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    A CASE OF CONFINED PLACENTAL MOSAICISIVI WITH TRISOMY 15 ASSOCIATED WITH TURNER SYNDROME
    (Medecine Et Hygiene, 2016) Ekici, C.; Sahin, Y.; Yaykasli, K. O.; Melekoglu, R.; Sahin, N.; Yuksel, S.
    A case of confined placental mosaicism with trisomy 15 associated with Turner syndrome: We here present a rare case of a Turner syndrome with mosaic trisomy 15 identified on chorionic villous sampling (CVS). Although there are several reports in the literature indicating confined placental mosaicism (CPM), counseling parents of a fetus with trisomy 15 mosaicism at CVS remains difficult because of the phenotypic variability. To illuminate that condition an amniocentesis or cord blood study should be offered in conjunction with genetic counseling.
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    Genotoxic effects of tacrolimus on human lymphocyte cells
    (Maik Nauka/Interperiodica/Springer, 2012) Kurtoglu, E. L.; Yuksel, S.
    We designed in vitro study to determine possible genotoxic effects of tacrolimus (FK-506), which is used as a potent immunosuppressive drug, by using sister chromatid exchange (SCEs), chromosome aberration (CAs), micronuclei tests (MN) and cell growth kinetics such as mitotic index (MI) and replication index (RI) in human lymphocytes. The ceils were treated with 5, 25, 50, and 100 ng/ml concentrations of tacrolimus, for 24 and 48 h treatment periods. Tacrolimus induced CA and MN frequency at all concentrations for 24 and 48 h. In additon, it induced the SCE at the highest concentration for 24 h and at 25 and 100 ng/ml for 48 h. Tacrolimus decreased MI at all concentrations (except 5 ng/ml) for all treatment periods. It also inhibited the RI at 50 and 100 ng/ml concentrations for 24 h and at all concentrations for 48 h. Treatments given with tacrolimus result in the enhance of the different endpoints of genotoxicity, suggesting its mutagenic action on lymphocytes in vitro.
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    Protective effect of thymoquinone against cyclophosphamide-induced genotoxic damage in human lymphocytes
    (Comenius Univ, 2017) Yuksel, S.; Tasdemir, S.; Korkmaz, S.
    OBJECTIVE: Protective effect of thymoquinone (TQ) against the cytotoxic and genotoxic effects of cyclophosphamide (CP) was assessed in human peripheral blood lymphocyte culture. METHODS: Mitotic indices were determined as endpoints of cytotoxicity, while sister chromatid exchanges (SCE) served as endpoints of genotoxicity. Firstly, the genotoxic effect of 0.16 mu g/ml of CP was tested and CP was detected as genotoxic. In the second set, CP group was treated with 20 mu M and 40 mu M TQ. RESULTS: TQ reduced the SCE frequencies, suggesting its protective action on human lymphocytes in vitro against the CP induced genotoxic damage. CONCLUSIONS: Our results suggest that TQ produces a protective mechanism against CP-induced genetic damage, and suggest a role of DNA strand breaks in the genotoxicity (Tab. 1, Fig. 1, Ref. 19). Text in PDF www.elis.sk.