Apricot attenuates oxidative stress and modulates of Bax, Bcl-2, caspases, NF?-B, AP-1, CREB expression of rats bearing DMBA-induced liver damage and treated with a combination of radiotherapy

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dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridGurocak, Asc Prof Simay/0000-0002-3707-5183
dc.authoridKıran, Tugba Raika/0000-0002-3724-0249
dc.authoridKaradag Soylu, Nese/0000-0002-6303-5484
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidGurocak, Asc Prof Simay/N-3351-2014
dc.authorwosidKıran, Tugba Raika/HFZ-9643-2022
dc.authorwosidKaradag Soylu, Nese/ABH-9544-2020
dc.authorwosidkıran, tugba/AAG-4452-2020
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorKaradag, Nese
dc.contributor.authorGurocak, Simay
dc.contributor.authorKiran, Tugba
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorSahin, Kazim
dc.date.accessioned2024-08-04T20:39:43Z
dc.date.available2024-08-04T20:39:43Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe evaluated the ability of apricot to attenuate apoptosis and oxidative stress developed during the process of 7,12-dimethylbenz[a]anthracene (DMBA) and radiotherapy in the liver of rats bearing liver damage. Fifty female Wistar rats were divided into 7 groups; (i) normal control rats; (ii) rats fed with standard diet with apricot (20%), (ii) rats fed with standard diet and administrated 6 gray radiotherapy with Co 60 device applied to a single fraction, (iv) rats fed with standard diet and administered intraperitoneally DMBA (20 mg/kg), (v) rats fed with standard diet and administered DMBA and 6 gray radiotherapy, (vi) rats fed with standard rat diet and administered DMBA and supplemented apricot, (vii) rats fed with standard diet supplemented apricot administered DMBA and radiotherapy (RT) for 6 weeks. Expression of Bax, caspase 3, and glutathione activity decreased in the liver but liver expression of NF-kappa B, AP-1, CREB, Bcl-2 and ALT, AST, 5'NT, MDA, NO levels increased in DMBA-induced liver damage rats. In conclusion, the results suggest that apricot supplementation and irradiation given in combination, offer maximum protection against DMBA-induced hepatic carcinogenesis. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipTurkish Academy of Sciences; Inonu University Scientific Research Projects Unit (IUBAP) [2011-95]en_US
dc.description.sponsorshipAuthors thank Inonu University Scientific Research Projects Unit (IUBAP) for supporting this study (2011-95). This work was also supported in part by the Turkish Academy of Sciences.en_US
dc.identifier.doi10.1016/j.fct.2014.04.036
dc.identifier.endpage133en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pmid24819963en_US
dc.identifier.scopus2-s2.0-84901776096en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage128en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2014.04.036
dc.identifier.urihttps://hdl.handle.net/11616/96468
dc.identifier.volume70en_US
dc.identifier.wosWOS:000339599800017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject7,12-Dimethylbenz[a]anthraceneen_US
dc.subjectLiver damageen_US
dc.subjectApricoten_US
dc.subjectRadiotherapyen_US
dc.subjectApoptosisen_US
dc.subjectOxidative stressen_US
dc.titleApricot attenuates oxidative stress and modulates of Bax, Bcl-2, caspases, NF?-B, AP-1, CREB expression of rats bearing DMBA-induced liver damage and treated with a combination of radiotherapyen_US
dc.typeArticleen_US

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