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    Association between pan-immune inflammatory value and ulcerative colitis
    (Taylor & Francis Ltd, 2024) Yildirim, Aslihan Mete; Yildirim, Oguzhan
    Objective: Ulcerative colitis is a chronic idiopathic disease that causes inflammation of the colon and rectum, progressing with relapses and remissions. Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) are newly developed biomarkers. There are many studies in the literature showing the relationship between SII and PIV with malignancies and inflammatory diseases. In this study we aimed to determine the relationship between SII and PIV with the activity of ulcerative colitis. Materials and methods: 146 Ulcerative colitis patients were retrospectively investigated by the time of diagnosis based on clinical, endoscopic and histolopathological findings. Patients and healthy individuals SII and PIV levels were calculated and compared with each other; and Mayo, DUBLIN, UCIES endoscopic subscores of patients were also obtained. Roc curve analysis were used to determine the cut-off value for PIV. Results: SII (468.6 +/- 203.5 vs. 823.1 +/- 555.1; p < .001), PIV (288.2 +/- 159.9 vs. 912.2 +/- 924.1; p < .001), were statistically different between groups. PIV (OR: 1.157; (1.041-1.432), p = .036), was also observed to be the independent predictor of ulcerative colitis. The best cut off value of PIV in the prediction of ulcerative colitis was >= 506 with 89.6% sensitivity and 63.7% specificity (AUC = 0.812; 95% CI 0.763-0.854, p < .001). Conclusion: Based on the results of our study, we found that SII and PIV levels were significantly increased in ulcerative colitis patients at the time of diagnosis and were associated with disease severity in the endoscopic scores RACHMILEWITZ, UCEIS and DUBLIN scores, but not for MES score.
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    Investigation of RDW and MPV levels in patients with upper gastrointestinal bleeding admitted to the emergency department
    (2021) Yildirim, Aslihan Mete; Gürbüz, Şükrü
    Comparison of red cell distribution width (RDW) and mean platelet volume (MPV) levels of patients with upper gastrointestinal bleeding and non-bleeding patients regis- tered in the emergency department. After the approval of the ethics committee, adult patients aged 16 years and over who were detected upper gastrointestinal bleeding at Emergency Service between 01.01.2010 and 31.12.2015 were retrospectively investigated. 102 patients with upper gastrointestinal haemorrhage (UGIH) and 110 healthy individuals were included in the study. There wasn’t any statistically significant negative or positive correlation of mpv with any complete blood count parameter. There was a statistically significant difference between the patient and control groups in terms of RDW and MPV values (p <0.0001, p <0.0001, respectively). RDW levels observed higher and MPV levels observed lower in patients with upper gastrointestinal bleeding who were registered to the emergency department. Considering MPV and RDW levels in patients detected upper gastrointestinal bleeding may be useful in predicting the mortality and morbidity. It should also be considered that MPV levels may vary in patients with gastrointestinal bleeding.
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    Pan-İmmune Inflammatory Index Predicts Increased Epicardial Adipose Tissue in Prediabetics
    (Springernature, 2025) Yildirim, Aslihan Mete; Bayramoglu, Adil
    Objectives Prediabetes is a global health problem due to its adverse effects on glucose metabolism. Prediabetes also triggers many inflammatory mechanisms that can lead to vascular and molecular damage of various systems and organs. Pan-immun inflammatory level (PIV) is a new biomarker that is considered with many ianflammatory conditions. Epicardial adipose tissue (EAT) is also considered an endocrine organ, which has been shown in many studies to be related to inflammation. There are studies showing that inflammatory parameters and epicardial adipose tissue are affected in diabetic patients. However, no such research has been conducted on prediabetic patients. In this study, we aimed to investigate inflammatory parameters and their relationship with epicardial adipose tissue in prediabetic patients. Methods 220 patients with prediabetes and 96 healthy controls were compared in the study regarding laboratory and demographic parameters and echocardiographic evaluations. Results There were significant differences between the groups in various parameters including epicardial adipose tissue (p < 0.001), NLR (p = 0.011); SII (p = 0.003); PIV (p < 0.001), In prediabetic patients, epicardial adipose tissue was correlated with PIV (r: 0.490; p < 0.001), SII (r: 0.248; p < 0.001), and NLR (r: 0.234; p: 0.001). PIV and presence of prediabetes were independent predictors of epicardial adipose tissue. Conclusion In this study, we observed that the presence of prediabetes is associated with EAT thickness. Again, in this patient group, we thought that PIV could be an easily obtainable parameter that could indicate an increase in EAT thickness.
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    The relationship between muscle strength, balance and falls in elderly postmenopausal osteoporosis patients
    (Elsevier Science Inc, 2026) Yakaryilmaz, Funda Datli; Yildirim, Aslihan Mete; Ozturk, Zeynel Abidin
    Objective: Osteoporosis (OP) poses a great risk for falls by causing both a decrease in muscle strength and a loss of balance ability by weakening postural control. In this study, it was aimed to determine the relationship between osteoporosis and falling in a group of older patients and to determine possible predictors that may affect it. Materials and methods: A total of 106 women aged 65 years and over were included in this cross-sectional study. Anthropometric measurement results, clinical and laboratory data of the participants were obtained from medical files. In addition to comprehensive geriatric assessment tests, Tinetti Balance and Gait Assessment Tool (TBGA) and hand grip strength (HGS) scores and the number of falls in the last year were obtained from the file records of the patients. Results: A total of 106 (71.2 +/- 6.4) older female outpatients, 43 (72.6 +/- 7.0) OP, participated in the study. HGS and TBGA scores were lower and the frequency of sarcopenia and probable sarcopenia was higher in the OP group (p = 0.007, p = 0.002, and p = 0.015; respectively). Femoral neck T score was positively correlated with the HGS and lumbar spine T score and negatively correlated with age (r = 0.369, p < 0.001; r = 0.556, p < 0.001; r = -0.329, p < 0.001; respectively). In addition there was a positive correlation between HGS and TBGA (r = 0.273, p = 0.005). Conclusion: Older women with osteoporosis demonstrated poorer muscle strength and balance performance and experienced falls more frequently than non-osteoporotic controls. Although several clinical parameters were associated with falls, only age and body mass index remained independently related to fall risk. These findings suggest that simple clinical measures such as handgrip strength and balance assessment may be useful for identifying fall-prone older women with osteoporosis.