Tıp Fakültesi, Psikiyatri Anabilim Dalı Koleksiyonu
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Öğe Relationship between childhood trauma and suicide probability in obsessive-compulsive disorder(ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND, 2018) Erbay Gönenir, LaleThe aim of this study is to assess the relationship between childhood trauma with the probability of suicide in obsessive compulsive disorders. Sixty-seven patients who were diagnosed with OCD were included in the study out of the patients who were admitted to Malatya Training and Research Hospital psychiatry outpatient clinic. The research data were collected using Yale Brawn Obsessive Compulsive Scale (YBOCS), Beck Depression (BDS) and Beck Anxiety Scales (BAS), Childhood Trauma Questionnaire-28 (CTQ-28), and Suicide Probability Scale (SPS). CTQ was detected as 35 in 36 of 67 patients who were included in the study. Aggression (p = 0.003), sexual (p = 0.007) and religious (p = 0.023) obsessions and rituelistic (p = 0.000) compulsions were significantly higher in the group with CTQ >= 35. Mild correlation was detected between the SPS score and the scores of CTQ. Correlation remained even when the effect of BAS and BDS scores were excluded. At the end of our study, childhood traumas were found to be associated with obsessive symptoms. In the group with childhood trauma, increased suicide probability was detected independently from depression and anxiety.Öğe Toxoplasma gondii - obsessive -compulsive disorder relationship: is itdifferent in children?(Taylor & francıs ltd, 2-4 park square, mılton park, abıngdon or14 4rn, oxon, england, 2018) Miman, Ozlem; Ozcan, Ozlem; Unal, Sueheyla; Atambay, MetinBackground and aim: Obsessive-compulsive disorder (OCD) is a common neuropsychiatric illness. Although the etiology of OCD is still unknown, recent investigations have associated development of OCD with infectious illness. Toxoplasma gondii (T. gondii) is a neurotropic protozoan parasite that causes infection of the central nervous system. In the last decade, a lot of researches have focused on the possible relationship between exposure to T. gondii and neuropsychiatric disorders such as schizophrenia. Therefore, in this study, it was aimed to investigate a possible association between Toxoplasma infection and OCD in children and adolescents.Methods: We selected 55 patients with OCD (aged between 7 and 16 years) and 59 healthy children and adolescents (aged between 7 and 16 years), and investigated the seropositivity rate for anti-Toxoplasma IgG antibodies by enzyme-linked immunosorbent assay.Results: The seropositivity rate for anti-T. gondii IgG antibodies among OCD patients (21.82%) was found to be higher than the rate in control group (15.25%). However, the difference between the OCD group and the control group was not statistically significant (p>.05).Conclusion: In contrast to studies in adult patients, the results of this study do not support the relationship between T. gondii and OCD children and adolescents.Öğe Predictors of Turkish University students’ marital attitudes(Springer New York LLC, 2018) Atlı, AIn Turkey, it has been observed that marital attitudes have changed in recent years. In this study, it is aimed to examine the relationship between university students’ marital attitudes and mate selection strategies, gender roles, sex, relationship status and age variables. The sample of the study is made up of 706 (412 females, 294 males) university students. As the data collection instruments, İnönü Marital Attitude Scale, Mate Selection Strategies Inventory and Bem Sex Role Inventory were used in the study. The data analysis was performed using hierarchical regression technique. According to the study findings, virginity and physical attributes mate selection strategies, feminine gender role, age, sex and relationship status variables are significant predictors of university students’ marital attitudes. It was found that importance given to physical attributes and virginity were associated with more positive attitudes towards marriage. Having a higher level of feminine characteristics was associated with more positive attitudes towards marriage.Öğe Serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α, and ıfn-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients(article) [ilaç kullanmayan ve komorbiditesi olmayan obsesif kompulsif bozukluk hastalarında serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α ve ıfn-γ düzeyleri](Cukurova University, Faculty of Medicine, 2018) Gönenir Erbay, L.; Akti Kavuran, N.; Taşkapan, Ç.; İnce, L.U.; Yoloğlu, S.; Temelli, H.G.; Ünal, S.Objective: Increasing evidence suggests that certain inflammatory factors, especially cytokines, can lead to neurochemical and behavioural changes via their role in the brain signalling system. Studies investigating cytokine abnormalities in obsessive-compulsive disorder (OCD) have yielded conflicting results thus far. The aim of this study was to investigate the serum IL-1, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free patients with OCD. Methods: Forty comorbidity-free, drug-free OCD patients and 40 age- and sex-matched healthy volunteers were included in the study. Clinical severity was assessed using the Yale-Brown Obsessive-Compulsive Evaluation Scale (YBOCES). Results: IL-1 levels were significantly higher and IL-2, IL-6, and TNF-α levels were significantly lower in patients than in controls. No differences were observed in IL-4, IL-10, and IFN-γ levels. How-ever, a negative relationship was found between IL-1 levels and compulsive symptoms (YBOCES) in OCD patients. Conclusions: Our findings suggest the possible role of cytokines in the pathogenesis of OCD. It is important to continue investigating the role of cytokines and other immunological markers in both the etiology and treatment of OCD. © 2018, Cukurova University, Faculty of Medicine. All rights resreved.Öğe Plasma allopregnanolone levels in drug-free, comorbidity-free obsessive-compulsive disorder(Cumhurıyet unıv tıp fak psıkıyatrı anabılım dalı, cumhurıyet unıv tıp fak psıkıyatrı abd, sıvas, 58140, turkey, 2018) Ince, Lara Utku; Erbay, Lale GonenirObjective: Although there are studies in the literature focusing on the relationship between neurosteroids and psychiatric disorders, the studies on patients with obsessive-compulsive disorder (OCD) are limited in number. Nevertheless, allopregnanolone, a neurosteroid, in OCD patients has not been investigated in this limited number of studies. Allopregnanolone is considered to have a role in the pathogenesis of many psychiatric disorders. Accordingly, the present study aimed to investigate the relationship between the neurosteroid allopregnanolone and OCD. Methods: The study included 40 OCD patients diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria and 40 healthy control subjects. The study participants completed the Yale-Brown Obsessive Compulsive Scale. Taking the diurnal rhythm of neurosteroids into consideration, blood samples for determination of plasma allopregnanolone levels were obtained from all patients and controls between 09:00 and 10:00 in the morning after 12 hours of fasting, tobacco abstinence, and 30 minutes of resting period. Plasma allopregnanolone level was analyzed using the enzyme-linked immunosorbent assay (ELISA). Results: No significant difference was determined between the patient and control groups regarding serum allopregnanolone levels. Evaluation of the allopregnanolone levels of the patients for each obsession type according to its presence and absence revealed no significant difference in any of them. Evaluation of the allopregnanolone levels of the patients for each compulsion type according to its presence and absence revealed that the allopregnanolone level of the patients with counting-organizing compulsive behavior was lower than that of those without. Discussion: Although there was no difference between OCD patients and controls regarding plasma allopregnanolone level, it is difficult to make a conclusion that allopregnanolone level does not play a role in the etiopathogenesis of disease. Conducting further studies, which would analyze allopregnanolone level in materials other than plasma such as cerebrospinal fluid using multiple analyses and separately evaluates females and males with higher number of patients, is of importance to enlighten at least some aspects of allopregnanolone-OCD relationship. Moreover, significantly lower plasma allopregnanolone level particularly in a single type of compulsion brings in mind again the suggestion that different etiopathogenesis might have a role in the symptom subtypes of OCD, which has begun to be discussed in the recent years.Öğe Plasma leptin, adiponectin, neuropeptide y levels in drug naive children with adhd(Sage publıcatıons ınc, 2455 teller rd, thousand oaks, ca 91320 usa, 2018) Ozcan, Ozlem; Arslan, Muejgan; Guengoer, Serdal; Yueksel, Tugba; Selimoglu, Mukadder AyseObjective: ADHD is one of the most common childhood psychiatric disorders. Research indicates that there is some link between obesity/overweight and ADHD, though the mechanism of this association remains uncertain. It is the aim of the present study to explore the association between ADHD, obesity, and plasma leptin, neuropeptide Y (NPY), and adiponectin levels. Method: Thirty-six patients diagnosed with ADHD were included in the study. The control group consisted of 40 healthy children and adolescents who had similar age and gender features with the patient group. Plasma leptin, adiponectin, NPY levels were measured, and body mass index (BMI), weight for height, and standard deviation scores (SDS) of height, weight, and BMI were calculated. Results: No significant difference was found between patients and healthy children in terms of BMI and BMI percentile. Participants were classified into three groups according to their weight to height values. There was no significant difference between the two groups, but 10% of the control group and 30.6% of the ADHD group were classified as overweight, which was 3 times higher than the control group. The adiponectin plasma level was significantly lower and leptin/adiponectin (L/A) ratio was significantly higher in the ADHD group. There was no significant difference between serum NPY levels. In the ADHD group, the mean leptin plasma level was high, but was not statistically significant. Conclusion: We think that a low adiponectin level and high L/A ratio may be the underlying mechanism of the obesity in ADHD patients.Öğe Does psychodrama affect perceived stress, anxiety-depression scores and saliva cortisol in patientswith depression?(Korean neuropsychıatrıc assoc, rn 522, g-fıve central plaza 1685-8 seocho 4-dong, seocho-gu, seoul, 137-882, south korea, 2018) Erbay, Lale Gonenir; Reyhani, Ismail; Unal, Suheyla; Ozcan, Cemal; Ozgocer, Tuba; Ucar, Cihat; Yildiz, SedatObjective Little is known about the effects of psychodrama group therapy on the level of stress, anxiety and depression of the group members, and the biological markers of stress. The aim of this study test cortisol level as a biological reflection of some mental characteristics gained by the psychodrama method in coping with stress. Methods Depressive patients aged between 18 and 65 years, who diagnosed with depression according to DSM-5, without psychiatric comorbidity, who do not use drugs and were available for psychodrama were enrolled into the study. These patients were evaluated using the Perceived Stress Scale, State-Trait Anxiety Inventory and Beck Depression Inventory. In order to observe the circadian rhythm of cortisol, samples were collected from the participants before lunch, before dinner and before going to sleep on the day before psychodrama and on the 0, 15th, and 30th minutes after awakening in the morning of the psychodrama day; as well as just before and after the psychodrama session. Saliva cortisol level just before the initial session of psychodrama group therapy was compared with the saliva cortisol level just after the last psychodrama session at the end of 16 weeks. Results Statistically significant difference was determined between the scores of perceived stress scale, STAI-1, STAI-2, beck depression inventory and salivary cortisol level before and after psychodrama session. There was significant decrease in both the scale scores and salivary cortisol after vs. before psychodrama. Conclusion This results is important as it shows the biological aspect of clinical improvement. Further studies would provide us with better understanding of the effects of psychodrama group psychotherapy on depressive mood and biological projections by means of short-term and long-term follow-up studies.Öğe Brain tumors and atypical psychiatric symptoms: two case presentations(Yerkure tanıtım & yayıncılık hızmetlerı a s, cumhuryet cad 48-3b, harbıye, ıstanb, 34367, turkey, 2018) Akan, Mustafa; Erbay, Lale Goneni; Erbay, Mehmet Fatih; Unal, SuheylaÖğe Bipolar affective disorders related to vitamin b12 and folic acid levels(Karger, allschwılerstrasse 10, ch-4009 basel, swıtzerland, 2018) Zayman, Esra Porgali; Karlidag, Rifat; Kurnaz, AhmetÖğe Investigation of the effect of expressive touch on physiological and psychological states of intensive care patients(İnönü Üniversitesi, 2016) Özer, Nadiye; Çıtlık Sarıtaş, SeyhanThe expressive touch is a complementary treatment method with the easiest practice among the independent functions of nurses Methods: The purpose of this study was to investigate the effect of expressive touch on physiological and psychological states of intensive care patients. The study was conducted by using the pretest-posttest experimental model with control group. 76 patients (38 control-38 experimental), who received treatment in the intensive care unit since they had a myocardial infarction for the first time, were included in the study after the power analysis. The State Anxiety Inventory was applied in the experimental group 15 minutes before the touch and 15 minutes after the touch; the haemoglobin, blood pressure and pulse values were recorded. In the control group, on the other hand, the data were collected within the same duration by using the same method without touching Results: The anxiety scores and blood pressure averages of patients before and after the touch on days 1 and 2 were found to be statistically significant between groups. The difference between the mean haemoglobin values was found to be significant on day 2. The difference between the pulse averages was not statistically significant. Conclusion: The expressive touch might be effective on decreasing the anxiety, increasing the haemoglobin values and decreasing the blood pressure and pulse of patients in the intensive care unit.Öğe Alexithymia is not a good predictor of suicidal ideation in patients with social anxiety disorder(Anadolu psıkıyatrı dergısı-anatolıan journal of psychıatry, 2018) Altintas, Ebru; Ozlem Kutuk, Meryem; Tufan, Ali Evren; Gozukara Bag, HarikaObjective: This study was to determine the relation between alexithymia and suicidal ideation and factors associated with suicidal ideation in patients with social anxiety disorder (SAD). Also we determined whether alexithymia is predictor of suicidal ideation related with SAD. Methods: One hundred and sixty-four SAD (n=57), panic disorder (PD) (n=58), healthy controls (HC) (n=49) subjects (according to DSM-5) were included to study. Alexithymia was measured by Toronto Alexithymia Scale-20(TAS-20), suicidal ideation was measured by Suicidal Ideation Scale (SIS), social anxiety level were evaluated with Liebowitz Social Anxiety Scale and anxiety and depression level evaluated with Beck Depression Inventory and Beck Anxiety Inventory, State and Trait Anxiety Scales. Results: Alexithymia, the rate of was found to be 38.6% in SAD patients and 29.3% in PD patients. In SAD group, significant correlation was found between TAS 20, its factors and SIS. With path analysis, it was found that TAS 20 total scores predicted SIS scores only indirectly and via their effects on trait anxiety and subjective depressive symptoms. Conclusion: In alexithymic SAD patient's suicidal ideation may occur when comorbid depression is present. Based upon the findings alexithymia may not be a good predictor of suicidal ideation for preventing suicidal attempts in patients with social anxiety disorder.Öğe Effect of ıntracerebroventricular administration of apelin-13 on the hypothalamus-pituitary-thyroid axis and peripheral uncoupling proteins(Internatıonal journal of peptıde research and therapeutıcs, 2018) Erden, Yavuz; Tekin, Cigdem; Ozyalin, Fatma; Yilmaz, Umit; Tekin, SuatApelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus-pituitary-thyroid (HPT) axis and mechanism of action on energy metabolism is not clear. This suggests that apelin may play a role in the HPT axis and energy metabolism. This study was designed to determine possible effects of centrally administered apelin-13 on the HPT axis and energy metabolism. A total of 40 adult male Sprague Dawley rats were divided into four groups (n=10 each group). Intact rats served as control group while the sham group received vehicle of apelin. Apelin-13 was injected intracerebroventricularly at the doses of 1 and 10nmol, for 7 days in the rats in the experimental group. At the end of the experimental protocol, animals were decapitated and brain, blood, white and brown adipose tissues samples were collected. There was no significant difference between the groups in terms of hypothalamic TRH mRNA levels. Serum TSH levels were significantly higher in all groups compared to the control group (p<0.05). Serum fT3 and fT4 levels were significantly lower in apelin-13 administered groups (p<0.05). Moreover, apelin-13 administered groups had lower levels of UCP1 mRNA in white and brown adipose tissues. UCP3 mRNA expression in muscle tissue was also lower in apelin-13 treated groups (p<0.05). These results indicates that apelin-13 exhibits a decreasing effect on energy consumption through a mechanism involving the peripheral rather than central arms of the HPT axis.
