Serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α, and ıfn-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients(article) [ilaç kullanmayan ve komorbiditesi olmayan obsesif kompulsif bozukluk hastalarında serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α ve ıfn-γ düzeyleri]
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cukurova University, Faculty of Medicine
Erişim Hakkı
info:eu-repo/semantics/restrictedAccess
Özet
Objective: Increasing evidence suggests that certain inflammatory factors, especially cytokines, can lead to neurochemical and behavioural changes via their role in the brain signalling system. Studies investigating cytokine abnormalities in obsessive-compulsive disorder (OCD) have yielded conflicting results thus far. The aim of this study was to investigate the serum IL-1, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free patients with OCD. Methods: Forty comorbidity-free, drug-free OCD patients and 40 age- and sex-matched healthy volunteers were included in the study. Clinical severity was assessed using the Yale-Brown Obsessive-Compulsive Evaluation Scale (YBOCES). Results: IL-1 levels were significantly higher and IL-2, IL-6, and TNF-α levels were significantly lower in patients than in controls. No differences were observed in IL-4, IL-10, and IFN-γ levels. How-ever, a negative relationship was found between IL-1 levels and compulsive symptoms (YBOCES) in OCD patients. Conclusions: Our findings suggest the possible role of cytokines in the pathogenesis of OCD. It is important to continue investigating the role of cytokines and other immunological markers in both the etiology and treatment of OCD. © 2018, Cukurova University, Faculty of Medicine. All rights resreved.
Açıklama
Anahtar Kelimeler
Cytokines, Immunological markers, OCD
Kaynak
Anadolu Psikiyatri Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
19
Sayı
2
Künye
Gönenir Erbay, L. Akti Kavuran, N.Taşkapan, Ç. İnce, L.U. Yoloğlu, S. Temelli, H.G.Ünal, S.(2018). Serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α, and ıfn-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients(article) [ilaç kullanmayan ve komorbiditesi olmayan obsesif kompulsif bozukluk hastalarında serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α ve ıfn-γ düzeyleri]. Cilt:19. Sayı:2. 157-162 ss.
