurcan; Akanil Fener, Neslihan; Urer, Halide Nur
    Aim: The aim of our study is to evaluate the cases with invasive mucinous adenocarcinoma (IMA) detected separately from lung adenocarcinoma in the 2015 WHO classification and to associate the clinicopathological findings and evaluate their prognostic significance based on computed tomography (CT) findings. Materials and Methods: The materials of patients who underwent resection from January 1 2011 to June 31 2019 at our hospital were reviewed after archive screening and those belonging to the Invasive mucinous adenocarcinoma group were determined according to the WHO 2015 classification. Clinical and radiological data of the cases were collected. Tumors were classified as solitary or pneumonic type based on CT findings, and the data obtained were compared statistically. Results: Based on CT findings (pneumonic and solitary), pathological T stages were significantly different between the two groups. Based on CT findings, pneumonic type-IMA was associated with a more advanced stage (p<0.001) and worse prognosis than solitary type-IMA. In addition, while pneumonic type IMA has a higher rate of aerogenous spread (STAS), there was no statistically significant relationship between other clinicopathological findings. Conclusion: Invasive mucinous tumors can be created with different CT images. Based on CT findings, evaluation of invasive mucinous adenocarcinoma before surgical resection may be useful in predicting prognosis.
  • Küçük Resim
    Öğe
    Inflammatory parameters and insulin resistance and cigarette smoking in type 2 diabetes mellitus
    (2018) Kayar, Yusuf; Agin, Mehmet; Unver, Nurcan
    Aim: Smoking remains a global problem and it is known as a cause of many diseases. Globally, tobacco use is the most important cause of preventable morbidity and mortality. The aim of this study is to evaluate the impact of smoking on insulin parameters and inflammatory markers, and the variation of these parameters according to the duration of smoking cessation in patients who quit smoking. Material and Methods: 612 patients aged 18-70 years (n = 612) who were undergoing treatment and follow-up for type 2 diabetes mellitus were included in this study. The patients were categorized into 3 groups (i.e., smokers, ex-smokers, and nonsmokers). Test results ofof hemoglobin A1c (HbA1c), cholesterol, triglyceride, high density lipoprotein (HDL) levels, low density lipoprotein, leukocyte count, C-reactive protein, fibrinogen, and ferritin levels were obtained. Body mass indexes (BMI) and blood pressure were also measured. Results: Smoking was significantly associated with the male gender, HbA1c, HDL level, BMI, waist circumference, the homeostatic model assessment-insulin resistance (HOMA-IR) core, and inflammatory markers. Current smokers who smoked ≥20 packs/year demonstrated poorer metabolic results compared to those who smoked 0-10 pack(s)/year. The metabolic parameters were worse in ex-smokers who quit smoking <1 year ago compared to ex-smokers who quit 1-5 years, 5-10 years, and >10 years ago. Conclusion: We demonstrated that smoking increased insulin resistance, metabolic syndrome, and inflammation. Smoking was also observed to worsen glycemic control by further increasing insulin resistance in diabetic patients.
  • Küçük Resim
    Öğe
    The relation between life quality and subtype of the disease in patients with irritable bowel syndrome
    (2019) Kayar, Yusuf; Agin, Mehmet; Unver, Nurcan; Dertli, Ramazan; Kirpinar, Ismet
    Aim: Irritable bowel syndrome (IBS) is not a life-threatening condition; however, people with IBS have a low quality of life (QOL) that might affect their education, social and professional achievements. Many studies have shown that patients who have IBS have lower QOL compared to the general population together with patients who have chronic diseases. The relation between IBS subtype and QOL is still not clear. For this reason, our study aims to evaluate the relationship between subtypes of the disease and QOL in patients who have IBS. Material and Methods: The 100 patients with IBS and 100 healthy individuals who were aged from 18 to 65 years, were included in our study. The relationship between disease subtype and quality of life in IBS patients were analyzed. Results: Regarding quality of life between the groups in the examination; the overall health scores were lower at a significant level in the patients who had IBS subtype as predominant-constipation than those who had IBS subtypes as predominant-diarrhea and mixed type (p=0.013;p=0.045;p<0.05,respectively).The vitality scores were higher at a significant level in patients whose IBS subtypes were predominant-diarrhea than those who had the IBS subtype as predominant-constipation (p=0.007;p<0.01). There were no statistically significant differences between the IBS subtypes and other parameters(p>0.05). Conclusion: It was shown that the QOL of IBS patients were significantly lower than the healthy population, but some differences were also found between the disease subtypes. QOL measurement as part of future therapeutic trials in IBS will help ensure optimal treatment.
  • Küçük Resim
    Öğe
    Serum soluble TWEAK levels in non-alcoholic fatty liver disease
    (2019) Asil, Mehmet; Demir, Ali; Unver, Nurcan; Polat, Hakki; Ataseven, Huseyin; Uysal, Saliha; Kayar, Yusuf; Keskin, Muharrem; Yolacan, Ramazan; Biyik, Murat; Dertli, Ramazan
    Aim: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. The exact pathogenesis of NAFLD has not been fully elucidated. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of TNF superfamily and it has been implicated in the pathogenesis of several diseases including liver inflammation and fibrosis. Current study was conducted to evaluate serum sTWEAK levels in patients with NAFLD.Material and Methods: Seventeen patients with biopsy proven non-alcoholic steatohepatitis (NASH), 22 patients with simple hepatosteatosis and 30 healthy controls were included in the study and serum sTWEAK concentrations were measured using commercial ELISA kits.Results: Mean serum sTWEAK concentration was significantly lower in the NASH group when compared to the simple hepatosteatosis group and healthy controls (199.6±101.2 pg/mL, 246.1±65.7 pg/mL and 277.6±117.6 pg/mL respectively, p=0.029). ROC analyses for sTWEAK to differentiate NASH patients from healthy controls and from simple hepatosteatosis revealed that AUC for sTWEAK was 0.712 (%95 CI, 0.543-0.880). For the specified cut off value, 171.1 pg/mL positive and negative predictive values calculated were 64.3% and 85.5% respectively. Conclusion: Serum sTWEAK concentration is decreasedin patients with NASH when compared to patients with simple hepatosteatosis and healthy controls. Keywords: Nonalcoholic steatohepatitis; tumor necrosis factor-like weak inducer of apoptosis; sTWEAK; fibroblast growth factor-inducible 14; Fn 14.