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    Adenosine deaminase, xanthine oxidase, superoxide dismutase, glutathione peroxidase activities and malondialdehyde levels in the sera of patients with head and neck carcinoma.
    (2004) Kalcioglu M.T.; Kizilay A.; Yilmaz H.R.; Uz E.; Güleç M.; Ozturan O.; Akyol O.
    OBJECTIVES: Clinical and epidemiological findings have provided evidence supporting a role of free radicals in the etiology of cancer. Scavengers and inhibitors of free radical processes have been demonstrated to prevent or delay the neoplastic process. PATIENTS AND METHODS: Adenosine deaminase, xanthine oxidase, superoxide dismutase, and glutathione peroxidase activities and malondialdehyde levels were measured in the sera of 35 patients with head and neck cancers and were compared to those of healthy control subjects. RESULTS: Serum adenosine deaminase activity was found to be significantly increased in the patient group (p<0.001). Compared to the control group, glutathione peroxidase and xanthine oxidase activities and malondialdehyde levels were slightly higher and serum superoxide dismutase activity was slightly lower in the patient group, with none reaching statistical significance. CONCLUSION: The results indicate that serum adenosine deaminase activity may be helpful in the diagnosis and follow-up of head and neck cancers. Further studies with a larger cohort of patients are needed to clarify the exact mechanism of adenosine deaminase elevation.
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    Erythrocyte and plasma superoxide dismutase activities in acute appendicitis
    (1998) Koltuksuz U.; Uz E.; Gursoy H.; Demircan M.; Aydinc M.; Mutus M.; Cetin S.
    Although the role of oxygen free radicals in many inflammatory diseases has been well known, it has not been thoroughly investigated in the inflammatory diseases, of the abdomen. In order to investigate the possible role of oxygen free radicals in the mechanism of progression following the onset of inflammation, blood samples from 18 patients diagnosed as acute appendicitis and 10 healthy children as controls were collected. After plasma and erythrocytes of the blood samples were separated, superoxide dismutase (SOD) activities were measured in these compartments. Additionally, the patients with appendicitis were divided into perforated (n=8), and nonperforated (n=10) subgroups, according to intraoperative examination findings and histopathological classification. SOD activities were compared statistically between these two groups, and the control group. A significant difference in SOD activity between perforated and nonperforated appendicitis in both plasma and erythrocyte was observed (plasma: 4.2±1.7 and 2.0±0.7 U/ml, p<0.05; erythrocyte: 1690.7±799.6 and 1104.2±225.1 U/grHb, p<0.05). The difference between the nonperforated group and control group was not significant, whereas there was a significant difference between the perforated and control groups (plasma: 4.2±1.7 and 2.6±0.9 U/ml, p<0.05; erythrocyte: 1690.7±799.6 and 1148.8±152.2 U/grHb, p<0.05). According to these results, we may speculate that free oxygen radicals released from polymorphonuclear leucocytes following an inflammatory condition may play an important role in the progression of acute appendicitis with the contribution of some other possible factors.
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    The relationships between plasma and erythrocyte antioxidant enzymes and lipid peroxidation in patients with rheumatoid arthritis
    (Elsevier Masson SAS, 2001) Akyol Ö.; Işçi N.; Temel I.; Özgöçmen S.; Uz E.; Murat M.; Büyükberber S.
    Objective. The present study was undertaken to evaluate the activities of some key erythrocyte and plasma enzymes participating in free radical metabolism and the end product of lipid peroxidation in rheumatoid arthritis, and whether there are any differences for these parameters between newly diagnosed untreated patients and rheumatoid arthritis patients on drug therapy. Patients and methods. Superoxide dismutase and catalase activities, and malondialdehyde levels were determined in erythrocytes and plasma samples from 54 patients with rheumatoid arthritis (21 of whom without any treatment and 33 on classical therapy regimens) and from 33 healthy controls. Results. There were no statistically significant differences in mean values of activities of the erythrocyte enzymes between the patients and controls. Malondialdehyde levels were significantly increased in both newly diagnosed untreated patients and patients on drug therapy compared to control subjects. Malondialdehyde levels were lower in the treated group than the newly diagnosed untreated group (0.214 ± 0.111 ?mol/L and 0.388 ± 0.075 ?mol/L, respectively) (P < 0.0001). Mean plasma superoxide dismutase activity was lower in the group of newly diagnosed untreated patients compared to those of the treated and control groups (1.31 ± 0.069 U/mL, 1.79 ± 0.94 U/mL and 2.48 ± 0.94 U/mL, respectively) (P < 0.0001, untreated vs control groups). Conclusions. These results suggest sufficient antioxidant enzyme activities in erythrocytes in patients with rheumatoid arthritis and also increased lipid peroxidation end products in newly diagnosed untreated patients compared to control group and patients on drug therapy. © 2001 Éditions scientifiques et médicales Elsevier SAS.