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    Association between pan-immune inflammatory value and ulcerative colitis
    (Taylor & Francis Ltd, 2024) Yildirim, Aslihan Mete; Yildirim, Oguzhan
    Objective: Ulcerative colitis is a chronic idiopathic disease that causes inflammation of the colon and rectum, progressing with relapses and remissions. Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) are newly developed biomarkers. There are many studies in the literature showing the relationship between SII and PIV with malignancies and inflammatory diseases. In this study we aimed to determine the relationship between SII and PIV with the activity of ulcerative colitis. Materials and methods: 146 Ulcerative colitis patients were retrospectively investigated by the time of diagnosis based on clinical, endoscopic and histolopathological findings. Patients and healthy individuals SII and PIV levels were calculated and compared with each other; and Mayo, DUBLIN, UCIES endoscopic subscores of patients were also obtained. Roc curve analysis were used to determine the cut-off value for PIV. Results: SII (468.6 +/- 203.5 vs. 823.1 +/- 555.1; p < .001), PIV (288.2 +/- 159.9 vs. 912.2 +/- 924.1; p < .001), were statistically different between groups. PIV (OR: 1.157; (1.041-1.432), p = .036), was also observed to be the independent predictor of ulcerative colitis. The best cut off value of PIV in the prediction of ulcerative colitis was >= 506 with 89.6% sensitivity and 63.7% specificity (AUC = 0.812; 95% CI 0.763-0.854, p < .001). Conclusion: Based on the results of our study, we found that SII and PIV levels were significantly increased in ulcerative colitis patients at the time of diagnosis and were associated with disease severity in the endoscopic scores RACHMILEWITZ, UCEIS and DUBLIN scores, but not for MES score.
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    Öğe
    Investigation of RDW and MPV levels in patients with upper gastrointestinal bleeding admitted to the emergency department
    (2021) Yildirim, Aslihan Mete; Gürbüz, Şükrü
    Comparison of red cell distribution width (RDW) and mean platelet volume (MPV) levels of patients with upper gastrointestinal bleeding and non-bleeding patients regis- tered in the emergency department. After the approval of the ethics committee, adult patients aged 16 years and over who were detected upper gastrointestinal bleeding at Emergency Service between 01.01.2010 and 31.12.2015 were retrospectively investigated. 102 patients with upper gastrointestinal haemorrhage (UGIH) and 110 healthy individuals were included in the study. There wasn’t any statistically significant negative or positive correlation of mpv with any complete blood count parameter. There was a statistically significant difference between the patient and control groups in terms of RDW and MPV values (p <0.0001, p <0.0001, respectively). RDW levels observed higher and MPV levels observed lower in patients with upper gastrointestinal bleeding who were registered to the emergency department. Considering MPV and RDW levels in patients detected upper gastrointestinal bleeding may be useful in predicting the mortality and morbidity. It should also be considered that MPV levels may vary in patients with gastrointestinal bleeding.