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Öğe Anticancer agents: Saponin and tannin(Academic Journals Inc., 2015) Yildirim I.; Kutlu T.Herbs are ancient sources of flavoring aromatic compounds and medicines, not only for merely culinary application. The increasing interest in the powerful biological activities makes them interesting in terms of their phytochemical contents. Saponin and tannin are coined as effective phytochemical agents. Saponins have long been known to be plant- originated, but they can also be found in marine organisms. Saponnins, from a structural viewpoint, are composed of one or more hydrophilic glycoside moieties along with a lipophilic and derived aglycone and finally one or more sugar chains. Therefore, it is not a surprise that they exhibit pharmacological effects. Anticancer activity is one of these important properties. Saponins interfere with the replication of cellular DNA and they prevent the proliferation of cancer cells. Tannins, on the other hand, are of polyphenolic nature. The features distinguishing tannins from plant-based polyphenols of other types are basically the properties of the binding of the former to proteins, basic compounds, pigments, large-molecular compounds and metallic ions and also the display of anti-oxidant activities. In this review we reported the anticancer activity of different plants having a rich content of saponin and tannin. © 2015 Academic Journals Inc.Öğe Comparison of antioxidant activity of rheum ribes fruits and seed methanolic extracts against protein oxidation and lipid peroxidation(Asian Network for Scientific Information, 2015) Yildirim I.; Kutlu T.; Takim K.This work was performed to comparison antioxidant activity of Rheum ribes fruit and seed methanolic extracts against to protein oxidation. Consequently determined that antioxidant capacity with cupric of method, respectively in fruit extract to be 2.44±0.212, in seed to be extract 5.30±0.245 mmol g-1, antioxidant radical scavenging with ABTS* method in fruit extract to be 11-78%, in seed extract 2-15% levels. The OH· power reduction for the Rheum ribes fruit extract 34-49, 22±0.04%, while seed extract to be 49-80±0.04%, H2O2 removal activity for fruit extract was at 30.31-57.87 %, while seed extract was at %33.33-54.57 levels. Also were determined the total phenolic content, respectively in fruit extract to be 2.312±0.0007 in seed extract to be 3.298±0.0007 mg of GA equivalent/g, total flavonoid content in fruit extract to be 2.79±0.0066, in seed extract to be 7.31± mg 0.1787 of Q equivalent/g, total anthocyanin content, respectively in fruit extract to be 0.5 mg of cyanidin-3-glucoside equivalent/L, in seed extract to be 1.26 mg of cyanidin-3-glucoside equivalent/L. were found. Protein oxidation in fruit was 40.64-56.5%, in seed extract it was 37.98-51.46% were determined. Anti-lipid peroxidation inhibition % in fruit extract to be 13.72-27.4%, in seed extract to be 8.459-27.09% was determined. © 2015 Asian Network for Scientific Information.Öğe How does apoptosis occur with oxidative stress, ROS and lipid peroxidation?(Nova Science Publishers, Inc., 2018) Yildirim I.Molecular oxygen is used in various biochemical reactions including the process of oxidative phosphorylation, but when oxygen control is not provided, ROS genesis increases. The product of increased ROS genesis is the product oxidative stress formation; mitochondrial function may be impaired or cell viability may be affected. Depending on the effect, the cells may activate pathways that result in cellular suicide or damage that can be corrected. Therefore, this study, aims to give information about the mechanisms of oxidative stress-mediated apoptosis, to provide updatesfor previous studies update and some of the current paradigms discussed and to provide a basis for future studies. This review highlights the elementary value of apoptosis, including its effect on tissue homeostasis and cellular stress. © 2018 Nova Science Publishers, Inc. All rights reserved.Öğe A systematic overview of the mechanisms of apoptosis in the Wound Healing Process(Nova Science Publishers, Inc., 2018) Yildirim I.Wound healing is a widespread special feature of multicellular organisms. Evidence illustrates that apoptosis has very important roles in the various phases of the wound healing process. While the rise of cell proliferation, invasion, and metastasis during early wound healing is regulated by a decrease of apoptosis, however, the reduction of cell proliferation, invasion and metastasis during recent wound maturation may be controlled by a promotion of apoptotic cell deaths. In this study, I hypothesis that keeping up-to-date with studies on apoptosis and its associated mechanisms highlighted in the wound healing process will help to guide in future work. This review provides a systematic analysis of recent molecular research in wound healing applications. © 2018 Nova Science Publishers, Inc. All rights reserved.
