Comparison of the Effects of Low-Level Laser Therapy and Ozone Therapy on Bone Healing
Yükleniyor...
Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
JOURNAL OF CRANIOFACIAL SURGERY
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study aims to compare the effect of low-level laser therapy (LLLT) and ozone therapy on the bone healing. Thirty-six adult male Wistar albino rats were used for this study. Monocortical defects were shaped in right femur of all rats. Defects were filled with nano-hydroxyapatite graft. The animals were divided into 3 groups and each group was than divided into 2 subgroups. Then, LLLT with a diode laser was applied to the first group (G1), ozone therapy was applied to the second group (G2), and no treatment was applied to the third group as a control group (G3). Animals were sacrificed after 4th and 8th weeks and the sections were examined to evaluate the density of the inflammation, the formation of connective tissue, the osteogenic potential, and osteocalcin activity. As a result, there were no significant differences among the groups of 4 weeks in terms of new bone formation. In the immunohistochemical assessment, the number of osteocalcin-positive cells was higher in the laser group compared to the other group of 4 weeks; this difference was statistically significant in the LLLT and ozone groups (P < 0.05). Histomorphometric assessment showed that the new bone areas were higher in the LLLT and ozone groups; furthermore, there was a statistically significant difference in the LLLT in comparison with the control group at 8th week (P < 0.05). At the same time immunohistochemical assessment showed that osteocalcin-positive cells were considerably higher in G2 than G1 at 8th week (P < 0.05). The findings of this study may be the result of differences in the number of treatment sessions. Further studies are therefore needed to determine the optimal treatment modality.
Açıklama
LIPPINCOTT WILLIAMS & WILKINS, TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
Anahtar Kelimeler
Bone healing, Low-level laser therapy, Ozone, Rat
Kaynak
JOURNAL OF CRANIOFACIAL SURGERY
WoS Q DeÄŸeri
Scopus Q DeÄŸeri
Cilt
26
Sayı
5
Künye
Alan, H., Vardi, N., Ozgur, C. Huseyin, A., Yolcu, U., Dogan, D.O. (2015). Comparison of the Effects of Low-Level Laser Therapy and Ozone Therapy on Bone Healing. İnönü Üniversitesi, Malatya.
