Adenosine deaminase, xanthine oxidase, superoxide dismutase, glutathione peroxidase activities and malondialdehyde levels in the sera of patients with head and neck carcinoma.
Küçük Resim Yok
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVES: Clinical and epidemiological findings have provided evidence supporting a role of free radicals in the etiology of cancer. Scavengers and inhibitors of free radical processes have been demonstrated to prevent or delay the neoplastic process. PATIENTS AND METHODS: Adenosine deaminase, xanthine oxidase, superoxide dismutase, and glutathione peroxidase activities and malondialdehyde levels were measured in the sera of 35 patients with head and neck cancers and were compared to those of healthy control subjects. RESULTS: Serum adenosine deaminase activity was found to be significantly increased in the patient group (p<0.001). Compared to the control group, glutathione peroxidase and xanthine oxidase activities and malondialdehyde levels were slightly higher and serum superoxide dismutase activity was slightly lower in the patient group, with none reaching statistical significance. CONCLUSION: The results indicate that serum adenosine deaminase activity may be helpful in the diagnosis and follow-up of head and neck cancers. Further studies with a larger cohort of patients are needed to clarify the exact mechanism of adenosine deaminase elevation.
Açıklama
Anahtar Kelimeler
adenosine deaminase, glutathione peroxidase, malonaldehyde, superoxide dismutase, tumor marker, xanthine oxidase, adult, aged, article, blood, case control study, female, head and neck tumor, human, male, middle aged, prediction and forecasting, squamous cell carcinoma, Adenosine Deaminase, Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Case-Control Studies, Female, Glutathione Peroxidase, Head and Neck Neoplasms, Humans, Male, Malondialdehyde, Middle Aged, Predictive Value of Tests, Superoxide Dismutase, Tumor Markers, Biological, Xanthine Oxidase
Kaynak
Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
12
Sayı
1-2
