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Öğe Accidental Displacement of Dental Implants Into Both Maxillary Sinuses During Surgery(Allen Press Inc, 2015) Eltas, Abubekir; Dundar, Serkan; Eltas, Seydanur Dengizek; Altun, Oguzhan; Yolcu, Umit; Saybak, Arif[Abstract Not Available]Öğe Biostimulatory Effects of Diode Laser and Ozone on Wound Healing in Rats(Galenos Yayincilik, 2018) Alan, Hilal; Guler, Cigdem; Yolcu, Umit; Koparal, Mahmut; Cakir, Ebru; Demir, PinarObjective: Diode laser and ozone can be used to healing of skin wounds. The aim of this study is to evaluate the biostimulatory effects of diode laser and ozone on the healing of sutured skin wounds in rats. Materials and Methods: In this study, 21 adult males Wistar albino rats were used. Three 1-cm-longs, full-thickness incisions were applied to the back of each animal and closed with sutures. Diode laser treatment, irrigation with 0.9% saline solution and ozone therapy was applied to the wounds through 7 days. Animals were euthanized on the 3rd, 7th, and 14th days after treatment, and all wounds were surgically removed for histopathological evaluation. Results: According to histological results, a statistically significant difference was found among the three treatment methods in acute inflammatory reactions on 3rd day (p<0.05). Ozone treatment reduced the intensity of acute inflammatory reactions by the 3rd day (p<0.05). In addition, a statistically significant difference was found between the follow-up periods in all treatment groups for fibrosis (p<0.01). Conclusion: It was found that ozone treatment was more effective when compared to the other treatments for reducing the intensity of acute inflammatory reactions on the healing of sutured skin wounds.Öğe Bone decortication rate and guided bone regeneration under an occlusive titanium dome: Micro-CT analysis(2019) Acar, Ahmet Huseyin; Yolcu, UmitAim: We aimed to evaluate how the rate of bone decortication influences guided bone regeneration. Material and Methods: Twenty-four titanium domes were placed bilaterally on the parietal bones of sixteen New Zealand rabbits after drilling the bone with a small round burr to induce bleeding from the marrow space (Group A: one hole; Group B: three holes; Group C: nine holes), while the bone surface was left intact at the control sites (Control group). Each group included six samples. Bone decortication rates were approximately 4% in group A, 12% in group B, and 36% in group C. All rabbits were killed after a 12- week bone-healing period, and results were evaluated by micro-CT. Results: Both newly generated tissue formation and mineralized bone formation were higher in all experimental groups than in the control group (P < 0.05), increasing in proportion to the increasing number of holes to a peak in Group C. Conclusion: Bone decortication improves mineralized bone and newly regenerated augmented tissue during guided bone regeneration. Bone decortication can be used as an integral part of guided bone regeneration procedures. Also more bone decortication rate seems to be more effective.Öğe Bone regeneration by low-level laser therapy and low-intensity pulsed ultrasound therapy in the rabbit calvarium(Pergamon-Elsevier Science Ltd, 2016) Acar, Ahmet Huseyin; Yolcu, Umit; Altindis, Sedat; Gul, Mehmet; Alan, Hilal; Malkoc, SiddikObjective: We evaluated the efficacy of low-level laser therapy (LLLT) and low-intensity pulsed ultrasound (LIPUS), alone and in combination, in triggering new bone formation. Study design: Sixteen New Zealand white rabbits were given two calvarial defects by using a 6-mm trephine bur, then divided into four treatment groups: control, LLLT, LIPUS, and LLLT + LIPUS. The LLLT and LIPUS groups were treated three times a week for two weeks. The LLLT + LIPUS group received each treatment on the same day, 12 h apart, three days a week for two weeks. The animals were sacrificed after three weeks. Results: LLLT and LIPUS, alone and in combination, enhanced new bone formation in comparison to the untreated controls after three weeks (P < 0.05); the combined therapy did not produce an additive effect. Conclusions: Our results demonstrate the efficacy of LLLT or LIPUS in triggering bone regeneration. Therapeutic dose and duration requires further study. (C) 2015 Elsevier Ltd. All rights reserved.Öğe Comparison of the Effects of Low-Level Laser Therapy and Ozone Therapy on Bone Healing(JOURNAL OF CRANIOFACIAL SURGERY, 2015) Alan, Hilal; Vardi, Nigar; Ozgur, Cem; Huseyin, Ahmet; Yolcu, Umit; Dogan, Derya OzdemirThis study aims to compare the effect of low-level laser therapy (LLLT) and ozone therapy on the bone healing. Thirty-six adult male Wistar albino rats were used for this study. Monocortical defects were shaped in right femur of all rats. Defects were filled with nano-hydroxyapatite graft. The animals were divided into 3 groups and each group was than divided into 2 subgroups. Then, LLLT with a diode laser was applied to the first group (G1), ozone therapy was applied to the second group (G2), and no treatment was applied to the third group as a control group (G3). Animals were sacrificed after 4th and 8th weeks and the sections were examined to evaluate the density of the inflammation, the formation of connective tissue, the osteogenic potential, and osteocalcin activity. As a result, there were no significant differences among the groups of 4 weeks in terms of new bone formation. In the immunohistochemical assessment, the number of osteocalcin-positive cells was higher in the laser group compared to the other group of 4 weeks; this difference was statistically significant in the LLLT and ozone groups (P < 0.05). Histomorphometric assessment showed that the new bone areas were higher in the LLLT and ozone groups; furthermore, there was a statistically significant difference in the LLLT in comparison with the control group at 8th week (P < 0.05). At the same time immunohistochemical assessment showed that osteocalcin-positive cells were considerably higher in G2 than G1 at 8th week (P < 0.05). The findings of this study may be the result of differences in the number of treatment sessions. Further studies are therefore needed to determine the optimal treatment modality.Öğe Comparison of the Effects of Low-Level Laser Therapy and Ozone Therapy on Bone Healing(Lippincott Williams & Wilkins, 2015) Alan, Hilal; Vardi, Nigar; Ozgur, Cem; Huseyin, Ahmet; Yolcu, Umit; Dogan, Derya OzdemirThis study aims to compare the effect of low-level laser therapy (LLLT) and ozone therapy on the bone healing. Thirty-six adult male Wistar albino rats were used for this study. Monocortical defects were shaped in right femur of all rats. Defects were filled with nano-hydroxyapatite graft. The animals were divided into 3 groups and each group was than divided into 2 subgroups. Then, LLLT with a diode laser was applied to the first group (G1), ozone therapy was applied to the second group (G2), and no treatment was applied to the third group as a control group (G3). Animals were sacrificed after 4th and 8th weeks and the sections were examined to evaluate the density of the inflammation, the formation of connective tissue, the osteogenic potential, and osteocalcin activity. As a result, there were no significant differences among the groups of 4 weeks in terms of new bone formation. In the immunohistochemical assessment, the number of osteocalcin-positive cells was higher in the laser group compared to the other group of 4 weeks; this difference was statistically significant in the LLLT and ozone groups (P < 0.05). Histomorphometric assessment showed that the new bone areas were higher in the LLLT and ozone groups; furthermore, there was a statistically significant difference in the LLLT in comparison with the control group at 8th week (P < 0.05). At the same time immunohistochemical assessment showed that osteocalcin-positive cells were considerably higher in G2 than G1 at 8th week (P < 0.05). The findings of this study may be the result of differences in the number of treatment sessions. Further studies are therefore needed to determine the optimal treatment modality.Öğe Cytotoxicity Evaluation of Bioresorbable Fixation Screws on Human Gingival Fibroblasts and Mouse Osteoblasts by Real-Time Cell Analysis(W B Saunders Co-Elsevier Inc, 2015) Yolcu, Umit; Alan, Hilal; Malkoc, Siddik; Bozkurt, Serife Buket; Hakki, Sema SezginPurpose: To evaluate the effects of bioresorbable fixation screws (BFSs) on human gingival fibroblast (HGF) and mouse osteoblast (MC3T3-E1) cell viability. Materials and Methods: The KLS Martin SonicPins Rx, Synthes RapidSorb Cortex Screws, and Inion CPS Bioabsorbable Fixation System each were incubated in Dulbecco's Modified Eagle Medium for 72 hours according to ISO 10993-5 standards. A real-time cell analyzer was used to evaluate cell survival. After seeding 200-mu L cell suspensions in the wells of an E-plate View 96, HGF and MC3T3-E1 cells were treated with the bioactive components released by the bioresorbable materials and monitored every 15 minutes for 96 hours. Statistical significance was determined using 1-way analysis of variance and Tukey-Kramer tests. Results: There were significant differences in the HGF responses to the untreated control conditions and the Synthes (P < .01), Inion (P < .05), and KLS Martin (P < .05) treatments over 48 hours. The Synthes (P < .01) and Inion (P < .01) treatments produced lower HGF cell index values than the untreated control at 72 hours, whereas the KLS Martin treatment did not. When left to elute for 96 hours, there were no significant differences in values among the control and study groups for HGFs (P > .05). All tested BFSs decreased cell survival rates of M3T3C1 cells for 48 hours (P < .01), 72 hours (P < .001), and 96 hours (P < .001). Conclusion: Differences in the sensitivities of the 2 tested cell lines to the different BFSs might be the result of the different materials used to manufacture the screws. These results provide fundamental knowledge and new insights for the future design and development of new biocompatible BFSs for oral and maxillofacial surgery. (C) 2015 American Association of Oral and Maxillofacial SurgeonsÖğe DENTAL STEM CELL SOURCES AND THEIR POTENTIALS FOR BONE TISSUE ENGINEERING(Istanbul Univ Press, Istanbul Univ Rectorate, 2015) Asutay, Fatih; Acar, Ahmet H.; Yolcu, Umit; Kirtay, Mustafa; Alan, HilalTissue engineering arouses excitement in all medical fields that deal with bone healing. The ultimate aim of these approaches are to shorten the healing process, obtain highly differentiated functional tissues and eliminate the need for a second surgical site required for autogenous bone grafts. Mesenchymal stem cells have been increasingly used in the experiments which were conducted in these fields and the results are promising. Dental stem cells have come to the forefront both because of their relative ease of access and also their superior characteristics. This article investigates the importance of dental stem cells for bone tissue engineering and their regeneration potentials.Öğe Displacement of Dental Implant Into the Submental Space After Surgical Integration(Lippincott Williams & Wilkins, 2017) Kirtay, Mustafa; Yolcu, Umit; Dundar, SerkanOsseointegrated dental implants are common and widely used to treat edentulism. Implant displacement into the maxillofacial spaces during surgery or after a period of use is a complication recognized in the literature. Foreign objects such as titanium dental implants in the maxillofacial region must be removed because they cause infection due to tissue reaction. In this report, the authors present the case of a patient whose dental implant slipped into the submental space after surgical integration and describe the surgical removal of the implant via an extraoral approach.Öğe Effects of laser irradiation at different wavelengths (660, 810, 980, and 1064 nm) on transient receptor potential melastatin channels in an animal model of wound healing(Springer London Ltd, 2015) Isman, Eren; Aras, Mutan Hamdi; Cengiz, Beyhan; Bayraktar, Recep; Yolcu, Umit; Topcuoglu, Tolga; Usumez, AslihanThe aim of the present study was to compare the effectiveness of four different laser wavelengths used for low-level laser therapy(LLLT) on healing of mucositis in an animal model of wound healing, by investigating expression of transient receptor potential melastatin(TRPM) ion channels. Forty-five rats were intraperitoneally injected with 100 mg/kg 5-fluorouracil on day 1 and 65 mg/kg on day 3. Superficial scratching on left cheek pouch mucosa was performed on days 3 and 5. After ulcerative mucositis was clinically detected, LLLT was started (660 nm, HELBO; 810 nm, Fotona-XD; 980 nm, ARC-Fox; and 1064 nm, Fidelis-Plus3) at 8 J/cm(2)/day from days 1 to 4. Oval excisional biopsy was performed at the wound site, and expression of TRPM2 to TRPM8 was evaluated. Student's t test was used for evaluation of significance of TRPM gene expression according to 0 value (alpha = 0.05). In 980-nm group, TRPM4, TRPM6, and TRPM7 were significantly higher than in the control group (p < 0.005). In 660, 810, and 1064 nm groups, only TRPM6 was significantly higher than in control group (p < 0.005). There were no significant differences between control and sham groups (p > 0.05). These findings suggest that expression of TRPM6 gene was significantly affected by irradiation with lasers at different wavelengths, whereas the TRPM4 and TRPM7 genes were only expressed in the 980-nm diode laser group. TRPM6 gene was highly expressed during LLLT, which may lead to accelerated wound healing and tissue repair. In contrast, there was some evidence that the 980-nm diode laser caused increased expression of TRPM4, TRPM6, and TRPM7 which are responsible for stimulation of Ca2+ and Mg2+ metabolism, as well as apoptotic pathways of controlled cell death.Öğe Evaluating the Effect of Resveratrol on the Healing of Extraction Sockets in Cyclosporine A-Treated Rats(W B Saunders Co-Elsevier Inc, 2018) Ozcan-Kucuk, Ayse; Alan, Hilal; Gul, Mehmet; Yolcu, UmitPurpose: The objective of this study was to investigate the effects of resveratrol on alveolar socket healing after tooth extraction in normal and cyclosporin A (CsA)-treated rats. Materials and Methods: Seventy-two female Sprague-Dawley rats were separated into 4 groups of 18. Group 1 was injected with a placebo solution intraperitoneally. Group 2 was injected with resveratrol (10 mu mol/kg) intraperitoneally. Groups 3 and 4 were injected with CsA (10 mg/kg) subcutaneously for 8 days once daily before tooth extraction. Next, the teeth were extracted and CsA injection continued until the animals were sacrificed. Eight days after commencing the CsA injections, group 4 was injected with resveratrol while continuing with CsA injections. Nine rats from each group were sacrificed on days 14 and 28, and sections were examined to assess the degree of inflammation, formation of connective tissue, and new bone formation Immunohistochemical analysis was used to evaluate the alveolar socket healing process using osteocalcin and osteopontin markers. A P value less than .05 was considered significant. Results: There was more new bone formation in group 2 than in the other 3 groups on day 14 after tooth extraction (P < .05), and there was more new bone formation in group 2 than in groups 3 and 4 on day 28 after extraction (P < .05). Based on the immunohistochemical assessment, the amount of osteocalcin and osteopontin labeling was greater in group 2 compared with the other 3 groups on day 14 (P < .05); however, on day 28 after extraction, it was greater in group 4 compared with group 3 (P < .05). Conclusions: Resveratrol improves alveolar socket healing in normal and CsA-treated rats. Resveratrol also increases levels of osteocalcin and osteopontin in normal and CsA-treated rats. These results suggest that this natural compound is useful for alveolar socket healing after tooth extraction. (C) 2018 American Association of Oral and Maxillofacial SurgeonsÖğe Evaluation of the effects of the low-level laser therapy on swelling, pain, and trismus after removal of impacted lower third molar(Biomed Central Ltd, 2016) Alan, Hilal; Yolcu, Umit; Koparal, Mahmut; Ozgur, Cem; Ozturk, Seyit Ahmet; Malkoc, SiddikBackground: In current study we aimed to examine the effect of a low-level laser therapy on the pain, mouth opening and swelling of patients whose impacted 3rd molar tooth was extracted in addition measurement volumetrically to the edema with 3dMD face system. Methods: It was surveyed 15 patients who had bilateral symmetric lower 3rd molars. Surgical sides of patients were randomly separated into two groups: the study group and the control group. It was applied extra oral low-level laser therapy (LLLT, 0.3 W, 40 s, 4 J/cm(2)) to the study group (n = 15) after the surgical operation and on the 2nd day. Only routine postoperative recommendation (ice application) was made in the control (n = 15) group. The maximum mouth opening, pain level and facial swelling evaluated. 3dMD Face r (3dMD, Atlanta, GA) Photogrammetric System was used to evaluate volumetric changes of the swelling. Results: There was no statistically significant difference in the edema and interincisal opening between the groups and the pain level in the laser group was significantly lower than in the control group on the 7th postoperative day. Conclusions: Although there were decreasing trismus, swelling, and pain level, with this LLLT, there was significant difference only in the 7th day pain level in the laser group compared with the control group.Öğe Fate of abstracts presented at the Turkish Association of Oral and Maxillofacial Surgeons (TAOMS) meetings between 2007 and 2009(Korean Acad Oral & Maxillofacial Surgery, 2018) Yolcu, Umit; Kucuk, Ayse OzcanObjectives: The aim of this study was to determine the rate of peer-reviewed publication of abstracts presented at the annual meetings of the Turkish Association of Oral and Maxillofacial Surgeons (TAOMS) and to identify the time to publication, subspecialty. and study design. Materials and Methods: All abstracts accepted for presentation at a TAOMS meeting between 2007 and 2009 were identified from a book of abstracts and were searched for publication using PubMed and Google Scholar. The following variables were evaluated: publication rate, type of presentation (oral or poster), time to publication, subspecialty, study design, and name of the journal in which the article was published. Results: A total of 478 abstracts were presented at the TAOMS meetings between 2007 and 2009. Of these. 140 abstracts (29.3%) were subsequently published in peer-reviewed journals, including 38.2% of oral presentations and 26.6% of poster presentations. The mean time from presentation to publication was 22 months. Regarding publication fields, research and emerging technologies presentations had the highest publication rate (100%). With regard to study type, animal study (70.0%) and basic research (55.0%) had the highest publication rates. Conclusion: Only 29.3% of abstracts presented at the TAOMS meeting were subsequently published as full-text articles. This rate was found to be similar to the previously reported publication rates in the field of oral and maxillofacial surgery.Öğe Giant hepatic hemangioma: An unusual cause of gastric compression(2019) Yolcu, Umit; Erdogan, Eren; Akatlı, Ayşe Nur; Türkmen Şamdancı, Emine; Guvenc, Merve Nur[Abstract Not Acailable]Öğe Glandular odontogenıc cyst mımıckıng dentıgerous cyst: A case report(2014) Asutay, Fatih; Acar, Ahmet H.; Yolcu, Umit; Karadağ, Neşe; Geçör, OrhanAbstract: Glandüler odontojenik kistler, ender görülen ve karakteristik olmayan klinik ve radyolojik görüntüsü nedeniyle ayırıcı tanısı zor olan lezyonlardır. Bu sebeple, dikkatli tedavi edilmesi ve agresif doğasından dolayı uzun dönemli takibi gerekmektedir. Nadir görülen bu kistin teşhis ve tedavi yaklaşımları ile bir olgu raporu sunulmuştur.Öğe Histopathological Effects of Teriparatide in Medication-Related Osteonecrosis of the Jaw: An Animal Study(W B Saunders Co-Elsevier Inc, 2016) Keskinruzgar, Aydin; Bozdag, Zehra; Aras, Mutan Hamdi; Demir, Tuncer; Yolcu, Umit; Cetiner, SedatPurpose: Osteonecrosis of the jaw after tooth extraction is a major complication in patients using bisphosphonates (BPs) for bone lesions, such as for the treatment of osteoporosis. The purpose of this study was to investigate the histopathologic effects of teriparatide (a synthetic parathyroid hormone) on rats developing osteonecrosis with BP use. Materials and Methods: Rats (n = 80) that had been injected intraperitoneally with zoledronic acid for 7 weeks were used. Maxillary first molar extractions and bone defects were established in the same region in the eighth week. Teriparatidewas administered subcutaneously to prevent osteonecrosis. Animals were sacrificed and histopathologic changes were examined. Osteoblasts, osteoclasts, inflammatory phase of bone healing, and osteonecrotic areas were evaluated. Results: The osteoclast numbers were larger in the experimental groups (teriparatide administered before and immediately after tooth extraction) than in the control group (administered zoledronic acid). The inflammatory phase of bone healing was more pronounced in the experimental group (teriparatide administered before tooth extraction) than in the control group. There were significant differences in osteoclast numbers and in the inflammatory phase of bone healing between the experimental and control groups (P < .05). The osteoblast numbers and osteonecrotic areas were similar in size between the experimental and control groups. There were no significant differences (P > .05). Conclusions: BPs have negative effects on osteoclasts and the inflammatory phase of bone healing, whereas teriparatide was found to be effective in eliminating the negative effects of BPs. Teriparatide had positive effects in preventing osteonecrosis; therefore, teriparatide could be an effective agent for MRONJ. (C) 2016 American Association of Oral and Maxillofacial SurgeonsÖğe Is Conservative Surgical Treatment Sufficient to Treat Unicystic Mural Ameloblastoma in Infant?(Lippincott Williams & Wilkins, 2015) Acar, Ahmet Huseyin; Yolcu, Umit; Erdem, Necip Fazil; Asutay, FatihAmeloblastoma, a benign neoplasm derived from odontogenic epithelium, is an aggressive and locally invasive tumor. It represents 11% of all odontogenic tumors and 1% of all oral odontogenic epithelial tumors. In this case report, a 20-month-old boy was referred to our clinic with complaint of collapse in his symphysis region of the mandible. Radiographic examination revealed unilocular radiolucency in this region. The lesion was enucleated with 1 tooth germ under general anesthesia and diagnosed as mural unicystic ameloblastoma by histopathologic examination. After the surgery, complete healing was obtained clinically and radiographically. No sign of recurrence has been seen during the follow-up period of 4.5 years. To our knowledge, this was the second youngest case of ameloblastoma in the English literature. However, it is the youngest case of ameloblastoma that occurred in an infant boy.Öğe Is Ultrasonography Useful in the Diagnosis of Nasolabial Cyst?(Hindawi Ltd, 2014) Acar, Ahmet H.; Yolcu, Umit; Asutay, FatihNasolabial cysts are nonodontogenic cysts that occur beneath the ala nasi. Its pathogenesis is uncertain. Because the nasolabial cyst is a soft tissue lesion, plain radiographs are useless. CT and MRI should be evaluated. In this report, a nasolabial cyst is described including its features on ultrasonography (USG) and CT exams.Öğe Lichenoid hypersensitivity reaction against to dental amalgam: Case report(2019) Guvenc , Merve Nur; Türkmen Şamdancı, Emine; Akatlı, Ayşe Nur; Erdogan, Eren; Yolcu, UmitAbstract: Amalgam or its components may cause delayed hypersensitivity reactions and constitute lesions compatible with lichenoid mucositis in relation to localization. A white colored lesion was detected in the buccal mucosa of a 37-year-old male patient with amalgam filling in the tooth number 46. The lesion was histopathologically reported as lichenoid mucositis. This rare lesion with a specific morphology is presented with the literature.Öğe Micro-computed tomography and histomorphometric analysis of the effects of platelet-rich fibrin on bone regeneration in the rabbit calvarium(Pergamon-Elsevier Science Ltd, 2015) Acar, Ahmet Huseyin; Yolcu, Umit; Gul, Mehmet; Keles, Ali; Erdem, Necip Fazil; Kahraman, Sevil AltundagObjective: The present study aimed to investigate the effectiveness of platelet-rich fibrin (PRF) on bone regeneration when used alone or in combination with hydroxyapatite (HA)/beta-tricalcium phosphate (beta TCP). Design: In this study, 20 New Zealand white rabbits were used and four calvarial defects were prepared in each animal. PEP, Straumann (R) Bone Ceramic (SBC), or PEP + SBC was applied to the defects; one defect was left untreated as a control. Ten rabbits were sacrificed at week 4(T-1) and 10 at week 8 (T-2). After micro-computed tomography (micro-CT) scanning, the samples were sent for histological and histomorphometric analysis to evaluate and compare the volume and area of regenerated bone. Results: Histomorphometric and micro-CT analysis showed that both PEP and SBC significantly increased bone regeneration at T-1 and T-2 (P < 0.01). When PEP was used in combination with HA/beta TCP, a further significant increase in new bone formation was observed at T-1 and T-2 compared with that when PRF or SBC was used alone (P < 0.01). Conclusions: PRF has a positive effect on bone formation when used alone and in combination with HA/beta TCP. (C) 2014 Elsevier Ltd. All rights reserved.
