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Öğe Bipolar affective disorders related to vitamin b12 and folic acid levels(Karger, allschwılerstrasse 10, ch-4009 basel, swıtzerland, 2018) Zayman, Esra Porgali; Karlidag, Rifat; Kurnaz, AhmetÖğe Bipolar Affective Disorders Related to Vitamin B12 and Folic Acid Levels(Karger, 2018) Zayman, Esra Porgali; Karlidag, Rifat; Kurnaz, Ahmet[Abstract Not Available]Öğe Effects of preemptive intravenous paracetamol and ibuprofen on headache and myalgia in patients after electroconvulsive therapy A placebo-controlled, double-blind, randomized clinical trial(Lippincott Williams & Wilkins, 2019) Karaaslan, Erol; Akbas, Sedat; Ozkan, Ahmet Selim; Zayman, Esra PorgaliBackground: The aim of this study is to determine the efficacy of preemptive analgesia with paracetamol and ibuprofen to reduce the intensity and incidence of headache and myalgia after electroconvulsive therapy (ECT). Methods: Sixty patients with major depression who were treated with ECT were randomized to receive ECT 3 times a week. The first 3 sessions were included in the study. The patients were divided into 3 groups; Group C (Control, Saline, n = 20), Group P (Paracetamol, n = 20), and Group I (Ibuprofen, n = 20). Demographics, duration of seizure, visual analog scale (VAS) for headache and myalgia and nausea, vomiting and pruritus were evaluated at postoperative 24 hours period. Results: Duration of seizure after ECT was similar in all groups (P=.148). In the study, heart rate and mean arterial pressure were found to be some changes in some of the sessions. There were no significant differences in any comparison for all groups in all sessions regarding VAS scores for headache and myalgia. Incidence of headache and myalgia in Group I was lower than the other groups (P=.233, P=.011, respectively). But, there was no significant difference between the other groups. There was no significant difference in vomiting, intergroups, and intragroup. Conclusions: The findings of our study indicate that pain intensity of headache and myalgia did not show a significant change between groups and within groups. While pain intensity of myalgia between the groups reached no statistical significance, ibuprofen was significantly lowered the incidence of myalgia at postoperative 24 hours period.Öğe Evaluation of Transcranial Magnetic Stimulation Efficiency in Major Depressive Disorder Patients: A Magnetic Resonance Spectroscopy Study(Korean Neuropsychiatric Assoc, 2019) Erbay, Mehmet Fatih; Zayman, Esra Porgali; Erbay, Lale Gonenir; Unal, SuheylaObjective Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). This study evaluated the antidepressant effect of rTMS and examined how it affected N-asetyl aspartate (NAA), choline (Cho), creatine (Cr), lactate (Lac), inyoinositol (mins), glutamate (Glu), glutathione (GSH), and glutamine (Gln) metabolite levels in the left dorsolateral prefrontal cortex (DLPFC) of MDD patients who were not receiving antidepressant medication. Methods In total, 18 patients (10 female, 8 male) were evaluated. Each patient underwent H magnetic resonance spectroscopy (H-MRS) before and within 3 days of completion of TMS therapy. All patients completed 20 sessions of rTMS directed at the left DLPFC over a 2-week period. The Hamilton Depression Scale (HAMD) scores of patients were calculated, and their responses to treatment were assessed within 1-3 days of completion of TMS. Results We found statistically significant differences in HAMD scores before and after rTMS. Moreover, the peak metabolite ratios of NAA/Cr, GSH/Cr, and Gln/Cr were significantly higher after rTMS compared to those before rTMS. Conclusion Increased understanding of the mechanism of action of TMS will improve its application and may stimulate development of new generation therapeutic agents.Öğe IL-4, TGF-?, NF-?B and MPO levels in Patients with Treatment Resistant Schizophrenia(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2016) Kartalci, Sukru; Erbay, Lale Gonenir; Zayman, Esra Porgali; Otlu, Onder; Karabulut, Aysun Bay; Kartalci, GulsenObjective: Schizophrenia is a chronic psychotic disorder in which genetics and environmental factors such as infection and the corresponding immune response play a role in the etiopathogenesis. The aim of this study was to compare some immune factors such as nuclear factor-kappa B (NF-kappa B) activation, myeloperoxidase (MPO), the anti-inflammatory cytokine interleukin-4 (IL-4), and regulatory cytokine transforming growth factor-beta (TGF-beta) in schizophrenia patients and an age- and gender-matched control group. Method: Plasma levels of IL-4, TGF-beta, MPO, and NF-kappa B activation in 20 subjects with treatment-resistant schizophrenia and 20 age- and gender-matched healthy controls were analyzed. Disease severity was evaluated using the Brief Psychiatric Rating Scale (BPRS). Results: Plasma TGF-beta levels were found to be significantly lower and NF-kappa B to be significantly higher in antipsychotic treatment-resistant schizophrenia patients than in controls in this study. No significant differences were found between the patient and control groups for serum IL-4 and MPO levels. Conclusion: The low TGF-beta level in treatment-resistant schizophrenia patients in the symptom exacerbation period indicates that there is inadequate Th1/Th2 balance. Large-scale studies are required to investigate whether this is responsible for resistance in schizophrenia. The fact that the increase in NF-kappa B that we found in treatment resistant schizophrenia patients in this study has also been reported in the first attack in untreated schizophrenia patients in previous studies indicates that NF-kappa B plays a role in the disorder's physiopathology from the beginning.Öğe An Investgation About the Relationship Between Vasopressin and Oxytocin in Persistent Type Functional Neurological Symptom Disorder(Korean Neuropsychiatric Assoc, 2021) Ornek, Bahar Yesil; Cumurcu, Birgul Elbozan; Zayman, Esra PorgaliObjective Functional neurogical symptom disorder (FNSD) is a somatic symptom disorder with loss of voluntary motor or sensory functions, which cannot be explained by another medical condition. The study aimed to examine the relationship of vasopressin and oxytocin in persistent type FNSD. Methods This study included 27 female patients between the ages of 20-57 who were diagnosed with FNSD according to DSM-5 and 27 healthy controls matched in terms of age and gender. Serum vasopressin and oxytocin levels were measured twice on the same day in fasting blood samples and the results were compared statistically. Results Vasopressin were lower in patients compared to controls while there was no difference between oxytocin levels. Childhood traumas were more common in patient group, and mean oxytocin level was lower in patients who exposed to childhood trauma, compared to controls. No significant difference was found between the groups in terms of vasopressin. Conclusion Changes in vasopressin and oxytocin balance in the pathogenesis of persistant FNSD, may likely to lead to physiological and behavioral consequences. Lower oxytocin levels may also be a marker of exposure to childhood trauma in FNSD. These neuropeptides plays important role in neuroendocrine balance of emotional behavior. Psychiatry Investig 2021;18(10):1018-1024Öğe Investigation of the relationship between adult attention deficit hyperactivity disorder and reinforcement sensiti(Klinik Psikiyatri Dergisi, 2024) Zayman, Esra Porgali; Unal, Suheyla; Cumurcu, Hatice Birgul; Ozcan, Ozlem Ozel; Bilici, Rabia; Zayman, ErsahObjective: It is known that adult ADHD coexistence is high in patients with substance use disorder (SUD). With the prediction that the Behavioral Activation System (BAS) and Behavioral Inhibition System (BIS), which Gray suggested to underlie motivated behavior, may be effective in these two psychopathological conditions, this study investigated the relationship between BIS/DAS dimensions and ADHD symptoms in substance abusers. Method: The study included 91 male patients over the age of 18 diagnosed with substance use disorder according to DSM-5 who were admitted to the AMATEM outpatient clinic of Elazig Mental Health and Diseases Hospital for outpatient treatment and 99 male healthy controls with similar sociodemographic characteristics. Participants were given a form in which sociodemographic and substance use questions were asked and Adult Attention Deficit Hyperactivity Disorder SelfScale (BIS/BAS). Results: In our study, the prevalence of adult ADHD among substance abusers was found to be 10.1%. When the groups were compared according to the scale scores, a statistically significant difference was found between the individuals with substance use disorder and the control group according to BIS-anxiety, FFFSfear, WURS scale scores and total ASRS scores. Conclusion: Our findings suggest that in substance abusers, an attention by increasing the sense of pleasure rather than hyperactivity that impulsivity may provide.Öğe Moderator Effect of Chronic Disease on the Relationship Between Marriage Adjustment and Satisfaction in Married Couples(Pera Yayincilik Hizmetleri, 2023) Inceoglu, Feyza; Zayman, Esra PorgaliObjective: The purpose of our study is to show how the relationship between marital adjustment and satisfaction will change in cases of chronic disease in either or both spouses of married couples using a multivariate statistical analysis method. Methods: Marriage adjustment ve marriage satisfaction scales were used. A structural equation modeling - multiple group analysis method was used in the study, which was designed as a relational screening model. Results: In the study, which included 898 participants, 56.6% of the participants were female and 43.4% were male. The mean age of the participants was 36.94 +/- 8.72 standard deviations. First, the relationship between marital adjustment and satisfaction was analyzed using structural equation modeling, and the relationship between the scales was found to be statistically significant (p=0.001). In the model, which was significant and sufficient, the variable of chronic disease was coded on the arrow representing the regression coefficient between the scales, and multiple group analysis was applied. The relationship between marital adjustment and satisfaction was found to be weak among individuals with chronic diseases. The rate of marriage satisfaction explaining marriage adjustment was lower in individuals without chronic disease (R-2= 0.16) than in those without chronic disease (R-2= 0.10). While ego scores were not significant in individuals without chronic disease (p= 0.237), they were statistically significant in individuals with chronic disease (p= 0.017). Conclusion: Chronic diseases has been found to have a significant impact on the relationship between spouses. Many studies have examined the effects of chronic diseases on marriage. However, our study differs from other studies because of the analytical methods used. In the scales, it was determined whether the chronic disease showed a change in the relationship between the scales, not the scores in the chronic disease state.Öğe Neuroanatomical comparison of treatment-resistant and treatment-responsive schizophrenia patients using the cloud-based brain magnetic resonance image segmentation and parcellation system: An MRIcloud study(Elsevier Ireland Ltd, 2024) Zayman, Esra Porgali; Erbay, Mehmet FatihRecent developments in neuroimaging have improved our understanding of the biological mechanisms underlying schizophrenia. However, neuroimaging findings in treatment-resistant schizophrenia (TRS) remain unclear. In the present study, we aimed to explore potential neuroanatomical regions that may be associated with treatment resistance in schizophrenia patients by comparing neuroanatomical regions of TRS and non-TRS patients using the MRICloud method. A total of 33 schizophrenia patients (meeting DSM 5 diagnostic criteria for schizophrenia) were included in the study. Patients were dichotomized into TRS (n = 18) and non-TRS (n = 15) groups, and all patients underwent MRI. Neuroanatomical regions of TRS and non-TRS patients were compared using the MRICloud method. Disease severity was measured using the Positive and Negative Syndrome Scale (PANSS). Interestingly, a statistically significant greater left Corpus Collosum (CC) thickness was found in TRS patients compared to non-TRS patients. It is clear that further studies comparing TRS patients with non-TRS patients are needed, and these studies should focus on the circuits in the corpus callosum that are thought to play a role in treatment resistance. Further longitudinal studies are also needed to complement the crosssectional studies, using a multimodal imaging approach in the patients with clearly defined TRS criteria.Öğe Oxytocin and Vasopressin Blood Levels in People with Post-Traumatic Stress Disorder(Aves, 2023) Zayman, Esra Porgali; Karabulut, Aysun Bay; Ozdemir, Serdal; Kartalci, SukruBackground: The neuroendocrine system and the hypothalamic-pituitary-adrenal axis are among the possible neurobiological factors that may be involved in the emergence and persistence of post-traumatic stress disorder. Here, we determined the levels of vaso-pressin and oxytocin in the peripheral blood of people with post-traumatic stress disorder, investigating their correlation with post-traumatic stress disorder symptoms. Methods: The study included patients with post-traumatic stress disorder according to the Diagnostic and Statistical Manual of Mental Disorders Version 4 and healthy controls. People who accepted to participate in the study, who did not have any additional diseases, who had the ability to understand the questionnaires, and who did not use medications during the 3 months preceding the study onset were enrolled. The levels of vasopressin and oxytocin were measured using the enzyme-linked immunosorbent assay. Results:Twenty-eight subjects with post-traumatic stress disorder and 19 healthy controls were included. The 2 groups were not significantly different in terms of oxytocin blood levels (P = .481). However, subjects with post-traumatic stress disorder had a significantly lower vasopressin level than controls (P < .001). We found no significant correlations of trauma duration and scale scores with oxytocin or vasopressin levels. Conclusion: The findings of this study show that blood vasopressin may play a role in post-traumatic stress disorder. Prospective studies based on a larger number of partici-pants are warranted to clarify how neuromodulators may affect the pathogenesis of post -traumatic stress disorder.Öğe The Review of Thyroid Hormones Levels in Lithium Therapy Patients(Karger, 2018) Zayman, Esra Porgali; Karlidag, Rifat; Kurnaz, Ahmet[Abstract Not Available]Öğe The review of thyroid hormones levels in lithium therapy patients(Karger, allschwılerstrasse 10, ch-4009 basel, swıtzerland, 2018) Zayman, Esra Porgali; Karlidag, Rifat; Kurnaz, AhmetÖğe The Role of Insular Cortex in Response to Group Therapy in Vaginismus Patients: Magnetic Resonance Spectroscopy Study(Korean Neuropsychiatric Assoc, 2020) Erbay, Mehmet Fatih; Zayman, Esra PorgaliObjective Disgust has been propounded as a potential etiological factor in certain sexual dysfunctions such as vaginismus. Studies re-ports that insular cortex is activated as a response to disgust. The present study aimed to investigate the predictive role of metabolites in insular cortex in response to group therapy among vaginismus patients. Methods Study sample consisted of 51 vaginismus patients attended an ambulatory group therapy, of whom 26 benefited from 8-week group therapy and 25 were unresponsive to group therapy. All of the patients underwent H magnetic resonance spectroscopy (H-MRS), and insular cortex N-acetyl aspartate (NAA), Creatinine (Cr), Glutamine (Gln), Glutathione (GSH), Choline (Cho), Myo-inositol (mIns), Glutamate (Glu) and Lactate (Lac) concentrations were compared between the groups. Results Comparing insular cortex metabolite concentrations between the groups, Cho was statistically significantly higher (p=0.005) but mIns was significantly lower (p=0.001) in the unresponsive to group therapy group. Conclusion MR spectroscopy findings of the present study indicated significant metabolic changes such as increased Cho/Cr ratio and decreased mIns/Cr ratio in the insular cortex of vaginismus patients who were unresponsive to group therapy. Our results support the stud-ies suggesting that disgust is an important emotion in vaginismus patients and also that insula plays a role in the neurobiology of disgust.
