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Öğe Activities of the hypothalamo-pituitary-adrenal axis and autonomic nervous system following a strong earthquake(Wiley, 2024) Yilmaz, Yucehan; Ucar, Cihat; Yildiz, SedatThis study aimed to investigate the effects of post-traumatic stress, caused by a strong earthquake, on the hypothalamo-pituitary-adrenal axis (HPA) and autonomous nervous system activity (ANS). Activities of the HPA (as salivary cortisol) and ANS (as heart-rate variability [HRV]) were measured following the 2020 Elazig (Turkiye) earthquake (6.8 Richter Scale, classified as strong). A total of 227 participants (103 men (45%) and 124 women (%55)) provided saliva samples twice, namely, 1 week and 6 weeks after the earthquake. Of these participants, HRV was measured in 51 participants by 5 min continuous electrocardiogram (ECG) recording. Frequency- and time-domain parameters of the HRV were calculated to assess the activity of ANS and low/high frequency (LF/HF) ratio was used as surrogate for sympathovagal balance. Salivary cortisol levels decreased from week 1 towards week 6 (17.40. 1.48 and 15.32. 1.37 ng/mL, respectively, p < 0.05). There were no gender differences (17.99. 2.63 and 16.90. 1.60 ng/mL, respectively for females and males, p > 0.05) for salivary cortisol levels. There were no differences in time- and frequency domain parameters of the HRV including LF/HF ratio (2.95 +/- 0.38 ms(2) and 3.60 +/- 0.70 ms(2), respectively for week 1 and 6, p > 0.05). The data show that HPA axis activity, but not that of the ANS, remains higher 1 week after the earthquake but decreases afterwards towards the sixth week, suggesting that the HPA axis might be responsible for the long-term effects of a traumatic event like a strong earthquake.Öğe Analysis of long-term antibody response in COVID-19 patients by symptoms grade, gender, age, BMI, and medication(Wiley, 2022) Ozgocer, Tuba; Dagli, Seyda N.; Ceylan, Mehmet R.; Disli, Faruk; Ucar, Cihat; Yildiz, SedatThe first aim of the study was to analyze the change in antibody titer at 15-day intervals until 60 days postsymptom onset (PSO). The second aim was to analyze the relationship between antibody titer and symptom grade, gender, age, body mass index (BMI), medications, vitamin supplements, and herbal therapies. Blood samples were collected from 43 patients (5 mild, 21 moderate, 17 severe diseases), 18 women (41.9%), and 25 men (58.1%), on 15, 30, 45, and 60 days PSO after COVID-19 infection. The serum antibody titers were determined by measuring the COVID-19 immunoglobulin G (IgG) antibodies by enzyme-linked immunoassay (ELISA). Associations between the duration of symptoms, demographic and clinical parameters, medications and vitamins used, and herbal therapies were evaluated by interviewing the participants. Within the first 15 days of illness, 81.4% of the patients were positive. From Day 45 PSO, seropositivity was 89.5%. The anti-SARS-CoV-2 antibody titers were statistically higher in men than women at all times (p < 0.01). Antibody titer was higher in older participants compared to younger participants (p < 0.02). Plaquenil or favipiravir use did not affect antibody response (p > 0.05). Men had a higher fever (p = 0.006), shortness of breath (p = 0.004), and chest pain (p = 0.03) than women. We found powerful antibody response by 60 days PSO, as well as higher antibody response and severity of symptoms in the men gender. Data also showed that SARS-CoV-2 antibodies are higher in individuals with older age, whereas BMI, concomitant chronic disease, and medications had no effect on antibody titers.Öğe Analysis of the effects of hypothalamic-pituitary-adrenal axis activity in menstrual cycle on ankle proprioception, dynamic balance scores and visual-auditory reaction times in healthy young women(Jmni, 2021) Senol, Deniz; Ucar, Cihat; Toy, Seyma; Kisaoglu, Aysegul; Ozbag, Davut; Ersoy, Yuksel; Yildiz, SedatObjectives: Menstrual cycle (MC) can affect not only the female reproductive system, but also functions such as neuromuscular performance. For this reason. the aim of this study is to investigate the effect of hypothalamic-pituitary-adrenal axis (HPA) activity in MC on proprioception, balance and reaction times. Methods: For cortisol analysis, saliva samples were taken from the same women (n=43) in the four phases of MC. While State Trait Anxiety Inventory-I (STAI-I) was applied in each phase to support cortisol analysis, pain was measured with visual analogue scale (VAS). Proprioception, dynamic balance, visual and auditory reaction times (VRT-ART) measurements were made in the four phases of MC. Results: Cortisol, STAI-I and VAS scores, angular deviations in proprioception measurements, dynamic balance scores, VRT and ART measurements were found to show statistically significant difference between MC phases (p<0.05). As a result of the post hoc test conducted to find out which MC phase the statistical difference resulted from, it was found that statistically significant difference was caused by the mensturation (M) phase (p<0.05). Conclusions: It was found that neuromuscular performance and postural control was negatively affected by HPA axis activity in M phase of MC and by pain, which is a significant menstrual symptom.Öğe Antioxidative effects of curcumin, ?-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver(Sage Publications Inc, 2011) Ciftci, Osman; Ozdemir, Ilknur; Tanyildizi, Sadettin; Yildiz, Sedat; Oguzturk, HakanThe aim of this study was to investigate the effectiveness of curcumin, beta-myrcene (myrcene) and 1,8-cineole (cineole) on antioxidant defense system in rats given a persistent environmental pollutant (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD). Rats (n = 112) were divided randomly into 8 equal groups. One group was kept as control and given corn oil as carrier. TCDD was orally administered at the dose of 2 mu g/kg/week. Curcumin, myrcene and cineole were orally administered at the doses of 100 mg/kg/day, 200 mg/kg/day and 100 mg/kg/day, respectively, by gavages dissolved in corn oil with and without TCDD. The liver samples were taken from half of all rats on day 30 and from the remaining half on day 60 for the determination of thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), catalase (CAT), glutathione peroxidase (GSH-Px) and CuZn-SOD levels by spectrophotometric method. The results indicated that although TCDD significantly (p <= 0.01) increased formation of TBARS, it caused a significant decline in the levels of GSH, CAT, GSH-Px and CuZn-SOD in rats. In contrast, curcumin, myrcene and cineole significantly increased GSH, CAT, GSH-Px and CuZn-SOD levels but decreased formation of TBARS. Additionally, the antioxidative effects of curcumin, myrcene and cineole were increased at day 60 compared to day 30. In the TCDD groups given curcumin, myrcene and cineole, oxidative stress decreased by time. In conclusion, curcumin, myrcene and cineole showed antioxidant activity and eliminated TCDD-induced oxidative stress in rats in a time-dependent manner.Öğe Anxiety and Salivary Cortisol Levels in Children Undergoing Esophago-Gastro-Duodenoscopy Under Sedation(Lippincott Williams & Wilkins, 2019) Kara, Duygu; Bayrak, Nevzat Aykut; Volkan, Burcu; Ucar, Cihat; Cevizci, Mehmet Nuri; Yildiz, SedatObjectives: Esophagogastroduodenoscopy (EGD) can cause fear and anxiety in children. Cortisol, which is the most important glucocorticoid hormone in humans, can increase under physiological stress. The purpose of this study was to measure the salivary cortisol level (SCL) and anxiety level in patients undergoing EGD and evaluate their effects on the procedure. Methods: Children undergoing EGD under sedoanalgesia with propofol for various reasons were included. Their basal SCLs were compared with those of healthy age- and sex-matched controls. Moreover, SCL of the patient group at 30 minutes before EGD and 2 hours after the procedure were measured. Their anxiety scores were calculated using the modified Yale Preoperative Anxiety Scale before EGD. Duration of endoscopy, sedation, and recovery and total propofol doses were recorded. Results: Demographic properties of the patient group (n = 119; 10.9 +/- 3.2 years; 43.7% boys) and control group (n = 85; 11.8 +/- 2.8 years; 45.1% boys) were not significantly different. Basal SCLs of both groups were similar (16.9 +/- 0.7 vs 19.7 +/- 1.8 ng/mL, P = 0.16). SCL before EGD in the patient group was significantly higher than basal and post-EGD values (P < 0.001 for each). Pre-EGD SCL was positively correlated with anxiety level, propofol dose, and duration of sedation, procedure, and recovery. Anxiety levels of patients were positively correlated with propofol dose and duration of sedation and recovery, and negatively correlated with age. Conclusions: Childhood EGD is a significant stress factor, which was reflected by the pre-procedural SCL in this study. Increased anxiety resulted in increased propofol doses and sedoanalgesia-related procedural durations, which may cause potential complications.Öğe Attention Performance is not Decreased in the Health Professionals Throughout Their Night-shifts(Wiley, 2017) Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Autonomic nervous system activity under rotational shift programs: effects of shift period and gender(Natl Inst Occupational Safety & Health, Japan, 2022) Cakan, Pinar; Yildiz, SedatRotational shifts perturb homeostatic mechanisms in a sexually dimorphic way and may compromise the activity of the autonomic nervous system during day-and night-shifts. Heart rate variability (HRV) is a non-invasive measure to assess autonomic control of the heart. Our aim in this study was to assess HRV by short-term continuous electrocardiogram in female (n=40, average age: 31, average working year: 7) and male (n=40, average age: 29, average working year: 6) nurses under rotational shift programs, HRV is derived from short-term electrocardiogram recordings, carried out both at day-and night-shifts, and included time-domain [e.g., standard deviation of NN intervals, SDNN (ms); percentage of successive RR intervals that differ by more than 50 ms, pNN50 (%); root mean square of successive RR interval differences, RMSSD (ms)] and frequency-domain [very low frequency, VLF; low frequency, LF; high frequency, HF; LF/HF] parameters. Heart rates were similar across the groups but males had lower SDNN (p=0.020), RMSSD (p=0.001). pNN50 (p=0.001), VLF (p=0.048) and HF (p=0.001) but had higher LF/HF ratio (p=0.000) than females. In general, these parameters did not differ between day-and night-shifts (p>0.05). Lower HRV parameters and higher LF/HF in males suggest that they may be under greater threat for disease progression.Öğe Autonomous Nervous System Activity Does Not Change During Menstrual Cycle in Young Women(Wiley, 2017) Ugras, Seda; Yildiz, Sedat[Abstract Not Available]Öğe Cesarean delivery is associated with suppressed activities of the stress axes(Taylor & Francis Ltd, 2022) Ucar, Cihat; Bulbul, Mehmet; Yildiz, SedatMaternal pre- and post-delivery stress levels might be different for vaginal or cesarean deliveries. This study aimed to investigate the effects of type of delivery (vaginal or cesarean) and time of delivery (pre- and post-delivery) on the stress axes of the body, namely the hypothalamic-pituitary adrenal axis (HPA) and autonomic nervous system (ANS). Ninety-one pregnant women were volunteered to participate this prospective study. In these women, pre- and post-delivery HPA and ANS activities were measured noninvasively by salivary cortisol and heart rate variability (HRV), respectively. HRV was measured by 5-min electrocardiogram recording and time- and frequency-domain parameters were computed. Salivary cortisol concentration and HRV parameters were higher in women having vaginal delivery than those having cesarean delivery (p < 0.05). Cortisol levels did not differ between pre- and post-delivery (p > 0.05) but the time-domain parameters of HRV decreased post-delivery (p < 0.05). No interactions were observed between the types and times of delivery (p > 0.05). HPA and ANS axes had different activity patterns throughout the delivery process and they were higher during vaginal delivery, suggesting that they are integral parts of normal birth process and that cesarean delivery perturbs the activity of both axes.Öğe Comparison of Cortisol Awakening Response, Estradiol and Progesterone Levels Between Normally Cycling and Premenopausal Women(Wiley, 2017) Ozgocer, Tuba; Ucar, Cihat; Yildiz, Sedat[Abstract Not Available]Öğe The Comparison of Sympatho-Vagal Tonus According to Gender in Health Personnel Working in Shift System(Wiley, 2019) Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Cortisol Awakening Response and Heart Rate Variability in the Menstrual Cycle of Sportswomen(Routledge Journals, Taylor & Francis Ltd, 2021) Kayacan, Yildirim; Makaraci, Yucel; Ozgocer, Tuba; Ucar, Cihat; Yildiz, SedatPurpose: This study aimed to examine the activities of heart rate variability (HRV) and cortisol secretion as markers of the autonomous nervous system (ANS) and the hypothalamic-pituitary-adrenal axis (HPA) during the menstrual cycle in female athletes.Method: Saliva samples of the participants (n = 28) were collected successively at 0, 15, 30, and 60 min after awakening to assess cortisol awakening response (CAR) during each of four phases of the menstrual cycle (the menstruation, ovulation, luteal, and premenstrual phases). Diurnal saliva samples were collected at noon, in the evening (17:00) and 22:00 for cortisol analysis. HRV was measured in the menstrual and premenstrual phases at rest (12:00-14:00).Results: There was no difference betweenCARparameters in the menstrual phases.CARparameters and diurnal cortisol levels were significantly correlated with each other throughout the menstrual cycle. Mean cortisol was a strong predictor of the area under the curve (AUC: S = 0.042; R-Sq = 98.4%). Time-dependent parameters of HRV (standard deviation of the N-N interval [SDNN;P= .049] and the root mean square of the successive R-R differences [rMSSD;P= .038]) were significantly higher in the menstrual phase. There were no correlations betweenCARand HRV parameters.Conclusions: We suggest that the hypothalamic-pituitary-adrenal axis activity and the autonomic nervous system work in a separate manner that is not affected by the menstrual phases in sportswomen. The present study contributed to a better understanding of the relationship between the dynamics of cortisol release and the autonomic nervous system in different phases of the menstrual cycle in female athletes.Öğe Cortisol awakening response is blunted and pain perception is increased during menses in cyclic women(Pergamon-Elsevier Science Ltd, 2017) Ozgocer, Tuba; Ucar, Cihat; Yildiz, SedatBackground and aims: The incidence of menstrual symptoms is reported to be as high as 90% in cyclic women. These symptoms, including anxiety and pain, might be associated with cortisol, as its receptors are widely distributed in the brain areas associated with behavior. Therefore, the current study aimed to assess the cortisol awakening response (CAR) throughout the menstrual cycle and correlate it with pain perception and trait anxiety. Materials and methods: CAR was assessed by measuring salivary cortisol at 0, 15, 30, and 60 min following awakening in the same women (n = 59, age 22.2 +/- 0.37 years) at various stages of the menstrual cycle (menses, midcycle, luteal and premenstrual phases). Progesterone and estradiol concentrations were also determined in saliva samples to assess cyclic changes. Self-reported pain, trait anxiety, and menstrual symptoms were assessed by visual analog scale (VAS), state-trait anxiety inventory (STAI-T), and the Daily Record of Severity of Problems (DRSP), respectively. Results: Estradiol was significantly elevated during the midcycle period and remained high during the early luteal phase (p < 0.05). Progesterone was increased during the luteal phase (p < 0.05). Post awakening cortisol values increased during midcycle, luteal phase, and premenstrual phase (p < 0.05, classical CAR), but not during the menses (p > 0.05, blunted or flat CAR). Positive and significant correlations were found between cortisol and estradiol (R-2 = 0.322; p = 0.000), cortisol and progesterone (R-2 = 0.156; p = 0.000), and estradiol and progesterone (R-2 = 0.349; p = 0.001). Premenstrual symptom scores were higher in the menses and premenstrual phases than in the midcycle and luteal phases (p < 0.001). Pain perception was the highest during the menses followed by the premenstrual phase (p < 0.01). Conclusions: CAR was blunted during the menses, suggesting that cortisol might play a phase-specific role in the regulation of the cycle. Additionally, premenstrual symptoms, including pain, were more severe when ovarian steroid levels reduced (i.e., menses and the premenstrual phase). (C) 2016 Elsevier Ltd. All rights reserved.Öğe Cortisol awakening response is lower during menstrual stage in cyclic women with premenstrual syndrome(Wiley-Blackwell, 2016) Ozgocer, Tuba; Ucar, Cihat; Yildiz, Sedat[Abstract Not Available]Öğe Cortisol Awakening Response, Ovarian Steroids and Premenstrual Symptoms in Healthy Premenopausal Women(Wiley-Blackwell, 2016) Ozgocer, Tuba; Ucar, Cihat; Yildiz, Sedat; Barutcu, Ozlem[Abstract Not Available]Öğe Cytokines and Biochemical Parameters in rats Challenged Neonatally with Lipopolysaccharide and Fed Long-term with Fat-based diet(Wiley, 2017) Ucar, Cihat; Ozgocer, Tuba; Yildiz, Sedat[Abstract Not Available]Öğe Daily cortisol awakening response and menstrual symptoms in young females(Wiley, 2022) Ozgocer, Tuba; Ucar, Cihat; Yildiz, SedatMenstrual symptoms include some rhythmical changes and stress perception but women differ in duration and severity of these symptoms. It is not known whether these differences are associated with cortisol awakening response (CAR). The aim of the current study was to follow young women daily for the CAR and menstrual parameters throughout the whole menstrual cycle. Healthy and regularly cycling young women (n = 16, 17 to 31-year-old) participated in the current study. The daily records of severity of problems (DRSP) was filled in daily by the participants. CAR was also assessed daily form the salivary samples collected at a 0-, 15-, 30- and 60-min post-awakening. In terms of daily awakening cortisol profiles, women had either 2-20 (n = 3), or 20-200 (n = 8) or 200-2000 (n = 5) ng/ml cortisol according to the median levels throughout their cycle. CAR was weakly and negatively correlated with DRSP scores but strongly and positively with oestradiol (R-2 = 0.300; p = 0.000) and progesterone (R-2 = 0.490; p = 0.000) concentrations. Individuals with higher oestradiol and progesterone concentrations did not have high DRSP scores. In conclusion, CAR had a very high between-subject difference but had a low within-subject difference throughout the days of menstrual cycle, suggesting that CAR is a relatively stable personal trait. Moreover, the interplay between cortisol, progesterone and oestradiol appears to be important for the severity of menstrual symptoms.Öğe Daytime Fasting Appears to be Beneficial as it Increases Heart Rate Variability Towards Evening(Wiley, 2018) Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Decreased Sleep Duration Reduces Hypothalamo-pituitary-adrenal Axis Activity Without Affecting Autonomic Nervous System(Wiley-Blackwell, 2016) Ucar, Cihat; Ozgocer, Tuba; Yildiz, Sedat[Abstract Not Available]Öğe Development and validation of a corticosterone enzyme immunoassay for rat plasma(Wiley-Blackwell, 2016) Cakan, Pinar; Ozgocer, Tuba; Yildiz, Sedat[Abstract Not Available]
