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Öğe Alteration in Bone Metabolism Markers Fallowing 3-Months Insulin Therapy in Patients with Type 2 Diabetes Mellitus: Analogues Vs. Human Insulins(Endocrine Soc, 2014) Sahin, Ibrahim; Karaca, Zuhal; Taskapan, Cagatay; Ozyalin, Fatma; Yologlu, Saim[Abstract Not Available]Öğe The Alterations of the Anterior Chamber Parameters Measured with Pentacam with Age in Healthy Subjects(Turkish Ophthalmological Soc, 2008) Emre, Sinan; Koc, Bekir; Doganay, Selim; Yologlu, SaimPurpose: To determine the mean values and standard deviations of anterior chamber parameters with pentacam and evaluate the alterations of these parameters with age. Material-Method: 224 eyes of 112 patients with just basic refractive errors were included in this study. After complete ophthalmologic examination of patients, under standard conditions anterior chamber parameters were measured with pentacam. Central corneal thickness (CCT), anterior chamber depth (ACD), corneal volume (CV), anterior chamber volume (ACV), anterior chamber angle (ACA), and also horizontal, vertical and mean keratometry values were recorded with pentacam. Results: 55 female and 57 male patients were included in this study. Mean age of patients was 28.57. Mean of the keratometric measurements was 43.1 D. Mean values for CCT, ACD, CV, ACV and ACA were 534 mu m, 3.14 mm, 59.77 mm(3), 190.26 mm(3), 36.88 degrees, respectively. Evaluation of parameters according to gender and eye distribution did not reveale any difference. Analysis the effect of age on CCT, ACD, CV, ACV and ACA parameters documented statistical significance (p< 0.005) and correlation coefficents were r=-0.185, -0.373, -0.263, -0.320, -0.264, respectively. Conclusion: This study documented the negative effect of age on the anterior chamber parameters with different correlation coefficients.Öğe Analysis of Risk Factors Affecting the Development of Infection in Artificial Vascular Grafts Used for Reconstruction of Middle Hepatic Vein Tributaries in Living Donor Liver Transplantation(Lippincott Williams & Wilkins, 2019) Koc, Cemalettin; Akbulut, Sami; Ozdemir, Fatih; Kose, Adem; Isik, Burak; Yologlu, Saim; Yilmaz, SezaiBackground. To analyze the risk factors affecting the development of infection in artificial vascular grafts (AVGs) used for reconstruction of middle hepatic vein (MHV) tributaries in living donor liver transplantation (LDLT). Methods. Between January 2009 and January 2018, 1253 right lobe LDLTs were performed at our Transplant Institute, and MHV tributaries of the 640 right lobe liver grafts were reconstructed with AVG. Reconstructed MHV tributaries were removed due to AVG infection in 25 of these patients (case group; n = 25). To determine risk factors for AVG infection, right lobe LDLT patients without AVG infections were selected as control group (n = 615). Both groups were compared about demographic parameter, transcystic catheter usage, bile leakage, type of biliary anastomosis (duct-to-duct, telescopic duct-to-duct), number of graft biliary duct (=1 versus >1), number of biliary anastomosis (=1 versus >1), AVG thrombosis, AVG types (Dacron versus polytetrafluoroethylene). Univariate analyses were used for comparison of different variables, and variables with P <= 0.20 were taken into logistic regression model. Results. Univariate analysis shows that statistically significant differences were found between groups regarding bile leakage (P < 0.001), graft thrombosis (P = 0.002), transcystic catheter (P = 0.049), and AVG types (P = 0.013). Variables with P <= 0.20 were taken into logistic regression model. Multivariate analysis shows that bile leakage (odds ratio, 13.3) and AVG thrombosis (odds ratio, 9.8) were determined as independent and strong risk factors for development of AVG infection. Conclusions. This study revealed that bile leakage and graft thrombosis are independent and strong risk factors for infections of AVGs used for anterior sector drainage reconstruction.Öğe Anti-HAV IgG seropositivity in children aged between 2-16 years who were admitted to Turgut Ozal Medical Center(Aves, 2006) Ozen, Metehan; Yologlu, Saim; Isik, Yuksel; Tekerekoglu, Mehmet SaitObjective: We aimed to determine the seropositivity of hepatitis A infection in patients aged between 2-16 years who were admitted to the Department of Pediatrics of a university hospital in Eastern Anatolia. Material and Method: We studied 685 subjects, aged between 2-16 years, who were admitted to our Department between 2004 January and 2005 July. We used chi(2) test to evaluate serological results. Results: There is statistically significant increase of hepatitis A seropositivity in subjects attending school when compared with subjects before primary school (chi(2): 18,46, p< 0,00001). There is no significant difference of serological results between subjects of rural and urban origin (.2: 0,82, p= 0,365). Conclusions: Age of exposure to hepatitis A infection for children is increasing towards puberty. Hepatitis A vaccination should be recommended for susceptible children before attending primary school.Öğe AntiHBs seropositivity in children aged between 2-16 years who were admitted to Turgut Ozal Medical Center(Aves, 2006) Ozen, Metehan; Yologlu, Saim; Isik, Yusel; Yetkin, GuayObjective: We aimed to determine the ratio of antiHBs seropositivity in patients aged between 0-16 years who were admitted to the Department of Pediatrics of a university hospital in Eastern Anatolia. In addition, we wanted to show if there is any difference in children who were born after implementation of hepatitis B vaccine into national immunization programme. Material and Method: We studied 989 subjects, aged 2 months-16 years, who were admitted to our Department between 2004 January and 2005 July. We used x2 test to evaluate the serological results. Results: There is statistically significant decrease of antiHBs seropositivity with increasing age (x2: 72.8, p< 0.00001). On the contrary, there is significant increase in ratio of antiHBc-IgG seropositivity with increasing age (x2: 27.2, p< 0.0001). Conclusions: The ratio of antiHBs seropositivity is increasing in subjects born after implementation of hepatitis B vaccine into national immunization scheme, though not reached to targeted level yet.Öğe ARM: An Interactive Web Software for Association Rules Mining and an Application in Medicine(Ieee, 2019) Percin, Ibrahim; Yagin, Fatma Hilal; Guldogan, Emek; Yologlu, SaimIn this study, it is aimed to develop a user-friendly, interactive web software for association rules mining. In the developed software, among the association rule methods; Filtered Associatior, Apriori, Frequent Pattern Growth, Predictive Apriori, Generalized Sequential Patterns, HotSpot, Tertius algorithms are used. In addition, association rules algorithms have certain limitation(s) regarding the structure of the data set. Therefore, preprocess menu in the software includes missing value assignment and variable type conversion, methods. In order to evaluate the association rules, support and confidence criteria are present in the software. However, it is not always possible to distinguish interesting and important rules only according to criteria of support and confidence. Therefore, in the proposed software; leverage, lift and conviction criteria are also included. A medical application is performed by using association rules mining, and the experimental results are evaluated based on the outputs of the developed software.Öğe Artificial Intelligence-Based Prediction of Covid-19 Severity on the Results of Protein Profiling(Elsevier Ireland Ltd, 2021) Yasar, Seyma; Colak, Cemil; Yologlu, SaimBackground: COVID-19 progresses slowly and negatively affects many people. However, mild to moderate symptoms develop in most infected people, who recover without hospitalization. Therefore, the development of early diagnosis and treatment strategies is essential. One of these methods is proteomic technology based on the blood protein profiling technique. This study aims to classify three COVID-19 positive patient groups (mild, severe, and critical) and a control group based on the blood protein profiling using deep learning (DL), random forest (RF), and gradient boosted trees (GBTs). Methods: The dataset consists of 93 samples (60 COVID-19 patients, 33 control), and 370 variables obtained from an open-source website. The current dataset contains age, gender, and 368 protein, used to predict the relationship between disease severity and proteins using DL and machine learning approaches (RF, GBTs). An evolutionary algorithm tunes hyperparameters of the models and the predictions are assessed through accuracy, sensitivity, specificity, precision, F1 score, classification error, and kappa performance metrics. Results: The accuracy of RF (96.21%) was higher as compared to DL (94.73%). However, the ensemble classifier GBTs produced the highest accuracy (96.98%). TGB1BP2 in the cardiovascular II panel and MILR1 in the inflammation panel were the two most important proteins associated with disease severity. Conclusions: The proposed model (GBTs) achieved the best prediction of disease severity based on the proteins compared to the other algorithms. The results point out that changes in blood proteins associated with the severity of COVID-19 may be used in monitoring and early diagnosis/treatment of the disease. Background: COVID-19 progresses slowly and negatively affects many people. However, mild to moderate symptoms develop in most infected people, who recover without hospitalization. Therefore, the development of early diagnosis and treatment strategies is essential. One of these methods is proteomic technology based on the blood protein profiling technique. This study aims to classify three COVID-19 positive patient groups (mild, severe, and critical) and a control group based on the blood protein profiling using deep learning (DL), random forest (RF), and gradient boosted trees (GBTs). Methods: The dataset consists of 93 samples (60 COVID-19 patients, 33 control), and 370 variables obtained from an open-source website. The current dataset contains age, gender, and 368 protein, used to predict the relationship between disease severity and proteins using DL and machine learning approaches (RF, GBTs). An evolutionary algorithm tunes hyperparameters of the models and the predictions are assessed through accuracy, sensitivity, specificity, precision, F1 score, classification error, and kappa performance metrics. Results: The accuracy of RF (96.21%) was higher as compared to DL (94.73%). However, the ensemble classifier GBTs produced the highest accuracy (96.98%). TGB1BP2 in the cardiovascular II panel and MILR1 in the inflammation panel were the two most important proteins associated with disease severity. Conclusions: The proposed model (GBTs) achieved the best prediction of disease severity based on the proteins compared to the other algorithms. The results point out that changes in blood proteins associated with the severity of COVID-19 may be used in monitoring and early diagnosis/treatment of the disease. ? 2021 Elsevier B.V. All rights reserved.Öğe The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome (vol 19, pg 166, 2019)(Bentham Science Publ Ltd, 2019) Dikci, Seyhan; Ozturk, Emrah; Firat, Penpe Gul; Yilmaz, Turgut; Taskapan, Mehmet Cagatay; Yologlu, Saim[Abstract Not Available]Öğe Blood pressure is normal, but is the heart?(Sprınger, 233 sprıng st, new york, ny 10013 usa, 2018) Celik, Serkan Fazli; Karakurt, Cemsit; Tabel, Yilmaz; Elmas, Taner; Yologlu, SaimThere is no detailed strain analysis of cardiac functions in treated hypertensive pediatric patients. The aim of this study was to evaluate the cardio-protective effects of different drug classes in treated pediatric hypertensive patients. Sixty non-obese-treated hypertensive patients with preserved left ventricular (LV) systolic function and 45 age-, sex-, and body mass index-matched healthy subjects underwent clinical evaluation, including 24-h ambulatory blood pressure monitoring, standard echocardiographic examination, tissue Doppler imaging, and two-dimensional Speckle Tracking Echocardiography. The patients were divided into two subgroups based on the effects of the drugs on the Renin Angiotensin Aldosterone System. The subgroup hypertension (HT) 1 received angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and HT 2 subgroup received calcium channel blocker, beta-blocker, or diuretics. There was no difference between the two groups and subgroups with respect to clinical, demographic, ABPM, ventricular volumes, ejection fraction, and tissue Doppler imaging (TDI) parameters. For patients and controls, respectively, global longitudinal strain was - 18.70 +/- 3.41 versus - 21.01 +/- 3.82 (P < 0.001), and global radial strain was 40.6 +/- 9.8 versus 54.8 +/- 12.8 (P = 0.004). Peak LV twist and peak LV torsion were not significantly different. The patient subgroup analyses with each other revealed no difference in systolic and diastolic myocardial deformation properties. Strain parameters were reduced in all treated hypertensive children compared to normotensive children, and the various cardiac mechanic parameters were similarly abnormal no matter what type of antihypertensive agent was used.Öğe Blood pressure is normal, but is the heart?(Springer, 2018) Celik, Serkan Fazli; Karakurt, Cemsit; Tabel, Yilmaz; Elmas, Taner; Yologlu, SaimThere is no detailed strain analysis of cardiac functions in treated hypertensive pediatric patients. The aim of this study was to evaluate the cardio-protective effects of different drug classes in treated pediatric hypertensive patients. Sixty non-obese-treated hypertensive patients with preserved left ventricular (LV) systolic function and 45 age-, sex-, and body mass index-matched healthy subjects underwent clinical evaluation, including 24-h ambulatory blood pressure monitoring, standard echocardiographic examination, tissue Doppler imaging, and two-dimensional Speckle Tracking Echocardiography. The patients were divided into two subgroups based on the effects of the drugs on the Renin Angiotensin Aldosterone System. The subgroup hypertension (HT) 1 received angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and HT 2 subgroup received calcium channel blocker, beta-blocker, or diuretics. There was no difference between the two groups and subgroups with respect to clinical, demographic, ABPM, ventricular volumes, ejection fraction, and tissue Doppler imaging (TDI) parameters. For patients and controls, respectively, global longitudinal strain was - 18.70 +/- 3.41 versus - 21.01 +/- 3.82 (P < 0.001), and global radial strain was 40.6 +/- 9.8 versus 54.8 +/- 12.8 (P = 0.004). Peak LV twist and peak LV torsion were not significantly different. The patient subgroup analyses with each other revealed no difference in systolic and diastolic myocardial deformation properties. Strain parameters were reduced in all treated hypertensive children compared to normotensive children, and the various cardiac mechanic parameters were similarly abnormal no matter what type of antihypertensive agent was used.Öğe The changes in bone mineral density of the forearm and distal radius-ulna subcortical bone due to ulnar variance(Springer, 2009) Ertem, Kadir; Kekilli, Ersoy; Karakoc, Yunus; Yologlu, SaimThe aim of this study was to evaluate the changes in subcortical bone mineralization of the distal radius and ulna in the presence of negative ulnar variance. A total of 77 healthy right hand-dominant volunteers [34 women and 43 men of mean age 38 +/- A 14.8 years (range 14-71)] were enrolled in this study. Bilateral bone mineral density (BMD) and bone mineral density ratio (BMDR) measurements of the distal radius and ulna were performed by using dual energy X-ray absorptiometry. We found a significant decrease of ulnar subcortical BMD and BMDR subcortical in the dominant forearms of the subjects with negative ulnar variance when compared to that of subjects with neutral ulnar variance (P < 0.02). But this difference was not seen on the non-dominant side. There was no significant difference in BMDRs between the dominant and non-dominant forearms for all subjects. Radial and ulnar subcortical BMD values were significantly different between dominant and non-dominant forearms in subjects with bilateral neutral ulnar variance, whereas not significantly different in subjects with bilateral negative ulnar variance. The increase found in the BMD value of radial subcortical bone in subjects with negative ulnar variance may be due to the indirect shift of axial forces through the ulna to radius.Öğe Comparative evaluation of root canal preparations of maxillary first molars with self-adjusting file, reciproc single file, and revo-s rotary file: A micro-computed tomography study(Wiley-Hindawi, 2015) Ahmetoglu, Fuat; Keles, Ali; Simsek, Neslihan; Ocak, M. Sinan; Yologlu, SaimThis study was aimed to use micro-computed tomography (-CT) to evaluate the canal shaping properties of three nickel-titanium instruments, Self-Adjusting File (SAF), Reciproc, and Revo-S rotary file, in maxillary first molars. Thirty maxillary molars were scanned preoperatively by using micro-computed tomography (-CT) scans at 13,68m resolution. The teeth were randomly assigned to three groups (n=10). The root canals were shaped with SAF, Reciproc, and Revo-S, respectively. The shaped root canals were rescanned. Changes in canal volumes and surface areas were compared with preoperative values. The data were analyzed using Kruskal-Wallis and Conover's post hoc tests, with p<.05 denoting a statistically significant difference. Preoperatively canal volumes and surface area were statistically similar among the three groups (p>.05). There were statistically significant differences in all measures comparing preoperative and postoperative canal models (p=0.0001). These differences occurred after instrumentation among the three experimental groups showed no statistically significant difference for volume (p>.05). Surface area showed the similar activity in buccal canals in each of the three techniques whereas no statistically significant difference was detected among surface area, the SAF, and the Revo-S in the palatal (P) canal. Each of three shaping system showed the similar volume activity in all canals, but SAF and Revo-S provided more effectively root planning in comparison with Reciproc in P canal. SCANNING 37:218-225, 2015. (c) 2015 Wiley Periodicals, Inc.Öğe Comparison of clinical and histopathological features of patients who underwent incidental or emergency appendectomy(Baishideng Publishing Group Inc, 2019) Akbulut, Sami; Koc, Cemalettin; Kocaaslan, Huseyin; Gonultas, Fatih; Samdanci, Emine; Yologlu, Saim; Yilmaz, SezaiBACKGROUND Incidental appendectomy can be defined as the removal of a clinically normal appendix during another surgical procedure unrelated to appendicitis or other appendicular diseases. AIM To compare the demographic, biochemical, and histopathological features of the patients who underwent incidental and standard appendectomy. METHODS The demographic, biochemical, and histopathological data of 72 patients (Incidental App group) who underwent incidental appendectomy during living donor hepatectomy at our Liver Transplant Center between June 2009 and December 2016 were compared with data of 288 patients (Acute App group) who underwent appendectomy for presumed acute appendicitis. The Incidental App group was matched at random in a 1: 4 ratio with the Acute App group in the same time frame. Appendectomy specimens of both groups were re-evaluated by two experienced pathologists. RESULTS Statistically significant differences were found between groups in terms of age (P = 0.044), white blood cell count (P < 0.001), neutrophil (P < 0.001), lymphocyte (P < 0.001), red cell distribution width (P = 0.036), mean corpuscular hemoglobin (P = 0.001), bilirubin (P = 0.002), appendix width (P < 0.001), and presence of acute appendicitis histopathologically (P < 0.001). However, no statistically significant differences were found between groups in terms of gender, platelet, mean platelet volume, mean corpuscular volume, platelet distribution width, appendix length. While the most common histopathological findings in the Incidental App group were normal appendix vermiformis (72.2%), fibrous obliteration (9.7%) and acute appendicitis (6.9%), the most common histopathological findings in the Acute App group were non-perforated acute appendicitis (62.8%), perforated appendicitis (16.7%), lymphoid hyperplasia (8.3%), and appendix vermiformis (6.3%). CONCLUSION Careful inspection of the entire abdominal cavity is useful for patients undergoing major abdominal surgery such as donor hepatectomy. We think that experience is parallel to the surgeon's foresight, and we should not hesitate to perform incidental appendectomy when necessaryÖğe Comparison of different retreatment techniques and root canal sealers: a scanning electron microscopic study(Sociedade Brasileira De Pesquisa Odontologica, 2014) Simsek, Neslihan; Keles, Ali; Ahmetoglu, Fuat; Ocak, Mevlut Sinan; Yologlu, SaimThe aim of this study was to evaluate the effectiveness of two retreatment techniques, in terms of the operating time and scanning electron microscopy (SEM) results, in removing three different root canal sealers from root canals that were previously filled with gutta-percha. Sixty extracted single-rooted human premolars were divided into three groups and filled with iRoot SP, MM Seal, and AH Plus sealers, along with gutta-percha, through a lateral compaction technique. Root canal fillings of the samples were removed by ESI ultrasonic tips or R-Endo files. The time to reach the working length was recorded. Longitudinally sectioned samples were examined under SEM magnification. Each picture was evaluated in terms of the residual debris. Data were statistically analyzed with the Kruskall-Wallis test. No statistically significant differences were found in terms of operating time (p>0.05). Significant differences in the number of debris-free dentinal tubules were found among the root canal thirds, but this finding was not influenced by the experimental group (p<0.05). Resin sealer tags were observed inside the dentinal tubules in the MM Seal group. Under the conditions of this study, it may be established that there was no difference among the sealers and retreatment techniques.Öğe Comparison of GAM and DLNM Methods for Disease Modeling in Environmental Epidemiology(2021) Karadağ, Mehmet; Kul, Seval; Yologlu, Saim; Boğan, Mustafa; Al, BehcetABSTRACT Objective: In this study, it was aimed to compare the performance results of the methods modeled by using generalized additive models (GAM) and distributed lag non-linear models (DLNM) methods from real data of three different outcome variables of three separate diseases related to air pollution. Material and Methods: The data were retrospectively obtained from three hospitals under the General Secretariat of Gaziantep province public hospitals for a total of 1,916 days between 01 January 2009 and 31 March 2014. Response variables were number of the emergency unit admission, hospitalization and mortality due to asthma, chronic obstructive pulmonary disease (COPD) and pneumonia. The response variables were estimated by GAM and DLNM methods by building four different models and the performances of the models were compared. Results: When the estimation performances of GAM and DLNM methods are compared for each of the dependent variables in the prediction of hospitalizations due to asthma, GAM model IV [Akaike Information Criteria (AIC) (4,280.63)] values were found to perform the best. It was observed that DLNM method performed better than GAM in models established for the prediction of almost all other dependent variables. For when compare the odds ratio (OR) plot estimated on particulate matter (PM10); it was seen that GAM method made predictions with lower standard error compared to DLNM methods. Conclusion: When the models created with each dependent variable were compared; it was generally observed that superior performance was obtained from the DLNM method. However, the lowest standard error in the OR charts were observed in the models using the GAM method.Öğe Comparison of intravenous ibuprofen and acetaminophen for postoperative multimodal pain management in bariatric surgery: A randomized controlled trial(Elsevier Science Inc, 2018) Kayhan, Gulay Erdogan; Sanli, Mukadder; Ozgul, Ulku; Kirteke, Ramazan; Yologlu, SaimStudy objective: Multimodal analgesic strategies are recommended to decrease opioid requirements and opioid-induced respiratory complications in patients undergoing laparoscopic bariatric surgery. Recent studies have demonstrated that intravenous ibuprofen decreases opioid consumption compared with placebo. The primary aim of this study was to compare the effect of intravenous ibuprofen and intravenous acetaminophen on opioid consumption. We also aimed to compare postoperative pain levels and side effects of the drugs. Design: Randomized, double-blinded study. Setting: University hospital. Patients: Eighty patients, aged 18-65 years, (ASA physical status undergoing laparoscopic sleeve gastrectomy or laparoscopic Roux-en-Y gastric bypass surgery were included in this study. Interventions: Patients were randomized to receive 800 mg ibuprofen or 1 g acetaminophen intravenously every 6 h for the first 24 h following surgery; in addition, patient-controlled analgesia with morphine was administered. Measurements: Postoperative morphine consumption in the first 24 h, visual analog scale (VAS) pain scores at rest and with movement, and opioid related side effects were assessed. In addition, time to passage of flatus, surgical complications, lengths of intensive care unit and hospital stay, and laboratory parameters were recorded. Main results: The mean morphine consumption was 23.94 +/- 13.89 mg in iv ibuprofen group and 30.23 +/- 13.76 mg in the acetaminophen group [mean difference: -6.28 (95% CI, -12.70, 0.12); P = 0.055]. The use of intravenous ibuprofen was associated with reduction in pain at rest (AUC, 1- to 24-h, P < 0.001 and 12- to 24-h, P = 0.021) and pain with movement (AUC, 1-24, 6-24, and 12-24 h, P < 0.001). Intravenous ibuprofen was well tolerated with no serious side effects except dizziness. Conclusions: Intravenous ibuprofen did not significantly reduce opioid consumption compared to intravenous acetaminophen; however, it reduced the severity of pain. Intravenous ibuprofen may be a good alternative to intravenous acetaminophen as part of a multimodal postoperative analgesia in patients undergoing bariatric surgery.Öğe Comparison of Two Pancreatic Anastomosis Techniques in terms of Postoperative Complications After Pancreaticoduodenectomy(Aves, 2021) Koc, Suleyman; Dirican, Abuzer; Soyer, Vural; Ara, Cengiz; Yologlu, Saim; Yilmaz, SezaiObjective: in this retrospective study, we compared the postoperative complications by using both the Clavien-Dindo classification and the Revised 2016 International Study Group on Pancreatic Surgery (ISGPS) classification methods after pancreaticoduodenectomy. Materials and Methods: The data of patients were retrospectively reviewed. Pancreaticojejunostomy (PJ) and pancreaticogastrostomy (PG) were performed on 41 and 40 patients, respectively. The patients were assigned into two groups for anastomosis types and compared with each other according to postoperative complications. The postoperative follow-up period of the patients was limited to 90 days. Results: No significant difference was detected between the two groups in terms of gender (P = 581) and age (P = .809). According to the Clavien-Dindo classification system, grade I complication rates were 29.3% and 35.0% in. PJ and PG groups. respectively. Also, grade 2 complication rates were 34.1% and 325% in PJ and PG groups, respectively. Besides, grade 3B complication rates were 9.8% and 17.5% in PJ and PG groups, respectively. No grade 3A, grade 4A, and grade 4B complications were detected in both groups. But, grade 5 complications rates were 2.4% and 5.0% in 11 and PG groups, respectively. Based on the ISGPS classification system, the pancreatic fistulas were classified. The biochemical leak rates were calculated as 26.8% and 37.5% in PJ and PG groups, respectively. The rates were 14.6% and 10% in PJ and PG groups, respectively, for grade B complications. Also, grade C complication rates were 9.75% and 115% in. PJ and PG groups, respectively. No statistically significant differences were detected between the two groups for postoperative complications. Conclusion: The evidence from this retrospective study suggests that there is no difference between the two types of pancreatic anastomosis techniques (PJ or PG) in terms of the rate of postoperative complications.Öğe Determination of biomarker candidates for the placenta accreta spectrum by plasma proteomic analysis(Nature Portfolio, 2024) Melekoglu, Rauf; Yasar, Seyma; Colak, Cemil; Kasap, Murat; Dogan, Umran Karabulut; Yologlu, Saim; Yilmaz, ErcanPlacenta accreta spectrum (PAS) presents a significant obstetric challenge, associated with considerable maternal and fetal-neonatal morbidity and mortality. Nevertheless, it is imperative to acknowledge that a noteworthy subset of PAS cases remains undetected until the time of delivery, thereby contributing to an augmented incidence of morbidity among the affected individuals. The delayed identification of PAS not only hinders timely intervention but also exacerbates the associated health risks for both the maternal and fetal outcomes. This underscores the urgency to innovate strategies for early PAS diagnosis. In this study, we aimed to explore plasma proteins as potential diagnostic biomarkers for PAS. Integrated transcriptome and proteomic analyses were conducted to establish a novel diagnostic approach. A cohort of 15 pregnant women diagnosed with PAS and delivering at Inonu University Faculty of Medicine between 01/04/2021 and 01/01/2023, along with a matched control group of 15 pregnant women without PAS complications, were enrolled. Plasma protein identification utilized enzymatic digestion and liquid chromatography-tandem mass spectrometry techniques. Proteomic analysis identified 228 plasma proteins, of which 85 showed significant differences (P < 0.001) between PAS and control cases. We refined this to a set of 20 proteins for model construction, resulting in a highly accurate classification model (96.9% accuracy). Notable associations were observed for proteins encoded by P01859 (Immunoglobulin heavy constant gamma 2), P02538 (Keratin type II cytoskeletal 6A), P29622 [Kallistatin (also known as Serpin A4)], P17900 (Ganglioside GM2 activator Calmodulin-like protein 5), and P01619 (Immunoglobulin kappa variable 3-20), with fold changes indicating their relevance in distinguishing PAS from control groups. In conclusion, our study has identified novel plasma proteins that could serve as potential biomarkers for early diagnosis of PAS in pregnant women. Further research and validation in larger PAS cohorts are necessary to determine the clinical utility and reliability of these proteomic biomarkers for diagnosing PAS.Öğe A Developed web-based software can easily fulfill the assumptions of correlation, classification and regression tasks in data processing(Ieee, 2019) Yasar, Seyma; Arslan, A. Kadir; Colak, Cemil; Yologlu, SaimThere are many assumptions that should be provided in regression and correlation analyses. If the assumptions are not met, the results of the analysis lead to errors. Multivariate regression analyses are performed by many software. However, many of this software are commercial and platform dependent. In this study, open source web-based software is developed to test the assumptions of simple/multiple linear regression, simple/multiple logistic regression analysis and correlation analysis, which are classification and regression techniques in machine learning. This software also provides a statistical interpretation of the results to researchers.Öğe Diffusion-weighted magnetic resonance imaging in differentiation of postobstructive consolidation from central lung carcinoma(Elsevier Science Inc, 2009) Baysal, Tamer; Mutlu, Deniz Yakar; Yologlu, SaimPurpose: To prospectively evaluate diffusion-weighted (DW) magnetic resonance (MR) imaging for differentiation of postobstructive consolidation from centrally located lung carcinomas by using apparent diffusion coefficients (ADCs). Materials and Methods: An institutional review board approved this study; informed consent was obtained from patients. Forty-nine consecutive patients (3 women, 46 men; mean age, 63.6 years; age range, 42-85 years) with lung carcinoma underwent DW MR imaging. Forty patients had central and nine patients had peripheral lung carcinomas. ADC of each lung carcinoma was calculated from DW MR images obtained with two different h Values (0, 1000 s/mm(2)). In the final Study group including 27 patients with central lung carcinoma accompanying distal lung consolidation (mean age, 67.2 years, 3 women, 24 men), ADCs Of lung carcinomas were statistically compared among cytologic/histologic types and accompanying postobstructive consolidations. Unpaired t test was used for measurable variables with normal distribution, and Kruskal-Wallis variance analysis and Mann-Whitney U tests were used for the Measurable variables without normal distribution. Results: There was no significant difference between mean ADC values of all types of carcinomas (P=.302) and also between mean ADC values of central (1.91 +/- 0.7 x 10(-3) mm(2)/s) and peripheral carcinomas (1.58 +/- 0.6 x 10(-3) mm(2)/s) (P=.224). The mean ADC value for the masses Of Central lung carcinoma with postobstructive consolidations was 1.83 +/- 0.75 x 10(-3) mm(2)/s, and for consolidation was 2.50 +/- 0.76 x 10(-3) mm(2)/s. ADC of central carcinoma masses was significantly lower than that of postobstructive consolidations (P=.003). Conclusions: A DC values of central lung I I Ling carcinoma masses appear to be lower than accompanying postobstructive consolidations. A DC values Could be considered useful as a differentiating parameter among central lung carcinomas and accompanying postobstructive consolidations. (C) 2009 Elsevier Inc. All rights reserved.
