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    Adenosine deaminase, xanthine oxidase, superoxide dismutase, glutathione peroxidase activities and malondialdehyde levels in the sera of patients with head and neck carcinoma.
    (2004) Kalcioglu M.T.; Kizilay A.; Yilmaz H.R.; Uz E.; Güleç M.; Ozturan O.; Akyol O.
    OBJECTIVES: Clinical and epidemiological findings have provided evidence supporting a role of free radicals in the etiology of cancer. Scavengers and inhibitors of free radical processes have been demonstrated to prevent or delay the neoplastic process. PATIENTS AND METHODS: Adenosine deaminase, xanthine oxidase, superoxide dismutase, and glutathione peroxidase activities and malondialdehyde levels were measured in the sera of 35 patients with head and neck cancers and were compared to those of healthy control subjects. RESULTS: Serum adenosine deaminase activity was found to be significantly increased in the patient group (p<0.001). Compared to the control group, glutathione peroxidase and xanthine oxidase activities and malondialdehyde levels were slightly higher and serum superoxide dismutase activity was slightly lower in the patient group, with none reaching statistical significance. CONCLUSION: The results indicate that serum adenosine deaminase activity may be helpful in the diagnosis and follow-up of head and neck cancers. Further studies with a larger cohort of patients are needed to clarify the exact mechanism of adenosine deaminase elevation.
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    The effect of indole-3-acetic acid on some metabolic enzymes in kidney of the second cross maternal mice and their offsprings
    (2004) Yilmaz H.R.; Yiiksel E.
    Objective: Indole-3-acetic acid (IAA) generates reactive oxygen species (ROS) and excited oxygen intermediates- IAA causes renal dysfunction, hypoglycemia, and myotonia. The first aim of the study is to investigate the possible indirect effect of the plant growth hormone IAA on some renal enzyme activities such as hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), lactate dehydrogenase (LDH), and malate dehydrogenase (MDH) of second cross offsprings of the second cross maternal mice (Mus musculus) that are given IAA. The second aim was to investigate the possible direct effect of IAA on the same renal enzymes in second cross maternal mice. Method: Female mice was divided into two groups: IAA administered group and ethanol control group. Two chemicals used were applied intraperitoneally IAA was administrated to maternal mice as a 1/40 dilution of 300 mg/kg body weights in 3-day intervals. Ethanol was administrated in the controls. Spectrophotometric methods were used to determine the activities of enzymes in the kidney of the second cross-maternal mice and their offsprings. Results: In the second cross-maternal mice, the activities of LDH, MDH, and G6PD were higher in IAA administrated animals than in controls. 6PGD and HK showed decreases in IAA study group compared to control group. In the offsprings of the second cross maternal mice, the activities of G6PD, HK, and MDH enzymes were decreased, and6PGDand LDH enzymes were increased in IAA group compared to control group. Even so differences were not statistically significant. Conclusion: The results obtained suggested that metabolic enzymes studied were not affected from IAA toxicity. This may be due to low dose of IAA.
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    The Effects of Cisplatin on the Kidney Metabolism: Role of Ginkgo Biloba Extract
    (2004) Yilmaz H.R.; Işik B.; Güleç M.; Sö?üt S.; Akyol Ö.
    In this study, we aimed to examine whether antitumour drug cisplatin affect the metabolism of the kidney and consequently causes kidney damage and, Ginkgo biloba extract prevents this damage in rats. The experimental groups were as follows: Control group, Cisplatin-treated group (Cisplatin), and a group treated with Cisplatin plus Ginkgo biloba extract (GBE). The Cisplatin and Cisplatin+GBE groups were treated intraperitoneally with a single dose of 7 mg/kg body weight sisplatin at 4th day of the treatment. GBE was administrated at a dose of 100 mg/kg body weight orally, three days before and seven days after the treatment with cisplatin in the cisplatin+GBE group. Kidney tissues were taken 7 day after the cisplatin administration. The activities of kidney hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) serum enzymes were determined in each sample. The results of the experiment demonstrated that HK, G6PD, LDH, and MDH activities were increased significantly in the cisplatin group compared with control group. HK and G6PD activities were increased significantly in the cisplatin group compared with control group. G6PD activity was increased significantly in the cisplatin+GBE group compared with cisplatin group, and LDH activity was decreased significantly in the cisplatin+GBE group compared with cisplatin group. From these results, it can be concluded that cisplatin may cause kidney damage through metabolic enzymes and, GBE may prevent damage caused by cisplatin.
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    A study on the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase enzymes in some Spalax populations
    (1999) Yilmaz H.R.; Yüksel E.
    The purpose in planing this investigation was to contribute to the speciation problems in genus Spalax. For this, we examined the activities of Glucose-6-Phosphate Dehydrogenase (G-6-PD) and 6-Phosphogluconate Dehydrogenase (6-PGD) enzymes from the liver of Spalax samples taken from both sides of river Euphrates. The samples belonging to genus Spalax were separated into two populationsin the research area. The spesific activities of G-6-PD and 6-PGD enzymes were measured at 0.01 level of significance. The results were given in a table. The observed differences between the mean specific activities of te enzymes of the two populatons were discussed.