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Öğe Abnormal glucose challenge test and mild gestational diabetes(2008) Kafkasli A.; Sertkaya A.C.; Selcuk E.B.; Dogan K.; Burak F.; Yologlu S.Objective. The status of carbohydrate metabolism of pregnant women with positive glucose challenge test (GCT), but normal oral glucose tolerance test (OGTT) and their neonates are not defined clearly. Study Design. Pregnant women with normal GCT (n: 120), with abnormal glucose challenge test (AGCT) but normal OGTT (n: 67) and with gestational diabetes (GDM, n: 67) were included into the study. Insulin sensitivity was evaluated by fasting insulin level, homeostasis model assessment of insulin resistance index (HOMA-IR); quantitative insulin check index (QUICKI) and ISOGTT. Serum insulin and glucose values during OGTT were documented. Perinatal outcome and delivery modalities were compared. Results. Both GDM (31.6±5.9 yrs) and AGCT groups (29.0±4.0 yrs) were older than controls (28.1±4.9 yrs). Body mass index (BMI) was the predominant factor affecting both AGCT and GDM groups (OR: 3.78 and 5.97 respectively). Despite there was no significance between insulin indices; serum glucose and insulin values were similarly different; macrosomic infant and caesarean section rates were higher than controls in both GDM and AGCT groups in favor of gestational diabetics (6.6% vs. 18.9%; p=0.0001 and 20% vs. 27.7% p=0.0001 respectively). Conclusion. Pregnant woman with abnormal glucose challenge test have impaired carbohydrate metabolism as in gestational diabetics with a lesser severe degree.Öğe Comparison of different retreatment techniques and root canal sealers: a scanning electron microscopic study.(2014) Simsek N.; Keles A.; Ahmetoglu F.; Ocak M.S.; Yologlu S.The aim of this study was to evaluate the effectiveness of two retreatment techniques, in terms of the operating time and scanning electron microscopy (SEM) results, in removing three different root canal sealers from root canals that were previously filled with gutta-percha. Sixty extracted single-rooted human premolars were divided into three groups and filled with iRoot SP, MM Seal, and AH Plus sealers, along with gutta-percha, through a lateral compaction technique. Root canal fillings of the samples were removed by ESI ultrasonic tips or R-Endo files. The time to reach the working length was recorded. Longitudinally sectioned samples were examined under SEM magnification. Each picture was evaluated in terms of the residual debris. Data were statistically analyzed with the Kruskall-Wallis test. No statistically significant differences were found in terms of operating time (p>0.05). Significant differences in the number of debris-free dentinal tubules were found among the root canal thirds, but this finding was not influenced by the experimental group (p<0.05). Resin sealer tags were observed inside the dentinal tubules in the MM Seal group. Under the conditions of this study, it may be established that there was no difference among the sealers and retreatment techniques.Öğe Comparison of fluconazole and ketoconazole in the treatment of superficial dermatophyte infections(1996) Dogan G.; Sasmaz S.; Ozcan A.; Senol M.; Yologlu S.Background and design.- In this study, we compared the efficacy of fluconazole and ketoconazole in dermatophytosis. Fifty six patients with superficial dermatophyte infection, were randomly given either once-weekly of oral fluconazole 150 mg, or oral ketoconazole 200 mg/d for four weeks. The efficacy of the treatment was evaluated clinically cure and direct microscopic examination at 30th, 60th and 90th day after cessation of the drug. Side effect profile was decided with patients' complaints and laboratory examination. Results.- At the end of study, 85.71% on the 30th day, 92.86% on the 60th day and 85.71% on the 90th day in the fluconazole group showed mycologic eradication; in the ketoconazole group were found 89.28%, 85.71% and 82.14%, respectively. But there was no statistical difference between the two agents. None of the patients described any subjective side effects and all laboratory examination results were normal. Conclusion.- Finally, fluconazole and ketoconazole were found to be equally effective in superficial dermatophyte infections.Öğe Comparison of itraconazole and terbinafine in the treatment of superficial dermatophyte infections(1995) Hazneci E.; Oram Y.; Yologlu S.Background and design. - In recent years, itraconazole and terbinafine have been widely used in the treatment of superficial fungal diseases. In this study, we aimed to compare the efficacy and side effects of these 2 agents. Seventy eight patients with superficial dermatophyte infection, were given either itraconazol (100 mg/d) or terbinafine (250 mg/d) for two weeks. The efficacy of the treatment was evaluated by KOH examination at 30th, 60th and 90th day after cessation of the drug. Side effect profile was decided with patients' complaints and laboratory examinations. Results. - At the end of the study 30 of 39 patients in the itraconazole group and 31 of 39 patients in the terbinafine group, completed the study. There was no statistical difference between the two treatment groups regarding the efficacy of the treatment. Conclusion. - None of the patients described any subjective side effects and all laboratory examination results were either negative or normal. Itraconazole and terbinafine were found to be equally effective in superficial dermatophyte infections.Öğe Does Systemic Isotretinoin Treatment Constitute a Predisposition to Allergic Sensitization?(NLM (Medline), 2021) Cenk H.; Kapicioglu Y.; Yologlu S.13-cis-retinoic acid (13-cRA) is a safe treatment for severe acne, as it has immunomodulatory effects such as enhancing the antigen-presenting activity of epidermal Langerhans cells (LCs) and T-cell activity. The aim of this study was to prospectively show the alteration of sensitization and irritation reactions in acne patients undergoing 13-cRA therapy. This cross-sectional descriptive study consisted of 65 severe to refractory acne patients. The standard thin-layer rapid-use epicutaneous test (T.R.U.E. test) was used to screen sensitization and irritation reactions before and after 3-month 13-cRA treatment. Patch test results after 13-cRA therapy revealed an increase in newly formed sensitization and irritation reactions. Sensitization rate was significantly higher (43.1%) in the second patch test, when compared with the first patch test results (27.7%; P = 0.002). No statistical difference was found in irritation rates. In this study, the sensitization rate was higher after treatment, which could be attributed to the greater antigen penetration due to the disrupted barrier and/or the upregulation of antigen-presenting activity in LC. This would cause a more prominent immune reaction to antigens. Based on these findings, we suggest that 13-cRA may have a sensitization effect, and physicians should be aware of this complication due to 13-cRA treatment. (SKINmed. 2021;19:-0).Öğe The effect of injury level, associated injuries, the type of nerve repair, and age on the prognosis of patients with median and ulnar nerve injuries(2005) Ertem K.; Denizhan Y.; Yologlu S.; Bora A.OBJECTIVES: In this study, we aimed to evaluate the functional results of nerve repair (median and/or ulnar) in patients with forearm clean-cut injuries and investigated the effect of injury level, associated injuries, the type of repair (primary or secondary), and age on the prognosis. METHODS: The study included 42 patients (34 males, 8 females; mean age 31 years; range 9 to 62 years) who were treated for forearm clean-cut injuries. Involvement was in the proximal forearm in four, mid-forearm in 11, and distal forearm in 27 cases. There were 51 nerve injuries affecting the median nerve (n=30) and the ulnar nerve (n=21). Nerve injuries were isolated in 12 patients, associated with tendon injuries in nine patients, and with tendon and artery injuries in 21 patients. The patients were evaluated in four age groups including 0-15, 16-30, 31-45 years, and 46 years or above. Functional evaluations were made using the Seddon classification. The effect of injury level, associated injuries, the type of repair, and age on the prognosis was assessed. The mean follow-up was 39 months (range 11 to 57 months). RESULTS: Although the clinical and functional results of primary and late-primary repairs were less favorable than those of secondary repairs, the difference did not reach a significant level (p>0.05). The injury level, associated injuries, and age did not influence the Seddon scores significantly (p>0.05). In the age group of 0-15 years, the results were very good in all the patients (100%), but good and very good results accounted for only 20% in the age group of 46 years or above. CONCLUSION: In appropriate cases with clean-cut nerve injuries, primary repair must be the first choice. Taking the low regeneration capacity into consideration, priority should be given to reconstructive procedures in patients at older ages.Öğe The investigation of polymorphisms in DNA repair genes (XRCC1, APE1 and XPD) in women with polycystic ovary syndrome(Asian Pacific Organization for Cancer Prevention, 2017) Gulbay G.; Yesilada E.; Celik O.; Yologlu S.Background: PCOS was reported to arise from the interaction of genetic and environmental factors. Some studies reported that women with PCOS have DNA damage and chromosome breakage. Such studies bring to mind the genes that are involved in DNA repairing. At present, several DNA repair genes and, as products of these genes, certain polymorphisms that alter the activity of proteins are known in the literature. The aim of this dissertation is to study the genomic instability that have been reported in PCOS cases along with the relationship between XRCC1 Arg194Trp, XRCC1 Arg399Gln, APE1 Asp148Glu, and XPD Lys751Gln polymorphisms in order to contribute to the pathogenesis of PCOS. Methods: Polymorphisms in DNA repair genes have been associated with the increased risk of various diseases and could also be related to the etiology of PCOS. Therefore, we conducted a study including 114 women with PCOS and 91 controls. These polymorphisms were determined by quantitative real time PCR and melting curve analysis using LightCycler. Results: Comparing the control groups at the end of the study, the results have not shown any statistically significant difference as far as XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XPD Lys751Gln polymorphisms are concerned. However, there were notable differences between the groups in terms of APE1 Asp148Glu polymorphism. Associated with this condition, it has been noted that both mutant allele (Glu) frequency (37.72 % in the study group; 19.23% in the control group, p=0.0001) and homozygous mutant genotype (Glu/Glu) frequency (%12.28 in the study group; %6.60 in the control group, p=0.015) have been higher in the study group.Öğe Micronucleus frequency in peripheral blood lymphocytes and exfoliated buccal cells of untreated cancer patients.(2006) Yildirim I.H.; Yesilada E.; Yologlu S.Some genetic diseases may increase the cellular instability. Since most human tumors have some genetic base, this study was undertaken for the genetic instability in cancer patients by micronucleus analysis, a mutation-screening test, which is more practical and economic technique than metaphase analysis carried out for chromosomal aberrations. Genetic changes were assessed in untreated cancer patients (lung, stomach and colon cancer) by different genotoxical screening methods; the cytokinesis-block micronucleus test and the buccal mucosa cell micronucleus test. The evaluation of micronuclei number in peripheral blood lymphocytes and buccal cells showed a genomic instability in somatic cells. There was a significant increase in the number of micronuclei in cancer patients prior to the initiation of chemotherapy, and/or radiotherapy compared with healthy human subjects. Furthermore, there was no significant difference between smokers and non-smoking groups or male and female groups. These results suggest that cancer in humans is characterized by an increase of chromosomal damage and thus, the micronucleus assay carried out here may be useful in routine cytogenetic studies of cancer.Öğe MR spectroscopy features of normal appearing white matter in patients with lung cancer(Scientific Publishers of India, 2017) Dogan A.; Sigirci A.; Ermis H.; Aytemur Z.A.; Baysal T.; Alkan A.; Yologlu S.Context: Spectroscopic imaging can be helpful to identify metabolite changes in a normal appearing brain parenchyma after MR imaging in patients with lung cancer. Aims: To detect metabolic changes in the cerebellar and cerebral normal appearing white matter with single-voxel H-MR spectroscopy (MRS) in patients with lung cancer. Methods and material: MRS was performed in the Cerebellar White Matter (CWM) and Parietal White Matter (PWM) of patients with lung cancer (n=38; age range: 44-82 y; mean age: 66.1 ± 8.7) and an age-matched control group (n=32; age range: 42-80 y; mean age: 62.9 ± 8). Biopsies of lung masses showed 25 Non-Small Cell Lung Cancer (NSCLC) and 13 Small Cell Lung Cancer (SCLC). NAA/Cr, NAA/Cho and Cho/Cr ratios were calculated. Statistical analysis used: The unpaired-t test was used for the assessment of metabolite ratio differences between patients and control subjects. Mann-Whitney U test was used among SCLC, NSCLC, and control group for the evaluation of metabolite ratio differences. Results: The Cho/Cr ratios in the CWM were significantly lower in the patients compared to controls (p=0.03). The Cho/Cr ratio of patients with SCLC was significantly lower in PWM than both NSCLC (p=0.02) and control group (p=0.03). Conclusion: Decreased Cho/Cr ratio possibly represents increased uptake of Cho or reduced brain function. These results may be important in assessing patients with lung cancer in order to help with treatment planning and prognosis. © 2017, Scientific Publishers of India, All rights reserved.Öğe Plasma endothelin-1, homocysteine and serum nitric oxide values in patients with left-to-right shunt(2004) Ozerol I.H.; Pac F.A.; Ozerol E.; Ege E.; Yologlu S.; Temel I.; Pac M.Background: This study aimed to evaluate the effect of pulmonary blood flow and pulmonary hypertension on plasma endothelin-1, homocysteine and serum nitric oxide levels in patients with left-to-right shunt lesions with pulmonary hypertension and also with normal pulmonary arterial pressure. Methods and Results: Plasma endothelin-1, homocysteine and nitric oxide levels were measured in 44 patients (Group 1) with left-to-right shunt and normal pulmonary arterial pressure (Qp/Qs: 2.1), 65 patients (Group 2) with left-to-right shunt and pulmonary hypertension (Qp/Qs: 2.4), 20 healthy control subjects (Group 3), and 17 post-operative patients (Group 4). Plasma endothelin-1 and serum nitric oxide levels were significantly higher in Group 2 than in groups 1, 3, and 4 (p<0.001). Plasma homocysteine levels were significantly higher in Group 2 than in Groups 1 and 4 (p<0.001 and p<0.01, respectively). Conclusions: The increase in serum nitric oxide levels in patients with left-to-right shunt and pulmonary hypertension may be attributed to the compensatory mechanism. However, this increase does not improve pulmonary hypertension because of increased endothelin-1 and homocysteine levels. In the light of present study, we conclude that vascular changes caused by increased homocysteine and endothelin-1 may provoke pulmonary hypertension in patients with left-to-right shunt.
