Serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α, and ıfn-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients(article) [ilaç kullanmayan ve komorbiditesi olmayan obsesif kompulsif bozukluk hastalarında serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α ve ıfn-γ düzeyleri]

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dc.contributor.authorGönenir Erbay, L.
dc.contributor.authorAkti Kavuran, N.
dc.contributor.authorTaşkapan, Ç.
dc.contributor.authorİnce, L.U.
dc.contributor.authorYoloğlu, S.
dc.contributor.authorTemelli, H.G.
dc.contributor.authorÜnal, S.
dc.date.accessioned2019-07-19T12:13:10Z
dc.date.available2019-07-19T12:13:10Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Increasing evidence suggests that certain inflammatory factors, especially cytokines, can lead to neurochemical and behavioural changes via their role in the brain signalling system. Studies investigating cytokine abnormalities in obsessive-compulsive disorder (OCD) have yielded conflicting results thus far. The aim of this study was to investigate the serum IL-1, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free patients with OCD. Methods: Forty comorbidity-free, drug-free OCD patients and 40 age- and sex-matched healthy volunteers were included in the study. Clinical severity was assessed using the Yale-Brown Obsessive-Compulsive Evaluation Scale (YBOCES). Results: IL-1 levels were significantly higher and IL-2, IL-6, and TNF-α levels were significantly lower in patients than in controls. No differences were observed in IL-4, IL-10, and IFN-γ levels. How-ever, a negative relationship was found between IL-1 levels and compulsive symptoms (YBOCES) in OCD patients. Conclusions: Our findings suggest the possible role of cytokines in the pathogenesis of OCD. It is important to continue investigating the role of cytokines and other immunological markers in both the etiology and treatment of OCD. © 2018, Cukurova University, Faculty of Medicine. All rights resreved.en_US
dc.identifier.citationGönenir Erbay, L. Akti Kavuran, N.Taşkapan, Ç. İnce, L.U. Yoloğlu, S. Temelli, H.G.Ünal, S.(2018). Serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α, and ıfn-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients(article) [ilaç kullanmayan ve komorbiditesi olmayan obsesif kompulsif bozukluk hastalarında serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α ve ıfn-γ düzeyleri]. Cilt:19. Sayı:2. 157-162 ss.en_US
dc.identifier.doi10.5455/apd.274680en_US
dc.identifier.endpage162en_US
dc.identifier.issue2en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://hdl.handle.net/11616/12799
dc.identifier.volume19en_US
dc.language.isoenen_US
dc.publisherCukurova University, Faculty of Medicineen_US
dc.relation.ispartofAnadolu Psikiyatri Dergisien_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectCytokinesen_US
dc.subjectImmunological markersen_US
dc.subjectOCDen_US
dc.titleSerum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α, and ıfn-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients(article) [ilaç kullanmayan ve komorbiditesi olmayan obsesif kompulsif bozukluk hastalarında serum ıl-1, ıl-2, ıl-4, ıl-6, ıl-10, tnf-α ve ıfn-γ düzeyleri]en_US
dc.typeArticleen_US

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