Achillea goniocephala Extract Loaded into Nanochitosan: In Vitro Cytotoxic and Antioxidant Activity

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dc.contributor.authorTaskin, Duygu
dc.contributor.authorDogan, Murat
dc.contributor.authorErmanoglu, Mizgin
dc.contributor.authorArabaci, Turan
dc.date.accessioned2022-12-02T11:26:09Z
dc.date.available2022-12-02T11:26:09Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: The present study aimed to prepare Achillea goniocephala chloroform extract and evaluate antioxidant and cytotoxic effects. Then, the nanoparticles (NPs) were synthesized on the most efficient extracts and the biological activities of the free forms of the extracts were compared with the NPs forms. Methods: Antioxidant capacities of 14 extracts (A-N) prepared using column chromatography were determined by FRAP, DPPH and CUPRAC methods. Again, the cytotoxic activities of all fractions were evaluated on MCF-7 and HT-29 cell lines using the XTT cell viability assay. Chitosantripolyphosphate (TPP) NPs of the extracts with the most active biological properties were formed using the ionic gelation method. Results: The particle size of the NPs synthesized from the two most efficient extracts was found to be between 274.12 and 296.25 nm. The extract-encapsulation and loading-efficiency of the most active NPs were found 77.6±0.04% and 7.76±0.01% for the F extract and 10.2±0.02 and 1.39±0.07% for the H extract, respectively. Conclusions: While antioxidant activity results of chitosan NPs were close to unencapsulated extracts, cytotoxic activity results were found to be better than unencapsulated extracts. Based on these results, it is thought that it would be more effective to use the encapsulated forms of A. goniocephala instead of the raw extract of the plant in the treatment.en_US
dc.identifier.citationTAŞKIN D, DOĞAN M, ERMANOGLU M, ARABACI T (2021). Achillea goniocephala Extract Loaded into Nanochitosan: In Vitro Cytotoxic and Antioxidant Activity. Clinical and Experimental Health Sciences, 11(4), 659 - 666. 10.33808/clinexphealthsci.972180en_US
dc.identifier.doi10.33808/clinexphealthsci.972180en_US
dc.identifier.endpage666en_US
dc.identifier.issn2459-1459
dc.identifier.issue4en_US
dc.identifier.startpage659en_US
dc.identifier.trdizinid482365en_US
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.972180
dc.identifier.urihttps://hdl.handle.net/11616/85530
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/482365
dc.identifier.volume11en_US
dc.identifier.wosWOS:000743967900007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.relation.ispartofClinical and Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAchillea goniocephala Extract Loaded into Nanochitosan: In Vitro Cytotoxic and Antioxidant Activityen_US
dc.typeArticleen_US

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